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Journal Articles

Optimized Proteomic Analysis of Insulin Granules From MIN6 Cells Identifies Scamp3, a Novel Regulator of Insulin Secretion and Content

Nicholas Norris, Belinda Yau, Carlo Famularo, Hayley Webster, Thomas Loudovaris, Helen E. Thomas, Mark Larance, Alistair M. Senior, Melkam A. Kebede
Journal: Diabetes
Diabetes 2024;73(12):2045–2054
https://doi.org/10.2337/db24-0355
Published: 25 September 2024
View articletitled, Optimized Proteomic Analysis of Insulin Granules From MIN6 Cells Identifies Scamp3, a Novel Regulator of Insulin Secretion and Content
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Journal Articles

The Chd4 Helicase Regulates Chromatin Accessibility and Gene Expression Critical for β-Cell Function In Vivo

Rebecca K. Davidson, Sukrati Kanojia, Wenting Wu, Tatsuyoshi Kono, Jerry Xu, Meredith Osmulski, Robert N. Bone, Nolan Casey, Carmella Evans-Molina, Emily K. Sims, Jason M. Spaeth
Journal: Diabetes
Diabetes 2023;72(6):746–757
https://doi.org/10.2337/db22-0939
Published: 13 March 2023
View articletitled, The Chd4 Helicase Regulates Chromatin Accessibility and Gene Expression Critical for β-Cell Function In Vivo
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Journal Articles

Cathepsin D Drives the Formation of Hybrid Insulin Peptides Relevant to the Pathogenesis of Type 1 Diabetes

Samantha A. Crawford, Timothy A. Wiles, Janet M. Wenzlau, Roger L. Powell, Gene Barbour, Mylinh Dang, Jason Groegler, Jessie M. Barra, KaLia S. Burnette, Anita C. Hohenstein, Rocky L. Baker, Hubert M. Tse, Kathryn Haskins, Thomas Delong
Journal: Diabetes
Diabetes 2022;71(12):2793–2803
https://doi.org/10.2337/db22-0303
Published: 30 August 2022
View articletitled, Cathepsin D Drives the Formation of Hybrid Insulin Peptides Relevant to the Pathogenesis of Type 1 Diabetes
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Journal Articles

Dopamine Negatively Regulates Insulin Secretion Through Activation of D1-D2 Receptor Heteromer

Fumiya Uefune, Toru Aonishi, Tetsuya Kitaguchi, Harumi Takahashi, Susumu Seino, Daisuke Sakano, Shoen Kume
Journal: Diabetes
Diabetes 2022;71(9):1946–1961
https://doi.org/10.2337/db21-0644
Published: 22 June 2022
View articletitled, Dopamine Negatively Regulates Insulin Secretion Through Activation of D1-D2 Receptor Heteromer
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Meeting Abstracts

314-OR: Synaptotagmin-9 Regulates Early Phase Insulin Secretion by Regulating Tomosyn-1

MD MOSTAFIZUR RAHMAN, HAIFA ALSHARIF, SUSHANT BHATNAGAR
Journal: Diabetes
Diabetes 2022;71(Supplement_1):314-OR
https://doi.org/10.2337/db22-314-OR
Published: 01 June 2022
View articletitled, 314-OR: Synaptotagmin-9 Regulates Early Phase Insulin Secretion by Regulating Tomosyn-1
Journal Articles

A Selective Look at Autophagy in Pancreatic β-Cells

Gemma L. Pearson, Morgan A. Gingerich, Emily M. Walker, Trevor J. Biden, Scott A. Soleimanpour
Journal: Diabetes
Diabetes 2021;70(6):1229–1241
https://doi.org/10.2337/dbi20-0014
Published: 02 July 2021
View articletitled, A Selective Look at Autophagy in Pancreatic β-Cells
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Meeting Abstracts

125-OR: Synaptotagmin 9 Regulates Tomosyn-2 Protein Abundance to Affect Early Phase of Insulin Secretion

