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Journal Articles

Recognition of mRNA Splice Variant and Secretory Granule Epitopes by CD4⁺ T Cells in Type 1 Diabetes

Perrin Guyer, David Arribas-Layton, Anthony Manganaro, Cate Speake, Sandra Lord, Decio L. Eizirik, Sally C. Kent, Roberto Mallone, Eddie A. James

Diabetes 2023;72(1):85–96

DOI: https://doi.org/10.2337/db22-0191

Published: 06 October 2022

View article titled, Recognition of mRNA Splice Variant and Secretory Granule Epitopes by CD4<sup>+</sup> T Cells in Type 1 Diabetes

Journal Articles

Carbonyl Posttranslational Modification Associated With Early-Onset Type 1 Diabetes Autoimmunity

Mei-Ling Yang, Sean E. Connolly, Renelle J. Gee, TuKiet T. Lam, Jean Kanyo, Jian Peng, Perrin Guyer, Farooq Syed, Hubert M. Tse, Steven G. Clarke, Catherine F. Clarke, Eddie A. James, Cate Speake, Carmella Evans-Molina, Peter Arvan, Kevan C. Herold, Li Wen, Mark J. Mamula

Diabetes 2022;71(9):1979–1993

DOI: https://doi.org/10.2337/db21-0989

Published: 22 June 2022

View article titled, Carbonyl Posttranslational Modification Associated With Early-Onset Type 1 Diabetes Autoimmunity

Journal Articles

T-Cell Receptor/HLA Humanized Mice Reveal Reduced Tolerance and Increased Immunogenicity of Posttranslationally Modified GAD65 Epitope

Yi Jing, Yuelin Kong, John McGinty, Gabriele Blahnik-Fagan, Thomas Lee, Stephanie Orozco-Figueroa, Matthew L. Bettini, Eddie A. James, Maria Bettini

Diabetes 2022;71(5):1012–1022

DOI: https://doi.org/10.2337/db21-0993

Published: 18 February 2022

View article titled, T-Cell Receptor/HLA Humanized Mice Reveal Reduced Tolerance and Increased Immunogenicity of Posttranslationally Modified GAD65 Epitope

Journal Articles

Impact of Proinflammatory Cytokines on Alternative Splicing Patterns in Human Islets

Wenting Wu, Farooq Syed, Edward Simpson, Chih-Chun Lee, Jing Liu, Garrick Chang, Chuanpeng Dong, Clayton Seitz, Decio L. Eizirik, Raghavendra G. Mirmira, Yunlong Liu, Carmella Evans-Molina

Diabetes 2022;71(1):116–127

DOI: https://doi.org/10.2337/db20-0847

Published: 25 October 2021

View article titled, Impact of Proinflammatory Cytokines on Alternative Splicing Patterns in Human Islets

Journal Articles

From Pancreatic β-Cell Gene Networks to Novel Therapies for Type 1 Diabetes

Decio L. Eizirik, Florian Szymczak, Maria Inês Alvelos, Frank Martin

Diabetes 2021;70(9):1915–1925

DOI: https://doi.org/10.2337/dbi20-0046

Published: 07 September 2021

View article titled, From Pancreatic β-Cell Gene Networks to Novel Therapies for Type 1 Diabetes

Journal Articles

Etiology of Autoimmune Islet Disease: Timing Is Everything

Åke Lernmark

Diabetes 2021;70(7):1431–1439

DOI: https://doi.org/10.2337/dbi18-0034

Published: 28 July 2021

View article titled, Etiology of Autoimmune Islet Disease: Timing Is Everything

Meeting Abstracts

1125-P: Do Non-HLA Genes Contribute to Age of Type 1 Diabetes Onset in Monozygotic Twins?

TAYLOR M. TRIOLO, FRAN DONG, HALI C. BRONCUCIA, SUNA ONENGUT-GUMUSCU, ANDREA STECK, STEPHEN S. RICH

Diabetes 2021;70(Supplement_1):1125-P

DOI: https://doi.org/10.2337/db21-1125-P

Published: 01 June 2021

View article titled, 1125-P: Do Non-HLA Genes Contribute to Age of Type 1 Diabetes Onset in Monozygotic Twins?

Journal Articles

Novel Linkage Peaks Discovered for Diabetic Nephropathy in Individuals With Type 1 Diabetes

Jani Haukka, Niina Sandholm, Erkka Valo, Carol Forsblom, Valma Harjutsalo, Joanne B. Cole, Stuart J. McGurnaghan, Helen M. Colhoun, Per-Henrik Groop

Diabetes 2021;70(4):986–995

DOI: https://doi.org/10.2337/db20-0158

Published: 07 January 2021

View article titled, Novel Linkage Peaks Discovered for Diabetic Nephropathy in Individuals With Type 1 Diabetes

Journal Articles

Plasma Metabolome and Circulating Vitamins Stratified Onset Age of an Initial Islet Autoantibody and Progression to Type 1 Diabetes: The TEDDY Study

