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Meeting Abstracts

532-P: Voluntary Exercise during Food Restriction Promotes a Sustained Increase in Hepatic Oxidative Metabolism

STANISLAW DEJA, BLANKA KUCEJOVA, ADRIANNA MAURER, MONIKA N. MIZERSKA, XIAORONG FU, JOHN P. THYFAULT, SHAWN C. BURGESS

Diabetes 2022;71(Supplement_1):532-P

DOI: https://doi.org/10.2337/db22-532-P

Published: 01 June 2022

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Meeting Abstracts

216-LB: Hepatocyte N6-Methyladenosine mRNA Modification in Hepatic Gluconeogenesis and Diabetes

QIANTAO ZHENG, XIAO ZHONG, DECHENG REN, LIANGYOU RUI

Diabetes 2022;71(Supplement_1):216-LB

DOI: https://doi.org/10.2337/db22-216-LB

Published: 01 June 2022

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Meeting Abstracts

195-OR: A Novel 13C5 Glutamine Tracer Method (Q Flux) Reveals a Key Role of Succinyl CoA Anaplerosis in Promoting Increased Rates of Hepatic Gluconeogenesis during Hyperglucagonemia

BRANDON T. HUBBARD, GERALD I. SHULMAN

Diabetes 2022;71(Supplement_1):195-OR

DOI: https://doi.org/10.2337/db22-195-OR

Published: 01 June 2022

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Meeting Abstracts

360-OR: Hyperglucagonemia Reduces De Novo Lipogenesis and Increases Gluconeogenesis in Healthy Subjects

XI CHEN, FABRIZIA CARLI, SAMANTHA PEZZICA, GABRIELE MOCCIARO, DEMETRIO CIOCIARO, AMALIA GASTALDELLI, RALPH A. DEFRONZO, DEVJIT TRIPATHY

Diabetes 2022;71(Supplement_1):360-OR

DOI: https://doi.org/10.2337/db22-360-OR

Published: 01 June 2022

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Meeting Abstracts

207-LB: Simultaneous 2H/13C Assessment of Liver and Kidney Metabolic Fluxes Reveals Reciprocal Upregulation of Renal Gluconeogenesis in Hepatic PEPCK-C Knockout Mice

MOHSIN RAHIM, CLINTON M. HASENOUR, TOMASZ BEDNARSKI, CURTIS C. HUGHEY, DAVID WASSERMAN, JAMEY YOUNG

Diabetes 2021;70(Supplement_1):207-LB

DOI: https://doi.org/10.2337/db21-207-LB

Published: 01 June 2021

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Meeting Abstracts

204-LB: GADD45b Regulates Hepatic Gluconeogenesis via Modulating the Protein Stability of FoxO1

HYUNMI KIM

Diabetes 2021;70(Supplement_1):204-LB

DOI: https://doi.org/10.2337/db21-204-LB

Published: 01 June 2021

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Meeting Abstracts

279-OR: Hydroxylation Regulation of Hepatic Gluconeogenesis via Prolyl-Hydroxylase 3 in Mice

YAQIAN XUE, GENXIANG CAI, FENGGUANG MA, ZHENGSHUAI LIU, YUXIAO LIU, WEITONG SU, ZENGPENG ZHENG, DONG DING, YANG JIANG, JING GAO, XIAOZHEN DAI, AOYUAN CUI, YU LI

Diabetes 2021;70(Supplement_1):279-OR

DOI: https://doi.org/10.2337/db21-279-OR

Published: 01 June 2021

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Journal Articles

Metformin’s Therapeutic Efficacy in the Treatment of Diabetes Does Not Involve Inhibition of Mitochondrial Glycerol Phosphate Dehydrogenase

Michael J. MacDonald, Israr-ul H. Ansari, Melissa J. Longacre, Scott W. Stoker

Diabetes 2021;70(7):1575–1580

DOI: https://doi.org/10.2337/db20-1143

Published: 13 April 2021

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Journal Articles

Heme Oxygenase-1 Regulates Ferrous Iron and Foxo1 in Control of Hepatic Gluconeogenesis

Wang Liao, Wanbao Yang, Zheng Shen, Weiqi Ai, Quan Pan, Yuxiang Sun, Shaodong Guo

