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Meeting Abstracts

432-P: Role of Patatin-Like Phospholipase Domain–Containing 3 Gene for Kidney Dysfunction in Diabetes Endotypes

OANA P. ZAHARIA, KLAUS STRASSBURGER, BIRGIT KNEBEL, YULIYA KUPRIYANOVA, JORG KOTZKA, KÁLMÁN BÓDIS, MARTIN SCHÖN, MARIA BOMBRICH, CLARA MÖSER, KATSIARYNA PRYSTUPA, HADI AL-HASANI, VERA SCHRAUWEN-HINDERLING, KARIN JANDELEIT-DAHM, ROBERT WAGNER, MICHAEL RODEN
Journal: Diabetes
Diabetes 2023;72(Supplement_1):432-P
https://doi.org/10.2337/db23-432-P
Published: 20 June 2023
View article titled, 432-P: Role of Patatin-Like Phospholipase Domain–Containing 3 Gene for Kidney Dysfunction in Diabetes Endotypes
Journal Articles

Systematic Heritability and Heritability Enrichment Analysis for Diabetes Complications in UK Biobank and ACCORD Studies

Juhyun Kim, Aubrey Jensen, Seyoon Ko, Sridharan Raghavan, Lawrence S. Phillips, Adriana Hung, Yan Sun, Hua Zhou, Peter Reaven, Jin J. Zhou
Journal: Diabetes
Diabetes 2022;71(5):1137–1148
https://doi.org/10.2337/db21-0839
Published: 08 February 2022
View article titled, Systematic Heritability and Heritability Enrichment Analysis for Diabetes Complications in UK Biobank and ACCORD Studies
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Journal Articles

Genetic Predictors of Change in Waist Circumference and Waist-to-Hip Ratio With Lifestyle Intervention: The Trans-NIH Consortium for Genetics of Weight Loss Response to Lifestyle Intervention

Jeanne M. McCaffery, Kathleen A. Jablonski, Qing Pan, Arne Astrup, Malene Revsbech Christiansen, Dolores Corella, Lauren M.L. Corso, Jose C. Florez, Paul W. Franks, Christopher Gardner, Torben Hansen, Tuomas O. Kilpeläinen, William C. Knowler, Jaana Lindström, Wim H.M. Saris, Thorkild I.A. Sørensen, Jaakko Tuomilehto, Matti Uusitupa, Rena R. Wing, Tanya Agurs-Collins
Journal: Diabetes
Diabetes 2022;71(4):669–676
https://doi.org/10.2337/db21-0741
Published: 18 January 2022
View article titled, Genetic Predictors of Change in Waist Circumference and Waist-to-Hip Ratio With Lifestyle Intervention: The Trans-NIH Consortium for Genetics of Weight Loss Response to Lifestyle Intervention
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Journal Articles

Genetically Predicted Glucose-Dependent Insulinotropic Polypeptide (GIP) Levels and Cardiovascular Disease Risk Are Driven by Distinct Causal Variants in the GIPR Region

Nicholas Bowker, Robert Hansford, Stephen Burgess, Christopher N. Foley, Victoria P.W. Auyeung, A. Mesut Erzurumluoglu, Isobel D. Stewart, Eleanor Wheeler, Maik Pietzner, Fiona Gribble, Frank Reimann, Pallav Bhatnagar, Matthew P. Coghlan, Nicholas J. Wareham, Claudia Langenberg
Journal: Diabetes
Diabetes 2021;70(11):2706–2719
https://doi.org/10.2337/db21-0103
Published: 23 August 2021
View article titled, Genetically Predicted Glucose-Dependent Insulinotropic Polypeptide (GIP) Levels and Cardiovascular Disease Risk Are Driven by Distinct Causal Variants in the <em>GIPR</em> Region
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Journal Articles

Mutations of NRG4 Contribute to the Pathogenesis of Nonalcoholic Fatty Liver Disease and Related Metabolic Disorders

