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Journal Articles

No evidence for persistent enteroviral B infection of pancreatic islets in type 1 diabetic and pre-diabetic patients from RNA-Seq data

Elisabetta Manduchi, PhD, Héléne C. Descamps, PhD, Jonathan Schug, PhD, Tong Da, PhD, Deeksha Lahori, MS, Hilana El-Mekkoussi, BS, Michael R. Betts, PhD, Klaus H. Kaestner, PhD
Journal: Diabetes
Diabetes db240076
https://doi.org/10.2337/db24-0076
Published: 31 July 2024
View article titled, No evidence for persistent enteroviral B infection of pancreatic islets in type 1 diabetic and pre-diabetic patients from RNA-Seq data
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Journal Articles

Optogenetics in pancreatic islets: Actuators and effects

Christina G Gangemi, Harald Janovjak
Journal: Diabetes
Diabetes db231022
https://doi.org/10.2337/db23-1022
Published: 08 July 2024
View article titled, Optogenetics in pancreatic islets: Actuators and effects
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Journal Articles

Cell-Surface ZnT8 Antibody Prevents and Reverses Autoimmune Diabetes in Mice

Devi Kasinathan, Zheng Guo, Dylan C. Sarver, G. William Wong, Shumei Yun, Aaron W. Michels, Liping Yu, Chandan Sona, Matthew N. Poy, Maria L. Golson, Dax Fu
Journal: Diabetes
Diabetes 2024;73(5):806–818
https://doi.org/10.2337/db23-0568
Published: 22 February 2024
View article titled, Cell-Surface ZnT8 Antibody Prevents and Reverses Autoimmune Diabetes in Mice
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Journal Articles

DNA Methylation–Based Assessment of Cell Composition in Human Pancreas and Islets

Zeina Drawshy, Daniel Neiman, Ori Fridlich, Ayelet Peretz, Judith Magenheim, Andrea V. Rozo, Nicolai M. Doliba, Doris A. Stoffers, Klaus H. Kaestner, Desmond A. Schatz, Clive Wasserfall, Martha Campbell-Thompson, James Shapiro, Tommy Kaplan, Ruth Shemer, Benjamin Glaser, Agnes Klochendler, Yuval Dor
Journal: Diabetes
Diabetes 2024;73(4):554–564
https://doi.org/10.2337/db23-0704
Published: 24 January 2024
View article titled, DNA Methylation–Based Assessment of Cell Composition in Human Pancreas and Islets
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Journal Articles

Local Dialogues Between the Endocrine and Exocrine Cells in the Pancreas

Marjan Slak Rupnik, Manami Hara
Journal: Diabetes
Diabetes 2024;73(4):533–541
https://doi.org/10.2337/db23-0760
Published: 12 January 2024
View article titled, Local Dialogues Between the Endocrine and Exocrine Cells in the Pancreas
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Journal Articles

Bridging the Gap: Pancreas Tissue Slices From Organ and Tissue Donors for the Study of Diabetes Pathogenesis

Christian M. Cohrs, Chunguang Chen, Mark A. Atkinson, Denise M. Drotar, Stephan Speier
Journal: Diabetes
Diabetes 2024;73(1):11–22
https://doi.org/10.2337/dbi20-0018
Published: 20 December 2023
View article titled, Bridging the Gap: Pancreas Tissue Slices From Organ and Tissue Donors for the Study of Diabetes Pathogenesis
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Journal Articles

Overexpression of UBE2E2 in Mouse Pancreatic β-Cells Leads to Glucose Intolerance via Reduction of β-Cell Mass

Yoshitaka Sakurai, Naoto Kubota, Iseki Takamoto, Nobuhiro Wada, Masakazu Aihara, Takanori Hayashi, Tetsuya Kubota, Yuta Hiraike, Takayoshi Sasako, Harumi Nakao, Atsu Aiba, Yoko Chikaoka, Takeshi Kawamura, Takashi Kadowaki, Toshimasa Yamauchi
Journal: Diabetes
Diabetes 2024;73(3):474–489
https://doi.org/10.2337/db23-0150
Published: 08 December 2023
View article titled, Overexpression of UBE2E2 in Mouse Pancreatic β-Cells Leads to Glucose Intolerance via Reduction of β-Cell Mass
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Journal Articles

RFX6 Maintains Gene Expression and Function of Adult Human Islet α-Cells

Vy M.N. Coykendall, Mollie F. Qian, Krissie Tellez, Austin Bautista, Romina J. Bevacqua, Xueying Gu, Yan Hang, Martin Neukam, Weichen Zhao, Charles Chang, Patrick E. MacDonald, Seung K. Kim
Journal: Diabetes
Diabetes 2024;73(3):448–460
https://doi.org/10.2337/db23-0483
Published: 08 December 2023
View article titled, RFX6 Maintains Gene Expression and Function of Adult Human Islet α-Cells
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Journal Articles

