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Meeting Abstracts

193-OR: Muscle α-Parvin Deletion Results in Insulin Resistance by Impairing GLUT4 Translocation and Hexokinase II Association with Mitochondria in Mice

DAVID A. CAPPEL, JOHN W. DEAVER, LUCIANO COZZANI, DEANNA BRACY, LOUISE LANTIER, XINYU DONG, RICHARD PRINTZ, ROY ZENT, AMBRA POZZI, DAVID H. WASSERMAN

Diabetes 2023;72(Supplement_1):193-OR

https://doi.org/10.2337/db23-193-OR

Published: 20 June 2023

View article titled, 193-OR: Muscle α-Parvin Deletion Results in Insulin Resistance by Impairing GLUT4 Translocation and Hexokinase II Association with Mitochondria in Mice

Meeting Abstracts

206-LB: Increase of Hexokinase-2 Protein without Increase of Other Glycolytic Enzymes in Myotubes with High Glucose Concentration Supports the Hypothesis of Hexokinase-2-Linked Unscheduled Glycolysis as a Driver of Insulin Resistance

MINGZHAN XUE, NAILA RABBANI, PAUL THORNALLEY

Diabetes 2022;71(Supplement_1):206-LB

https://doi.org/10.2337/db22-206-LB

Published: 01 June 2022

View article titled, 206-LB: Increase of Hexokinase-2 Protein without Increase of Other Glycolytic Enzymes in Myotubes with High Glucose Concentration Supports the Hypothesis of Hexokinase-2-Linked Unscheduled Glycolysis as a Driver of Insulin Resistance

Meeting Abstracts

293-OR: Mitochondrial Hexokinase Dissociation Correlates with Obesity-Induced Inflammation and Regulates the Fate of Glucose

FARNAZ KEYHANI NEJAD, ADAM DEJESUS, JUSTIN A. GEIER, HOSSEIN ARDEHALI

Diabetes 2020;69(Supplement_1):293-OR

https://doi.org/10.2337/db20-293-OR

Published: 01 June 2020

View article titled, 293-OR: Mitochondrial Hexokinase Dissociation Correlates with Obesity-Induced Inflammation and Regulates the Fate of Glucose

Meeting Abstracts

1447-P: Epistatic Interactions of Known Gene Variants for Glycated Hemoglobin: Evidence from the Long Life Family Study

PING AN, BHARAT THYAGARAJAN, JOSEPH H. LEE, NICOLE SCHUPF, JOSEPH M. ZMUDA, MICHAEL PROVINCE

Diabetes 2019;68(Supplement_1):1447-P

https://doi.org/10.2337/db19-1447-P

Published: 01 June 2019

View article titled, 1447-P: Epistatic Interactions of Known Gene Variants for Glycated Hemoglobin: Evidence from the Long Life Family Study

Journal Articles

Altered miR-29 Expression in Type 2 Diabetes Influences Glucose and Lipid Metabolism in Skeletal Muscle

Julie Massart, Rasmus J.O. Sjögren, Leonidas S. Lundell, Jonathan M. Mudry, Niclas Franck, Donal J. O’Gorman, Brendan Egan, Juleen R. Zierath, Anna Krook

Diabetes 2017;66(7):1807–1818

https://doi.org/10.2337/db17-0141

Published: 12 April 2017

View article titled, Altered miR-29 Expression in Type 2 Diabetes Influences Glucose and Lipid Metabolism in Skeletal Muscle

Includes: Supplementary data

Journal Articles

Congenital Hyperinsulinism Caused by Hexokinase I Expression or Glucokinase-Activating Mutation in a Subset of β-Cells

Jean-Claude Henquin, Christine Sempoux, Joelle Marchandise, Sebastien Godecharles, Yves Guiot, Myriam Nenquin, Jacques Rahier

Diabetes 2013;62(5):1689–1696

https://doi.org/10.2337/db12-1414

Published: 16 April 2013

View article titled, Congenital Hyperinsulinism Caused by Hexokinase I Expression or Glucokinase-Activating Mutation in a Subset of β-Cells

Includes: Supplementary data

Journal Articles

New Insights and New Conundrums in Neonatal Hypoglycemia: Enigmas Wrapped in Mystery

Mark A. Sperling

Diabetes 2013;62(5):1373–1375

https://doi.org/10.2337/db12-1839

Published: 16 April 2013

View article titled, New Insights and New Conundrums in Neonatal Hypoglycemia: Enigmas Wrapped in Mystery

Journal Articles

Phosphorylation Barriers to Skeletal and Cardiac Muscle Glucose Uptakes in High-Fat–Fed Mice: Studies in Mice With a 50% Reduction of Hexokinase II

Patrick T. Fueger, Robert S. Lee-Young, Jane Shearer, Deanna P. Bracy, Sami Heikkinen, Markku Laakso, Jeffrey N. Rottman, David H. Wasserman

