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Journal Articles

Elevated Thrombospondin 2 Contributes to Delayed Wound Healing in Diabetes

Britta Kunkemoeller, Tara Bancroft, Hao Xing, Aaron H. Morris, Amelia K. Luciano, Jason Wu, Carlos Fernandez-Hernando, Themis R. Kyriakides

Diabetes 2019;68(10):2016–2023

https://doi.org/10.2337/db18-1001

Published: 07 August 2019

View article titled, Elevated Thrombospondin 2 Contributes to Delayed Wound Healing in Diabetes

Includes: Supplementary data

Meeting Abstracts

266-LB: Evidence for a Hexosamine Biosynthesis Pathway-Mediated Sp1 Cholesterolgenic Response Being an Early Etiological Factor of Insulin Resistance

BRIAN A. GRICE, JACOB D. COVERT, ALEC M. KREILACH, MATTHEW THORNBURG, LIXUAN TACKETT, DON MCCLAIN, JEFFREY S. ELMENDORF

Diabetes 2019;68(Supplement_1):266-LB

https://doi.org/10.2337/db19-266-LB

Published: 01 June 2019

View article titled, 266-LB: Evidence for a Hexosamine Biosynthesis Pathway-Mediated Sp1 Cholesterolgenic Response Being an Early Etiological Factor of Insulin Resistance

Journal Articles

TRIB3 Mediates Glucose-Induced Insulin Resistance via a Mechanism That Requires the Hexosamine Biosynthetic Pathway

Wei Zhang, Jiarong Liu, Ling Tian, Qinglan Liu, Yuchang Fu, W. Timothy Garvey

Diabetes 2013;62(12):4192–4200

https://doi.org/10.2337/db13-0312

Published: 16 November 2013

View article titled, TRIB3 Mediates Glucose-Induced Insulin Resistance via a Mechanism That Requires the Hexosamine Biosynthetic Pathway

Journal Articles

The Pathobiology of Diabetic Complications: A Unifying Mechanism

Michael Brownlee

Diabetes 2005;54(6):1615–1625

https://doi.org/10.2337/diabetes.54.6.1615

Published: 01 June 2005

View article titled, The Pathobiology of Diabetic Complications: <subtitle>A Unifying Mechanism</subtitle>

Journal Articles

Differential Responses of Visceral and Subcutaneous Fat Depots to Nutrients

Francine H. Einstein, Gil Atzmon, Xiao-man Yang, Xiao-Hui Ma, Marielisa Rincon, Eric Rudin, Radhika Muzumdar, Nir Barzilai

Diabetes 2005;54(3):672–678

https://doi.org/10.2337/diabetes.54.3.672

Published: 01 March 2005

View article titled, Differential Responses of Visceral and Subcutaneous Fat Depots to Nutrients

Journal Articles

Hexosamine Pathway Is Responsible for Inhibition by Diabetes of Phenylephrine-Induced Inotropy

Yi Pang, Pam Bounelis, John C. Chatham, Richard B. Marchase

Diabetes 2004;53(4):1074–1081

https://doi.org/10.2337/diabetes.53.4.1074

Published: 01 April 2004

View article titled, Hexosamine Pathway Is Responsible for Inhibition by Diabetes of Phenylephrine-Induced Inotropy

Journal Articles

Palmitate-Induced Activation of the Hexosamine Pathway in Human Myotubes: Increased Expression of Glutamine:Fructose-6-Phosphate Aminotransferase

Cora Weigert, Karsten Klopfer, Christiana Kausch, Katrin Brodbeck, Michael Stumvoll, Hans U. Häring, Erwin D. Schleicher

Diabetes 2003;52(3):650–656

https://doi.org/10.2337/diabetes.52.3.650

Published: 01 March 2003

View article titled, Palmitate-Induced Activation of the Hexosamine Pathway in Human Myotubes: <subtitle>Increased Expression of Glutamine:Fructose-6-Phosphate Aminotransferase </subtitle>

Journal Articles

Are Oxidative Stress−Activated Signaling Pathways Mediators of Insulin Resistance and β-Cell Dysfunction?

Joseph L. Evans, Ira D. Goldfine, Betty A. Maddux, Gerold M. Grodsky

Diabetes 2003;52(1):1–8

https://doi.org/10.2337/diabetes.52.1.1

Published: 01 January 2003

View article titled, Are Oxidative Stress−Activated Signaling Pathways Mediators of Insulin Resistance and β-Cell Dysfunction?