Single-Cell Transcriptome Profiling of Pancreatic Islets From Early Diabetic Mice Identifies Anxa10 for Ca2+ Allostasis Toward β-Cell Failure

Kaori Motomura, Takashi Matsuzaka, Shigeyuki Shichino, Tatsuro Ogawa, Hao Pan, Takuya Nakajima, Yasuhito Asano, Toshitsugu Okayama, Tomoyo Takeuchi, Hiroshi Ohno, Song-iee Han, Takafumi Miyamoto, Yoshinori Takeuchi, Motohiro Sekiya, Hirohito Sone, Naoya Yahagi, Yoshimi Nakagawa, Tatsuya Oda, Satoshi Ueha, Kazuho Ikeo, Atsushi Ogura, Kouji Matsushima, Hitoshi Shimano
Journal: Diabetes
Diabetes 2024;73(1):75–92
https://doi.org/10.2337/db23-0212
Published: 23 October 2023
View article titled, Single-Cell Transcriptome Profiling of Pancreatic Islets From Early Diabetic Mice Identifies Anxa10 for Ca<sup>2+</sup> Allostasis Toward β-Cell Failure
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Journal Articles

Association of Serum Very-Long-Chain Saturated Fatty Acids With Changes in Insulin Sensitivity and β-Cell Function: The Prospective Metabolism and Islet Cell Evaluation (PROMISE) Cohort

Kira Zhi Hua Lai, Zhila Semnani-Azad, Beatrice A. Boucher, Ravi Retnakaran, Stewart B. Harris, Vasanti Malik, Richard P. Bazinet, Anthony J. Hanley
Journal: Diabetes
Diabetes 2023;72(11):1664–1670
https://doi.org/10.2337/db22-1050
Published: 16 August 2023
View article titled, Association of Serum Very-Long-Chain Saturated Fatty Acids With Changes in Insulin Sensitivity and β-Cell Function: The Prospective Metabolism and Islet Cell Evaluation (PROMISE) Cohort
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Journal Articles

An Integrated Map of Cell Type–Specific Gene Expression in Pancreatic Islets

Ruth M. Elgamal, Parul Kudtarkar, Rebecca L. Melton, Hannah M. Mummey, Paola Benaglio, Mei-Lin Okino, Kyle J. Gaulton
Journal: Diabetes
Diabetes 2023;72(11):1719–1728
https://doi.org/10.2337/db23-0130
Published: 15 August 2023
View article titled, An Integrated Map of Cell Type–Specific Gene Expression in Pancreatic Islets
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Journal Articles

An Enhancer Within Abcb11 Regulates G6pc2 in C57BL/6 Mouse Pancreatic Islets

Mark P. Keller, Emily M. Hawes, Kathryn L. Schueler, Donnie S. Stapleton, Kelly A. Mitok, Shane P. Simonett, James K. Oeser, Leesa L. Sampson, Alan D. Attie, Mark A. Magnuson, Richard M. O’Brien
Journal: Diabetes
Diabetes 2023;72(11):1621–1628
https://doi.org/10.2337/db23-0215
Published: 08 August 2023
View article titled, An Enhancer Within <em>Abcb11</em> Regulates <em>G6pc2</em> in C57BL/6 Mouse Pancreatic Islets
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Journal Articles

Optimization of a Glucagon-Like Peptide 1 Receptor Antagonist Antibody for Treatment of Hyperinsulinism

Sean M. Peterson, Christine A. Juliana, Cameron F. Hu, Jinghua Chai, Carson Holliday, Kara Y. Chan, Ana G. Lujan Hernandez, Zoe Challocombe, Linya Wang, Zhen Han, Nikhil Haas, Ryan Stafford, Fumiko Axelrod, Tom Z. Yuan, Diva D. De León, Aaron K. Sato
Journal: Diabetes
Diabetes 2023;72(9):1320–1329
https://doi.org/10.2337/db22-1039
Published: 26 June 2023
View article titled, Optimization of a Glucagon-Like Peptide 1 Receptor Antagonist Antibody for Treatment of Hyperinsulinism
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Meeting Abstracts

836-P: Glucose-Dependent Insulin Production and Insulin-Independence in Type 1 Diabetes from Stem Cell–Derived, Fully Differentiated Islet Cells—Updated Data from the VX-880 Clinical Trial

