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Meeting Abstracts

1808-PUB: Effective and Durable Stem-Cell-Enabled Therapy of Autoimmune T1DM in Rodents and Dogs Provides the Scientific Basis for the First-in-Human Trial Using I.P. Administered “Neo-Islets,” 3-D Organoids of Allogeneic Islet, and Mesenchymal Stromal Cells—The Omentum Becomes the New Endocrine Pancreas without the Need for Antirejection Drugs

ANNA GOOCH, CHRISTOF WESTENFELDER

Diabetes 2023;72(Supplement_1):1808-PUB

https://doi.org/10.2337/db23-1808-PUB

Published: 23 June 2023

View article titled, 1808-PUB: Effective and Durable Stem-Cell-Enabled Therapy of Autoimmune T1DM in Rodents and Dogs Provides the Scientific Basis for the First-in-Human Trial Using I.P. Administered “Neo-Islets,” 3-D Organoids of Allogeneic Islet, and Mesenchymal Stromal Cells—The Omentum Becomes the New Endocrine Pancreas without the Need for Antirejection Drugs

Meeting Abstracts

831-P: Allogeneic Neo-Islets (NIs), an Immune-Privileged Cellular Therapy for T1DM, Is Safe and Effective in Spontaneously Diabetic Pet Dogs, Reducing Insulin Need by up to 50% over Three Years

ANNA GOOCH, CHRISTOF WESTENFELDER

Diabetes 2023;72(Supplement_1):831-P

https://doi.org/10.2337/db23-831-P

Published: 20 June 2023

View article titled, 831-P: Allogeneic Neo-Islets (NIs), an Immune-Privileged Cellular Therapy for T1DM, Is Safe and Effective in Spontaneously Diabetic Pet Dogs, Reducing Insulin Need by up to 50% over Three Years

Meeting Abstracts

89-LB: Oral Delivery of a GLP-1 Agonist with High Bioavailability in Dogs and Humans

APRIL T. VO, ALYSON YAMAGUCHI, ARVINDER DHALLA, KYLE HORLEN, LEONARD FUNG, BABER SYED, MIR IMRAN, MIR HASHIM

Diabetes 2023;72(Supplement_1):89-LB

https://doi.org/10.2337/db23-89-LB

Published: 20 June 2023

View article titled, 89-LB: Oral Delivery of a GLP-1 Agonist with High Bioavailability in Dogs and Humans

Journal Articles

Profound Sensitivity of the Liver to the Direct Effect of Insulin Allows Peripheral Insulin Delivery to Normalize Hepatic but Not Muscle Glucose Uptake in the Healthy Dog

Guillaume Kraft, Katie C. Coate, Marta Smith, Ben Farmer, Melanie Scott, Jon Hastings, Alan D. Cherrington, Dale S. Edgerton

Diabetes 2023;72(2):196–209

https://doi.org/10.2337/db22-0471

Published: 24 October 2022

View article titled, Profound Sensitivity of the Liver to the Direct Effect of Insulin Allows Peripheral Insulin Delivery to Normalize Hepatic but Not Muscle Glucose Uptake in the Healthy Dog

Meeting Abstracts

841-P: Scientific Basis for the First-in-Human Trial of “Neo-Islet”–Mediated Functional Cure of T1DM: The Intraperitoneal Administration of “Neo-Islets,” 3-D Organoids of Allogeneic Islet and Mesenchymal Stromal Cells from Rodents, Dogs, and Humans Durably Cures

CHRISTOF WESTENFELDER, SABIHA S. CHOWDHURY, ANNA GOOCH

Diabetes 2022;71(Supplement_1):841-P

https://doi.org/10.2337/db22-841-P

Published: 01 June 2022

View article titled, 841-P: Scientific Basis for the First-in-Human Trial of “Neo-Islet”–Mediated Functional Cure of T1DM: The Intraperitoneal Administration of “Neo-Islets,” 3-D Organoids of Allogeneic Islet and Mesenchymal Stromal Cells from Rodents, Dogs, and Humans Durably Cures

