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Journal Articles

Soluble RAGE Prevents Type 1 Diabetes Expanding Functional Regulatory T Cells

Sherman S. Leung, Danielle J. Borg, Domenica A. McCarthy, Tamar E. Boursalian, Justen Cracraft, Aowen Zhuang, Amelia K. Fotheringham, Nicole Flemming, Thomas Watkins, John J. Miles, Per-Henrik Groop, Jean L. Scheijen, Casper G. Schalkwijk, Raymond J. Steptoe, Kristen J. Radford, Mikael Knip, Josephine M. Forbes
Journal: Diabetes
Diabetes 2022;71(9):1994–2008
https://doi.org/10.2337/db22-0177
Published: 17 June 2022
View article titled, Soluble RAGE Prevents Type 1 Diabetes Expanding Functional Regulatory T Cells
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Journal Articles

Immune and Metabolic Effects of Antigen-Specific Immunotherapy Using Multiple β-Cell Peptides in Type 1 Diabetes

Yuk-Fun Liu, Jake Powrie, Sefina Arif, Jennie H.M. Yang, Evangelia Williams, Leena Khatri, Mamta Joshi, Loic Lhuillier, Nikolaos Fountoulakis, Emma Smith, Craig Beam, Anna Lorenc, Mark Peakman, Timothy Tree
Journal: Diabetes
Diabetes 2022;71(4):722–732
https://doi.org/10.2337/db21-0728
Published: 24 January 2022
View article titled, Immune and Metabolic Effects of Antigen-Specific Immunotherapy Using Multiple β-Cell Peptides in Type 1 Diabetes
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Journal Articles

Reduced Follicular Regulatory T Cells in Spleen and Pancreatic Lymph Nodes of Patients With Type 1 Diabetes

Andrea Vecchione, Tatiana Jofra, Jolanda Gerosa, Kimberly Shankwitz, Roberta Di Fonte, Giuseppe Galvani, Elio Ippolito, Maria Pia Cicalese, Andrew R. Schultz, Howie R. Seay, Mariagrazia Favellato, Giulia Milardi, Angela Stabilini, Francesca Ragogna, Pauline Grogan, Eleonora Bianconi, Andrea Laurenzi, Amelia Caretto, Rita Nano, Raffaela Melzi, Nichole Danzl, Emanuele Bosi, Lorenzo Piemonti, Alessandro Aiuti, Todd Brusko, Constantinos Petrovas, Manuela Battaglia, Georgia Fousteri
Journal: Diabetes
Diabetes 2021;70(12):2892–2902
https://doi.org/10.2337/db21-0091
Published: 07 October 2021
View article titled, Reduced Follicular Regulatory T Cells in Spleen and Pancreatic Lymph Nodes of Patients With Type 1 Diabetes
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Meeting Abstracts

1668-P: Novel Mechanism of Negative Regulation of FOXP3 Expression in Autoimmune Diabetes

PARAMESWARAN RAMAKRISHNAN, TRISTAN J. DE JESUS, JOSHUA CENTORE
Journal: Diabetes
Diabetes 2020;69(Supplement_1):1668-P
https://doi.org/10.2337/db20-1668-P
Published: 01 June 2020
View article titled, 1668-P: Novel Mechanism of Negative Regulation of FOXP3 Expression in Autoimmune Diabetes
Journal Articles

Low-Dose Interleukin-2 Combined With Rapamycin Led to an Expansion of CD4+CD25+FOXP3+ Regulatory T Cells and Prolonged Human Islet Allograft Survival in Humanized Mice

Min Hu, Wayne J. Hawthorne, Leigh Nicholson, Heather Burns, Yi Wen Qian, David Liuwantara, Elvira Jimenez Vera, Yi Vee Chew, Lindy Williams, Shounan Yi, Karen Keung, Debbie Watson, Natasha Rogers, Stephen I. Alexander, Philip J. O’Connell
Journal: Diabetes
Diabetes 2020;69(8):1735–1748
https://doi.org/10.2337/db19-0525
Published: 07 May 2020
View article titled, Low-Dose Interleukin-2 Combined With Rapamycin Led to an Expansion of CD4<sup>+</sup>CD25<sup>+</sup>FOXP3<sup>+</sup> Regulatory T Cells and Prolonged Human Islet Allograft Survival in Humanized Mice
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Journal Articles

