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Journal Articles

Liver-Secreted Hexosaminidase A Regulates Insulin-Like Growth Factor Signaling and Glucose Transport in Skeletal Muscle

Magdalene K. Montgomery, Jacqueline Bayliss, Shuai Nie, William de Nardo, Stacey N. Keenan, Marziyeh Anari, Amanuiel Z. Taddese, Nicholas A. Williamson, Geraldine J. Ooi, Wendy A. Brown, Paul R. Burton, Paul Gregorevic, Craig A. Goodman, Kevin I. Watt, Matthew J. Watt

Diabetes 2023;72(6):715–727

DOI: https://doi.org/10.2337/db22-0590

Published: 29 December 2022

View article titled, Liver-Secreted Hexosaminidase A Regulates Insulin-Like Growth Factor Signaling and Glucose Transport in Skeletal Muscle

Journal Articles

High-Fat Diet–Induced DeSUMOylation of E4BP4 Promotes Lipid Droplet Biogenesis and Liver Steatosis in Mice

Sujuan Wang, Meichan Yang, Pei Li, Julian Sit, Audrey Wong, Kyle Rodrigues, Daniel Lank, Deqiang Zhang, Kezhong Zhang, Lei Yin, Xin Tong

Diabetes 2023;72(3):348–361

DOI: https://doi.org/10.2337/db22-0332

Published: 12 December 2022

View article titled, High-Fat Diet–Induced DeSUMOylation of E4BP4 Promotes Lipid Droplet Biogenesis and Liver Steatosis in Mice

Journal Articles

Systemic LSD1 Inhibition Prevents Aberrant Remodeling of Metabolism in Obesity

Bastian Ramms, Dennis P. Pollow, Han Zhu, Chelsea Nora, Austin R. Harrington, Ibrahim Omar, Philip L.S.M. Gordts, Matthew Wortham, Maike Sander

Diabetes 2022;71(12):2513–2529

DOI: https://doi.org/10.2337/db21-1131

Published: 28 September 2022

View article titled, Systemic LSD1 Inhibition Prevents Aberrant Remodeling of Metabolism in Obesity

Journal Articles

Maternal Exercise and Paternal Exercise Induce Distinct Metabolite Signatures in Offspring Tissues

Diego Hernández-Saavedra, Christina Markunas, Hirokazu Takahashi, Lisa A. Baer, Johan E. Harris, Michael F. Hirshman, Olga Ilkayeva, Christopher B. Newgard, Kristin I. Stanford, Laurie J. Goodyear

Diabetes 2022;71(10):2094–2105

DOI: https://doi.org/10.2337/db22-0341

Published: 15 July 2022

View article titled, Maternal Exercise and Paternal Exercise Induce Distinct Metabolite Signatures in Offspring Tissues

Journal Articles

Long Noncoding RNA lncRHPL Regulates Hepatic VLDL Secretion by Modulating hnRNPU/BMAL1/MTTP Axis

Xuan Shen, Yajun Zhang, Xuetao Ji, Bo Li, Yuzhu Wang, Yun Huang, Xu Zhang, Jingxian Yu, Ruihan Zou, Dongdong Qin, Hongwen Zhou, Qian Wang, John Zhong Li

Diabetes 2022;71(9):1915–1928

DOI: https://doi.org/10.2337/db21-1145

Published: 30 June 2022

View article titled, Long Noncoding RNA lncRHPL Regulates Hepatic VLDL Secretion by Modulating hnRNPU/BMAL1/MTTP Axis

Meeting Abstracts

1342-P: Reduction of Glucokinase and Glucokinase Regulatory Protein Expression by siRNA Is Associated with the Reduction of Lactate and Pyruvate Export from Canine Hepatocytes

MORVARID KABIR, MARILYN ADER, RICHARD N. BERGMAN

Diabetes 2022;71(Supplement_1):1342-P

DOI: https://doi.org/10.2337/db22-1342-P

Published: 01 June 2022

View article titled, 1342-P: Reduction of Glucokinase and Glucokinase Regulatory Protein Expression by siRNA Is Associated with the Reduction of Lactate and Pyruvate Export from Canine Hepatocytes

