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Journal Articles

Phenotypic Characterization of Congenital Hyperinsulinism Due to Novel Activating Glucokinase Mutations

Changhong Li, Christine A. Juliana, Yue Yuan, Ming Li, Ming Lu, Pan Chen, Kara E. Boodhansingh, Nicolai M. Doliba, Tricia R. Bhatti, N. Scott Adzick, Charles A. Stanley, Diva D. De León

Diabetes 2023;72(12):1809–1819

https://doi.org/10.2337/db23-0465

Published: 19 September 2023

View article titled, Phenotypic Characterization of Congenital Hyperinsulinism Due to Novel Activating Glucokinase Mutations

Meeting Abstracts

297-LB: Dorzagliatin, a Glucokinase Activator, Repairs Defective Islet Function in High-Fat Diet-Induced Diabetic Mice

DONGNA HAN, SHI MENG, XUE ZHOU, RUYUE LI, CHANGHONG LI

Diabetes 2023;72(Supplement_1):297-LB

https://doi.org/10.2337/db23-297-LB

Published: 20 June 2023

View article titled, 297-LB: Dorzagliatin, a Glucokinase Activator, Repairs Defective Islet Function in High-Fat Diet-Induced Diabetic Mice

Meeting Abstracts

293-LB: Dorzagliatin, a Glucokinase Activator, Restores Glucose-Sensing in Type 2 Diabetic Human Islets

JEFFEREY ROMAN, QIUSHA ZHU, YUE YUAN, CHANGHONG LI, LI CHEN, NICOLAI M. DOLIBA

Diabetes 2023;72(Supplement_1):293-LB

https://doi.org/10.2337/db23-293-LB

Published: 20 June 2023

View article titled, 293-LB: Dorzagliatin, a Glucokinase Activator, Restores Glucose-Sensing in Type 2 Diabetic Human Islets

Meeting Abstracts

1688-P: Glucokinase Activator Triggers PERK-UPR Pathway in Diet-Induced Obese Mice via Inducing Hepatic Lipid Accumulation

NAN CAI, XUANRONG CHEN, JIA LIU, ZHEYAO WEN, SIYING WEN, WEN ZENG, SHUO LIN, YANMING CHEN, GUOJUN SHI, LONGYI ZENG

Diabetes 2023;72(Supplement_1):1688-P

https://doi.org/10.2337/db23-1688-P

Published: 20 June 2023

View article titled, 1688-P: Glucokinase Activator Triggers PERK-UPR Pathway in Diet-Induced Obese Mice via Inducing Hepatic Lipid Accumulation

Meeting Abstracts

221-LB: Identification of PAM as Novel Monogenic Diabetes Gene

JAMES FEINER, NICOLAS PERROT, MICHAEL CHONG, RICKY LALI, ROBERT MORTON, PEDRUM MOHAMMADI-SHEMIRANI, SALIM YUSUF, HERTZEL C. GERSTEIN, GUILLAUME PARE, MARIE PIGEYRE

Diabetes 2023;72(Supplement_1):221-LB

https://doi.org/10.2337/db23-221-LB

Published: 20 June 2023

View article titled, 221-LB: Identification of PAM as Novel Monogenic Diabetes Gene

Meeting Abstracts

860-P: Evaluation of Efficacy and Safety of Glucokinase Activators—A Systematic Review and Meta-analysis

WENJIA YANG

Diabetes 2023;72(Supplement_1):860-P

https://doi.org/10.2337/db23-860-P

Published: 20 June 2023

View article titled, 860-P: Evaluation of Efficacy and Safety of Glucokinase Activators—A Systematic Review and Meta-analysis

Meeting Abstracts

1607-P: FGF1 Induces Glucokinase Upregulation and Increased Lactate Export in Mouse Hepatocytes