Diabetes 2021;70(3):696–709

DOI: https://doi.org/10.2337/db20-0954

Published: 06 January 2021

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Meeting Abstracts

368-OR: Activation of Hepatic Gluconeogenesis Is Required to Suppress DNL and Stimulate Ketogenesis during Fasting

STANISLAW DEJA, JOAO DUARTE, JUSTIN A. FLETCHER, BLANKA KUCEJOVA, XIAORONG FU, GONÇALO VALE, JAMEY YOUNG, JEFFREY BROWNING, SHAWN C. BURGESS

Diabetes 2020;69(Supplement_1):368-OR

DOI: https://doi.org/10.2337/db20-368-OR

Published: 01 June 2020

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Meeting Abstracts

1108-P: Resveratrol Inhibits Dapagliflozin-Induced Renal Gluconeogenesis through Modulating the PI3k/Akt/Foxo1 Pathway in HK-2 Cells

XIAOYA SUN

Diabetes 2020;69(Supplement_1):1108-P

DOI: https://doi.org/10.2337/db20-1108-P

Published: 01 June 2020

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Meeting Abstracts

1806-P: Vitamin D Deficiency Impairs mTORC2/Akt Signaling through Downregulating SIRT1 and Results in Increased Hepatic Gluconeogenesis

QI YUAN, JINGLEI YANG, MENGYUE SUN, SHAN TANG, MEIJUAN DONG, LI MAO

Diabetes 2020;69(Supplement_1):1806-P

DOI: https://doi.org/10.2337/db20-1806-P

Published: 01 June 2020

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Meeting Abstracts

1860-P: Alanine Transaminase 2 Is Induced in Diabetic Liver and Contributes to Gluconeogenesis from Amino Acids

MICHAEL R. MARTINO, MANUEL GUTIERREZ AGUILAR, KYLE S. MCCOMMIS, JUN YOSHINO, BRIAN N. FINCK

Diabetes 2020;69(Supplement_1):1860-P

DOI: https://doi.org/10.2337/db20-1860-P

Published: 01 June 2020

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Meeting Abstracts

707-P: Physical Exercise Decreases Notch1 Activation and Reduces the Gluconeogenesis in Liver of Obese Mice

RAFAEL C. GASPAR, VITOR MUÑOZ, SUSANA C. NAKANDAKARI, BARBARA M. CRISOL, RENAN F.L. VIEIRA, LUCIANA R. CONCEIÇÃO, ADELINO SILVA, DENNYS E. CINTRA, LEANDRO P. MOURA, EDUARDO R. ROPELLE, JOSÉ R. PAULI

Diabetes 2020;69(Supplement_1):707-P

DOI: https://doi.org/10.2337/db20-707-P

Published: 01 June 2020

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Meeting Abstracts

1918-P: YWHAB Inhibits Hepatic Gluconeogenesis through Suppression of Glucagon Signaling Pathway

LI WEI, LINLIN JI, CHAOYU ZHU

Diabetes 2020;69(Supplement_1):1918-P

DOI: https://doi.org/10.2337/db20-1918-P

Published: 01 June 2020

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Meeting Abstracts

224-LB: Role of the Mitochondrial Calcium Uniporter in the Regulation of Hepatic Mitochondrial Metabolism and Gluconeogenesis

TRACI E. LAMOIA, JI EUN LEE, MATEUS GUERRA, RUSSELL GOODMAN, GERALD I. SHULMAN

Diabetes 2020;69(Supplement_1):224-LB

DOI: https://doi.org/10.2337/db20-224-LB

Published: 01 June 2020

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Meeting Abstracts

1574-P: Plasma Glycolysis/Gluconeogenesis and TCA-Related Metabolites, Mediterranean Dietary Pattern, and Risk of Type 2 Diabetes

Diabetes 2019;68(Supplement_1):1574-P

DOI: https://doi.org/10.2337/db19-1574-P

Published: 01 June 2019

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Meeting Abstracts

288-LB: Effects of the Hepatic Mitochondrial Calcium Uniporter on Hepatic Gluconeogenesis and Mitochondrial Metabolism in Awake Mice

