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Meeting Abstracts

456-P: HMGB1 Inhibition Protects Schwann Cells from High Glucose–Induced Cytotoxicity

MIN SHI, JING SONG, YANNA CHEN, WENSHA GU, YUTING LIU, HONG ZHANG

Diabetes 2022;71(Supplement_1):456-P

https://doi.org/10.2337/db22-456-P

Published: 01 June 2022

View articletitled, 456-P: HMGB1 Inhibition Protects Schwann Cells from High Glucose–Induced Cytotoxicity

Journal Articles

Cytotoxicity-Related Gene Expression and Chromatin Accessibility Define a Subset of CD4⁺ T Cells That Mark Progression to Type 1 Diabetes

Naiara G. Bediaga, Alexandra L. Garnham, Gaetano Naselli, Esther Bandala-Sanchez, Natalie L. Stone, Joanna Cobb, Jessica E. Harbison, John M. Wentworth, Annette-G. Ziegler, Jennifer J. Couper, Gordon K. Smyth, Leonard C. Harrison

Diabetes 2022;71(3):566–577

https://doi.org/10.2337/db21-0612

Published: 18 January 2022

View articletitled, Cytotoxicity-Related Gene Expression and Chromatin Accessibility Define a Subset of CD4+ T Cells That Mark Progression to Type 1 Diabetes

Journal Articles

Differentiating MHC-Dependent and -Independent Mechanisms of Lymph Node Stromal Cell Regulation of Proinsulin-Specific CD8⁺ T Cells in Type 1 Diabetes

Terri C. Thayer, Joanne Davies, James A. Pearson, Stephanie J. Hanna, Li Wen, F. Susan Wong

Diabetes 2021;70(2):529–537

https://doi.org/10.2337/db19-1050

Published: 29 November 2020

View articletitled, Differentiating MHC-Dependent and -Independent Mechanisms of Lymph Node Stromal Cell Regulation of Proinsulin-Specific CD8+ T Cells in Type 1 Diabetes

Journal Articles

VMAT2 Safeguards β-Cells Against Dopamine Cytotoxicity Under High-Fat Diet–Induced Stress

Daisuke Sakano, Fumiya Uefune, Hiraku Tokuma, Yuki Sonoda, Kumi Matsuura, Naoki Takeda, Naomi Nakagata, Kazuhiko Kume, Nobuaki Shiraki, Shoen Kume

Diabetes 2020;69(11):2377–2391

https://doi.org/10.2337/db20-0207

Published: 21 August 2020

View articletitled, VMAT2 Safeguards β-Cells Against Dopamine Cytotoxicity Under High-Fat Diet–Induced Stress

Meeting Abstracts

1673-P: Plasmablasts Contribute to the Development of Type 1 Diabetes via Enhancing T-Cell Cytotoxicity

BI YAN, QING LING, JING LU, DALONG ZHU

Diabetes 2020;69(Supplement_1):1673-P

https://doi.org/10.2337/db20-1673-P

Published: 01 June 2020

View articletitled, 1673-P: Plasmablasts Contribute to the Development of Type 1 Diabetes via Enhancing T-Cell Cytotoxicity

Journal Articles

Type 1 Interferons Potentiate Human CD8⁺ T-Cell Cytotoxicity Through a STAT4- and Granzyme B–Dependent Pathway

Brittney N. Newby, Todd M. Brusko, Baiming Zou, Mark A. Atkinson, Michael Clare-Salzler, Clayton E. Mathews

Diabetes 2017;66(12):3061–3071

https://doi.org/10.2337/db17-0106

Published: 06 September 2017

View articletitled, Type 1 Interferons Potentiate Human CD8+ T-Cell Cytotoxicity Through a STAT4- and Granzyme B–Dependent Pathway

Includes: Supplementary data

Journal Articles

Deoxysphingolipids, Novel Biomarkers for Type 2 Diabetes, Are Cytotoxic for Insulin-Producing Cells

Richard A. Zuellig, Thorsten Hornemann, Alaa Othman, Adrian B. Hehl, Heiko Bode, Tanja Güntert, Omolara O. Ogunshola, Enrica Saponara, Kamile Grabliauskaite, Jae-Hwi Jang, Udo Ungethuem, Yu Wei, Arnold von Eckardstein, Rolf Graf, Sabrina Sonda

Diabetes 2014;63(4):1326–1339

https://doi.org/10.2337/db13-1042

Published: 13 March 2014

View articletitled, Deoxysphingolipids, Novel Biomarkers for Type 2 Diabetes, Are Cytotoxic for Insulin-Producing Cells

Includes: Supplementary data

Journal Articles

Human β-Cell Killing by Autoreactive Preproinsulin-Specific CD8 T Cells Is Predominantly Granule-Mediated With the Potency Dependent Upon T-Cell Receptor Avidity

Robin R. Knight, Deborah Kronenberg, Min Zhao, Guo Cai Huang, Martin Eichmann, Anna Bulek, Linda Wooldridge, David K. Cole, Andrew K. Sewell, Mark Peakman, Ania Skowera