Meeting Abstracts

1334-P: Hepatocyte D-ß-Hydroxybutyrate Dehydrogenase Deficiency Improves Glucose Homeostasis and Prevents Diet-Induced Liver Fibrosis

DAVID B. STAGG, ALISHA R. SEAY, ALISA B. NELSON, DANA ANDRE A. D’AVIGNON, CURTIS C. HUGHEY, PATRYCJA PUCHALSKA, PETER A. CRAWFORD

Diabetes 2022;71(Supplement_1):1334-P

DOI: https://doi.org/10.2337/db22-1334-P

Published: 01 June 2022

View article titled, 1334-P: Hepatocyte D-ß-Hydroxybutyrate Dehydrogenase Deficiency Improves Glucose Homeostasis and Prevents Diet-Induced Liver Fibrosis

Meeting Abstracts

216-LB: Hepatocyte N6-Methyladenosine mRNA Modification in Hepatic Gluconeogenesis and Diabetes

QIANTAO ZHENG, XIAO ZHONG, DECHENG REN, LIANGYOU RUI

Diabetes 2022;71(Supplement_1):216-LB

DOI: https://doi.org/10.2337/db22-216-LB

Published: 01 June 2022

View article titled, 216-LB: Hepatocyte N6-Methyladenosine mRNA Modification in Hepatic Gluconeogenesis and Diabetes

Meeting Abstracts

838-P: Lipotoxicity-Induced Liver Cell Injury Is Prevented by a Novel Positive Allosteric Modulator of the GABAA Receptor

ELISABETH ROHBECK, ALEJANDRA ROMERO, BIRGIT KNEBEL, BENGT-FREDERIK BELGARDT, MICHAEL RODEN, TANIA ROMACHO, JÜRGEN ECKEL

Diabetes 2022;71(Supplement_1):838-P

DOI: https://doi.org/10.2337/db22-838-P

Published: 01 June 2022

View article titled, 838-P: Lipotoxicity-Induced Liver Cell Injury Is Prevented by a Novel Positive Allosteric Modulator of the GABAA Receptor

Meeting Abstracts

3-OR: Hepatocyte Gdf15 Is Sufficient for Increased Plasma GDF15 Levels and Body Weight Constraint during High-Fat–Diet Feeding and Restores Insulin Sensitivity in a Liver-Specific Manner

BINGXIAN XIE, ANJANA MURALI, AMBER VANDEVENDER, AGUSTIN A. GIL SILVA, FIONA BELLO, IAN J. SIPULA, NIKOLAOS DEDOUSIS, JONATHAN ALDER, MICHAEL J. JURCZAK

Diabetes 2022;71(Supplement_1):3-OR

DOI: https://doi.org/10.2337/db22-3-OR

Published: 01 June 2022

View article titled, 3-OR: Hepatocyte Gdf15 Is Sufficient for Increased Plasma GDF15 Levels and Body Weight Constraint during High-Fat–Diet Feeding and Restores Insulin Sensitivity in a Liver-Specific Manner

Journal Articles

Hepatic GSK3β-Dependent CRY1 Degradation Contributes to Diabetic Hyperglycemia

Ye Young Kim, Hagoon Jang, Gung Lee, Yong Geun Jeon, Jee Hyung Sohn, Ji Seul Han, Won Taek Lee, Jeu Park, Jin Young Huh, Hahn Nahmgoong, Sang Mun Han, Jeesoo Kim, Minwoo Pak, Sun Kim, Jong-Seo Kim, Jae Bum Kim

Diabetes 2022;71(7):1373–1387

DOI: https://doi.org/10.2337/db21-0649

Published: 27 April 2022

View article titled, Hepatic GSK3β-Dependent CRY1 Degradation Contributes to Diabetic Hyperglycemia

Journal Articles

EET Analog Treatment Improves Insulin Signaling in a Genetic Mouse Model of Insulin Resistance

Kakali Ghoshal, Xiyue Li, Dungeng Peng, John R. Falck, Raghunath Reddy Anugu, Manuel Chiusa, John M. Stafford, David H. Wasserman, Roy Zent, James M. Luther, Ambra Pozzi