Diabetes 2007;56(10):2476–2484

https://doi.org/10.2337/db07-0532

Published: 01 October 2007

View article titled, Phosphorylation Barriers to Skeletal and Cardiac Muscle Glucose Uptakes in High-Fat–Fed Mice: <subtitle>Studies in Mice With a 50% Reduction of Hexokinase II</subtitle>

Journal Articles

Skeletal Muscle Adaptation to Exercise Training : AMP-Activated Protein Kinase Mediates Muscle Fiber Type Shift

Katja S.C. Röckl, Michael F. Hirshman, Josef Brandauer, Nobuharu Fujii, Lee A. Witters, Laurie J. Goodyear

Diabetes 2007;56(8):2062–2069

https://doi.org/10.2337/db07-0255

Published: 01 August 2007

View article titled, Skeletal Muscle Adaptation to Exercise Training : <subtitle>AMP-Activated Protein Kinase Mediates Muscle Fiber Type Shift</subtitle>

Journal Articles

Glucokinase Regulatory Network in Pancreatic β-Cells and Liver

Simone Baltrusch, Markus Tiedge

Diabetes 2006;55(Supplement_2):S55–S64

https://doi.org/10.2337/db06-S008

Published: 01 December 2006

View article titled, Glucokinase Regulatory Network in Pancreatic β-Cells and Liver

Journal Articles

Changes in Exercise-Induced Gene Expression in 5′-AMP–Activated Protein Kinase γ3–Null and γ3 R225Q Transgenic Mice

Brian R. Barnes, Yun Chau Long, Tatiana L. Steiler, Ying Leng, Dana Galuska, Jørgen F.P. Wojtaszewski, Leif Andersson, Juleen R. Zierath

Diabetes 2005;54(12):3484–3489

https://doi.org/10.2337/diabetes.54.12.3484

Published: 01 December 2005

View article titled, Changes in Exercise-Induced Gene Expression in 5′-AMP–Activated Protein Kinase γ3–Null and γ3 R225Q Transgenic Mice

Journal Articles

Modular Kinetic Analysis of the Adenine Nucleotide Translocator–Mediated Effects of Palmitoyl-CoA on the Oxidative Phosphorylation in Isolated Rat Liver Mitochondria

Jolita Ciapaite, Gerco Van Eikenhorst, Stephan J.L. Bakker, Michaela Diamant, Robert J. Heine, Marijke J. Wagner, Hans V. Westerhoff, Klaas Krab

Diabetes 2005;54(4):944–951

https://doi.org/10.2337/diabetes.54.4.944

Published: 01 April 2005

View article titled, Modular Kinetic Analysis of the Adenine Nucleotide Translocator–Mediated Effects of Palmitoyl-CoA on the Oxidative Phosphorylation in Isolated Rat Liver Mitochondria

Journal Articles

Sterol Regulatory Element-Binding Protein-1 Mediates the Effect of Insulin on Hexokinase II Gene Expression in Human Muscle Cells

Yvan Gosmain, Etienne Lefai, Stephan Ryser, Marina Roques, Hubert Vidal

Diabetes 2004;53(2):321–329

https://doi.org/10.2337/diabetes.53.2.321

Published: 01 February 2004

View article titled, Sterol Regulatory Element-Binding Protein-1 Mediates the Effect of Insulin on Hexokinase II Gene Expression in Human Muscle Cells

Journal Articles

Hexokinase II Overexpression Improves Exercise-Stimulated But Not Insulin-Stimulated Muscle Glucose Uptake in High-Fat-Fed C57BL/6J Mice

Patrick T. Fueger, Deanna P. Bracy, Carlo M. Malabanan, R. Richard Pencek, Daryl K. Granner, David H. Wasserman

Diabetes 2004;53(2):306–314

https://doi.org/10.2337/diabetes.53.2.306

Published: 01 February 2004

View article titled, Hexokinase II Overexpression Improves Exercise-Stimulated But Not Insulin-Stimulated Muscle Glucose Uptake in High-Fat-Fed C57BL/6J Mice

Journal Articles

Programming of Islet Functions in the Progeny of Hyperinsulinemic/Obese Rats

Malathi Srinivasan, Ravikumar Aalinkeel, Fei Song, Mulchand S. Patel

Diabetes 2003;52(4):984–990

https://doi.org/10.2337/diabetes.52.4.984

Published: 01 April 2003

View article titled, Programming of Islet Functions in the Progeny of Hyperinsulinemic/Obese Rats

Journal Articles

Hexokinase Isozyme Distribution in Human Skeletal Muscle

Vladimir B. Ritov, David E. Kelley

Diabetes 2001;50(6):1253–1262

https://doi.org/10.2337/diabetes.50.6.1253

Published: 01 June 2001

View article titled, Hexokinase Isozyme Distribution in Human Skeletal Muscle

Journal Articles

Regulation by Insulin of Gene Expression in Human Skeletal Muscle and Adipose Tissue: Evidence for Specific Defects in Type 2 Diabetes

