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Journal Articles

G6PC2: A Negative Regulator of Basal Glucose-Stimulated Insulin Secretion

Lynley D. Pound, James K. Oeser, Tracy P. O’Brien, Yingda Wang, Chandler J. Faulman, Prasanna K. Dadi, David A. Jacobson, John C. Hutton, Owen P. McGuinness, Masakazu Shiota, Richard M. O’Brien
Journal: Diabetes
Diabetes 2013;62(5):1547–1556
https://doi.org/10.2337/db12-1067
Published: 16 April 2013
View article titled, G6PC2: A Negative Regulator of Basal Glucose-Stimulated Insulin Secretion
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Journal Articles

Deletion of the G6pc2 Gene Encoding the Islet-Specific Glucose-6-Phosphatase Catalytic Subunit–Related Protein Does Not Affect the Progression or Incidence of Type 1 Diabetes in NOD/ShiLtJ Mice

James K. Oeser, Vrajesh V. Parekh, Yingda Wang, Naresh K. Jegadeesh, Suparna A. Sarkar, Randall Wong, Catherine E. Lee, Lynley D. Pound, John C. Hutton, Luc Van Kaer, Richard M. O’Brien
Journal: Diabetes
Diabetes 2011;60(11):2922–2927
https://doi.org/10.2337/db11-0220
Published: 17 October 2011
View article titled, Deletion of the <em>G6pc2</em> Gene Encoding the Islet-Specific Glucose-6-Phosphatase Catalytic Subunit–Related Protein Does Not Affect the Progression or Incidence of Type 1 Diabetes in NOD/ShiLtJ Mice
Open the PDF for Deletion of the <em>G6pc2</em> Gene Encoding the Islet-Specific Glucose-6-Phosphatase Catalytic Subunit–Related Protein Does Not Affect the Progression or Incidence of Type 1 Diabetes in NOD/ShiLtJ Mice in another window
Includes: Supplementary data
Journal Articles

A Single-Nucleotide Polymorphism in a Methylatable Foxa2 Binding Site of the G6PC2 Promoter Is Associated With Insulin Secretion In Vivo and Increased Promoter Activity In Vitro

Christine Dos Santos, Pierre Bougnères, Delphine Fradin
Journal: Diabetes
Diabetes 2009;58(2):489–492
https://doi.org/10.2337/db08-0587
Published: 01 February 2009
View article titled, A Single-Nucleotide Polymorphism in a Methylatable Foxa2 Binding Site of the <em>G6PC2</em> Promoter Is Associated With Insulin Secretion In Vivo and Increased Promoter Activity In Vitro
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Journal Articles

Long-Range Enhancers Are Required to Maintain Expression of the Autoantigen Islet-Specific Glucose-6-Phosphatase Catalytic Subunit–Related Protein in Adult Mouse Islets In Vivo

Yingda Wang, Brian P. Flemming, Cyrus C. Martin, Shelley R. Allen, Jay Walters, James K. Oeser, John C. Hutton, Richard M. O'Brien
Journal: Diabetes
Diabetes 2008;57(1):133–141
https://doi.org/10.2337/db07-0092
Published: 01 January 2008
View article titled, Long-Range Enhancers Are Required to Maintain Expression of the Autoantigen Islet-Specific Glucose-6-Phosphatase Catalytic Subunit–Related Protein in Adult Mouse Islets In Vivo
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Includes: Supplementary data
Journal Articles

The Proximal Islet-Specific Glucose-6-Phosphatase Catalytic Subunit–Related Protein Autoantigen Promoter Is Sufficient to Initiate but not Maintain Transgene Expression in Mouse Islets in Vivo

Claudia Frigeri, Cyrus C. Martin, Christina A. Svitek, James K. Oeser, John C. Hutton, Maureen Gannon, Richard M. O’Brien
Journal: Diabetes
Diabetes 2004;53(7):1754–1764
https://doi.org/10.2337/diabetes.53.7.1754
Published: 01 July 2004
View article titled, The Proximal Islet-Specific Glucose-6-Phosphatase Catalytic Subunit–Related Protein Autoantigen Promoter Is Sufficient to Initiate but not Maintain Transgene Expression in Mouse Islets in Vivo
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Journal Articles

Glucose 6-Phosphate Regulates Hepatic Glycogenolysis Through Inactivation of Phosphorylase

