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Meeting Abstracts

1630-P: Reduced Fatty Acid Oxidation Does Not Prevent Intralipid-Induced Peripheral Insulin Resistance in Humans

MELANIE B. GILLINGHAM, ASHLEY N. GREGOR, OLEG VARLAMOV, JACOB J. ROBINO, CARRIE E. MCCURDY, KEENAN T. GREYSLAK, DONGSEOK CHOI, ERIC BAETSCHER, WILLIAM ROONEY, JONATHAN Q. PURNELL
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1630-P
https://doi.org/10.2337/db23-1630-P
Published: 20 June 2023
View article titled, 1630-P: Reduced Fatty Acid Oxidation Does Not Prevent Intralipid-Induced Peripheral Insulin Resistance in Humans
Meeting Abstracts

226-OR: Reduced Fatty Acid Oxidation Prevents Intralipid-Induced Hepatic Insulin Resistance in Humans

JONATHAN Q. PURNELL, ASHLEY N. GREGOR, DONGSEOK CHOI, ERIC BAETSCHER, WILLIAM ROONEY, CARY O. HARDING, MELANIE B. GILLINGHAM
Journal: Diabetes
Diabetes 2022;71(Supplement_1):226-OR
https://doi.org/10.2337/db22-226-OR
Published: 01 June 2022
View article titled, 226-OR: Reduced Fatty Acid Oxidation Prevents Intralipid-Induced Hepatic Insulin Resistance in Humans
Meeting Abstracts

379-P: Aldose Reductase Inhibition by AT-001 Prevents Diabetic Cardiomyopathy via Reducing Myocardial Fatty Acid Oxidation Rates

KESHAV GOPAL, QUTUBA G. KARWI, SEYED AMIRHOSSEIN TABATABAEI DAKHILI, CORY S. WAGG, RICCARDO PERFETTI, RAVICHANDRAN RAMASAMY, JOHN R. USSHER, GARY LOPASCHUK
Journal: Diabetes
Diabetes 2021;70(Supplement_1):379-P
https://doi.org/10.2337/db21-379-P
Published: 01 June 2021
View article titled, 379-P: Aldose Reductase Inhibition by AT-001 Prevents Diabetic Cardiomyopathy via Reducing Myocardial Fatty Acid Oxidation Rates
Journal Articles

SGLT2 Inhibition Does Not Affect Myocardial Fatty Acid Oxidation or Uptake, but Reduces Myocardial Glucose Uptake and Blood Flow in Individuals With Type 2 Diabetes: A Randomized Double-Blind, Placebo-Controlled Crossover Trial

Katrine M. Lauritsen, Bent R.R. Nielsen, Lars P. Tolbod, Mogens Johannsen, Jakob Hansen, Troels K. Hansen, Henrik Wiggers, Niels Møller, Lars C. Gormsen, Esben Søndergaard
Journal: Diabetes
Diabetes 2021;70(3):800–808
https://doi.org/10.2337/db20-0921
Published: 17 December 2020
View article titled, SGLT2 Inhibition Does Not Affect Myocardial Fatty Acid Oxidation or Uptake, but Reduces Myocardial Glucose Uptake and Blood Flow in Individuals With Type 2 Diabetes: A Randomized Double-Blind, Placebo-Controlled Crossover Trial
Open the PDF for SGLT2 Inhibition Does Not Affect Myocardial Fatty Acid Oxidation or Uptake, but Reduces Myocardial Glucose Uptake and Blood Flow in Individuals With Type 2 Diabetes: A Randomized Double-Blind, Placebo-Controlled Crossover Trial in another window
Meeting Abstracts

410-P: Effects of Palmitate and Oleate on Apoptosis, Autophagy, Stress, Kinase Phosphorylation, and Enzymes of Fatty Acid Oxidation in Human Cardiac Progenitor Cells from Control and Diabetic Subjects