Yangyang Li, Li Jin, Feng Jiang, Jing Yan, Yan Lu, Qing Yang, Yi Zhang, Hong Zhang, Hairong Yu, Yuemei Zhang, Zhen He, Rong Zhang, Jianjun Yang, Cheng Hu
Journal: Diabetes
Diabetes 2021;70(10):2213–2224
https://doi.org/10.2337/db21-0064
Published: 14 July 2021
View article titled, Mutations of <em>NRG4</em> Contribute to the Pathogenesis of Nonalcoholic Fatty Liver Disease and Related Metabolic Disorders
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Journal Articles

Novel Linkage Peaks Discovered for Diabetic Nephropathy in Individuals With Type 1 Diabetes

Jani Haukka, Niina Sandholm, Erkka Valo, Carol Forsblom, Valma Harjutsalo, Joanne B. Cole, Stuart J. McGurnaghan, Helen M. Colhoun, Per-Henrik Groop
Journal: Diabetes
Diabetes 2021;70(4):986–995
https://doi.org/10.2337/db20-0158
Published: 07 January 2021
View article titled, Novel Linkage Peaks Discovered for Diabetic Nephropathy in Individuals With Type 1 Diabetes
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Journal Articles

Genetic Loci and Physiologic Pathways Involved in Gestational Diabetes Mellitus Implicated Through Clustering

Camille E. Powe, Miriam S. Udler, Sarah Hsu, Catherine Allard, Alan Kuang, Alisa K. Manning, Patrice Perron, Luigi Bouchard, William L. Lowe, Jr., Denise Scholtens, Jose C. Florez, Marie-France Hivert
Journal: Diabetes
Diabetes 2021;70(1):268–281
https://doi.org/10.2337/db20-0772
Published: 13 October 2020
View article titled, Genetic Loci and Physiologic Pathways Involved in Gestational Diabetes Mellitus Implicated Through Clustering
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Journal Articles

CACNB2 Is a Novel Susceptibility Gene for Diabetic Retinopathy in Type 1 Diabetes

Nadja Vuori, Niina Sandholm, Anmol Kumar, Kustaa Hietala, Anna Syreeni, Carol Forsblom, Kati Juuti-Uusitalo, Heli Skottman, Minako Imamura, Shiro Maeda, Paula A. Summanen, Markku Lehto, Per-Henrik Groop
Journal: Diabetes
Diabetes 2019;68(11):2165–2174
https://doi.org/10.2337/db19-0130
Published: 22 August 2019
View article titled, <em>CACNB2</em> Is a Novel Susceptibility Gene for Diabetic Retinopathy in Type 1 Diabetes
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Includes: Supplementary data
Meeting Abstracts

1387-P: Genotyping Cell-Free Fetal DNA to Decide whether to Treat Hyperglycemia during Pregnancy in Women with GCK Monogenic Diabetes—A Case Study

SOO HEON KWAK, SE SONG JANG, SUNYOUNG KANG, HAK CHUL JANG, SEUNG MI LEE, JONG HEE CHAE, KYONG SOO PARK
Journal: Diabetes
Diabetes 2019;68(Supplement_1):1387-P
https://doi.org/10.2337/db19-1387-P
Published: 01 June 2019
View article titled, 1387-P: Genotyping Cell-Free Fetal DNA to Decide whether to Treat Hyperglycemia during Pregnancy in Women with GCK Monogenic Diabetes—A Case Study
Journal Articles

Genetic Regulation of Pigment Epithelium-Derived Factor (PEDF): An Exome-Chip Association Analysis in Chinese Subjects With Type 2 Diabetes

Chloe Y.Y. Cheung, Chi-Ho Lee, Clara S. Tang, Aimin Xu, Ka-Wing Au, Carol H.Y. Fong, Kelvin K.K. Ng, Kelvin H.M. Kwok, Wing-Sun Chow, Yu-Cho Woo, Michele M.A. Yuen, JoJo Hai, Kathryn C.B. Tan, Tai-Hing Lam, Hung-Fat Tse, Pak-Chung Sham, Karen S.L. Lam
Journal: Diabetes
Diabetes 2019;68(1):198–206
https://doi.org/10.2337/db18-0500
Published: 10 October 2018
View article titled, Genetic Regulation of Pigment Epithelium-Derived Factor (PEDF): An Exome-Chip Association Analysis in Chinese Subjects With Type 2 Diabetes
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Includes: Supplementary data
Journal Articles