Susan Aiston, Birgitte Andersen, Loranne Agius
Journal: Diabetes
Diabetes 2003;52(6):1333–1339
https://doi.org/10.2337/diabetes.52.6.1333
Published: 01 June 2003
View article titled, Glucose 6-Phosphate Regulates Hepatic Glycogenolysis Through Inactivation of Phosphorylase
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Journal Articles

Novel Arguments in Favor of the Substrate-Transport Model of Glucose-6-Phosphatase

Isabelle Gerin, Gaëtane Noël, Emile Van Schaftingen
Journal: Diabetes
Diabetes 2001;50(7):1531–1538
https://doi.org/10.2337/diabetes.50.7.1531
Published: 01 July 2001
View article titled, Novel Arguments in Favor of the Substrate-Transport Model of Glucose-6-Phosphatase
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Journal Articles

Characterization of the Mouse Islet-Specific Glucose-6-Phosphatase Catalytic Subunit–Related Protein Gene Promoter by In Situ Footprinting: Correlation With Fusion Gene Expression in the Islet-Derived βTC-3 and Hamster Insulinoma Tumor Cell Lines

Larry J. Bischof, Cyrus C. Martin, Christina A. Svitek, Beth T. Stadelmaier, Lauri A. Hornbuckle, Joshua K. Goldman, James K. Oeser, John C. Hutton, Richard M. O’Brien
Journal: Diabetes
Diabetes 2001;50(3):502–514
https://doi.org/10.2337/diabetes.50.3.502
Published: 01 March 2001
View article titled, Characterization of the Mouse Islet-Specific Glucose-6-Phosphatase Catalytic Subunit–Related Protein Gene Promoter by In Situ Footprinting: <subtitle>Correlation With Fusion Gene Expression in the Islet-Derived βTC-3 and Hamster Insulinoma Tumor Cell Lines</subtitle>
Open the PDF for Characterization of the Mouse Islet-Specific Glucose-6-Phosphatase Catalytic Subunit–Related Protein Gene Promoter by In Situ Footprinting: <subtitle>Correlation With Fusion Gene Expression in the Islet-Derived βTC-3 and Hamster Insulinoma Tumor Cell Lines</subtitle> in another window
Meeting Abstracts

Glucose-6-phosphatase flux in vitro is increased in type 2 diabetes.

J N Clore, J Stillman, H Sugerman
Journal: Diabetes
Diabetes 2000;49(6):969–974
https://doi.org/10.2337/diabetes.49.6.969
Published: 01 June 2000
View article titled, Glucose-6-phosphatase flux in vitro is increased in type 2 diabetes.
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Meeting Abstracts

5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase.

P A Lochhead, I P Salt, K S Walker, D G Hardie, C Sutherland
Journal: Diabetes
Diabetes 2000;49(6):896–903
https://doi.org/10.2337/diabetes.49.6.896
Published: 01 June 2000
View article titled, 5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase.
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Meeting Abstracts

Conservation of an insulin response unit between mouse and human glucose-6-phosphatase catalytic subunit gene promoters: transcription factor FKHR binds the insulin response sequence.

J E Ayala, R S Streeper, J S Desgrosellier, S K Durham, A Suwanichkul, C A Svitek, J K Goldman, F G Barr, D R Powell, R M O'Brien
Journal: Diabetes
Diabetes 1999;48(9):1885–1889
https://doi.org/10.2337/diabetes.48.9.1885
Published: 01 September 1999
View article titled, Conservation of an insulin response unit between mouse and human glucose-6-phosphatase catalytic subunit gene promoters: transcription factor FKHR binds the insulin response sequence.
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Meeting Abstracts

Dehydroepiandrosterone suppresses the elevated hepatic glucose-6-phosphatase and fructose-1,6-bisphosphatase activities in C57BL/Ksj-db/db mice: comparison with troglitazone.

K Aoki, T Saito, S Satoh, K Mukasa, M Kaneshiro, S Kawasaki, A Okamura, H Sekihara
Journal: Diabetes
Diabetes 1999;48(8):1579–1585
https://doi.org/10.2337/diabetes.48.8.1579
Published: 01 August 1999
View article titled, Dehydroepiandrosterone suppresses the elevated hepatic glucose-6-phosphatase and fructose-1,6-bisphosphatase activities in C57BL/Ksj-db/db mice: comparison with troglitazone.
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Meeting Abstracts

Molecular cloning of a pancreatic islet-specific glucose-6-phosphatase catalytic subunit-related protein.