LUIGI LAVIOLA, ROSSELLA SCHIPANI, ROSSELLA DORIA, CRISTINA CACCIOPPOLI, ANNA LEONARDINI, ANNALISA NATALICCHIO, SEBASTIO PERRINI, ANGELO CIGNARELLI, FRANCESCO GIORGINO
Journal: Diabetes
Diabetes 2020;69(Supplement_1):410-P
https://doi.org/10.2337/db20-410-P
Published: 01 June 2020
View article titled, 410-P: Effects of Palmitate and Oleate on Apoptosis, Autophagy, Stress, Kinase Phosphorylation, and Enzymes of Fatty Acid Oxidation in Human Cardiac Progenitor Cells from Control and Diabetic Subjects
Meeting Abstracts

1823-P: Bromocriptine (BC) Normalizes Elevated Expression of Liver Genes Involved in Fatty Acid Oxidation, Lipogenesis, Inflammation, and Endoplasmic Reticulum (ER) Stress and Glucose Intolerance of High-Fat/Sucrose Diet-Fed Rats

YAHONG ZHANG, MICHAEL EZROKHI, NICHOLAS COMINOS, ANTHONY H. CINCOTTA
Journal: Diabetes
Diabetes 2020;69(Supplement_1):1823-P
https://doi.org/10.2337/db20-1823-P
Published: 01 June 2020
View article titled, 1823-P: Bromocriptine (BC) Normalizes Elevated Expression of Liver Genes Involved in Fatty Acid Oxidation, Lipogenesis, Inflammation, and Endoplasmic Reticulum (ER) Stress and Glucose Intolerance of High-Fat/Sucrose Diet-Fed Rats
Meeting Abstracts

700-P: Mechanism for the Beneficial Effects of Maternal Exercise to Improve Offspring Metabolic Health

JOJI KUSUYAMA, ANA B. WAGNER, ROYCE H. CONLIN, NATHAN S. MAKAREWICZ, MAGNUS MØLLER, EMILY M. MIELE, ROELAND MIDDELBEEK, NIELS JESSEN, PER G. OVESEN, MICHAEL F. HIRSHMAN, KRISTI B. ADAMO, EVA N. GRAYCK, LAURIE J. GOODYEAR
Journal: Diabetes
Diabetes 2020;69(Supplement_1):700-P
https://doi.org/10.2337/db20-700-P
Published: 01 June 2020
View article titled, 700-P: Mechanism for the Beneficial Effects of Maternal Exercise to Improve Offspring Metabolic Health
Meeting Abstracts

1945-P: The Mitochondrial Protein DRP1 Is Required for Endogenous Fatty Acid Oxidation

WILLIAM T. KING, CHRISTOPHER L. AXELROD, GANGARAO DAVULURI, ROBERT C. NOLAND, JOHN P. KIRWAN
Journal: Diabetes
Diabetes 2019;68(Supplement_1):1945-P
https://doi.org/10.2337/db19-1945-P
Published: 01 June 2019
View article titled, 1945-P: The Mitochondrial Protein DRP1 Is Required for Endogenous Fatty Acid Oxidation
Meeting Abstracts

Reprograming of Human Adipocytes to a Briter Phenotype—Enhanced Fatty Acid Oxidation and Lipid Droplet Remodeling

MI-JEONG LEE, SUKANTA JASH, VISHWAJEET PURI, SUSAN K. FRIED
Journal: Diabetes
Diabetes 2018;67(Supplement_1):272-OR
https://doi.org/10.2337/db18-272-OR
Published: 01 July 2018
View article titled, Reprograming of Human Adipocytes to a Briter Phenotype—Enhanced Fatty Acid Oxidation and Lipid Droplet Remodeling
Meeting Abstracts

Skeletal Muscle Dysfunction and Metabolic Abnormalities in Individuals with Familial Partial Lipodystrophy Is Associated with Diminished Mitochondrial Fatty Acid Oxidation