TREVOR W. REICHMAN, CAMILLO RICORDI, ALI NAJI, JAMES F. MARKMANN, BRUCE A. PERKINS, MARTIN WIJKSTROM, STEVEN PARASKEVAS, BOTE BRUINSMA, GAUTHAM MARIGOWDA, JUDY L. SHIH, CHENKUN WANG, DOUGLAS MELTON, FELICIA PAGLIUCA, BASTIANO SANNA, LESLIE S. KEAN, ANNE L. PETERS, PIOTR WITKOWSKI, MICHAEL R. RICKELS
Journal: Diabetes
Diabetes 2023;72(Supplement_1):836-P
https://doi.org/10.2337/db23-836-P
Published: 23 June 2023
View article titled, 836-P: Glucose-Dependent Insulin Production and Insulin-Independence in Type 1 Diabetes from Stem Cell–Derived, Fully Differentiated Islet Cells—Updated Data from the VX-880 Clinical Trial
Meeting Abstracts

1808-PUB: Effective and Durable Stem-Cell-Enabled Therapy of Autoimmune T1DM in Rodents and Dogs Provides the Scientific Basis for the First-in-Human Trial Using I.P. Administered “Neo-Islets,” 3-D Organoids of Allogeneic Islet, and Mesenchymal Stromal Cells—The Omentum Becomes the New Endocrine Pancreas without the Need for Antirejection Drugs

ANNA GOOCH, CHRISTOF WESTENFELDER
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1808-PUB
https://doi.org/10.2337/db23-1808-PUB
Published: 23 June 2023
View article titled, 1808-PUB: Effective and Durable Stem-Cell-Enabled Therapy of Autoimmune T1DM in Rodents and Dogs Provides the Scientific Basis for the First-in-Human Trial Using I.P. Administered “Neo-Islets,” 3-D Organoids of Allogeneic Islet, and Mesenchymal Stromal Cells—The Omentum Becomes the New Endocrine Pancreas without the Need for Antirejection Drugs
Meeting Abstracts

1513-P: IAPP25 in Beta Cells and DNSP11 in Alpha Cells Inhibit IAPP37 Fibrillation

QING-RONG LIU, MIN ZHU, JOSEPHINE M. EGAN
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1513-P
https://doi.org/10.2337/db23-1513-P
Published: 20 June 2023
View article titled, 1513-P: IAPP25 in Beta Cells and DNSP11 in Alpha Cells Inhibit IAPP37 Fibrillation
Meeting Abstracts

1777-P: Three-Dimensional Imaging Reveals Pancreatic Islet Fast Calcium Wave Origin Formation

YI YU
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1777-P
https://doi.org/10.2337/db23-1777-P
Published: 20 June 2023
View article titled, 1777-P: Three-Dimensional Imaging Reveals Pancreatic Islet Fast Calcium Wave Origin Formation
Meeting Abstracts

229-LB: Generation of Human CAR-Treg Cells for Inducing Immunological Tolerance against Diabetogenic T Cells in Human Pancreatic Islets

SHAHNAWAZ IMAM, SHAFIYA IMTIAZ RAFIQI, JUAN C. JAUME
Journal: Diabetes
Diabetes 2023;72(Supplement_1):229-LB
https://doi.org/10.2337/db23-229-LB
Published: 20 June 2023
View article titled, 229-LB: Generation of Human CAR-Treg Cells for Inducing Immunological Tolerance against Diabetogenic T Cells in Human Pancreatic Islets
Meeting Abstracts

135-OR: Mapping Cis-Regulatory Programs Affecting Diabetes Risk in Pancreatic Islet Cell Types Using Single-Cell Multimodal Profiling

HANNAH MUMMEY, WESTON ELISON, KATHA KORGAONKAR, YUN S. LEE, JACKLYN M. NEWSOME ASHMUS, PAOLA BENAGLIO, MICHAEL T. MILLER, JOCELYN E. MANNING FOX, ANNA L. GLOYN, PATRICK MACDONALD, SEBASTIAN PREISSL, KYLE J. GAULTON
Journal: Diabetes
Diabetes 2023;72(Supplement_1):135-OR
https://doi.org/10.2337/db23-135-OR
Published: 20 June 2023
View article titled, 135-OR: Mapping Cis-Regulatory Programs Affecting Diabetes Risk in Pancreatic Islet Cell Types Using Single-Cell Multimodal Profiling
Meeting Abstracts

1739-P: Ontogeny of Bihormonal Islet Cells within the Human Pancreas

JIWON HAHM, JUAN A. FERNANDEZ ANDRADE, EDITH ARANY, DAVID J. HILL
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1739-P
https://doi.org/10.2337/db23-1739-P
Published: 20 June 2023
View article titled, 1739-P: Ontogeny of Bihormonal Islet Cells within the Human Pancreas