MORVARID KABIR, MARILYN ADER, NAREG THOMAS, EKIHIRO SEKI, RICHARD N. BERGMAN

Diabetes 2023;72(Supplement_1):1607-P

https://doi.org/10.2337/db23-1607-P

Published: 20 June 2023

View article titled, 1607-P: FGF1 Induces Glucokinase Upregulation and Increased Lactate Export in Mouse Hepatocytes

Meeting Abstracts

1736-P: Effect of Glucokinase Haploinsufficiency on Pancreatic Beta-Cell Function and Mass in High-Fat, High-Sucrose Diet-Fed Mice

IKUMI SHIGESAWA, AKINOBU NAKAMURA, YUKI YAMAUCHI, SHINICHIRO KAWATA, ASUKA MIYAZAKI, HIROSHI NOMOTO, HIRAKU KAMEDA, HIDEAKI MIYOSHI, YASUO TERAUCHI, TATSUYA ATSUMI

Diabetes 2023;72(Supplement_1):1736-P

https://doi.org/10.2337/db23-1736-P

Published: 20 June 2023

View article titled, 1736-P: Effect of Glucokinase Haploinsufficiency on Pancreatic Beta-Cell Function and Mass in High-Fat, High-Sucrose Diet-Fed Mice

Meeting Abstracts

1474-P: Identification and Management of MODY2 Pregnancy Patients

LIMEI LIU, YANYAN JIANG, YATING CHEN, CHANWEI LIU, TIANTIAN LI

Diabetes 2023;72(Supplement_1):1474-P

https://doi.org/10.2337/db23-1474-P

Published: 20 June 2023

View article titled, 1474-P: Identification and Management of MODY2 Pregnancy Patients

Journal Articles

Glucokinase Inhibition: A Novel Treatment for Diabetes?

Maria S. Remedi, Colin G. Nichols

Diabetes 2023;72(2):170–174

https://doi.org/10.2337/db22-0731

Published: 20 January 2023

View article titled, Glucokinase Inhibition: A Novel Treatment for Diabetes?

Journal Articles

Dorzagliatin, a Dual-Acting Glucokinase Activator, Increases Insulin Secretion and Glucose Sensitivity in Glucokinase Maturity-Onset Diabetes of the Young and Recent-Onset Type 2 Diabetes

Elaine Chow, Ke Wang, Cadmon K.P. Lim, Sandra T.F. Tsoi, Baoqi Fan, Emily Poon, Andrea O.Y. Luk, Ronald C.W. Ma, Ele Ferrannini, Andrea Mari, Li Chen, Juliana C.N. Chan

Diabetes 2023;72(2):299–308

https://doi.org/10.2337/db22-0708

Published: 28 October 2022

View article titled, Dorzagliatin, a Dual-Acting Glucokinase Activator, Increases Insulin Secretion and Glucose Sensitivity in Glucokinase Maturity-Onset Diabetes of the Young and Recent-Onset Type 2 Diabetes

Journal Articles

Franz Matschinsky, MD (1931–2022): Paragon of Scientific Rigor and Curiosity Who Discovered Glucokinase as the Pancreatic Glucose Sensor

Mitchell A. Lazar, Mark A. Magnuson, Klaus H. Kaestner

Diabetes 2022;71(10):2078–2083

https://doi.org/10.2337/dbi22-0017

Published: 12 September 2022

View article titled, Franz Matschinsky, MD (1931–2022): Paragon of Scientific Rigor and Curiosity Who Discovered Glucokinase as the Pancreatic Glucose Sensor

Meeting Abstracts

261-OR: Dorzagliatin, a Dual-Acting Glucokinase Activator. Improves Insulin Secretion and Glucose Sensitivity in Glucokinase-Maturity-Onset Diabetes of the Young (GCK-MODY)

ELAINE CHOW, KE WANG, CADMON K.P. LIM, SANDRA TSOI, BAOQI FAN, ANDREA LUK, RONALD C. MA, ELE FERRANNINI, ANDREA MARI, LI CHEN, JULIANA C. CHAN