ASMITA PATHAK, HAIFA ALSHARIF, JOHN E. TROMBLEY, MD MOSTAFIZUR RAHMAN, SUSHANT BHATNAGAR
Journal: Diabetes
Diabetes 2021;70(Supplement_1):125-OR
https://doi.org/10.2337/db21-125-OR
Published: 01 June 2021
View articletitled, 125-OR: Synaptotagmin 9 Regulates Tomosyn-2 Protein Abundance to Affect Early Phase of Insulin Secretion
Journal Articles

Melanophilin Accelerates Insulin Granule Fusion without Predocking to the Plasma Membrane

Hao Wang, Kouichi Mizuno, Noriko Takahashi, Eri Kobayashi, Jun Shirakawa, Yasuo Terauchi, Haruo Kasai, Katsuhide Okunishi, Tetsuro Izumi
Journal: Diabetes
Diabetes 2020;69(12):2655–2666
https://doi.org/10.2337/db20-0069
Published: 29 November 2020
View articletitled, Melanophilin Accelerates Insulin Granule Fusion without Predocking to the Plasma Membrane
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Journal Articles

There Is Something About Insulin Granules

Bart O. Roep
Journal: Diabetes
Diabetes 2020;69(12):2575–2577
https://doi.org/10.2337/dbi20-0039
Published: 16 November 2020
View articletitled, There Is Something About Insulin Granules
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Journal Articles

Peptides Derived From Insulin Granule Proteins Are Targeted by CD8+ T Cells Across MHC Class I Restrictions in Humans and NOD Mice

Marie Eliane Azoury, Mahmoud Tarayrah, Georgia Afonso, Aurore Pais, Maikel L. Colli, Claire Maillard, Cassandra Lavaud, Laure Alexandre-Heymann, Sergio Gonzalez-Duque, Yann Verdier, Joelle Vinh, Sheena Pinto, Soren Buus, Danièle Dubois-Laforgue, Etienne Larger, Jean-Paul Beressi, Graziella Bruno, Decio L. Eizirik, Sylvaine You, Roberto Mallone
Journal: Diabetes
Diabetes 2020;69(12):2678–2690
https://doi.org/10.2337/db20-0013
Published: 14 September 2020
View articletitled, Peptides Derived From Insulin Granule Proteins Are Targeted by CD8+ T Cells Across MHC Class I Restrictions in Humans and NOD Mice
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Meeting Abstracts

82-OR: Exosomes from Human ß-Cells Incorporate Stress Granule Components and May Serve as Biomarkers of ß-Cell Stress in Type 1 Diabetes

FAROOQ SYED, BERNHARD F. MAIER, EMILY ANDERSON-BAUCUM, TERESA L. MASTRACCI, CARMELLA EVANS-MOLINA, RAGHAVENDRA MIRMIRA
Journal: Diabetes
Diabetes 2020;69(Supplement_1):82-OR
https://doi.org/10.2337/db20-82-OR
Published: 01 June 2020
View articletitled, 82-OR: Exosomes from Human ß-Cells Incorporate Stress Granule Components and May Serve as Biomarkers of ß-Cell Stress in Type 1 Diabetes
Journal Articles

Potential Protection Against Type 2 Diabetes in Obesity Through Lower CD36 Expression and Improved Exocytosis in β-Cells

Mototsugu Nagao, Jonathan L.S. Esguerra, Akira Asai, Jones K. Ofori, Anna Edlund, Anna Wendt, Hitoshi Sugihara, Claes B. Wollheim, Shinichi Oikawa, Lena Eliasson
Journal: Diabetes
Diabetes 2020;69(6):1193–1205
https://doi.org/10.2337/db19-0944
Published: 20 March 2020
View articletitled, Potential Protection Against Type 2 Diabetes in Obesity Through Lower CD36 Expression and Improved Exocytosis in β-Cells
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Journal Articles

RILP Restricts Insulin Secretion Through Mediating Lysosomal Degradation of Proinsulin