Diabetes 2013;62(1):205–213

https://doi.org/10.2337/db12-0315

Published: 13 December 2012

View articletitled, Human β-Cell Killing by Autoreactive Preproinsulin-Specific CD8 T Cells Is Predominantly Granule-Mediated With the Potency Dependent Upon T-Cell Receptor Avidity

Includes: Supplementary data

Journal Articles

Natural Killer Cells From Children With Type 1 Diabetes Have Defects in NKG2D-Dependent Function and Signaling

Huilian Qin, I-Fang Lee, Constadina Panagiotopoulos, Xiaoxia Wang, Alvina D. Chu, Paul J. Utz, John J. Priatel, Rusung Tan

Diabetes 2011;60(3):857–866

https://doi.org/10.2337/db09-1706

Published: 21 February 2011

View articletitled, Natural Killer Cells From Children With Type 1 Diabetes Have Defects in NKG2D-Dependent Function and Signaling

Journal Articles

Activation of Insulin-Reactive CD8 T-Cells for Development of Autoimmune Diabetes

F. Susan Wong, Lai Khai Siew, Gwen Scott, Ian J. Thomas, Stephen Chapman, Christophe Viret, Li Wen

Diabetes 2009;58(5):1156–1164

https://doi.org/10.2337/db08-0800

Published: 10 February 2009

View articletitled, Activation of Insulin-Reactive CD8 T-Cells for Development of Autoimmune Diabetes

Includes: Supplementary data

Journal Articles

Inhibition of AMP-Activated Protein Kinase Protects Pancreatic β-Cells From Cytokine-Mediated Apoptosis and CD8⁺ T-Cell–Induced Cytotoxicity

Audrey Riboulet-Chavey, Frédérique Diraison, L. Khai Siew, F. Susan Wong, Guy A. Rutter

Diabetes 2008;57(2):415–423

https://doi.org/10.2337/db07-0993

Published: 01 February 2008

View articletitled, Inhibition of AMP-Activated Protein Kinase Protects Pancreatic β-Cells From Cytokine-Mediated Apoptosis and CD8+ T-Cell–Induced Cytotoxicity

Journal Articles

In Vivo Cytotoxicity of Insulin-Specific CD8⁺ T-Cells in HLA-A*0201 Transgenic NOD Mice

Irene Jarchum, Jason C. Baker, Tatsuya Yamada, Toshiyuki Takaki, Michele P. Marron, David V. Serreze, Teresa P. DiLorenzo

Diabetes 2007;56(10):2551–2560

https://doi.org/10.2337/db07-0332

Published: 01 October 2007

View articletitled, In Vivo Cytotoxicity of Insulin-Specific CD8+ T-Cells in HLA-A*0201 Transgenic NOD Mice

Journal Articles

Pro- and Antiapoptotic Proteins Regulate Apoptosis but Do Not Protect Against Cytokine-Mediated Cytotoxicity in Rat Islets and β-Cell Lines

J. Jason Collier, Patrick T. Fueger, Hans E. Hohmeier, Christopher B. Newgard

Diabetes 2006;55(5):1398–1406

https://doi.org/10.2337/db05-1000

Published: 01 May 2006

View articletitled, Pro- and Antiapoptotic Proteins Regulate Apoptosis but Do Not Protect Against Cytokine-Mediated Cytotoxicity in Rat Islets and β-Cell Lines

Journal Articles

Complete Protection Against Interleukin-1β–Induced Functional Suppression and Cytokine-Mediated Cytotoxicity in Rat Pancreatic Islets In Vitro Using an Interleukin-1 Cytokine Trap

Tobias Rydgren, Daniel Bengtsson, Stellan Sandler

Diabetes 2006;55(5):1407–1412

https://doi.org/10.2337/db05-1273

Published: 01 May 2006

View articletitled, Complete Protection Against Interleukin-1β–Induced Functional Suppression and Cytokine-Mediated Cytotoxicity in Rat Pancreatic Islets In Vitro Using an Interleukin-1 Cytokine Trap

Journal Articles

A Salen-Manganese Catalytic Free Radical Scavenger Inhibits Type 1 Diabetes and Islet Allograft Rejection

Angelica P. Olcott, Georges Tocco, Jide Tian, Dan Zekzer, Jon Fukuto, Louis Ignarro, Daniel L. Kaufman

Diabetes 2004;53(10):2574–2580

https://doi.org/10.2337/diabetes.53.10.2574

Published: 01 October 2004

View articletitled, A Salen-Manganese Catalytic Free Radical Scavenger Inhibits Type 1 Diabetes and Islet Allograft Rejection

Journal Articles

An Insulin-Degrading Enzyme Inhibitor Decreases Amylin Degradation, Increases Amylin-Induced Cytotoxicity, and Increases Amyloid Formation in Insulinoma Cell Cultures

Robert G. Bennett, Frederick G. Hamel, William C. Duckworth

Diabetes 2003;52(9):2315–2320

https://doi.org/10.2337/diabetes.52.9.2315

Published: 01 September 2003

View articletitled, An Insulin-Degrading Enzyme Inhibitor Decreases Amylin Degradation, Increases Amylin-Induced Cytotoxicity, and Increases Amyloid Formation in Insulinoma Cell Cultures

