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Journal Articles

Glutamine Production by Glul Promotes Thermogenic Adipocyte Differentiation Through Prdm9-Mediated H3K4me3 and Transcriptional Reprogramming

Xiaowen Pan, Lingxia Ye, Xiaozhen Guo, Weihua Wang, Ziyin Zhang, Qintao Wang, Jingjing Huang, Jingya Xu, Yanhan Cai, Xinxin Shou, Yuting Wang, Yu Feng, Cen Xie, Pengfei Shan, Zhuo-Xian Meng
Journal: Diabetes
Diabetes 2023;72(11):1574–1596
https://doi.org/10.2337/db23-0162
Published: 14 August 2023
View article titled, Glutamine Production by Glul Promotes Thermogenic Adipocyte Differentiation Through Prdm9-Mediated H3K4me3 and Transcriptional Reprogramming
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Meeting Abstracts

195-OR: A Novel 13C5 Glutamine Tracer Method (Q Flux) Reveals a Key Role of Succinyl CoA Anaplerosis in Promoting Increased Rates of Hepatic Gluconeogenesis during Hyperglucagonemia

BRANDON T. HUBBARD, GERALD I. SHULMAN
Journal: Diabetes
Diabetes 2022;71(Supplement_1):195-OR
https://doi.org/10.2337/db22-195-OR
Published: 01 June 2022
View article titled, 195-OR: A Novel 13C5 Glutamine Tracer Method (Q Flux) Reveals a Key Role of Succinyl CoA Anaplerosis in Promoting Increased Rates of Hepatic Gluconeogenesis during Hyperglucagonemia
Journal Articles

Glutamine Regulates Skeletal Muscle Immunometabolism in Type 2 Diabetes

Lucile Dollet, Michael Kuefner, Elena Caria, David Rizo-Roca, Logan Pendergrast, Ahmed M. Abdelmoez, Håkan K.R. Karlsson, Marie Bjrnholm, Emilie Dalbram, Jonas T. Treebak, Jun Harada, Erik Näslund, Mikael Rydén, Juleen R. Zierath, Nicolas J. Pillon, Anna Krook
Journal: Diabetes
Diabetes 2022;71(4):624–636
https://doi.org/10.2337/db20-0814
Published: 18 January 2022
View article titled, Glutamine Regulates Skeletal Muscle Immunometabolism in Type 2 Diabetes
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Journal Articles

Association of the 1q25 Diabetes-Specific Coronary Heart Disease Locus With Alterations of the γ-Glutamyl Cycle and Increased Methylglyoxal Levels in Endothelial Cells

Caterina Pipino, Hetal Shah, Sabrina Prudente, Natalia Di Pietro, Lixia Zeng, Kyoungmin Park, Vincenzo Trischitta, Subramanian Pennathur, Assunta Pandolfi, Alessandro Doria
Journal: Diabetes
Diabetes 2020;69(10):2206–2216
https://doi.org/10.2337/db20-0475
Published: 10 July 2020
View article titled, Association of the 1q25 Diabetes-Specific Coronary Heart Disease Locus With Alterations of the γ-Glutamyl Cycle and Increased Methylglyoxal Levels in Endothelial Cells
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Meeting Abstracts

369-OR: [1,2-13C2]-L-Glutamine Mass Isotopomers Map Hepatic Mitochondrial Metabolism without Tracer Interference

STEPHAN SIEBEL, REBECCA L. CARDONE, ABUDUKADIER ABULIZI, RAAISA RAAISA, RICHARD M. WILLIAMS, RAGHAV SEHGAL, GINA MARIE BUTRICO, GARY CLINE, DOUGLAS L. ROTHMAN, GRAEME F. MASON, RICHARD KIBBEY, IV
Journal: Diabetes
Diabetes 2020;69(Supplement_1):369-OR
https://doi.org/10.2337/db20-369-OR
Published: 01 June 2020
View article titled, 369-OR: [1,2-13C2]-L-Glutamine Mass Isotopomers Map Hepatic Mitochondrial Metabolism without Tracer Interference
Journal Articles

Impaired Amino Acid and TCA Metabolism and Cardiovascular Autonomic Neuropathy Progression in Type 1 Diabetes

Anna V. Mathew, Mamta Jaiswal, Lynn Ang, George Michailidis, Subramaniam Pennathur, Rodica Pop-Busui
Journal: Diabetes
Diabetes 2019;68(10):2035–2044
https://doi.org/10.2337/db19-0145
Published: 23 July 2019
View article titled, Impaired Amino Acid and TCA Metabolism and Cardiovascular Autonomic Neuropathy Progression in Type 1 Diabetes
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Includes: Supplementary data
Meeting Abstracts