Diabetes 2022;71(1):83–92

DOI: https://doi.org/10.2337/db21-0298

Published: 21 October 2021

View article titled, EET Analog Treatment Improves Insulin Signaling in a Genetic Mouse Model of Insulin Resistance

Journal Articles

Hepatic CPT1A Facilitates Liver–Adipose Cross Talk via Induction of FGF21 in Mice

Diabetes 2022;71(1):31–42

DOI: https://doi.org/10.2337/db21-0363

Published: 21 October 2021

View article titled, Hepatic CPT1A Facilitates Liver–Adipose Cross Talk via Induction of FGF21 in Mice

Journal Articles

Hepatocytic Activating Transcription Factor 3 Protects Against Steatohepatitis via Hepatocyte Nuclear Factor 4α

Yanyong Xu, Shuwei Hu, Kavita Jadhav, Yingdong Zhu, Xiaoli Pan, Fathima Cassim Bawa, Liya Yin, Yanqiao Zhang

Diabetes 2021;70(11):2506–2517

DOI: https://doi.org/10.2337/db21-0181

Published: 02 September 2021

View article titled, Hepatocytic Activating Transcription Factor 3 Protects Against Steatohepatitis via Hepatocyte Nuclear Factor 4α

Journal Articles

Critical Role for Hepatocyte-Specific eNOS in NAFLD and NASH

Rory P. Cunningham, Mary P. Moore, Ryan J. Dashek, Grace M. Meers, Takamune Takahashi, Ryan D. Sheldon, Andrew A. Wheeler, Alberto Diaz-Arias, Jamal A. Ibdah, Elizabeth J. Parks, John P. Thyfault, R. Scott Rector

Diabetes 2021;70(11):2476–2491

DOI: https://doi.org/10.2337/db20-1228

Published: 11 August 2021

View article titled, Critical Role for Hepatocyte-Specific eNOS in NAFLD and NASH

Journal Articles

Mutations of NRG4 Contribute to the Pathogenesis of Nonalcoholic Fatty Liver Disease and Related Metabolic Disorders

Yangyang Li, Li Jin, Feng Jiang, Jing Yan, Yan Lu, Qing Yang, Yi Zhang, Hong Zhang, Hairong Yu, Yuemei Zhang, Zhen He, Rong Zhang, Jianjun Yang, Cheng Hu

Diabetes 2021;70(10):2213–2224

DOI: https://doi.org/10.2337/db21-0064

Published: 14 July 2021

View article titled, Mutations of NRG4 Contribute to the Pathogenesis of Nonalcoholic Fatty Liver Disease and Related Metabolic Disorders

Meeting Abstracts

213-LB: Mechanisms of Metabolic Cross Talk between Mitochondrial Pyruvate Carrier Inhibition and Branched-Chain Amino Acid Catabolism in Hepatocytes

DANIEL FERGUSON, NICOLE K.H. YIEW, KYLE S. MCCOMMIS, JERRY R. COLCA, BRIAN N. FINCK

Diabetes 2021;70(Supplement_1):213-LB

DOI: https://doi.org/10.2337/db21-213-LB

Published: 01 June 2021

View article titled, 213-LB: Mechanisms of Metabolic Cross Talk between Mitochondrial Pyruvate Carrier Inhibition and Branched-Chain Amino Acid Catabolism in Hepatocytes

Meeting Abstracts

284-OR: Hepatocyte-Specific CCN2 Gene Deletion Prevents NASH Fibrosis in a Mouse Model of High-Fat Feeding and Diabetes

SARAH N. PARRY, XIAOYU WANG, DANQING MIN, JACINTHA S. LOURDESAMY, PAUL F. WILLIAMS, ANDREW LEASK, STEPHEN M. TWIGG

Diabetes 2021;70(Supplement_1):284-OR

DOI: https://doi.org/10.2337/db21-284-OR

Published: 01 June 2021

View article titled, 284-OR: Hepatocyte-Specific CCN2 Gene Deletion Prevents NASH Fibrosis in a Mouse Model of High-Fat Feeding and Diabetes

Meeting Abstracts

752-P: LIVRQNac (AXA1125) Enhances Insulin Sensitivity in Primary Human Hepatocytes and in Subjects with NAFLD and T2D