Journal Articles

Hyperglycemia Inhibits Capacitative Calcium Entry and Hypertrophy in Neonatal Cardiomyocytes

Yi Pang, Dacia L. Hunton, Pam Bounelis, Richard B. Marchase

Diabetes 2002;51(12):3461–3467

https://doi.org/10.2337/diabetes.51.12.3461

Published: 01 December 2002

View article titled, Hyperglycemia Inhibits Capacitative Calcium Entry and Hypertrophy in Neonatal Cardiomyocytes

Journal Articles

Flux Through the Hexosamine Pathway Is a Determinant of Nuclear Factor κB– Dependent Promoter Activation

Leighton R. James, Damu Tang, Alistair Ingram, Hao Ly, Kerri Thai, Lu Cai, James W. Scholey

Diabetes 2002;51(4):1146–1156

https://doi.org/10.2337/diabetes.51.4.1146

Published: 01 April 2002

View article titled, Flux Through the Hexosamine Pathway Is a Determinant of Nuclear Factor κB– Dependent Promoter Activation

Journal Articles

A Novel Variant of Glutamine: Fructose-6-Phosphate Amidotransferase-1 (GFAT1) mRNA Is Selectively Expressed in Striated Muscle

John E. DeHaven, Katherine A. Robinson, Bryce A. Nelson, Maria G. Buse

Diabetes 2001;50(11):2419–2424

https://doi.org/10.2337/diabetes.50.11.2419

Published: 01 November 2001

View article titled, A Novel Variant of Glutamine: <subtitle>Fructose-6-Phosphate Amidotransferase-1 (GFAT1) mRNA Is Selectively Expressed in Striated Muscle </subtitle>

Journal Articles

Hexosamine-Induced Fibronectin Protein Synthesis in Mesangial Cells Is Associated With Increases in cAMP Responsive Element Binding (CREB) Phosphorylation and Nuclear CREB: The Involvement of Protein Kinases A and C

Lalit P. Singh, Jack Andy, Vivian Anyamale, Kennieth Greene, Michelle Alexander, Errol D. Crook

Diabetes 2001;50(10):2355–2362

https://doi.org/10.2337/diabetes.50.10.2355

Published: 01 October 2001

View article titled, Hexosamine-Induced Fibronectin Protein Synthesis in Mesangial Cells Is Associated With Increases in cAMP Responsive Element Binding (CREB) Phosphorylation and Nuclear CREB: <subtitle>The Involvement of Protein Kinases A and C</subtitle>

Journal Articles

Free Fatty Acids Induce Peripheral Insulin Resistance Without Increasing Muscle Hexosamine Pathway Product Levels in Rats

Cheol S. Choi, Felix N. Lee, Jang H. Youn

Diabetes 2001;50(2):418–424

https://doi.org/10.2337/diabetes.50.2.418

Published: 01 February 2001

View article titled, Free Fatty Acids Induce Peripheral Insulin Resistance Without Increasing Muscle Hexosamine Pathway Product Levels in Rats

Meeting Abstracts

Transgenic mice with increased hexosamine flux specifically targeted to beta-cells exhibit hyperinsulinemia and peripheral insulin resistance.

J Tang, J L Neidigh, R C Cooksey, D A McClain

Diabetes 2000;49(9):1492–1499

https://doi.org/10.2337/diabetes.49.9.1492

Published: 01 September 2000

View article titled, Transgenic mice with increased hexosamine flux specifically targeted to beta-cells exhibit hyperinsulinemia and peripheral insulin resistance.

Meeting Abstracts

Evidence for glucose/hexosamine in vivo regulation of insulin/IGF-I hybrid receptor assembly.

M Federici, A Giaccari, M L Hribal, B Giovannone, D Lauro, L Morviducci, L Pastore, G Tamburrano, R Lauro, G Sesti

Diabetes 1999;48(12):2277–2285

https://doi.org/10.2337/diabetes.48.12.2277

Published: 01 December 1999

View article titled, Evidence for glucose/hexosamine in vivo regulation of insulin/IGF-I hybrid receptor assembly.

Meeting Abstracts

Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance of early postreceptor insulin signaling events in skeletal muscle.