1923-P: Quantitative Measurement of Whole-Body Glycogen Metabolism and Gluconeogenic Flux

TARA TESLAA
Journal: Diabetes
Diabetes 2019;68(Supplement_1):1923-P
https://doi.org/10.2337/db19-1923-P
Published: 01 June 2019
View article titled, 1923-P: Quantitative Measurement of Whole-Body Glycogen Metabolism and Gluconeogenic Flux
Meeting Abstracts

1945-P: The Mitochondrial Protein DRP1 Is Required for Endogenous Fatty Acid Oxidation

WILLIAM T. KING, CHRISTOPHER L. AXELROD, GANGARAO DAVULURI, ROBERT C. NOLAND, JOHN P. KIRWAN
Journal: Diabetes
Diabetes 2019;68(Supplement_1):1945-P
https://doi.org/10.2337/db19-1945-P
Published: 01 June 2019
View article titled, 1945-P: The Mitochondrial Protein DRP1 Is Required for Endogenous Fatty Acid Oxidation
Journal Articles

Liver Glutamate Dehydrogenase Controls Whole-Body Energy Partitioning Through Amino Acid–Derived Gluconeogenesis and Ammonia Homeostasis

Melis Karaca, Juliette Martin-Levilain, Mariagrazia Grimaldi, Lingzi Li, Eva Dizin, Yalin Emre, Pierre Maechler
Journal: Diabetes
Diabetes 2018;67(10):1949–1961
https://doi.org/10.2337/db17-1561
Published: 12 July 2018
View article titled, Liver Glutamate Dehydrogenase Controls Whole-Body Energy Partitioning Through Amino Acid–Derived Gluconeogenesis and Ammonia Homeostasis
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Includes: Supplementary data
Meeting Abstracts

The Simultaneous Changes of Endogenous Glucose Production, Postprandial Glucagon, and Fasting Glutamine during Weight Loss in Type 2 Diabetes

JULIA OTTEN, ANDREAS STOMBY, MARIA WALING, ELIN CHORELL, MATS RYBERG, MICHAEL B. SVENSSON, JENS J. HOLST, TOMMY OLSSON
Journal: Diabetes
Diabetes 2018;67(Supplement_1):1960-P
https://doi.org/10.2337/db18-1960-P
Published: 01 July 2018
View article titled, The Simultaneous Changes of Endogenous Glucose Production, Postprandial Glucagon, and Fasting Glutamine during Weight Loss in Type 2 Diabetes
Journal Articles

Glutamine-Elicited Secretion of Glucagon-Like Peptide 1 Is Governed by an Activated Glutamate Dehydrogenase

Lotta E. Andersson, Liliya Shcherbina, Mahmoud Al-Majdoub, Neelanjan Vishnu, Claudia Balderas Arroyo, Jonathan Aste Carrara, Claes B. Wollheim, Malin Fex, Hindrik Mulder, Nils Wierup, Peter Spégel
Journal: Diabetes
Diabetes 2018;67(3):372–384
https://doi.org/10.2337/db16-1441
Published: 11 December 2017
View article titled, Glutamine-Elicited Secretion of Glucagon-Like Peptide 1 Is Governed by an Activated Glutamate Dehydrogenase
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Includes: Supplementary data
Journal Articles

Functional and Metabolomic Consequences of KATP Channel Inactivation in Human Islets

Changhong Li, Amanda M. Ackermann, Kara E. Boodhansingh, Tricia R. Bhatti, Chengyang Liu, Jonathan Schug, Nicolai Doliba, Bing Han, Karen E. Cosgrove, Indraneel Banerjee, Franz M. Matschinsky, Itzhak Nissim, Klaus H. Kaestner, Ali Naji, N. Scott Adzick, Mark J. Dunne, Charles A. Stanley, Diva D. De León
Journal: Diabetes
Diabetes 2017;66(7):1901–1913
https://doi.org/10.2337/db17-0029
Published: 25 April 2017
View article titled, Functional and Metabolomic Consequences of K<sub>ATP</sub> Channel Inactivation in Human Islets
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Includes: Supplementary data
Journal Articles

Interaction of Islet α-Cell and β-Cell in the Regulation of Glucose Homeostasis in HI/HA Syndrome Patients With the GDHH454Y Mutation

Guanghong Jia, James R. Sowers
Journal: Diabetes
Diabetes 2014;63(12):4008–4010
https://doi.org/10.2337/db14-1243
Published: 13 November 2014
View article titled, Interaction of Islet α-Cell and β-Cell in the Regulation of Glucose Homeostasis in HI/HA Syndrome Patients With the GDH<sup>H454Y</sup> Mutation
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Journal Articles

Mitochondrial GTP Insensitivity Contributes to Hypoglycemia in Hyperinsulinemia Hyperammonemia by Inhibiting Glucagon Release

