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Meeting Abstracts

835-P: The Hepatoselective Glucokinase Activator (GKA) TTP399 Does Not Increase Risk of Ketoacidosis in Type 1 Diabetes (T1D)

KLARA KLEIN, SCHAFER C. BOEDER, JENNIFER L. FREEMAN, SUPRADEEP MADDURI, ERIN R. GIOVANNETTI, CARMEN VALCARCE, JOHN B. BUSE, JEREMY PETTUS

Diabetes 2022;71(Supplement_1):835-P

DOI: https://doi.org/10.2337/db22-835-P

Published: 01 June 2022

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Meeting Abstracts

193-OR: Chronotherapy with the Glucokinase Activator AZD1656 Greatly Affects Its Ability to Improve Metabolism in Obese Zucker Rats

TOBIAS KROON, THERESE HAGSTEDT, IDA ALEXANDERSSON, ANNETT FERM, MARIE PETERSSON, STEFANIE MAURER, BADER ZARROUKI, KRISTINA WALLENIUS, NICHOLAS D. OAKES, JEREMIE BOUCHER

Diabetes 2022;71(Supplement_1):193-OR

DOI: https://doi.org/10.2337/db22-193-OR

Published: 01 June 2022

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Meeting Abstracts

1311-P: Glucokinase in AGRP Neurons Is Required for Normal Insulin Secretion and Action in Female Mice

MASA JOSIPOVIC, EMILY O. STARICOFF, CHRISTINE H. RICHES, LAURA SHEPPARD, MARK EVANS

Diabetes 2022;71(Supplement_1):1311-P

DOI: https://doi.org/10.2337/db22-1311-P

Published: 01 June 2022

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Meeting Abstracts

317-OR: The Novel Glucokinase GCK (Q26L) Gene Mutation Site Causes Diabetes

SHUHUI JI, HUA SHU, WENLI FENG, JINYANG ZHEN, JINGTING QIAO, YADI HUANG, SHANSHAN CHEN, MING LIU

Diabetes 2022;71(Supplement_1):317-OR

DOI: https://doi.org/10.2337/db22-317-OR

Published: 01 June 2022

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Meeting Abstracts

117-LB: Glucokinase Activator Restores Glucose Sensitivity and Early-Phase Insulin Secretion in T2DM Patient—A Post Hoc Analysis of Dorzagliatin

LINGGE FENG, QUANLE GUO, CHUNXIANG CHEN, XIANG LIU, LI CHEN, WENYING YANG

Diabetes 2022;71(Supplement_1):117-LB

DOI: https://doi.org/10.2337/db22-117-LB

Published: 01 June 2022

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Meeting Abstracts

1342-P: Reduction of Glucokinase and Glucokinase Regulatory Protein Expression by siRNA Is Associated with the Reduction of Lactate and Pyruvate Export from Canine Hepatocytes

MORVARID KABIR, MARILYN ADER, RICHARD N. BERGMAN

Diabetes 2022;71(Supplement_1):1342-P

DOI: https://doi.org/10.2337/db22-1342-P

Published: 01 June 2022

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Meeting Abstracts

261-OR: Dorzagliatin, a Dual-Acting Glucokinase Activator. Improves Insulin Secretion and Glucose Sensitivity in Glucokinase-Maturity-Onset Diabetes of the Young (GCK-MODY)

ELAINE CHOW, KE WANG, CADMON K.P. LIM, SANDRA TSOI, BAOQI FAN, ANDREA LUK, RONALD C. MA, ELE FERRANNINI, ANDREA MARI, LI CHEN, JULIANA C. CHAN

Diabetes 2022;71(Supplement_1):261-OR

DOI: https://doi.org/10.2337/db22-261-OR

Published: 01 June 2022

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Meeting Abstracts

117-LB: Glucokinase Activator Dorzagliatin (HMS5552) Regulates GLP-1 Release in T2D Patients and Is Synergistic with Sitagliptin and Empagliflozin in Optimizing Beta-Cell Function

LI CHEN, JIAYI ZHANG, RONG YANG, LINGGE FENG, HUA MEDICINE

Diabetes 2021;70(Supplement_1):117-LB

DOI: https://doi.org/10.2337/db21-117-LB

Published: 01 June 2021

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Journal Articles

Glucokinase Inactivation Paradoxically Ameliorates Glucose Intolerance by Increasing β-Cell Mass in db/db Mice