S D Arden, T Zahn, S Steegers, S Webb, B Bergman, R M O'Brien, J C Hutton
Journal: Diabetes
Diabetes 1999;48(3):531–542
https://doi.org/10.2337/diabetes.48.3.531
Published: 01 March 1999
View article titled, Molecular cloning of a pancreatic islet-specific glucose-6-phosphatase catalytic subunit-related protein.
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Meeting Abstracts

Structure and promoter activity of an islet-specific glucose-6-phosphatase catalytic subunit-related gene.

D H Ebert, L J Bischof, R S Streeper, S C Chapman, C A Svitek, J K Goldman, C E Mathews, E H Leiter, J C Hutton, R M O'Brien
Journal: Diabetes
Diabetes 1999;48(3):543–551
https://doi.org/10.2337/diabetes.48.3.543
Published: 01 March 1999
View article titled, Structure and promoter activity of an islet-specific glucose-6-phosphatase catalytic subunit-related gene.
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Meeting Abstracts

Development and regulation of glucose-6-phosphatase gene expression in rat liver, intestine, and kidney: in vivo and in vitro studies in cultured fetal hepatocytes.

F Chatelain, J P Pégorier, C Minassian, N Bruni, S Tarpin, J Girard, G Mithieux
Journal: Diabetes
Diabetes 1998;47(6):882–889
https://doi.org/10.2337/diabetes.47.6.882
Published: 01 June 1998
View article titled, Development and regulation of glucose-6-phosphatase gene expression in rat liver, intestine, and kidney: in vivo and in vitro studies in cultured fetal hepatocytes.
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Journal Articles

Induction of Hepatic Glucose-6-Phosphatase Gene Expression by Lipid Infusion

Duna Massillon, Nir Barzilai, Meredith Hawkins, Dina Prus-Wertheimer, Luciano Rossetti
Journal: Diabetes
Diabetes 1997;46(1):153–157
https://doi.org/10.2337/diab.46.1.153
Published: 01 January 1997
View article titled, Induction of Hepatic Glucose-6-Phosphatase Gene Expression by Lipid Infusion
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Journal Articles

Regulation of Rat Liver Glucose-6-Phosphatase Gene Expression in Different Nutritional and Hormonal States: Gene Structure and 5′-Flanking Sequence

Doriane Argaud, Qing Zhang, Wansong Pan, Subir Maitra, Simon J Pilkis, Alex J Lange
Journal: Diabetes
Diabetes 1996;45(11):1563–1571
https://doi.org/10.2337/diab.45.11.1563
Published: 01 November 1996
View article titled, Regulation of Rat Liver Glucose-6-Phosphatase Gene Expression in Different Nutritional and Hormonal States: Gene Structure and 5′-Flanking Sequence
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Journal Articles

Glucose-6-Phosphatase mRNA and Activity Are Increased to the Same Extent in Kidney and Liver of Diabetic Rats

Gilles Mithieux, Hubert Vidal, Carine Zitoun, Nathalie Bruni, Nathalie Daniele, Carol Minassian
Journal: Diabetes
Diabetes 1996;45(7):891–896
https://doi.org/10.2337/diab.45.7.891
Published: 01 July 1996
View article titled, Glucose-6-Phosphatase mRNA and Activity Are Increased to the Same Extent in Kidney and Liver of Diabetic Rats
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Journal Articles

Evolution of β-Cell Dysfunction in the Male Zucker Diabetic Fatty Rat

Yoshiharu Tokuyama, Jeppe Sturis, Alex M DePaoli, Jun Takeda, Markus Stoffel, Jiping Tang, Xiaohong Sun, Kenneth S Polonsky, Graeme I Bell
Journal: Diabetes
Diabetes 1995;44(12):1447–1457
https://doi.org/10.2337/diab.44.12.1447
Published: 01 December 1995
View article titled, Evolution of β-Cell Dysfunction in the Male Zucker Diabetic Fatty Rat
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Journal Articles

The Role of Glucose-6-Phosphatase in the Action of Insulin on Hepatic Glucose Production in the Rat

Lawrence B Gardner, Zhenqi Liu, Eugene J Barrett
Journal: Diabetes
Diabetes 1993;42(11):1614–1620
https://doi.org/10.2337/diab.42.11.1614
Published: 01 November 1993
View article titled, The Role of Glucose-6-Phosphatase in the Action of Insulin on Hepatic Glucose Production in the Rat
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