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Meeting Abstracts

227-OR: Disruption of Adipocyte YAP Improves Glucose Homeostasis in Mice and Decreases Adipose Tissue Fibrosis

DANIEL JONG JIN HAN, RUKHSANA ASLAM, TANVI OJHA, DARREN YUEN, CYNTHIA T. LUK

Diabetes 2022;71(Supplement_1):227-OR

DOI: https://doi.org/10.2337/db22-227-OR

Published: 01 June 2022

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Meeting Abstracts

1374-P: In Type 2 Diabetes, the Exocrine Pancreas Has Greater Fibrosis, Fat, Metaplastic Changes, and Microangiopathy

JORDAN J. WRIGHT, ADEL ESKAROS, ANNIKA L. WINDON, DIANE C. SAUNDERS, RITA BOTTINO, HUMAN PANCREAS ANALYSIS PROGRAM, MARCELA BRISSOVA, ALVIN C. POWERS

Diabetes 2022;71(Supplement_1):1374-P

DOI: https://doi.org/10.2337/db22-1374-P

Published: 01 June 2022

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Meeting Abstracts

1121-P: The Combination of the ELF and FIB-4 Scores Have High Predictive Performance for Significant or Advanced Fibrosis in Patients with NAFLD

ZOBAIR YOUNOSSI, SEAN FELIX, THOMAS JEFFERS, ELENA YOUNOSSI, FATEMA NADER, ANDREI RACILA, BRIAN P. LAM, MARIA STEPANOVA

Diabetes 2022;71(Supplement_1):1121-P

DOI: https://doi.org/10.2337/db22-1121-P

Published: 01 June 2022

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Meeting Abstracts

821-P: Randomized Clinical Trial on the Renoprotective Effect of CU01-10in Patients with Diabetic Kidney Disease (DKD)

JUN SUNG MOON, KYU CHANG WON, MIN-JI KIM, IN-KYU LEE, SO HEE KWON, JUNG-IN PYO, JI-HYE KANG, YOUNG-GUEN KWON, HEEWON SEO

Diabetes 2022;71(Supplement_1):821-P

DOI: https://doi.org/10.2337/db22-821-P

Published: 01 June 2022

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Meeting Abstracts

736-P: Effect of Semaglutide on Liver Steatosis/Fibrosis Indexes in Patients with Diabetes and Obesity

JUANA CARRETERO GOMEZ, FRANCISCO JAVIER CARRASCO-SÁNCHEZ, JOSE MARIA FERNANDEZ, PEDRO CASADO, PANISH SOCIETY OF INTERNAL MEDICINE DIABETES, NUTRITION AND OBESITY WORKING GROUP OF S, JOSE CARLOS AREVALO LORIDO, JOSE PABLO MIRAMONTES GONZÁLEZ, JOSÉ MIGUEL SEGÍ-RIPOLL, JAVIER ENA

Diabetes 2022;71(Supplement_1):736-P

DOI: https://doi.org/10.2337/db22-736-P

Published: 01 June 2022

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Meeting Abstracts

735-P: Direct Anti-Inflammatory and Antifibrotic Effects of a Novel Long-Acting Glucagon/GIP/GLP-1 Triple Agonist, HM15211, in Thioacetamide-Induced Mouse Model of Liver Injury and Fibrosis

JUNG KUK KIM, JONG SUK LEE, YOHAN KIM, SEON MYEONG LEE, HYUNJOO KWON, EUNJIN PARK, JAEHYUK CHOI, SUNGMIN BAE, DAEJIN KIM, SANG HYUN LEE, IN YOUNG CHOI

Diabetes 2022;71(Supplement_1):735-P

DOI: https://doi.org/10.2337/db22-735-P

Published: 01 June 2022

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Meeting Abstracts

1117-P: High Rate of Histologically Proven NASH and Advanced Fibrosis in Outpatients with Type 2 Diabetes Screened for NAFLD

JEAN-FRANÇOIS GAUTIER, LAURENT CASTERA, TIPHAINE VIDAL-TRECAN, VALERIE PARADIS, THIERRY POYNARD, SEBASTIEN CZERNICHOW, BENOIT TERRIS, PAULINE MANCHON, DOMINIQUE ROULOT, HELENE BIHAN, JEAN-BAPTISTE JULLA, ETIENNE LARGER, STANISLAS POL, PIERRE BEDOSSA, CEDRIC LAOUENAN, DOMINIQUE C. VALLA

Diabetes 2022;71(Supplement_1):1117-P

DOI: https://doi.org/10.2337/db22-1117-P

Published: 01 June 2022

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Meeting Abstracts

408-P: Fibrosis 4 Index Related to Microalbuminuria in Tibetan Patients with T2D and NAFLD

CHENGHUI ZHANG

Diabetes 2022;71(Supplement_1):408-P

DOI: https://doi.org/10.2337/db22-408-P

Published: 01 June 2022

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Meeting Abstracts

1207-P: Hepatic Steatosis Index and Fibrosis-4 Scores in Relation to Cardiometabolic Risk in Healthy Offspring of Parents with Type 2 Diabetes