Diabetes 2022;71(Supplement_1):261-OR

https://doi.org/10.2337/db22-261-OR

Published: 01 June 2022

View article titled, 261-OR: Dorzagliatin, a Dual-Acting Glucokinase Activator. Improves Insulin Secretion and Glucose Sensitivity in Glucokinase-Maturity-Onset Diabetes of the Young (GCK-MODY)

Meeting Abstracts

193-OR: Chronotherapy with the Glucokinase Activator AZD1656 Greatly Affects Its Ability to Improve Metabolism in Obese Zucker Rats

TOBIAS KROON, THERESE HAGSTEDT, IDA ALEXANDERSSON, ANNETT FERM, MARIE PETERSSON, STEFANIE MAURER, BADER ZARROUKI, KRISTINA WALLENIUS, NICHOLAS D. OAKES, JEREMIE BOUCHER

Diabetes 2022;71(Supplement_1):193-OR

https://doi.org/10.2337/db22-193-OR

Published: 01 June 2022

View article titled, 193-OR: Chronotherapy with the Glucokinase Activator AZD1656 Greatly Affects Its Ability to Improve Metabolism in Obese Zucker Rats

Meeting Abstracts

1342-P: Reduction of Glucokinase and Glucokinase Regulatory Protein Expression by siRNA Is Associated with the Reduction of Lactate and Pyruvate Export from Canine Hepatocytes

MORVARID KABIR, MARILYN ADER, RICHARD N. BERGMAN

Diabetes 2022;71(Supplement_1):1342-P

https://doi.org/10.2337/db22-1342-P

Published: 01 June 2022

View article titled, 1342-P: Reduction of Glucokinase and Glucokinase Regulatory Protein Expression by siRNA Is Associated with the Reduction of Lactate and Pyruvate Export from Canine Hepatocytes

Meeting Abstracts

1311-P: Glucokinase in AGRP Neurons Is Required for Normal Insulin Secretion and Action in Female Mice

MASA JOSIPOVIC, EMILY O. STARICOFF, CHRISTINE H. RICHES, LAURA SHEPPARD, MARK EVANS

Diabetes 2022;71(Supplement_1):1311-P

https://doi.org/10.2337/db22-1311-P

Published: 01 June 2022

View article titled, 1311-P: Glucokinase in AGRP Neurons Is Required for Normal Insulin Secretion and Action in Female Mice

Meeting Abstracts

317-OR: The Novel Glucokinase GCK (Q26L) Gene Mutation Site Causes Diabetes

SHUHUI JI, HUA SHU, WENLI FENG, JINYANG ZHEN, JINGTING QIAO, YADI HUANG, SHANSHAN CHEN, MING LIU

Diabetes 2022;71(Supplement_1):317-OR

https://doi.org/10.2337/db22-317-OR

Published: 01 June 2022

View article titled, 317-OR: The Novel Glucokinase GCK (Q26L) Gene Mutation Site Causes Diabetes

Meeting Abstracts

835-P: The Hepatoselective Glucokinase Activator (GKA) TTP399 Does Not Increase Risk of Ketoacidosis in Type 1 Diabetes (T1D)

KLARA KLEIN, SCHAFER C. BOEDER, JENNIFER L. FREEMAN, SUPRADEEP MADDURI, ERIN R. GIOVANNETTI, CARMEN VALCARCE, JOHN B. BUSE, JEREMY PETTUS

Diabetes 2022;71(Supplement_1):835-P

https://doi.org/10.2337/db22-835-P

Published: 01 June 2022

View article titled, 835-P: The Hepatoselective Glucokinase Activator (GKA) TTP399 Does Not Increase Risk of Ketoacidosis in Type 1 Diabetes (T1D)

Meeting Abstracts

117-LB: Glucokinase Activator Restores Glucose Sensitivity and Early-Phase Insulin Secretion in T2DM Patient—A Post Hoc Analysis of Dorzagliatin