Nonsynonymous Variants in PAX4 and GLP1R Are Associated With Type 2 Diabetes in an East Asian Population

Soo Heon Kwak, Jeesoo Chae, Seungbok Lee, Sungkyoung Choi, Bo Kyung Koo, Ji Won Yoon, Jin-Ho Park, Belong Cho, Min Kyong Moon, Soo Lim, Young Min Cho, Sanghoon Moon, Young Jin Kim, Sohee Han, Mi Yeong Hwang, Yoon Shin Cho, Myung-Shik Lee, Hak C. Jang, Hyun Min Kang, Taesung Park, Nam H. Cho, Kyunga Kim, Jong-Il Kim, Kyong Soo Park
Journal: Diabetes
Diabetes 2018;67(9):1892–1902
https://doi.org/10.2337/db18-0361
Published: 25 June 2018
View article titled, Nonsynonymous Variants in <em>PAX4</em> and <em>GLP1R</em> Are Associated With Type 2 Diabetes in an East Asian Population
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Includes: Supplementary data
Journal Articles

Improved Murine MHC-Deficient HLA Transgenic NOD Mouse Models for Type 1 Diabetes Therapy Development

Jeremy J. Racine, Isabel Stewart, Jeremy Ratiu, Greg Christianson, Emily Lowell, Kelsay Helm, Jennifer Allocco, Richard S. Maser, Yi-Guang Chen, Cathleen M. Lutz, Derry Roopenian, Jennifer Schloss, Teresa P. DiLorenzo, David V. Serreze
Journal: Diabetes
Diabetes 2018;67(5):923–935
https://doi.org/10.2337/db17-1467
Published: 22 February 2018
View article titled, Improved Murine MHC-Deficient HLA Transgenic NOD Mouse Models for Type 1 Diabetes Therapy Development
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Includes: Supplementary data
Journal Articles

A Genome-Wide Association Study Using a Custom Genotyping Array Identifies Variants in GPR158 Associated With Reduced Energy Expenditure in American Indians

Paolo Piaggi, Ivica Masindova, Yunhua L. Muller, Josep Mercader, Gregory B. Wiessner, Peng Chen, SIGMA Type 2 Diabetes Consortium, Sayuko Kobes, Wen-Chi Hsueh, Milliejoan Mongalo, William C. Knowler, Jonathan Krakoff, Robert L. Hanson, Clifton Bogardus, Leslie J. Baier
Journal: Diabetes
Diabetes 2017;66(8):2284–2295
https://doi.org/10.2337/db16-1565
Published: 05 May 2017
View article titled, A Genome-Wide Association Study Using a Custom Genotyping Array Identifies Variants in <em>GPR158</em> Associated With Reduced Energy Expenditure in American Indians
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Includes: Supplementary data
Journal Articles

An Exome-Chip Association Analysis in Chinese Subjects Reveals a Functional Missense Variant of GCKR That Regulates FGF21 Levels

Chloe Y.Y. Cheung, Clara S. Tang, Aimin Xu, Chi-Ho Lee, Ka-Wing Au, Lin Xu, Carol H.Y. Fong, Kelvin H.M. Kwok, Wing-Sun Chow, Yu-Cho Woo, Michele M.A. Yuen, Stacey S. Cherny, JoJo Hai, Bernard M.Y. Cheung, Kathryn C.B. Tan, Tai-Hing Lam, Hung-Fat Tse, Pak-Chung Sham, Karen S.L. Lam
Journal: Diabetes
Diabetes 2017;66(6):1723–1728
https://doi.org/10.2337/db16-1384
Published: 06 April 2017
View article titled, An Exome-Chip Association Analysis in Chinese Subjects Reveals a Functional Missense Variant of <em>GCKR</em> That Regulates FGF21 Levels
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Includes: Supplementary data
Journal Articles

CRISPR-Cas9–Mediated Modification of the NOD Mouse Genome With Ptpn22R619W Mutation Increases Autoimmune Diabetes