Meeting Abstracts

120-OR: Dapagliflozin Increases Adiponectin and Its Receptors, and Reduces Inflammation and Ceramide Synthesis Enzymes in the Obese Prediabetic Dog

MORVARID KABIR, RICHARD N. BERGMAN, V. SASHI GOPAUL, HSIUCHIUNG YANG, CATHRYN M. KOLKA

Diabetes 2021;70(Supplement_1):120-OR

https://doi.org/10.2337/db21-120-OR

Published: 01 June 2021

View article titled, 120-OR: Dapagliflozin Increases Adiponectin and Its Receptors, and Reduces Inflammation and Ceramide Synthesis Enzymes in the Obese Prediabetic Dog

Meeting Abstracts

202-LB: Reduced Glucose Effectiveness Exacerbates Impaired Glucose Tolerance in Prediabetic Dogs

CATHRYN M. KOLKA, JAY PORTER, MARILYN ADER, RICHARD N. BERGMAN

Diabetes 2021;70(Supplement_1):202-LB

https://doi.org/10.2337/db21-202-LB

Published: 01 June 2021

View article titled, 202-LB: Reduced Glucose Effectiveness Exacerbates Impaired Glucose Tolerance in Prediabetic Dogs

Journal Articles

The Importance of the Mechanisms by Which Insulin Regulates Meal-Associated Liver Glucose Uptake in the Dog

Guillaume Kraft, Katie C. Coate, Marta Smith, Ben Farmer, Melanie Scott, Alan D. Cherrington, Dale S. Edgerton

Diabetes 2021;70(6):1292–1302

https://doi.org/10.2337/db20-1271

Published: 23 March 2021

View article titled, The Importance of the Mechanisms by Which Insulin Regulates Meal-Associated Liver Glucose Uptake in the Dog

Meeting Abstracts

1711-P: Dapagliflozin Promotes Adipose Beiging and Lipolysis and Reduces Adipocyte Size in the Obese Prediabetic Dog

MORVARID KABIR, RICHARD N. BERGMAN, FRANCESCA PICCININI, DARKO STEFANOVSKI, V. SASHI GOPAUL, HSIU-CHIUNG YANG, CATHRYN M. KOLKA

Diabetes 2020;69(Supplement_1):1711-P

https://doi.org/10.2337/db20-1711-P

Published: 01 June 2020

View article titled, 1711-P: Dapagliflozin Promotes Adipose Beiging and Lipolysis and Reduces Adipocyte Size in the Obese Prediabetic Dog

Meeting Abstracts

1951-P: Glucose Effectiveness Fails to Compensate for Insulin Resistance after Fat Feeding in Dogs

MARILYN ADER, CATHRYN M. KOLKA, RICHARD N. BERGMAN

Diabetes 2020;69(Supplement_1):1951-P

https://doi.org/10.2337/db20-1951-P

Published: 01 June 2020

View article titled, 1951-P: Glucose Effectiveness Fails to Compensate for Insulin Resistance after Fat Feeding in Dogs

Meeting Abstracts

614-P: Optimal Control of Glucose and Lipid Profiles Is Critical to the Effective “Neo-Islet” Therapy of Insulin Dependent Pet Dogs

ANNA GOOCH, SABIHA S. CHOWDHURY, CHRISTOF WESTENFELDER

Diabetes 2019;68(Supplement_1):614-P

https://doi.org/10.2337/db19-614-P

Published: 01 June 2019

View article titled, 614-P: Optimal Control of Glucose and Lipid Profiles Is Critical to the Effective “Neo-Islet” Therapy of Insulin Dependent Pet Dogs

Meeting Abstracts

125-LB: An Ingestible Capsule to Deliver Parenteral Pharmaceuticals into the Jejunal Wall

Diabetes 2019;68(Supplement_1):125-LB

https://doi.org/10.2337/db19-125-LB

Published: 01 June 2019

View article titled, 125-LB: An Ingestible Capsule to Deliver Parenteral Pharmaceuticals into the Jejunal Wall

Meeting Abstracts

262-OR: INAD 012-776 Pilot Study: Allogeneic “Neo-Islets,” Composed of Mesenchymal Stem and Islet Cells, Are Immune Protected and Dose-Dependently and Durably Control Autoimmune T1DM in Pet Dogs