Qian Li, Xiang Liu, Jimin Yang, Iris Erlund, Åke Lernmark, William Hagopian, Marian Rewers, Jin-Xiong She, Jorma Toppari, Anette-G. Ziegler, Beena Akolkar, Jeffrey P. Krischer, the TEDDY Study Group

Diabetes 2021;70(1):282–292

DOI: https://doi.org/10.2337/db20-0696

Published: 26 October 2020

View article titled, Plasma Metabolome and Circulating Vitamins Stratified Onset Age of an Initial Islet Autoantibody and Progression to Type 1 Diabetes: The TEDDY Study

Journal Articles

Peptides Derived From Insulin Granule Proteins Are Targeted by CD8⁺ T Cells Across MHC Class I Restrictions in Humans and NOD Mice

Diabetes 2020;69(12):2678–2690

DOI: https://doi.org/10.2337/db20-0013

Published: 14 September 2020

View article titled, Peptides Derived From Insulin Granule Proteins Are Targeted by CD8<sup>+</sup> T Cells Across MHC Class I Restrictions in Humans and NOD Mice

Journal Articles

Next-Generation HLA Sequence Analysis Uncovers Seven HLA-DQ Amino Acid Residues and Six Motifs Resistant to Childhood Type 1 Diabetes

Lue Ping Zhao, George K. Papadopoulos, William W. Kwok, Antonis K. Moustakas, George P. Bondinas, Annelie Carlsson, Helena Elding Larsson, Johnny Ludvigsson, Claude Marcus, Ulf Samuelsson, Ruihan Wang, Chul-Woo Pyo, Wyatt C. Nelson, Daniel E. Geraghty, Åke Lernmark

Diabetes 2020;69(11):2523–2535

DOI: https://doi.org/10.2337/db20-0374

Published: 31 August 2020

View article titled, Next-Generation HLA Sequence Analysis Uncovers Seven HLA-DQ Amino Acid Residues and Six Motifs Resistant to Childhood Type 1 Diabetes

Journal Articles

T-Cell Epitopes and Neo-epitopes in Type 1 Diabetes: A Comprehensive Update and Reappraisal

Eddie A. James, Roberto Mallone, Sally C. Kent, Teresa P. DiLorenzo

Diabetes 2020;69(7):1311–1335

DOI: https://doi.org/10.2337/dbi19-0022

Published: 15 June 2020

View article titled, T-Cell Epitopes and Neo-epitopes in Type 1 Diabetes: A Comprehensive Update and Reappraisal

Meeting Abstracts

1617-P: Association of High-Affinity Autoantibodies with High-Risk HLA Haplotypes

TAYLOR M. TRIOLO, LAURA PYLE, LIPING YU, PETER GOTTLIEB, ANDREA STECK

Diabetes 2020;69(Supplement_1):1617-P

DOI: https://doi.org/10.2337/db20-1617-P

Published: 01 June 2020

View article titled, 1617-P: Association of High-Affinity Autoantibodies with High-Risk HLA Haplotypes

Meeting Abstracts

1677-P: Higher Frequency of HLA DRB108:03 and DRB104:01 Observed in A-beta+ Ketosis-Prone Type 2 Diabetes in Japanese Subjects

AKIRA SHIMADA, ATSUSHI SATOMURA, SEIYA SUZUKI, AKIFUMI HAISA, YOICHI OIKAWA

Diabetes 2020;69(Supplement_1):1677-P

DOI: https://doi.org/10.2337/db20-1677-P

Published: 01 June 2020

View article titled, 1677-P: Higher Frequency of HLA DRB1*08:03 and DRB1*04:01 Observed in A-beta+ Ketosis-Prone Type 2 Diabetes in Japanese Subjects

Meeting Abstracts

343-OR: HOMA2ß Stratifies Risk for Type 1 Diabetes (T1D) Development among TrialNet Pathway to Prevention Participants

JAMIE L. FELTON, KULDEEP LOHANO, FARAH MEAH, JAY SOSENKO, CARMELLA EVANS-MOLINA

Diabetes 2020;69(Supplement_1):343-OR

DOI: https://doi.org/10.2337/db20-343-OR

Published: 01 June 2020

View article titled, 343-OR: HOMA2ß Stratifies Risk for Type 1 Diabetes (T1D) Development among TrialNet Pathway to Prevention Participants

Meeting Abstracts

109-OR: Genetic Discrepancy of HLA Class I Alleles in Chinese Patients with Type 1 Diabetes at Different Onset Ages

ZIYU JIANG, WENQIAN REN, YINGXIN XIAN, JINHUA YAN, DAIZHI YANG, SIHUI LUO, XUEYING ZHENG, WEN XU, JIN-XIN BEI, LEIF GROOP, JIANPING WENG

Diabetes 2020;69(Supplement_1):109-OR

DOI: https://doi.org/10.2337/db20-109-OR

Published: 01 June 2020

View article titled, 109-OR: Genetic Discrepancy of HLA Class I Alleles in Chinese Patients with Type 1 Diabetes at Different Onset Ages