Xiaotian Lin, Stephane Pelletier, Sebastien Gingras, Stephanie Rigaud, Christian J. Maine, Kristi Marquardt, Yang D. Dai, Karsten Sauer, Alberto R. Rodriguez, Greg Martin, Sergey Kupriyanov, Ling Jiang, Liping Yu, Douglas R. Green, Linda A. Sherman
Journal: Diabetes
Diabetes 2016;65(8):2134–2138
https://doi.org/10.2337/db16-0061
Published: 26 April 2016
View article titled, CRISPR-Cas9–Mediated Modification of the NOD Mouse Genome With <em>Ptpn22<sup>R619W</sup></em> Mutation Increases Autoimmune Diabetes
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Includes: Supplementary data
Journal Articles

Impact of Common Diabetes Risk Variant in MTNR1B on Sleep, Circadian, and Melatonin Physiology

Jacqueline M. Lane, Anne-Marie Chang, Andrew C. Bjonnes, Daniel Aeschbach, Clare Anderson, Brian E. Cade, Sean W. Cain, Charles A. Czeisler, Sina A. Gharib, Joshua J. Gooley, Daniel J. Gottlieb, Struan F.A. Grant, Elizabeth B. Klerman, Diane S. Lauderdale, Steven W. Lockley, Miriam Munch, Sanjay Patel, Naresh M. Punjabi, Shanthakumar M.W. Rajaratnam, Melanie Rueger, Melissa A. St. Hilaire, Nayantara Santhi, Karin Scheuermaier, Eliza Van Reen, Phyllis C. Zee, Steven A. Shea, Jeanne F. Duffy, Orfeu M. Buxton, Susan Redline, Frank A.J.L. Scheer, Richa Saxena
Journal: Diabetes
Diabetes 2016;65(6):1741–1751
https://doi.org/10.2337/db15-0999
Published: 16 February 2016
View article titled, Impact of Common Diabetes Risk Variant in <em>MTNR1B</em> on Sleep, Circadian, and Melatonin Physiology
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Includes: Supplementary data
Journal Articles

Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes

Alexander Teumer, Adrienne Tin, Rossella Sorice, Mathias Gorski, Nan Cher Yeo, Audrey Y. Chu, Man Li, Yong Li, Vladan Mijatovic, Yi-An Ko, Daniel Taliun, Alessandro Luciani, Ming-Huei Chen, Qiong Yang, Meredith C. Foster, Matthias Olden, Linda T. Hiraki, Bamidele O. Tayo, Christian Fuchsberger, Aida Karina Dieffenbach, Alan R. Shuldiner, Albert V. Smith, Allison M. Zappa, Antonio Lupo, Barbara Kollerits, Belen Ponte, Bénédicte Stengel, Bernhard K. Krämer, Bernhard Paulweber, Braxton D. Mitchell, Caroline Hayward, Catherine Helmer, Christa Meisinger, Christian Gieger, Christian M. Shaffer, Christian Müller, Claudia Langenberg, Daniel Ackermann, David Siscovick, DCCT/EDIC, Eric Boerwinkle, Florian Kronenberg, Georg B. Ehret, Georg Homuth, Gerard Waeber, Gerjan Navis, Giovanni Gambaro, Giovanni Malerba, Gudny Eiriksdottir, Guo Li, H. Erich Wichmann, Harald Grallert, Henri Wallaschofski, Henry Völzke, Herrmann Brenner, Holly Kramer, I. Mateo Leach, Igor Rudan, Hans L. Hillege, Jacques S. Beckmann, Jean Charles Lambert, Jian'an Luan, Jing Hua Zhao, John Chalmers, Josef Coresh, Joshua C. Denny, Katja Butterbach, Lenore J. Launer, Luigi Ferrucci, Lyudmyla Kedenko, Margot Haun, Marie Metzger, Mark Woodward, Matthew J. Hoffman, Matthias Nauck, Melanie Waldenberger, Menno Pruijm, Murielle Bochud, Myriam Rheinberger, Niek Verweij, Nicholas J. Wareham, Nicole Endlich, Nicole Soranzo, Ozren Polasek, Pim van der Harst, Peter Paul Pramstaller, Peter Vollenweider, Philipp S. Wild, Ron T. Gansevoort, Rainer Rettig, Reiner Biffar, Robert J. Carroll, Ronit Katz, Ruth J.F. Loos, Shih-Jen Hwang, Stefan Coassin, Sven Bergmann, Sylvia E. Rosas, Sylvia Stracke, Tamara B. Harris, Tanguy Corre, Tanja Zeller, Thomas Illig, Thor Aspelund, Toshiko Tanaka, Uwe Lendeckel, Uwe Völker, Vilmundur Gudnason, Vincent Chouraki, Wolfgang Koenig, Zoltan Kutalik, Jeffrey R. O'Connell, Afshin Parsa, Iris M. Heid, Andrew D. Paterson, Ian H. de Boer, Olivier Devuyst, Jozef Lazar, Karlhans Endlich, Katalin Susztak, Johanne Tremblay, Pavel Hamet, Howard J. Jacob, Carsten A. Böger, Caroline S. Fox, Cristian Pattaro, Anna Köttgen
Journal: Diabetes
Diabetes 2016;65(3):803–817
https://doi.org/10.2337/db15-1313
Published: 02 December 2015
View article titled, Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes
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Includes: Supplementary data
Journal Articles