Richard G. Kibbey, Cheol Soo Choi, Hui-Young Lee, Over Cabrera, Rebecca L. Pongratz, Xiaojian Zhao, Andreas L. Birkenfeld, Changhong Li, Per-Olof Berggren, Charles Stanley, Gerald I. Shulman
Journal: Diabetes
Diabetes 2014;63(12):4218–4229
https://doi.org/10.2337/db14-0783
Published: 13 November 2014
View article titled, Mitochondrial GTP Insensitivity Contributes to Hypoglycemia in Hyperinsulinemia Hyperammonemia by Inhibiting Glucagon Release
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Journal Articles

EphA5-EphrinA5 Interactions Within the Ventromedial Hypothalamus Influence Counterregulatory Hormone Release and Local Glutamine/Glutamate Balance During Hypoglycemia

Barbara Szepietowska, Wanling Zhu, Jan Czyzyk, Tore Eid, Robert S. Sherwin
Journal: Diabetes
Diabetes 2013;62(4):1282–1288
https://doi.org/10.2337/db12-0982
Published: 14 March 2013
View article titled, EphA5-EphrinA5 Interactions Within the Ventromedial Hypothalamus Influence Counterregulatory Hormone Release and Local Glutamine/Glutamate Balance During Hypoglycemia
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Journal Articles

Pathogenesis of A−β+ Ketosis-Prone Diabetes

Sanjeet G. Patel, Jean W. Hsu, Farook Jahoor, Ivonne Coraza, James R. Bain, Robert D. Stevens, Dinakar Iyer, Ramaswami Nalini, Kerem Ozer, Christiane S. Hampe, Christopher B. Newgard, Ashok Balasubramanyam
Journal: Diabetes
Diabetes 2013;62(3):912–922
https://doi.org/10.2337/db12-0624
Published: 14 February 2013
View article titled, Pathogenesis of A<sup>−</sup>β<sup>+</sup> Ketosis-Prone Diabetes
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Journal Articles

The Complex Mechanism of Glutamate Dehydrogenase in Insulin Secretion

Leonard A. Fahien, Michael J. MacDonald
Journal: Diabetes
Diabetes 2011;60(10):2450–2454
https://doi.org/10.2337/db10-1150
Published: 16 September 2011
View article titled, The Complex Mechanism of Glutamate Dehydrogenase in Insulin Secretion
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Journal Articles

Amino Acid Metabolism, β-Cell Function, and Diabetes

Philip Newsholme, Lorraine Brennan, Katrin Bender
Journal: Diabetes
Diabetes 2006;55(Supplement_2):S39–S47
https://doi.org/10.2337/db06-S006
Published: 01 December 2006
View article titled, Amino Acid Metabolism, β-Cell Function, and Diabetes
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Journal Articles

Scrutiny of the Glutamine-Fructose-6-Phosphate Transaminase 1 (GFPT1) Locus Reveals Conserved Haplotype Block Structure not Associated With Diabetic Nephropathy

Daniel P.K. Ng, William H. Walker, Kee-Seng Chia, Serena Choo, James H. Warram, Andrzej S. Krolewski
Journal: Diabetes
Diabetes 2004;53(3):865–869
https://doi.org/10.2337/diabetes.53.3.865
Published: 01 March 2004
View article titled, Scrutiny of the Glutamine-Fructose-6-Phosphate Transaminase 1 (<em>GFPT1</em>) Locus Reveals Conserved Haplotype Block Structure not Associated With Diabetic Nephropathy
Open the PDF for Scrutiny of the Glutamine-Fructose-6-Phosphate Transaminase 1 (<em>GFPT1</em>) Locus Reveals Conserved Haplotype Block Structure not Associated With Diabetic Nephropathy in another window
Includes: Supplementary data
Journal Articles

Palmitate-Induced Activation of the Hexosamine Pathway in Human Myotubes: Increased Expression of Glutamine:Fructose-6-Phosphate Aminotransferase

Cora Weigert, Karsten Klopfer, Christiana Kausch, Katrin Brodbeck, Michael Stumvoll, Hans U. Häring, Erwin D. Schleicher
Journal: Diabetes
Diabetes 2003;52(3):650–656
https://doi.org/10.2337/diabetes.52.3.650
Published: 01 March 2003
View article titled, Palmitate-Induced Activation of the Hexosamine Pathway in Human Myotubes: <subtitle>Increased Expression of Glutamine:Fructose-6-Phosphate Aminotransferase </subtitle>
Open the PDF for Palmitate-Induced Activation of the Hexosamine Pathway in Human Myotubes: <subtitle>Increased Expression of Glutamine:Fructose-6-Phosphate Aminotransferase </subtitle> in another window