Journal Articles

While Tinkering With the β-Cell… Metabolic Regulatory Mechanisms and New Therapeutic Strategies: American Diabetes Association Lilly Lecture, 2001

Christopher B. Newgard

Diabetes 2002;51(11):3141–3150

https://doi.org/10.2337/diabetes.51.11.3141

Published: 01 November 2002

View articletitled, While Tinkering With the β-Cell… Metabolic Regulatory Mechanisms and New Therapeutic Strategies: American Diabetes Association Lilly Lecture, 2001

Journal Articles

Inverse Relationship Between Cytotoxicity of Free Fatty Acids in Pancreatic Islet Cells and Cellular Triglyceride Accumulation

Miriam Cnop, Jean Claude Hannaert, Anne Hoorens, Décio L. Eizirik, Daniel G. Pipeleers

Diabetes 2001;50(8):1771–1777

https://doi.org/10.2337/diabetes.50.8.1771

Published: 01 August 2001

View articletitled, Inverse Relationship Between Cytotoxicity of Free Fatty Acids in Pancreatic Islet Cells and Cellular Triglyceride Accumulation

Meeting Abstracts

Selection of insulinoma cell lines with resistance to interleukin-1beta- and gamma-interferon-induced cytotoxicity.

G Chen, H E Hohmeier, R Gasa, V V Tran, C B Newgard

Diabetes 2000;49(4):562–570

https://doi.org/10.2337/diabetes.49.4.562

Published: 01 April 2000

View articletitled, Selection of insulinoma cell lines with resistance to interleukin-1beta- and gamma-interferon-induced cytotoxicity.

Journal Articles

STZ Transport and Cytotoxicity: Specific Enhancement in GLUT2-Expressing Cells

Wolfgang J Schnedl, Sarah Ferber, John H Johnson, Christopher B Newgard

Diabetes 1994;43(11):1326–1333

https://doi.org/10.2337/diab.43.11.1326

Published: 01 November 1994

View articletitled, STZ Transport and Cytotoxicity: Specific Enhancement in GLUT2-Expressing Cells

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456-P: HMGB1 Inhibition Protects Schwann Cells from High Glucose–Induced Cytotoxicity

Cytotoxicity-Related Gene Expression and Chromatin Accessibility Define a Subset of CD4⁺ T Cells That Mark Progression to Type 1 Diabetes

Differentiating MHC-Dependent and -Independent Mechanisms of Lymph Node Stromal Cell Regulation of Proinsulin-Specific CD8⁺ T Cells in Type 1 Diabetes

VMAT2 Safeguards β-Cells Against Dopamine Cytotoxicity Under High-Fat Diet–Induced Stress

1673-P: Plasmablasts Contribute to the Development of Type 1 Diabetes via Enhancing T-Cell Cytotoxicity

Type 1 Interferons Potentiate Human CD8⁺ T-Cell Cytotoxicity Through a STAT4- and Granzyme B–Dependent Pathway

Deoxysphingolipids, Novel Biomarkers for Type 2 Diabetes, Are Cytotoxic for Insulin-Producing Cells

Human β-Cell Killing by Autoreactive Preproinsulin-Specific CD8 T Cells Is Predominantly Granule-Mediated With the Potency Dependent Upon T-Cell Receptor Avidity

Natural Killer Cells From Children With Type 1 Diabetes Have Defects in NKG2D-Dependent Function and Signaling

Activation of Insulin-Reactive CD8 T-Cells for Development of Autoimmune Diabetes

Inhibition of AMP-Activated Protein Kinase Protects Pancreatic β-Cells From Cytokine-Mediated Apoptosis and CD8⁺ T-Cell–Induced Cytotoxicity

In Vivo Cytotoxicity of Insulin-Specific CD8⁺ T-Cells in HLA-A*0201 Transgenic NOD Mice

Pro- and Antiapoptotic Proteins Regulate Apoptosis but Do Not Protect Against Cytokine-Mediated Cytotoxicity in Rat Islets and β-Cell Lines

Complete Protection Against Interleukin-1β–Induced Functional Suppression and Cytokine-Mediated Cytotoxicity in Rat Pancreatic Islets In Vitro Using an Interleukin-1 Cytokine Trap

A Salen-Manganese Catalytic Free Radical Scavenger Inhibits Type 1 Diabetes and Islet Allograft Rejection

An Insulin-Degrading Enzyme Inhibitor Decreases Amylin Degradation, Increases Amylin-Induced Cytotoxicity, and Increases Amyloid Formation in Insulinoma Cell Cultures

While Tinkering With the β-Cell… Metabolic Regulatory Mechanisms and New Therapeutic Strategies: American Diabetes Association Lilly Lecture, 2001

Inverse Relationship Between Cytotoxicity of Free Fatty Acids in Pancreatic Islet Cells and Cellular Triglyceride Accumulation

Selection of insulinoma cell lines with resistance to interleukin-1beta- and gamma-interferon-induced cytotoxicity.

STZ Transport and Cytotoxicity: Specific Enhancement in GLUT2-Expressing Cells

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