Targeted Deep Sequencing in Multiple-Affected Sibships of European Ancestry Identifies Rare Deleterious Variants in PTPN22 That Confer Risk for Type 1 Diabetes

Yan Ge, Suna Onengut-Gumuscu, Aaron R. Quinlan, Aaron J. Mackey, Jocyndra A. Wright, Jane H. Buckner, Tania Habib, Stephen S. Rich, Patrick Concannon
Journal: Diabetes
Diabetes 2016;65(3):794–802
https://doi.org/10.2337/db15-0322
Published: 02 December 2015
View article titled, Targeted Deep Sequencing in Multiple-Affected Sibships of European Ancestry Identifies Rare Deleterious Variants in <em>PTPN22</em> That Confer Risk for Type 1 Diabetes
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Includes: Supplementary data
Journal Articles

Lifestyle and Metformin Ameliorate Insulin Sensitivity Independently of the Genetic Burden of Established Insulin Resistance Variants in Diabetes Prevention Program Participants

Marie-France Hivert, Costas A. Christophi, Paul W. Franks, Kathleen A. Jablonski, David A. Ehrmann, Steven E. Kahn, Edward S. Horton, Toni I. Pollin, Kieren J. Mather, Leigh Perreault, Elizabeth Barrett-Connor, William C. Knowler, Jose C. Florez, for the Diabetes Prevention Program Research Group
Journal: Diabetes
Diabetes 2016;65(2):520–526
https://doi.org/10.2337/db15-0950
Published: 02 November 2015
View article titled, Lifestyle and Metformin Ameliorate Insulin Sensitivity Independently of the Genetic Burden of Established Insulin Resistance Variants in Diabetes Prevention Program Participants
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Includes: Supplementary data
Journal Articles

DNA Methylation Variants at HIF3A Locus, B-Vitamin Intake, and Long-term Weight Change: Gene-Diet Interactions in Two U.S. Cohorts

Tao Huang, Yan Zheng, Qibin Qi, Min Xu, Sylvia H. Ley, Yanping Li, Jae H. Kang, Janey Wiggs, Louis R. Pasquale, Andrew T. Chan, Eric B. Rimm, David J. Hunter, JoAnn E. Manson, Walter C. Willett, Frank B. Hu, Lu Qi
Journal: Diabetes
Diabetes 2015;64(9):3146–3154
https://doi.org/10.2337/db15-0264
Published: 22 May 2015
View article titled, DNA Methylation Variants at <em>HIF3A</em> Locus, B-Vitamin Intake, and Long-term Weight Change: Gene-Diet Interactions in Two U.S. Cohorts
Open the PDF for DNA Methylation Variants at <em>HIF3A</em> Locus, B-Vitamin Intake, and Long-term Weight Change: Gene-Diet Interactions in Two U.S. Cohorts in another window
Includes: Supplementary data