CHRISTOF WESTENFELDER, SABIHA S. CHOWDHURY, ANNA GOOCH

Diabetes 2019;68(Supplement_1):262-OR

https://doi.org/10.2337/db19-262-OR

Published: 01 June 2019

View article titled, 262-OR: INAD 012-776 Pilot Study: Allogeneic “Neo-Islets,” Composed of Mesenchymal Stem and Islet Cells, Are Immune Protected and Dose-Dependently and Durably Control Autoimmune T1DM in Pet Dogs

Meeting Abstracts

2307-PUB: VN-B101: A New, Promising Drug Candidate for the Treatment of Diabetes

HUI-LING CHEN, PEI-RAN WANG

Diabetes 2019;68(Supplement_1):2307-PUB

https://doi.org/10.2337/db19-2307-PUB

Published: 01 June 2019

View article titled, 2307-PUB: VN-B101: A New, Promising Drug Candidate for the Treatment of Diabetes

Journal Articles

Sympathetic Denervation of the Common Hepatic Artery Lessens Glucose Intolerance in the Fat- and Fructose-Fed Dog

Guillaume Kraft, Anthony Vrba, Melanie Scott, Eric Allen, Dale S. Edgerton, Phil E. Williams, Scott B. Vafai, Bobak R. Azamian, Alan D. Cherrington

Diabetes 2019;68(6):1143–1155

https://doi.org/10.2337/db18-1209

Published: 01 April 2019

View article titled, Sympathetic Denervation of the Common Hepatic Artery Lessens Glucose Intolerance in the Fat- and Fructose-Fed Dog

Meeting Abstracts

Intraperitoneally Administered Neo-islets, Aggregates of Mesenchymal Stem Cells, and Cultured Islet Cells Improve Glycemic Control of Spontaneously Occurring Insulin-Dependent Diabetes Mellitus in Pet Dogs—A Pilot Study, INAD 012-776

CHRISTOF WESTENFELDER, ANNA GOOCH, NATASHA K. LOY SON, NICOLE AVILA, JULIE R. FISCHER

Diabetes 2018;67(Supplement_1):1746-P

https://doi.org/10.2337/db18-1746-P

Published: 01 July 2018

View article titled, Intraperitoneally Administered Neo-islets, Aggregates of Mesenchymal Stem Cells, and Cultured Islet Cells Improve Glycemic Control of Spontaneously Occurring Insulin-Dependent Diabetes Mellitus in Pet Dogs—A Pilot Study, INAD 012-776

Meeting Abstracts

Evidence of CB1-Receptor Antagonism in Fat-Fed Dogs Promoting Beiging of Adipose Tissue Mainly via Activation of Sarco/Endoplasmic Reticulum Ca2+ ATPase 2b and Ryanodine Receptor 2

REBECCA L. PASZKIEWICZ, RICHARD N. BERGMAN, JOYCE M. RICHEY, MALINI S. IYER, ORISON O. WOOLCOTT, CATHRYN M. KOLKA, DEBORAH CLEGG, MORVARID KABIR

Diabetes 2018;67(Supplement_1):2010-P

https://doi.org/10.2337/db18-2010-P

Published: 01 July 2018

View article titled, Evidence of CB1-Receptor Antagonism in Fat-Fed Dogs Promoting Beiging of Adipose Tissue Mainly via Activation of Sarco/Endoplasmic Reticulum Ca2+ ATPase 2b and Ryanodine Receptor 2

Journal Articles

Morning Hyperinsulinemia Primes the Liver for Glucose Uptake and Glycogen Storage Later in the Day

Mary Courtney Moore, Marta S. Smith, Ben Farmer, Katie C. Coate, Guillaume Kraft, Masakazu Shiota, Phillip E. Williams, Alan D. Cherrington

Diabetes 2018;67(7):1237–1245

https://doi.org/10.2337/db17-0979

Published: 17 April 2018

View article titled, Morning Hyperinsulinemia Primes the Liver for Glucose Uptake and Glycogen Storage Later in the Day

Journal Articles

Engineering Glucose Responsiveness Into Insulin

Diabetes 2018;67(2):299–308

https://doi.org/10.2337/db17-0577

Published: 02 November 2017

View article titled, Engineering Glucose Responsiveness Into Insulin

Includes: Supplementary data

Journal Articles

Comparative Pathogenesis of Autoimmune Diabetes in Humans, NOD Mice, and Canines: Has a Valuable Animal Model of Type 1 Diabetes Been Overlooked?