BRIGIDA COLON BARRETO, KRISHMITA SIWAKOTI, CHIMAROKE EDEOGA, SOTONTE EBENIBO, SAMUEL DAGOGO-JACK

Diabetes 2022;71(Supplement_1):1207-P

DOI: https://doi.org/10.2337/db22-1207-P

Published: 01 June 2022

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Meeting Abstracts

1206-P: Association of Hepatic Steatosis Index (HSI) and Fibrosis (Fib) -4 Score with Prediabetes Risk in the POP-ABC Study: Potential Mechanisms

BRIGIDA COLON BARRETO, SOTONTE EBENIBO, SAMUEL DAGOGO-JACK

Diabetes 2022;71(Supplement_1):1206-P

DOI: https://doi.org/10.2337/db22-1206-P

Published: 01 June 2022

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Meeting Abstracts

160-LB: Age-Related Adipose Tissue Fibrosis and Neuropathy in the Genetically Diverse HET3 Mouse

JAKE WILLOWS, GARGI MISHRA, MAGDALENA BLASZKIEWICZ, KRISTY L. TOWNSEND

Diabetes 2022;71(Supplement_1):160-LB

DOI: https://doi.org/10.2337/db22-160-LB

Published: 01 June 2022

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Meeting Abstracts

387-P: Novel Mitochondrial Complex I Modulator Reduces Diabetes-Associated Expression of Inflammation and Fibrosis Markers in Human Proximal Tubular Epithelial Cells

ARA ABOOLIAN, SOFIA URNER, MICHAEL RODEN, KARIN JANDELEIT-DAHM

Diabetes 2022;71(Supplement_1):387-P

DOI: https://doi.org/10.2337/db22-387-P

Published: 01 June 2022

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Meeting Abstracts

1451-P: Peri-Islet Fibrosis in Cystic Fibrosis Is Associated with Altered Alpha-Cell Phenotype

NICOLE KATTNER, YARA AL-SELWI, DINA TINIAKOS, GÜNTER KLÖPPEL, JAMES A. SHAW

Diabetes 2022;71(Supplement_1):1451-P

DOI: https://doi.org/10.2337/db22-1451-P

Published: 01 June 2022

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Journal Articles

Independent of Renox, NOX5 Promotes Renal Inflammation and Fibrosis in Diabetes by Activating ROS-Sensitive Pathways

Jay C. Jha, Aozhi Dai, Jessica Garzarella, Amelia Charlton, Sofia Urner, Jakob A. Østergaard, Jun Okabe, Chet E. Holterman, Alison Skene, David A. Power, Elif I. Ekinci, Melinda T. Coughlan, Harald H.H.W. Schmidt, Mark E. Cooper, Rhian M. Touyz, Chris R. Kennedy, Karin Jandeleit-Dahm

Diabetes 2022;71(6):1282–1298

DOI: https://doi.org/10.2337/db21-1079

Published: 11 March 2022

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Meeting Abstracts

952-P: Deranged Liver Enzyme Levels and Indices of Hepatic Steatosis and Fibrosis on the Development of Gestational Diabetes

THORA Y.L. CHAI, DHARMINTRA PASUPATHY, JACOB GEORGE, N. WAH CHEUNG

Diabetes 2021;70(Supplement_1):952-P

DOI: https://doi.org/10.2337/db21-952-P

Published: 01 June 2021

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Meeting Abstracts

656-P: Antifibrotic Potential of a Novel Long-Acting Glucagon/GIP/GLP-1 Triple Agonist (HM15211) in Preclinical Models of Fibrosis

JUNG KUK KIM, JONG SUK LEE, SEON MYEONG LEE, HYUNJOO KWON, JAEHYUK CHOI, EUNJIN PARK, SUNGMIN BAE, DAEJIN KIM, YOUNG HOON KIM, IN YOUNG CHOI

Diabetes 2021;70(Supplement_1):656-P

DOI: https://doi.org/10.2337/db21-656-P

Published: 01 June 2021

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Meeting Abstracts

1174-P: Application of NIS4 Technology for Stand-Alone and Sequential Identification of At-Risk NASH or Advanced Fibrosis in Nondiabetic, Prediabetic, and Type 2 Diabetic Patients

CHRISTIAN ROSENQUIST, YACINE HAJJI, JÉRÉMY MAGNANENSI, NICOLAS STANKOVIC-VALENTIN, SUNEIL HOSMANE, ARUN J. SANYAL

Diabetes 2021;70(Supplement_1):1174-P

DOI: https://doi.org/10.2337/db21-1174-P

Published: 01 June 2021

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Meeting Abstracts

385-P: Exosomal MiR-146a-5p from Macrophages Inhibits Diabetic Nephropathy Fibrosis by Targeting Smad4