Yuxia Zhou, Zhiyu Liu, Shengmei Zhang, Ruijuan Zhuang, Huiying Liu, Xiaoqing Liu, Xi Qiu, Ming Zhang, Yanpan Zheng, Liangcheng Li, Wanjin Hong, Tuanlao Wang
Journal: Diabetes
Diabetes 2020;69(1):67–82
https://doi.org/10.2337/db19-0086
Published: 17 October 2019
View articletitled, RILP Restricts Insulin Secretion Through Mediating Lysosomal Degradation of Proinsulin
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Includes: Supplementary data
Meeting Abstracts

335-LB: Towards Generating Spatiotemporal Multiscale Models of Pancreatic ß Cells

KATE L. WHITE, JITIN SINGLA, RAYMOND C. STEVENS
Journal: Diabetes
Diabetes 2019;68(Supplement_1):335-LB
https://doi.org/10.2337/db19-335-LB
Published: 01 June 2019
View articletitled, 335-LB: Towards Generating Spatiotemporal Multiscale Models of Pancreatic ß Cells
Meeting Abstracts

1784-P: Studying the Impact of Heterozygous Human INS Gene Mutation on Pancreatic ß Cell

NUR SHABRINA AMIRRUDDIN, YAW SING TAN, CHANDRA S. VERMA, DAPHNE GARDNER, YONG MONG BEE, SHAWN HOON, ADRIAN TEO
Journal: Diabetes
Diabetes 2019;68(Supplement_1):1784-P
https://doi.org/10.2337/db19-1784-P
Published: 01 June 2019
View articletitled, 1784-P: Studying the Impact of Heterozygous Human INS Gene Mutation on Pancreatic ß Cell
Meeting Abstracts

1772-P: Insulin Granule Biogenesis at the Golgi Requires a Metabolically-Regulated, Non-centrosomal Subpopulation of Microtubules

KATHRYN TROGDEN, CHRISTOPHER V. WRIGHT, GUOQIANG GU, IRINA KAVERINA
Journal: Diabetes
Diabetes 2019;68(Supplement_1):1772-P
https://doi.org/10.2337/db19-1772-P
Published: 01 June 2019
View articletitled, 1772-P: Insulin Granule Biogenesis at the Golgi Requires a Metabolically-Regulated, Non-centrosomal Subpopulation of Microtubules
Meeting Abstracts

39-OR: VPS41 Contributes to Insulin Granule Biogenesis

CHRISTIAN H. BURNS, BELINDA YAU, MELKAM A. KEBEDE, CEDRIC S. ASENSIO
Journal: Diabetes
Diabetes 2019;68(Supplement_1):39-OR
https://doi.org/10.2337/db19-39-OR
Published: 01 June 2019
View articletitled, 39-OR: VPS41 Contributes to Insulin Granule Biogenesis
Meeting Abstracts

2158-P: GLIS3 Is Crucial for Maintenance of Neonatal ß Cells

HONG SOON KANG, DAVID SCOVILLE, KILSOO JEON, SARA GRIMM, ANTON M. JETTEN
Journal: Diabetes
Diabetes 2019;68(Supplement_1):2158-P
https://doi.org/10.2337/db19-2158-P
Published: 01 June 2019
View articletitled, 2158-P: GLIS3 Is Crucial for Maintenance of Neonatal ß Cells
Meeting Abstracts

The CCR4-NOT Complex Maintains ß-Cell Identity through the Repression of ß-Cell Disallowed Genes

DINA MOSTAFA, AKINORI TAKAHASHI, AKIKO YANAGIYA, TADASHI YAMAMOTO
Journal: Diabetes
Diabetes 2018;67(Supplement_1):305-LB
https://doi.org/10.2337/db18-305-LB
Published: 01 July 2018
View articletitled, The CCR4-NOT Complex Maintains ß-Cell Identity through the Repression of ß-Cell Disallowed Genes
Meeting Abstracts

Mechanistic Role of IP3R Calcium Release Channel in Pancreatic Beta-Cell Function

JUN SHU, JESSICA GAMBARDELLA, DANIELA SORRIENTO, GAETANO SANTULLI
Journal: Diabetes
Diabetes 2018;67(Supplement_1):313-LB
https://doi.org/10.2337/db18-313-LB
Published: 01 July 2018
View articletitled, Mechanistic Role of IP3R Calcium Release Channel in Pancreatic Beta-Cell Function