Kazuno Omori, Akinobu Nakamura, Hideaki Miyoshi, Yuki Yamauchi, Shinichiro Kawata, Kiyohiko Takahashi, Naoyuki Kitao, Hiroshi Nomoto, Hiraku Kameda, Kyu Yong Cho, Yasuo Terauchi, Tatsuya Atsumi

Diabetes 2021;70(4):917–931

DOI: https://doi.org/10.2337/db20-0881

Published: 18 February 2021

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Journal Articles

Low-Frequency Genetic Variant in the Hepatic Glucokinase Gene Is Associated With Type 2 Diabetes and Insulin Resistance in Chinese Population

Yumin Ma, Yingying Luo, Siqian Gong, Xianghai Zhou, Yufeng Li, Wei Liu, Simin Zhang, Xiaoling Cai, Qian Ren, Lingli Zhou, Xiuying Zhang, Yanai Wang, Xiuting Huang, Xueying Gao, Mengdie Hu, Xueyao Han, Linong Ji

Diabetes 2021;70(3):809–816

DOI: https://doi.org/10.2337/db20-0564

Published: 09 December 2020

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Meeting Abstracts

122-LB: The Simplici-T1 Trial: Glucokinase Activator TTP399 Improves Glycemic Control in Patients with Type 1 Diabetes

JOHN B. BUSE, KLARA KLEIN, JENNIFER L. FREEMAN, IMOGENE DUNN, CARMEN VALCARCE

Diabetes 2020;69(Supplement_1):122-LB

DOI: https://doi.org/10.2337/db20-122-LB

Published: 01 June 2020

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Meeting Abstracts

182-OR: A Novel Dual-Acting Glucokinase Activator (GKA) Dorzagliatin (HMS5552) Achieved Primary Efficacy Endpoint with Good Safety Profiles in T2DM Patients after 24 Weeks of Treatment in a Phase III Monotherapy Trial

DALONG ZHU, YI ZHANG, LI CHEN

Diabetes 2020;69(Supplement_1):182-OR

DOI: https://doi.org/10.2337/db20-182-OR

Published: 01 June 2020

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Meeting Abstracts

2084-P: Hepatic Fat Accumulation Underlies the Inability of Glucokinase Activator to Achieve a Sustained Hypoglycemic Effect in db/db Mice

SHINICHIRO KAWATA, AKINOBU NAKAMURA, HIDEAKI MIYOSHI, KAZUHISA TSUCHIDA, KAZUNO OMORI, KIYOHIKO TAKAHASHI, HIROSHI NOMOTO, HIRAKU KAMEDA, KYUYONG CHO, YASUO TERAUCHI, TATSUYA ATSUMI

Diabetes 2020;69(Supplement_1):2084-P

DOI: https://doi.org/10.2337/db20-2084-P

Published: 01 June 2020

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Meeting Abstracts

1447-P: Epistatic Interactions of Known Gene Variants for Glycated Hemoglobin: Evidence from the Long Life Family Study

PING AN, BHARAT THYAGARAJAN, JOSEPH H. LEE, NICOLE SCHUPF, JOSEPH M. ZMUDA, MICHAEL PROVINCE

Diabetes 2019;68(Supplement_1):1447-P

DOI: https://doi.org/10.2337/db19-1447-P

Published: 01 June 2019

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Meeting Abstracts

167-LB: Cost Optimization of Dorzagliatin Using Artificial Intelligence-Powered Population Modeling

BRITTANY BENNETT, SYDNEY ALLEN, BRADLEY EILERMAN, LEONARD J. TESTA

Diabetes 2019;68(Supplement_1):167-LB

DOI: https://doi.org/10.2337/db19-167-LB

Published: 01 June 2019

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Meeting Abstracts

1151-P: Dorzagliatin Differentiates from Early Generation of Glucokinase Activators: An Enzyme Kinetics Study

LI CHEN, YONGQIANG SHAN, XIAOWEI JIN, XIAOBING LV

Diabetes 2019;68(Supplement_1):1151-P

DOI: https://doi.org/10.2337/db19-1151-P

Published: 01 June 2019

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Meeting Abstracts

Glucokinase-MODY Frequently Misdiagnosed and Inappropriately Treated

SEAN BOYD, MARIA M. BYRNE

Diabetes 2018;67(Supplement_1):1234-P

DOI: https://doi.org/10.2337/db18-1234-P

Published: 01 July 2018

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Meeting Abstracts

Lower Hepatic Insulin Sensitivity in a Family with a Recently Described Glucokinase Gene Variant