JI EUN LEE, LEIGH GOEDEKE, YE ZHANG, RACHEL J. PERRY, RUSSELL GOODMAN, VAMSI MOOTHA, GERALD I. SHULMAN

Diabetes 2019;68(Supplement_1):288-LB

DOI: https://doi.org/10.2337/db19-288-LB

Published: 01 June 2019

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Meeting Abstracts

287-LB: Autophagic Degradation of CRY1 and Control of Gluconeogenesis

MIRIAM TOLEDO SOLER, RAJAT SINGH

Diabetes 2019;68(Supplement_1):287-LB

DOI: https://doi.org/10.2337/db19-287-LB

Published: 01 June 2019

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Meeting Abstracts

1886-P: Hepatic Type 2 Innate Lymphoid Cells Suppress Gluconeogenesis via the IL-33/GATA3/IL-13 Axis

MASANORI FUJIMOTO, KOUTARO YOKOTE, TOMOAKI TANAKA

Diabetes 2019;68(Supplement_1):1886-P

DOI: https://doi.org/10.2337/db19-1886-P

Published: 01 June 2019

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2 3 4 5

NARROW

532-P: Voluntary Exercise during Food Restriction Promotes a Sustained Increase in Hepatic Oxidative Metabolism

216-LB: Hepatocyte N6-Methyladenosine mRNA Modification in Hepatic Gluconeogenesis and Diabetes

195-OR: A Novel 13C5 Glutamine Tracer Method (Q Flux) Reveals a Key Role of Succinyl CoA Anaplerosis in Promoting Increased Rates of Hepatic Gluconeogenesis during Hyperglucagonemia

360-OR: Hyperglucagonemia Reduces De Novo Lipogenesis and Increases Gluconeogenesis in Healthy Subjects

207-LB: Simultaneous 2H/13C Assessment of Liver and Kidney Metabolic Fluxes Reveals Reciprocal Upregulation of Renal Gluconeogenesis in Hepatic PEPCK-C Knockout Mice

204-LB: GADD45b Regulates Hepatic Gluconeogenesis via Modulating the Protein Stability of FoxO1

279-OR: Hydroxylation Regulation of Hepatic Gluconeogenesis via Prolyl-Hydroxylase 3 in Mice

Metformin’s Therapeutic Efficacy in the Treatment of Diabetes Does Not Involve Inhibition of Mitochondrial Glycerol Phosphate Dehydrogenase

Heme Oxygenase-1 Regulates Ferrous Iron and Foxo1 in Control of Hepatic Gluconeogenesis

368-OR: Activation of Hepatic Gluconeogenesis Is Required to Suppress DNL and Stimulate Ketogenesis during Fasting

1108-P: Resveratrol Inhibits Dapagliflozin-Induced Renal Gluconeogenesis through Modulating the PI3k/Akt/Foxo1 Pathway in HK-2 Cells

1806-P: Vitamin D Deficiency Impairs mTORC2/Akt Signaling through Downregulating SIRT1 and Results in Increased Hepatic Gluconeogenesis

1860-P: Alanine Transaminase 2 Is Induced in Diabetic Liver and Contributes to Gluconeogenesis from Amino Acids

707-P: Physical Exercise Decreases Notch1 Activation and Reduces the Gluconeogenesis in Liver of Obese Mice

1918-P: YWHAB Inhibits Hepatic Gluconeogenesis through Suppression of Glucagon Signaling Pathway

224-LB: Role of the Mitochondrial Calcium Uniporter in the Regulation of Hepatic Mitochondrial Metabolism and Gluconeogenesis

1574-P: Plasma Glycolysis/Gluconeogenesis and TCA-Related Metabolites, Mediterranean Dietary Pattern, and Risk of Type 2 Diabetes

288-LB: Effects of the Hepatic Mitochondrial Calcium Uniporter on Hepatic Gluconeogenesis and Mitochondrial Metabolism in Awake Mice

287-LB: Autophagic Degradation of CRY1 and Control of Gluconeogenesis

1886-P: Hepatic Type 2 Innate Lymphoid Cells Suppress Gluconeogenesis via the IL-33/GATA3/IL-13 Axis

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