Pierre-Henri Ducluzeau, Noël Perretti, Martine Laville, Fabrizio Andreelli, Nathalie Vega, Jean-Paul Riou, Hubert Vidal

Diabetes 2001;50(5):1134–1142

https://doi.org/10.2337/diabetes.50.5.1134

Published: 01 May 2001

View article titled, Regulation by Insulin of Gene Expression in Human Skeletal Muscle and Adipose Tissue: <subtitle>Evidence for Specific Defects in Type 2 Diabetes</subtitle>

Meeting Abstracts

Acyl-CoA inhibition of hexokinase in rat and human skeletal muscle is a potential mechanism of lipid-induced insulin resistance.

A L Thompson, G J Cooney

Diabetes 2000;49(11):1761–1765

https://doi.org/10.2337/diabetes.49.11.1761

Published: 01 November 2000

View article titled, Acyl-CoA inhibition of hexokinase in rat and human skeletal muscle is a potential mechanism of lipid-induced insulin resistance.

Meeting Abstracts

Allosteric regulation of glycogen synthase and hexokinase by glucosamine-6-phosphate during glucosamine-induced insulin resistance in skeletal muscle and heart.

A Virkamäki, H Yki-Järvinen

Diabetes 1999;48(5):1101–1107

https://doi.org/10.2337/diabetes.48.5.1101

Published: 01 May 1999

View article titled, Allosteric regulation of glycogen synthase and hexokinase by glucosamine-6-phosphate during glucosamine-induced insulin resistance in skeletal muscle and heart.

Meeting Abstracts

Distinguishing the type I and type II isozymes of hexokinase: the need for a reexamination of past practice.

J E Wilson

Diabetes 1998;47(10):1544–1548

https://doi.org/10.2337/diabetes.47.10.1544

Published: 01 October 1998

View article titled, Distinguishing the type I and type II isozymes of hexokinase: the need for a reexamination of past practice.

NARROW

193-OR: Muscle α-Parvin Deletion Results in Insulin Resistance by Impairing GLUT4 Translocation and Hexokinase II Association with Mitochondria in Mice

206-LB: Increase of Hexokinase-2 Protein without Increase of Other Glycolytic Enzymes in Myotubes with High Glucose Concentration Supports the Hypothesis of Hexokinase-2-Linked Unscheduled Glycolysis as a Driver of Insulin Resistance

293-OR: Mitochondrial Hexokinase Dissociation Correlates with Obesity-Induced Inflammation and Regulates the Fate of Glucose

1447-P: Epistatic Interactions of Known Gene Variants for Glycated Hemoglobin: Evidence from the Long Life Family Study

Altered miR-29 Expression in Type 2 Diabetes Influences Glucose and Lipid Metabolism in Skeletal Muscle

Congenital Hyperinsulinism Caused by Hexokinase I Expression or Glucokinase-Activating Mutation in a Subset of β-Cells

New Insights and New Conundrums in Neonatal Hypoglycemia: Enigmas Wrapped in Mystery

Phosphorylation Barriers to Skeletal and Cardiac Muscle Glucose Uptakes in High-Fat–Fed Mice: Studies in Mice With a 50% Reduction of Hexokinase II

Skeletal Muscle Adaptation to Exercise Training : AMP-Activated Protein Kinase Mediates Muscle Fiber Type Shift

Glucokinase Regulatory Network in Pancreatic β-Cells and Liver

Changes in Exercise-Induced Gene Expression in 5′-AMP–Activated Protein Kinase γ3–Null and γ3 R225Q Transgenic Mice

Modular Kinetic Analysis of the Adenine Nucleotide Translocator–Mediated Effects of Palmitoyl-CoA on the Oxidative Phosphorylation in Isolated Rat Liver Mitochondria

Sterol Regulatory Element-Binding Protein-1 Mediates the Effect of Insulin on Hexokinase II Gene Expression in Human Muscle Cells

Hexokinase II Overexpression Improves Exercise-Stimulated But Not Insulin-Stimulated Muscle Glucose Uptake in High-Fat-Fed C57BL/6J Mice

Programming of Islet Functions in the Progeny of Hyperinsulinemic/Obese Rats

Hexokinase Isozyme Distribution in Human Skeletal Muscle

Regulation by Insulin of Gene Expression in Human Skeletal Muscle and Adipose Tissue: Evidence for Specific Defects in Type 2 Diabetes

Acyl-CoA inhibition of hexokinase in rat and human skeletal muscle is a potential mechanism of lipid-induced insulin resistance.

Allosteric regulation of glycogen synthase and hexokinase by glucosamine-6-phosphate during glucosamine-induced insulin resistance in skeletal muscle and heart.

Distinguishing the type I and type II isozymes of hexokinase: the need for a reexamination of past practice.

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