KÁLMÁN BÓDIS, OANA P. ZAHARIA, YANISLAVA KARUSHEVA, PAVEL BOBROV, DANIEL F. MARKGRAF, BIRGIT KNEBEL, YULIYA KUPRIYANOVA, JONG-HEE HWANG, VOLKER BURKART, KARSTEN MÜSSIG, MICHAEL RODEN, JULIA SZENDROEDI

Diabetes 2018;67(Supplement_1):1509-P

DOI: https://doi.org/10.2337/db18-1509-P

Published: 01 July 2018

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Meeting Abstracts

Simplici-T1—First Clinical Trial to Test Activation of Glucokinase as an Adjunctive Treatment for Type 1 Diabetes

JOHN B. BUSE, CARMEN VALCARCE, JENNIFER L. FREEMAN, IMOGENE DUNN, CHRIS DVERGSTEN, M. SUE KIRKMAN, ALEXANDER KASS, JAMIE DINER, KATHERINE A. BERGAMO

Diabetes 2018;67(Supplement_1):126-LB

DOI: https://doi.org/10.2337/db18-126-LB

Published: 01 July 2018

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Meeting Abstracts

Functional Role and Mechanism of UCP2 Upregulation in Pancreatic ß Cells

RYOTA INOUE, JUN SHIRAKAWA, YU TOGASHI, YASUO TERAUCHI

Diabetes 2018;67(Supplement_1):2154-P

DOI: https://doi.org/10.2337/db18-2154-P

Published: 01 July 2018

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2 3 4 5

NARROW

835-P: The Hepatoselective Glucokinase Activator (GKA) TTP399 Does Not Increase Risk of Ketoacidosis in Type 1 Diabetes (T1D)

193-OR: Chronotherapy with the Glucokinase Activator AZD1656 Greatly Affects Its Ability to Improve Metabolism in Obese Zucker Rats

1311-P: Glucokinase in AGRP Neurons Is Required for Normal Insulin Secretion and Action in Female Mice

317-OR: The Novel Glucokinase GCK (Q26L) Gene Mutation Site Causes Diabetes

117-LB: Glucokinase Activator Restores Glucose Sensitivity and Early-Phase Insulin Secretion in T2DM Patient—A Post Hoc Analysis of Dorzagliatin

1342-P: Reduction of Glucokinase and Glucokinase Regulatory Protein Expression by siRNA Is Associated with the Reduction of Lactate and Pyruvate Export from Canine Hepatocytes

261-OR: Dorzagliatin, a Dual-Acting Glucokinase Activator. Improves Insulin Secretion and Glucose Sensitivity in Glucokinase-Maturity-Onset Diabetes of the Young (GCK-MODY)

117-LB: Glucokinase Activator Dorzagliatin (HMS5552) Regulates GLP-1 Release in T2D Patients and Is Synergistic with Sitagliptin and Empagliflozin in Optimizing Beta-Cell Function

Glucokinase Inactivation Paradoxically Ameliorates Glucose Intolerance by Increasing β-Cell Mass in db/db Mice

Low-Frequency Genetic Variant in the Hepatic Glucokinase Gene Is Associated With Type 2 Diabetes and Insulin Resistance in Chinese Population

122-LB: The Simplici-T1 Trial: Glucokinase Activator TTP399 Improves Glycemic Control in Patients with Type 1 Diabetes

182-OR: A Novel Dual-Acting Glucokinase Activator (GKA) Dorzagliatin (HMS5552) Achieved Primary Efficacy Endpoint with Good Safety Profiles in T2DM Patients after 24 Weeks of Treatment in a Phase III Monotherapy Trial

2084-P: Hepatic Fat Accumulation Underlies the Inability of Glucokinase Activator to Achieve a Sustained Hypoglycemic Effect in db/db Mice

1447-P: Epistatic Interactions of Known Gene Variants for Glycated Hemoglobin: Evidence from the Long Life Family Study

167-LB: Cost Optimization of Dorzagliatin Using Artificial Intelligence-Powered Population Modeling

1151-P: Dorzagliatin Differentiates from Early Generation of Glucokinase Activators: An Enzyme Kinetics Study

Glucokinase-MODY Frequently Misdiagnosed and Inappropriately Treated

Lower Hepatic Insulin Sensitivity in a Family with a Recently Described Glucokinase Gene Variant

Simplici-T1—First Clinical Trial to Test Activation of Glucokinase as an Adjunctive Treatment for Type 1 Diabetes

Functional Role and Mechanism of UCP2 Upregulation in Pancreatic ß Cells

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