Immunomodulation Followed by Antigen-Specific Treg Infusion Controls Islet Autoimmunity

Cecilia Cabello-Kindelan, Shane Mackey, Alexander Sands, Jennifer Rodriguez, Claudia Vazquez, Alberto Pugliese, Allison L. Bayer
Journal: Diabetes
Diabetes 2020;69(2):215–227
https://doi.org/10.2337/db19-0061
Published: 11 November 2019
View article titled, Immunomodulation Followed by Antigen-Specific T<sub>reg</sub> Infusion Controls Islet Autoimmunity
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Includes: Supplementary data
Meeting Abstracts

1740-P: Gene-Editing of FOXP3 in Antigen-Specific CD4+ T Cells for Restoration of Immune Tolerance in Type 1 Diabetes

YUFEI XIANG, KAREN SOMMER, YUCHI HONAKER, JESSICA SMITH, TROY R. TORGERSON, JANE BUCKNER, DAVID RAWLINGS
Journal: Diabetes
Diabetes 2019;68(Supplement_1):1740-P
https://doi.org/10.2337/db19-1740-P
Published: 01 June 2019
View article titled, 1740-P: Gene-Editing of FOXP3 in Antigen-Specific CD4<sup>+</sup> T Cells for Restoration of Immune Tolerance in Type 1 Diabetes
Journal Articles

Reversal of Diabetes in NOD Mice by Clinical-Grade Proinsulin and IL-10–Secreting Lactococcus lactis in Combination With Low-Dose Anti-CD3 Depends on the Induction of Foxp3-Positive T Cells

Tatiana Takiishi, Dana Paulina Cook, Hannelie Korf, Guido Sebastiani, Francesca Mancarella, João Paulo Monteiro Carvalho Mori Cunha, Clive Wasserfall, Noelia Casares, Juan José Lasarte, Lothar Steidler, Pieter Rottiers, Francesco Dotta, Conny Gysemans, Chantal Mathieu
Journal: Diabetes
Diabetes 2017;66(2):448–459
https://doi.org/10.2337/db15-1625
Published: 08 November 2016
View article titled, Reversal of Diabetes in NOD Mice by Clinical-Grade Proinsulin and IL-10–Secreting <em>Lactococcus lactis</em> in Combination With Low-Dose Anti-CD3 Depends on the Induction of Foxp3-Positive T Cells
Open the PDF for Reversal of Diabetes in NOD Mice by Clinical-Grade Proinsulin and IL-10–Secreting <em>Lactococcus lactis</em> in Combination With Low-Dose Anti-CD3 Depends on the Induction of Foxp3-Positive T Cells in another window
Includes: Supplementary data
Journal Articles

Antithymocyte Globulin Plus G-CSF Combination Therapy Leads to Sustained Immunomodulatory and Metabolic Effects in a Subset of Responders With Established Type 1 Diabetes

Michael J. Haller, Stephen E. Gitelman, Peter A. Gottlieb, Aaron W. Michels, Daniel J. Perry, Andrew R. Schultz, Maigan A. Hulme, Jonathan J. Shuster, Baiming Zou, Clive H. Wasserfall, Amanda L. Posgai, Clayton E. Mathews, Todd M. Brusko, Mark A. Atkinson, Desmond A. Schatz
Journal: Diabetes
Diabetes 2016;65(12):3765–3775
https://doi.org/10.2337/db16-0823
Published: 26 September 2016
View article titled, Antithymocyte Globulin Plus G-CSF Combination Therapy Leads to Sustained Immunomodulatory and Metabolic Effects in a Subset of Responders With Established Type 1 Diabetes
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Includes: Supplementary data
Journal Articles

T-Cell Costimulation Protects Obesity-Induced Adipose Inflammation and Insulin Resistance