WENNING ZHANG, HONGWEI JIANG, YUJIN MA, HUIFANG PENG, JING LIU, JINGYA YUAN, KEYAN HU, BING ZHAO, HONGLI WU

Diabetes 2021;70(Supplement_1):385-P

DOI: https://doi.org/10.2337/db21-385-P

Published: 01 June 2021

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Meeting Abstracts

319-OR: Effects of Empagliflozin on Markers of Liver Steatosis and Fibrosis and Their Relation to Cardiorenal Outcomes in the EMPA-REG OUTCOME Trial

SABINE KAHL, ANNE PERNILLE OFSTAD, BERNARD ZINMAN, CHRISTOPH WANNER, ELKE SCHUELER, SILVIO E. INZUCCHI, MICHAEL RODEN

Diabetes 2021;70(Supplement_1):319-OR

DOI: https://doi.org/10.2337/db21-319-OR

Published: 01 June 2021

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Meeting Abstracts

283-OR: Inadequate Hepatic Mitochondrial Adaptation in Patients with NASH Is Related to the Severity of Steatohepatitis and Fibrosis Stage

SRILAXMI KALAVALAPALLI, DIANA BARB, EDDISON GODINEZ, ROMINA LOMONACO, JEFFREY FRIEDMAN, STEPHANIE WOHLGEMUTH, NADA FANOUS, RACHEL E. DILLARD, TYLER M. COWAN, DANIELLE POULTON, LYDIA MANSOUR, SULAV SHRESTHA, FERNANDO BRIL, SREEVIDYA K. SUBBARAYAN, SUSHMA KADIYALA, KENNETH CUSI

Diabetes 2021;70(Supplement_1):283-OR

DOI: https://doi.org/10.2337/db21-283-OR

Published: 01 June 2021

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2 3 4 5

NARROW

227-OR: Disruption of Adipocyte YAP Improves Glucose Homeostasis in Mice and Decreases Adipose Tissue Fibrosis

1374-P: In Type 2 Diabetes, the Exocrine Pancreas Has Greater Fibrosis, Fat, Metaplastic Changes, and Microangiopathy

1121-P: The Combination of the ELF and FIB-4 Scores Have High Predictive Performance for Significant or Advanced Fibrosis in Patients with NAFLD

821-P: Randomized Clinical Trial on the Renoprotective Effect of CU01-10in Patients with Diabetic Kidney Disease (DKD)

736-P: Effect of Semaglutide on Liver Steatosis/Fibrosis Indexes in Patients with Diabetes and Obesity

735-P: Direct Anti-Inflammatory and Antifibrotic Effects of a Novel Long-Acting Glucagon/GIP/GLP-1 Triple Agonist, HM15211, in Thioacetamide-Induced Mouse Model of Liver Injury and Fibrosis

1117-P: High Rate of Histologically Proven NASH and Advanced Fibrosis in Outpatients with Type 2 Diabetes Screened for NAFLD

408-P: Fibrosis 4 Index Related to Microalbuminuria in Tibetan Patients with T2D and NAFLD

1207-P: Hepatic Steatosis Index and Fibrosis-4 Scores in Relation to Cardiometabolic Risk in Healthy Offspring of Parents with Type 2 Diabetes

1206-P: Association of Hepatic Steatosis Index (HSI) and Fibrosis (Fib) -4 Score with Prediabetes Risk in the POP-ABC Study: Potential Mechanisms

160-LB: Age-Related Adipose Tissue Fibrosis and Neuropathy in the Genetically Diverse HET3 Mouse

387-P: Novel Mitochondrial Complex I Modulator Reduces Diabetes-Associated Expression of Inflammation and Fibrosis Markers in Human Proximal Tubular Epithelial Cells

1451-P: Peri-Islet Fibrosis in Cystic Fibrosis Is Associated with Altered Alpha-Cell Phenotype

Independent of Renox, NOX5 Promotes Renal Inflammation and Fibrosis in Diabetes by Activating ROS-Sensitive Pathways

952-P: Deranged Liver Enzyme Levels and Indices of Hepatic Steatosis and Fibrosis on the Development of Gestational Diabetes

656-P: Antifibrotic Potential of a Novel Long-Acting Glucagon/GIP/GLP-1 Triple Agonist (HM15211) in Preclinical Models of Fibrosis

1174-P: Application of NIS4 Technology for Stand-Alone and Sequential Identification of At-Risk NASH or Advanced Fibrosis in Nondiabetic, Prediabetic, and Type 2 Diabetic Patients

385-P: Exosomal MiR-146a-5p from Macrophages Inhibits Diabetic Nephropathy Fibrosis by Targeting Smad4

319-OR: Effects of Empagliflozin on Markers of Liver Steatosis and Fibrosis and Their Relation to Cardiorenal Outcomes in the EMPA-REG OUTCOME Trial

283-OR: Inadequate Hepatic Mitochondrial Adaptation in Patients with NASH Is Related to the Severity of Steatohepatitis and Fibrosis Stage

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