VINAYA SIMHA, IAN R. LANZA, NATHAN LEBRASSEUR, KATHERINE KLAUS, JOHN PORT, MARCELLO C. LAURENTI, CLAUDIO COBELLI, K. SREEKUMARAN NAIR
Journal: Diabetes
Diabetes 2018;67(Supplement_1):1925-P
https://doi.org/10.2337/db18-1925-P
Published: 01 July 2018
View article titled, Skeletal Muscle Dysfunction and Metabolic Abnormalities in Individuals with Familial Partial Lipodystrophy Is Associated with Diminished Mitochondrial Fatty Acid Oxidation
Journal Articles

Hepatic ATF6 Increases Fatty Acid Oxidation to Attenuate Hepatic Steatosis in Mice Through Peroxisome Proliferator–Activated Receptor α

Xuqing Chen, Feifei Zhang, Qi Gong, Aoyuan Cui, Shu Zhuo, Zhimin Hu, Yamei Han, Jing Gao, Yixuan Sun, Zhengshuai Liu, Zhongnan Yang, Yingying Le, Xianfu Gao, Lily Q. Dong, Xin Gao, Yu Li
Journal: Diabetes
Diabetes 2016;65(7):1904–1915
https://doi.org/10.2337/db15-1637
Published: 12 April 2016
View article titled, Hepatic ATF6 Increases Fatty Acid Oxidation to Attenuate Hepatic Steatosis in Mice Through Peroxisome Proliferator–Activated Receptor α
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Includes: Supplementary data
Journal Articles

Tissue-Specific Inactivation of Type 2 Deiodinase Reveals Multilevel Control of Fatty Acid Oxidation by Thyroid Hormone in the Mouse. Diabetes 2014;63: 1594–1604

Tatiana L. Fonseca, Joao Pedro Werneck-De-Castro, Melany Castillo, Barbara M.L.C. Bocco, Gustavo W. Fernandes, Elizabeth A. McAninch, Daniele L. Ignacio, Caio C.S. Moises, Alexandre Ferreira, Balázs Gereben, Antonio C. Bianco
Journal: Diabetes
Diabetes 2014;63(8):2895
https://doi.org/10.2337/db14-er08
Published: 17 July 2014
View article titled, Tissue-Specific Inactivation of Type 2 Deiodinase Reveals Multilevel Control of Fatty Acid Oxidation by Thyroid Hormone in the Mouse. Diabetes 2014;63: 1594–1604
Open the PDF for Tissue-Specific Inactivation of Type 2 Deiodinase Reveals Multilevel Control of Fatty Acid Oxidation by Thyroid Hormone in the Mouse. Diabetes 2014;63: 1594–1604 in another window
Journal Articles

Tissue-Specific Inactivation of Type 2 Deiodinase Reveals Multilevel Control of Fatty Acid Oxidation by Thyroid Hormone in the Mouse

Tatiana L. Fonseca, Joao Pedro Werneck-De-Castro, Melany Castillo, Barbara M.L.C. Bocco, Gustavo W. Fernandes, Elizabeth A. McAninch, Daniele L. Ignacio, Caio C.S. Moises, Alexander R. Ferreira, Balázs Gereben, Antonio C. Bianco
Journal: Diabetes
Diabetes 2014;63(5):1594–1604
https://doi.org/10.2337/db13-1768
Published: 12 April 2014
View article titled, Tissue-Specific Inactivation of Type 2 Deiodinase Reveals Multilevel Control of Fatty Acid Oxidation by Thyroid Hormone in the Mouse
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Includes: Supplementary data
Journal Articles

HSP72 Is a Mitochondrial Stress Sensor Critical for Parkin Action, Oxidative Metabolism, and Insulin Sensitivity in Skeletal Muscle

Brian G. Drew, Vicente Ribas, Jamie A. Le, Darren C. Henstridge, Jennifer Phun, Zhenqi Zhou, Teo Soleymani, Pedram Daraei, Daniel Sitz, Laurent Vergnes, Jonathan Wanagat, Karen Reue, Mark A. Febbraio, Andrea L. Hevener
Journal: Diabetes
Diabetes 2014;63(5):1488–1505
https://doi.org/10.2337/db13-0665
Published: 12 April 2014
View article titled, HSP72 Is a Mitochondrial Stress Sensor Critical for Parkin Action, Oxidative Metabolism, and Insulin Sensitivity in Skeletal Muscle
Open the PDF for HSP72 Is a Mitochondrial Stress Sensor Critical for Parkin Action, Oxidative Metabolism, and Insulin Sensitivity in Skeletal Muscle in another window
Includes: Supplementary data
Journal Articles