SETH BAUM, STEPHEN A. HARRISON, NADEGE T. GUNN, ZIAD YOUNES, ANITA KOHLI, RASHMEE PATIL, JUAN P. FRIAS, MICHAEL HAMILL, NADINE DAOU, JEFF ZHAO, MANU CHAKRAVARTHY, MARGARET KOZIEL

Diabetes 2021;70(Supplement_1):752-P

DOI: https://doi.org/10.2337/db21-752-P

Published: 01 June 2021

View article titled, 752-P: LIVRQNac (AXA1125) Enhances Insulin Sensitivity in Primary Human Hepatocytes and in Subjects with NAFLD and T2D

Meeting Abstracts

1176-P: Effects of GLP-1 Therapy on GDF15 Expression in Hepatocytes of MAFLD

LU GAN, BEISI LIN, WEN XU, JINHUA YAN, YANNA SU, YALAN CHEN, DAIZHI YANG, HUA LIANG, FEN XU

Diabetes 2021;70(Supplement_1):1176-P

DOI: https://doi.org/10.2337/db21-1176-P

Published: 01 June 2021

View article titled, 1176-P: Effects of GLP-1 Therapy on GDF15 Expression in Hepatocytes of MAFLD

NARROW

Liver-Secreted Hexosaminidase A Regulates Insulin-Like Growth Factor Signaling and Glucose Transport in Skeletal Muscle

High-Fat Diet–Induced DeSUMOylation of E4BP4 Promotes Lipid Droplet Biogenesis and Liver Steatosis in Mice

Systemic LSD1 Inhibition Prevents Aberrant Remodeling of Metabolism in Obesity

Maternal Exercise and Paternal Exercise Induce Distinct Metabolite Signatures in Offspring Tissues

Long Noncoding RNA lncRHPL Regulates Hepatic VLDL Secretion by Modulating hnRNPU/BMAL1/MTTP Axis

1342-P: Reduction of Glucokinase and Glucokinase Regulatory Protein Expression by siRNA Is Associated with the Reduction of Lactate and Pyruvate Export from Canine Hepatocytes

1334-P: Hepatocyte D-ß-Hydroxybutyrate Dehydrogenase Deficiency Improves Glucose Homeostasis and Prevents Diet-Induced Liver Fibrosis

216-LB: Hepatocyte N6-Methyladenosine mRNA Modification in Hepatic Gluconeogenesis and Diabetes

838-P: Lipotoxicity-Induced Liver Cell Injury Is Prevented by a Novel Positive Allosteric Modulator of the GABAA Receptor

3-OR: Hepatocyte Gdf15 Is Sufficient for Increased Plasma GDF15 Levels and Body Weight Constraint during High-Fat–Diet Feeding and Restores Insulin Sensitivity in a Liver-Specific Manner

Hepatic GSK3β-Dependent CRY1 Degradation Contributes to Diabetic Hyperglycemia

EET Analog Treatment Improves Insulin Signaling in a Genetic Mouse Model of Insulin Resistance

Hepatic CPT1A Facilitates Liver–Adipose Cross Talk via Induction of FGF21 in Mice

Hepatocytic Activating Transcription Factor 3 Protects Against Steatohepatitis via Hepatocyte Nuclear Factor 4α

Critical Role for Hepatocyte-Specific eNOS in NAFLD and NASH

Mutations of NRG4 Contribute to the Pathogenesis of Nonalcoholic Fatty Liver Disease and Related Metabolic Disorders

213-LB: Mechanisms of Metabolic Cross Talk between Mitochondrial Pyruvate Carrier Inhibition and Branched-Chain Amino Acid Catabolism in Hepatocytes

284-OR: Hepatocyte-Specific CCN2 Gene Deletion Prevents NASH Fibrosis in a Mouse Model of High-Fat Feeding and Diabetes

752-P: LIVRQNac (AXA1125) Enhances Insulin Sensitivity in Primary Human Hepatocytes and in Subjects with NAFLD and T2D

1176-P: Effects of GLP-1 Therapy on GDF15 Expression in Hepatocytes of MAFLD

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