M E Patti, A Virkamäki, E J Landaker, C R Kahn, H Yki-Järvinen

Diabetes 1999;48(8):1562–1571

https://doi.org/10.2337/diabetes.48.8.1562

Published: 01 August 1999

View article titled, Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance of early postreceptor insulin signaling events in skeletal muscle.

Journal Articles

Increased Hexosamine Availability Similarly Impairs the Action of Insulin and IGF-1 on Glucose Disposal

Meredith Hawkins, Nir Barzilai, Wei Chen, Ivo Angelov, Meizhu Hu, Pinchas Cohen, Luciano Rossetti

Diabetes 1996;45(12):1734–1743

https://doi.org/10.2337/diab.45.12.1734

Published: 01 December 1996

View article titled, Increased Hexosamine Availability Similarly Impairs the Action of Insulin and IGF-1 on Glucose Disposal

Journal Articles

Hexosamines and Insulin Resistance

Donald A McClain, Errol D Crook

Diabetes 1996;45(8):1003–1009

https://doi.org/10.2337/diab.45.8.1003

Published: 01 August 1996

View article titled, Hexosamines and Insulin Resistance

Journal Articles

Regulation of Glycogen Synthase and Protein Phosphatase-1 by Hexosamines

Errol D Crook, Donald A McClain

Diabetes 1996;45(3):322–327

https://doi.org/10.2337/diab.45.3.322

Published: 01 March 1996

View article titled, Regulation of Glycogen Synthase and Protein Phosphatase-1 by Hexosamines

Journal Articles

Effects of Diabetes and Hyperglycemia on the Hexosamine Synthesis Pathway in Rat Muscle and Liver

Katherine A Robinson, Mitchell L Weinstein, George E Lindenmayer, Maria G Buse

Diabetes 1995;44(12):1438–1446

https://doi.org/10.2337/diab.44.12.1438

Published: 01 December 1995

View article titled, Effects of Diabetes and Hyperglycemia on the Hexosamine Synthesis Pathway in Rat Muscle and Liver

NARROW

Elevated Thrombospondin 2 Contributes to Delayed Wound Healing in Diabetes

266-LB: Evidence for a Hexosamine Biosynthesis Pathway-Mediated Sp1 Cholesterolgenic Response Being an Early Etiological Factor of Insulin Resistance

TRIB3 Mediates Glucose-Induced Insulin Resistance via a Mechanism That Requires the Hexosamine Biosynthetic Pathway

The Pathobiology of Diabetic Complications: A Unifying Mechanism

Differential Responses of Visceral and Subcutaneous Fat Depots to Nutrients

Hexosamine Pathway Is Responsible for Inhibition by Diabetes of Phenylephrine-Induced Inotropy

Palmitate-Induced Activation of the Hexosamine Pathway in Human Myotubes: Increased Expression of Glutamine:Fructose-6-Phosphate Aminotransferase

Are Oxidative Stress−Activated Signaling Pathways Mediators of Insulin Resistance and β-Cell Dysfunction?

Hyperglycemia Inhibits Capacitative Calcium Entry and Hypertrophy in Neonatal Cardiomyocytes

Flux Through the Hexosamine Pathway Is a Determinant of Nuclear Factor κB– Dependent Promoter Activation

A Novel Variant of Glutamine: Fructose-6-Phosphate Amidotransferase-1 (GFAT1) mRNA Is Selectively Expressed in Striated Muscle

Hexosamine-Induced Fibronectin Protein Synthesis in Mesangial Cells Is Associated With Increases in cAMP Responsive Element Binding (CREB) Phosphorylation and Nuclear CREB: The Involvement of Protein Kinases A and C

Free Fatty Acids Induce Peripheral Insulin Resistance Without Increasing Muscle Hexosamine Pathway Product Levels in Rats

Transgenic mice with increased hexosamine flux specifically targeted to beta-cells exhibit hyperinsulinemia and peripheral insulin resistance.

Evidence for glucose/hexosamine in vivo regulation of insulin/IGF-I hybrid receptor assembly.

Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance of early postreceptor insulin signaling events in skeletal muscle.

Increased Hexosamine Availability Similarly Impairs the Action of Insulin and IGF-1 on Glucose Disposal

Hexosamines and Insulin Resistance

Regulation of Glycogen Synthase and Protein Phosphatase-1 by Hexosamines

Effects of Diabetes and Hyperglycemia on the Hexosamine Synthesis Pathway in Rat Muscle and Liver

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