Jixin Zhong, Xiaoquan Rao, Zachary Braunstein, Anne Taylor, Vimal Narula, Jeffrey Hazey, Dean Mikami, Bradley Needleman, Jessica Rutsky, Qinghua Sun, Jeffrey A. Deiuliis, Abhay R. Satoskar, Sanjay Rajagopalan
Journal: Diabetes
Diabetes 2014;63(4):1289–1302
https://doi.org/10.2337/db13-1094
Published: 13 March 2014
View article titled, T-Cell Costimulation Protects Obesity-Induced Adipose Inflammation and Insulin Resistance
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Includes: Supplementary data
Journal Articles

β-Cell–Specific IL-2 Therapy Increases Islet Foxp3+Treg and Suppresses Type 1 Diabetes in NOD Mice

Mark C. Johnson, Alaina L. Garland, Sarah C. Nicolson, Chengwen Li, R. Jude Samulski, Bo Wang, Roland Tisch
Journal: Diabetes
Diabetes 2013;62(11):3775–3784
https://doi.org/10.2337/db13-0669
Published: 18 October 2013
View article titled, β-Cell–Specific IL-2 Therapy Increases Islet Foxp3<sup>+</sup>Treg and Suppresses Type 1 Diabetes in NOD Mice
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Includes: Supplementary data
Journal Articles

Combination Treatment With Anti-CD20 and Oral Anti-CD3 Prevents and Reverses Autoimmune Diabetes

Changyun Hu, Heyuan Ding, Xiaojun Zhang, F. Susan Wong, Li Wen
Journal: Diabetes
Diabetes 2013;62(8):2849–2858
https://doi.org/10.2337/db12-1175
Published: 17 July 2013
View article titled, Combination Treatment With Anti-CD20 and Oral Anti-CD3 Prevents and Reverses Autoimmune Diabetes
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Includes: Supplementary data
Journal Articles

Immune Regulatory Properties of Allogeneic Adipose-Derived Mesenchymal Stem Cells in the Treatment of Experimental Autoimmune Diabetes

Ênio J. Bassi, Pedro M.M. Moraes-Vieira, Carla S.R. Moreira-Sá, Danilo C. Almeida, Leonardo M. Vieira, Cláudia S. Cunha, Meire I. Hiyane, Alexandre S. Basso, Alvaro Pacheco-Silva, Niels O.S. Câmara
Journal: Diabetes
Diabetes 2012;61(10):2534–2545
https://doi.org/10.2337/db11-0844
Published: 13 September 2012
View article titled, Immune Regulatory Properties of Allogeneic Adipose-Derived Mesenchymal Stem Cells in the Treatment of Experimental Autoimmune Diabetes
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Includes: Supplementary data
Journal Articles

Following the Fate of One Insulin-Reactive CD4 T cell: Conversion Into Teffs and Tregs in the Periphery Controls Diabetes in NOD Mice

Georgia Fousteri, Jean Jasinski, Amy Dave, Maki Nakayama, Philippe Pagni, Florence Lambolez, Therese Juntti, Ghanashyam Sarikonda, Yang Cheng, Michael Croft, Hilde Cheroutre, George Eisenbarth, Matthias von Herrath
Journal: Diabetes
Diabetes 2012;61(5):1169–1179
https://doi.org/10.2337/db11-0671
Published: 13 April 2012
View article titled, Following the Fate of One Insulin-Reactive CD4 T cell: <subtitle>Conversion Into Teffs and Tregs in the Periphery Controls Diabetes in NOD Mice</subtitle>
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Includes: Supplementary data
Journal Articles

Early Treatment of NOD Mice With B7-H4 Reduces the Incidence of Autoimmune Diabetes

Xiaojie Wang, Jianqiang Hao, Daniel L. Metzger, Alice Mui, Ziliang Ao, Noushin Akhoundsadegh, Solomon Langermann, Linda Liu, Lieping Chen, Dawei Ou, C. Bruce Verchere, Garth L. Warnock
Journal: Diabetes
Diabetes 2011;60(12):3246–3255
https://doi.org/10.2337/db11-0375
Published: 13 November 2011
View article titled, Early Treatment of NOD Mice With B7-H4 Reduces the Incidence of Autoimmune Diabetes
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Journal Articles

Expansion of Th17 Cells and Functional Defects in T Regulatory Cells Are Key Features of the Pancreatic Lymph Nodes in Patients With Type 1 Diabetes