Meeting Abstracts

287-OR: TCR/HLA Humanized Mice Reveal Reduced Tolerance and Increased Immunogenicity of Posttranslationally Modified GAD65 Epitope

YI JING, YUELIN KONG, JOHN MCGINTY, GABRIELE BLAHNIK-FAGAN, MATTHEW BETTINI, EDDIE A. JAMES, MARIA BETTINI

Diabetes 2020;69(Supplement_1):287-OR

DOI: https://doi.org/10.2337/db20-287-OR

Published: 01 June 2020

View article titled, 287-OR: TCR/HLA Humanized Mice Reveal Reduced Tolerance and Increased Immunogenicity of Posttranslationally Modified GAD65 Epitope

Meeting Abstracts

1280-P: Improving Type 1 Diabetes (T1D) Prediction by Incorporating Growth Features into Landmark Models

ZHIGUO LI, VIBHA ANAND, JESSICA L. DUNNE, BRIGITTE I. FROHNERT, WILLIAM HAGOPIAN, HEIKKI HYOTY, MARLENA MAZIARZ, ANETTE-GABRIELE ZIEGLER, JORMA TOPPARI, T1DI STUDY

Diabetes 2020;69(Supplement_1):1280-P

DOI: https://doi.org/10.2337/db20-1280-P

Published: 01 June 2020

View article titled, 1280-P: Improving Type 1 Diabetes (T1D) Prediction by Incorporating Growth Features into Landmark Models

Meeting Abstracts

118-OR: HLA Matching and Clinical Outcomes in Islet Transplantation

VIRGINIA FUENMAYOR, CARMEN CHAVEZ, DAVID BAIDAL, ANA M. ALVAREZ, NATHALIA PADILLA, CAMILLO RICORDI, RODOLFO ALEJANDRO

Diabetes 2020;69(Supplement_1):118-OR

DOI: https://doi.org/10.2337/db20-118-OR

Published: 01 June 2020

View article titled, 118-OR: HLA Matching and Clinical Outcomes in Islet Transplantation

Journal Articles

Failed Genetic Protection: Type 1 Diabetes in the Presence of HLA-DQB1*06:02

Kimber M. Simmons, Angela M. Mitchell, Aimon A. Alkanani, Kristen A. McDaniel, Erin E. Baschal, Taylor Armstrong, Laura Pyle, Liping Yu, Aaron W. Michels

Diabetes 2020;69(8):1763–1769

DOI: https://doi.org/10.2337/db20-0038

Published: 21 May 2020

View article titled, Failed Genetic Protection: Type 1 Diabetes in the Presence of HLA-DQB1*06:02

NARROW

Recognition of mRNA Splice Variant and Secretory Granule Epitopes by CD4⁺ T Cells in Type 1 Diabetes

Carbonyl Posttranslational Modification Associated With Early-Onset Type 1 Diabetes Autoimmunity

T-Cell Receptor/HLA Humanized Mice Reveal Reduced Tolerance and Increased Immunogenicity of Posttranslationally Modified GAD65 Epitope

Impact of Proinflammatory Cytokines on Alternative Splicing Patterns in Human Islets

From Pancreatic β-Cell Gene Networks to Novel Therapies for Type 1 Diabetes

Etiology of Autoimmune Islet Disease: Timing Is Everything

1125-P: Do Non-HLA Genes Contribute to Age of Type 1 Diabetes Onset in Monozygotic Twins?

Novel Linkage Peaks Discovered for Diabetic Nephropathy in Individuals With Type 1 Diabetes

Plasma Metabolome and Circulating Vitamins Stratified Onset Age of an Initial Islet Autoantibody and Progression to Type 1 Diabetes: The TEDDY Study

Peptides Derived From Insulin Granule Proteins Are Targeted by CD8⁺ T Cells Across MHC Class I Restrictions in Humans and NOD Mice

Next-Generation HLA Sequence Analysis Uncovers Seven HLA-DQ Amino Acid Residues and Six Motifs Resistant to Childhood Type 1 Diabetes

T-Cell Epitopes and Neo-epitopes in Type 1 Diabetes: A Comprehensive Update and Reappraisal

1617-P: Association of High-Affinity Autoantibodies with High-Risk HLA Haplotypes

1677-P: Higher Frequency of HLA DRB108:03 and DRB104:01 Observed in A-beta+ Ketosis-Prone Type 2 Diabetes in Japanese Subjects

343-OR: HOMA2ß Stratifies Risk for Type 1 Diabetes (T1D) Development among TrialNet Pathway to Prevention Participants

109-OR: Genetic Discrepancy of HLA Class I Alleles in Chinese Patients with Type 1 Diabetes at Different Onset Ages

287-OR: TCR/HLA Humanized Mice Reveal Reduced Tolerance and Increased Immunogenicity of Posttranslationally Modified GAD65 Epitope

1280-P: Improving Type 1 Diabetes (T1D) Prediction by Incorporating Growth Features into Landmark Models

118-OR: HLA Matching and Clinical Outcomes in Islet Transplantation

Failed Genetic Protection: Type 1 Diabetes in the Presence of HLA-DQB1*06:02

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