Allison L. O’Kell, Clive Wasserfall, Brian Catchpole, Lucy J. Davison, Rebecka S. Hess, Jake A. Kushner, Mark A. Atkinson

Diabetes 2017;66(6):1443–1452

https://doi.org/10.2337/db16-1551

Published: 15 May 2017

View article titled, Comparative Pathogenesis of Autoimmune Diabetes in Humans, NOD Mice, and Canines: Has a Valuable Animal Model of Type 1 Diabetes Been Overlooked?

NARROW

831-P: Allogeneic Neo-Islets (NIs), an Immune-Privileged Cellular Therapy for T1DM, Is Safe and Effective in Spontaneously Diabetic Pet Dogs, Reducing Insulin Need by up to 50% over Three Years

89-LB: Oral Delivery of a GLP-1 Agonist with High Bioavailability in Dogs and Humans

Profound Sensitivity of the Liver to the Direct Effect of Insulin Allows Peripheral Insulin Delivery to Normalize Hepatic but Not Muscle Glucose Uptake in the Healthy Dog

841-P: Scientific Basis for the First-in-Human Trial of “Neo-Islet”–Mediated Functional Cure of T1DM: The Intraperitoneal Administration of “Neo-Islets,” 3-D Organoids of Allogeneic Islet and Mesenchymal Stromal Cells from Rodents, Dogs, and Humans Durably Cures

120-OR: Dapagliflozin Increases Adiponectin and Its Receptors, and Reduces Inflammation and Ceramide Synthesis Enzymes in the Obese Prediabetic Dog

202-LB: Reduced Glucose Effectiveness Exacerbates Impaired Glucose Tolerance in Prediabetic Dogs

The Importance of the Mechanisms by Which Insulin Regulates Meal-Associated Liver Glucose Uptake in the Dog

1711-P: Dapagliflozin Promotes Adipose Beiging and Lipolysis and Reduces Adipocyte Size in the Obese Prediabetic Dog

1951-P: Glucose Effectiveness Fails to Compensate for Insulin Resistance after Fat Feeding in Dogs

614-P: Optimal Control of Glucose and Lipid Profiles Is Critical to the Effective “Neo-Islet” Therapy of Insulin Dependent Pet Dogs

125-LB: An Ingestible Capsule to Deliver Parenteral Pharmaceuticals into the Jejunal Wall

262-OR: INAD 012-776 Pilot Study: Allogeneic “Neo-Islets,” Composed of Mesenchymal Stem and Islet Cells, Are Immune Protected and Dose-Dependently and Durably Control Autoimmune T1DM in Pet Dogs

2307-PUB: VN-B101: A New, Promising Drug Candidate for the Treatment of Diabetes

Sympathetic Denervation of the Common Hepatic Artery Lessens Glucose Intolerance in the Fat- and Fructose-Fed Dog

Intraperitoneally Administered Neo-islets, Aggregates of Mesenchymal Stem Cells, and Cultured Islet Cells Improve Glycemic Control of Spontaneously Occurring Insulin-Dependent Diabetes Mellitus in Pet Dogs—A Pilot Study, INAD 012-776

Evidence of CB1-Receptor Antagonism in Fat-Fed Dogs Promoting Beiging of Adipose Tissue Mainly via Activation of Sarco/Endoplasmic Reticulum Ca2+ ATPase 2b and Ryanodine Receptor 2

Morning Hyperinsulinemia Primes the Liver for Glucose Uptake and Glycogen Storage Later in the Day

Engineering Glucose Responsiveness Into Insulin

Comparative Pathogenesis of Autoimmune Diabetes in Humans, NOD Mice, and Canines: Has a Valuable Animal Model of Type 1 Diabetes Been Overlooked?

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