Alessandra Ferraro, Carlo Socci, Angela Stabilini, Andrea Valle, Paolo Monti, Lorenzo Piemonti, Rita Nano, Sven Olek, Paola Maffi, Marina Scavini, Antonio Secchi, Carlo Staudacher, Ezio Bonifacio, Manuela Battaglia
Journal: Diabetes
Diabetes 2011;60(11):2903–2913
https://doi.org/10.2337/db11-0090
Published: 17 October 2011
View article titled, Expansion of Th17 Cells and Functional Defects in T Regulatory Cells Are Key Features of the Pancreatic Lymph Nodes in Patients With Type 1 Diabetes
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Includes: Supplementary data
Journal Articles

Potential Role of Regulatory T Cells in Reversing Obesity-Linked Insulin Resistance and Diabetic Nephropathy

Kathrin Eller, Alexander Kirsch, Anna M. Wolf, Sieghart Sopper, Andrea Tagwerker, Ursula Stanzl, Dominik Wolf, Wolfgang Patsch, Alexander R. Rosenkranz, Philipp Eller
Journal: Diabetes
Diabetes 2011;60(11):2954–2962
https://doi.org/10.2337/db11-0358
Published: 17 October 2011
View article titled, Potential Role of Regulatory T Cells in Reversing Obesity-Linked Insulin Resistance and Diabetic Nephropathy
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Journal Articles

Defective Differentiation of Regulatory FoxP3+ T Cells by Small-Intestinal Dendritic Cells in Patients With Type 1 Diabetes

Ester Badami, Chiara Sorini, Margherita Coccia, Vera Usuelli, Laura Molteni, Andrea Mario Bolla, Marina Scavini, Alberto Mariani, Cecile King, Emanuele Bosi, Marika Falcone
Journal: Diabetes
Diabetes 2011;60(8):2120–2124
https://doi.org/10.2337/db10-1201
Published: 18 July 2011
View article titled, Defective Differentiation of Regulatory FoxP3<sup>+</sup> T Cells by Small-Intestinal Dendritic Cells in Patients With Type 1 Diabetes
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Includes: Supplementary data
Journal Articles

Defects in IL-2R Signaling Contribute to Diminished Maintenance of FOXP3 Expression in CD4+CD25+ Regulatory T-Cells of Type 1 Diabetic Subjects

S. Alice Long, Karen Cerosaletti, Paul L. Bollyky, Megan Tatum, Heather Shilling, Sheng Zhang, Zhong-Yin Zhang, Catherine Pihoker, Srinath Sanda, Carla Greenbaum, Jane H. Buckner
Journal: Diabetes
Diabetes 2010;59(2):407–415
https://doi.org/10.2337/db09-0694
Published: 29 October 2009
View article titled, Defects in IL-2R Signaling Contribute to Diminished Maintenance of FOXP3 Expression in CD4<sup>+</sup>CD25<sup>+</sup> Regulatory T-Cells of Type 1 Diabetic Subjects
Open the PDF for Defects in IL-2R Signaling Contribute to Diminished Maintenance of FOXP3 Expression in CD4<sup>+</sup>CD25<sup>+</sup> Regulatory T-Cells of Type 1 Diabetic Subjects in another window
Includes: Supplementary data
Journal Articles

Idd9.1 Locus Controls the Suppressive Activity of FoxP3+CD4+CD25+ Regulatory T-Cells

Jun Yamanouchi, Maria-Carmen Puertas, Joan Verdaguer, Paul A. Lyons, Daniel B. Rainbow, Giselle Chamberlain, Kara M. Hunter, Laurence B. Peterson, Linda S. Wicker, Pere Santamaria
Journal: Diabetes
Diabetes 2010;59(1):272–281
https://doi.org/10.2337/db09-0648
Published: 15 October 2009
View article titled, <em>Idd9.1</em> Locus Controls the Suppressive Activity of FoxP3<sup>+</sup>CD4<sup>+</sup>CD25<sup>+</sup> Regulatory T-Cells
Open the PDF for <em>Idd9.1</em> Locus Controls the Suppressive Activity of FoxP3<sup>+</sup>CD4<sup>+</sup>CD25<sup>+</sup> Regulatory T-Cells in another window
Includes: Supplementary data