Cdc2-Like Kinase 2 Suppresses Hepatic Fatty Acid Oxidation and Ketogenesis Through Disruption of the PGC-1α and MED1 Complex

Mitsuhisa Tabata, Joseph T. Rodgers, Jessica A. Hall, Yoonjin Lee, Mark P. Jedrychowski, Steven P. Gygi, Pere Puigserver
Journal: Diabetes
Diabetes 2014;63(5):1519–1532
https://doi.org/10.2337/db13-1304
Published: 12 April 2014
View article titled, Cdc2-Like Kinase 2 Suppresses Hepatic Fatty Acid Oxidation and Ketogenesis Through Disruption of the PGC-1α and MED1 Complex
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Includes: Supplementary data
Journal Articles

VASP Increases Hepatic Fatty Acid Oxidation by Activating AMPK in Mice

Sanshiro Tateya, Norma Rizzo-De Leon, Priya Handa, Andrew M. Cheng, Vicki Morgan-Stevenson, Kayoko Ogimoto, Jenny E. Kanter, Karin E. Bornfeldt, Guenter Daum, Alexander W. Clowes, Alan Chait, Francis Kim
Journal: Diabetes
Diabetes 2013;62(6):1913–1922
https://doi.org/10.2337/db12-0325
Published: 17 May 2013
View article titled, VASP Increases Hepatic Fatty Acid Oxidation by Activating AMPK in Mice
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Includes: Supplementary data
Journal Articles

Mitochondrial Deficiency Is Associated With Insulin Resistance

Bret H. Goodpaster
Journal: Diabetes
Diabetes 2013;62(4):1032–1035
https://doi.org/10.2337/db12-1612
Published: 14 March 2013
View article titled, Mitochondrial Deficiency Is Associated With Insulin Resistance
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Journal Articles

Blocking the Entrance to Open the Gate

Patrick Schrauwen, Silvie Timmers, Matthijs K.C. Hesselink
Journal: Diabetes
Diabetes 2013;62(3):703–705
https://doi.org/10.2337/db12-1663
Published: 14 February 2013
View article titled, Blocking the Entrance to Open the Gate
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Journal Articles

Inhibition of Carnitine Palmitoyltransferase-1 Activity Alleviates Insulin Resistance in Diet-Induced Obese Mice

Wendy Keung, John R. Ussher, Jagdip S. Jaswal, Monique Raubenheimer, Victoria H.M. Lam, Cory S. Wagg, Gary D. Lopaschuk
Journal: Diabetes
Diabetes 2013;62(3):711–720
https://doi.org/10.2337/db12-0259
Published: 14 February 2013
View article titled, Inhibition of Carnitine Palmitoyltransferase-1 Activity Alleviates Insulin Resistance in Diet-Induced Obese Mice
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Includes: Supplementary data
Journal Articles

Nonthyrotoxic Prevention of Diet-Induced Insulin Resistance by 3,5-Diiodo-L-Thyronine in Rats

Pieter de Lange, Federica Cioffi, Rosalba Senese, Maria Moreno, Assunta Lombardi, Elena Silvestri, Rita De Matteis, Lillà Lionetti, Maria Pina Mollica, Fernando Goglia, Antonia Lanni
Journal: Diabetes
Diabetes 2011;60(11):2730–2739
https://doi.org/10.2337/db11-0207
Published: 17 October 2011
View article titled, Nonthyrotoxic Prevention of Diet-Induced Insulin Resistance by 3,5-Diiodo-<sc>L</sc>-Thyronine in Rats
Open the PDF for Nonthyrotoxic Prevention of Diet-Induced Insulin Resistance by 3,5-Diiodo-<sc>L</sc>-Thyronine in Rats in another window