LINGGE FENG, QUANLE GUO, CHUNXIANG CHEN, XIANG LIU, LI CHEN, WENYING YANG

Diabetes 2022;71(Supplement_1):117-LB

https://doi.org/10.2337/db22-117-LB

Published: 01 June 2022

View article titled, 117-LB: Glucokinase Activator Restores Glucose Sensitivity and Early-Phase Insulin Secretion in T2DM Patient—A Post Hoc Analysis of Dorzagliatin

Meeting Abstracts

117-LB: Glucokinase Activator Dorzagliatin (HMS5552) Regulates GLP-1 Release in T2D Patients and Is Synergistic with Sitagliptin and Empagliflozin in Optimizing Beta-Cell Function

LI CHEN, JIAYI ZHANG, RONG YANG, LINGGE FENG, HUA MEDICINE

Diabetes 2021;70(Supplement_1):117-LB

https://doi.org/10.2337/db21-117-LB

Published: 01 June 2021

View article titled, 117-LB: Glucokinase Activator Dorzagliatin (HMS5552) Regulates GLP-1 Release in T2D Patients and Is Synergistic with Sitagliptin and Empagliflozin in Optimizing Beta-Cell Function

NARROW

Phenotypic Characterization of Congenital Hyperinsulinism Due to Novel Activating Glucokinase Mutations

297-LB: Dorzagliatin, a Glucokinase Activator, Repairs Defective Islet Function in High-Fat Diet-Induced Diabetic Mice

293-LB: Dorzagliatin, a Glucokinase Activator, Restores Glucose-Sensing in Type 2 Diabetic Human Islets

1688-P: Glucokinase Activator Triggers PERK-UPR Pathway in Diet-Induced Obese Mice via Inducing Hepatic Lipid Accumulation

221-LB: Identification of PAM as Novel Monogenic Diabetes Gene

860-P: Evaluation of Efficacy and Safety of Glucokinase Activators—A Systematic Review and Meta-analysis

1607-P: FGF1 Induces Glucokinase Upregulation and Increased Lactate Export in Mouse Hepatocytes

1736-P: Effect of Glucokinase Haploinsufficiency on Pancreatic Beta-Cell Function and Mass in High-Fat, High-Sucrose Diet-Fed Mice

1474-P: Identification and Management of MODY2 Pregnancy Patients

Glucokinase Inhibition: A Novel Treatment for Diabetes?

Dorzagliatin, a Dual-Acting Glucokinase Activator, Increases Insulin Secretion and Glucose Sensitivity in Glucokinase Maturity-Onset Diabetes of the Young and Recent-Onset Type 2 Diabetes

Franz Matschinsky, MD (1931–2022): Paragon of Scientific Rigor and Curiosity Who Discovered Glucokinase as the Pancreatic Glucose Sensor

261-OR: Dorzagliatin, a Dual-Acting Glucokinase Activator. Improves Insulin Secretion and Glucose Sensitivity in Glucokinase-Maturity-Onset Diabetes of the Young (GCK-MODY)

193-OR: Chronotherapy with the Glucokinase Activator AZD1656 Greatly Affects Its Ability to Improve Metabolism in Obese Zucker Rats

1342-P: Reduction of Glucokinase and Glucokinase Regulatory Protein Expression by siRNA Is Associated with the Reduction of Lactate and Pyruvate Export from Canine Hepatocytes

1311-P: Glucokinase in AGRP Neurons Is Required for Normal Insulin Secretion and Action in Female Mice

317-OR: The Novel Glucokinase GCK (Q26L) Gene Mutation Site Causes Diabetes

835-P: The Hepatoselective Glucokinase Activator (GKA) TTP399 Does Not Increase Risk of Ketoacidosis in Type 1 Diabetes (T1D)

117-LB: Glucokinase Activator Restores Glucose Sensitivity and Early-Phase Insulin Secretion in T2DM Patient—A Post Hoc Analysis of Dorzagliatin

117-LB: Glucokinase Activator Dorzagliatin (HMS5552) Regulates GLP-1 Release in T2D Patients and Is Synergistic with Sitagliptin and Empagliflozin in Optimizing Beta-Cell Function

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