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Journal Articles

Dual Tracer Test to measure tissue-specific insulin action in individual mice identifies in vivo insulin resistance without fasting hyperinsulinemia

Harry B. Cutler, Søren Madsen, Stewart W.C. Masson, Kristen C. Cooke, Meg Potter, James G. Burchfield, Jacqueline Stöckli, Marin E. Nelson, Gregory J. Cooney, David E. James

Diabetes db230035

https://doi.org/10.2337/db23-0035

Published: 12 September 2023

View article titled, Dual Tracer Test to measure tissue-specific insulin action in individual mice identifies in vivo insulin resistance without fasting hyperinsulinemia

Journal Articles

Optimization of a Glucagon-Like Peptide 1 Receptor Antagonist Antibody for Treatment of Hyperinsulinism

Sean M. Peterson, Christine A. Juliana, Cameron F. Hu, Jinghua Chai, Carson Holliday, Kara Y. Chan, Ana G. Lujan Hernandez, Zoe Challocombe, Linya Wang, Zhen Han, Nikhil Haas, Ryan Stafford, Fumiko Axelrod, Tom Z. Yuan, Diva D. De León, Aaron K. Sato

Diabetes 2023;72(9):1320–1329

https://doi.org/10.2337/db22-1039

Published: 26 June 2023

View article titled, Optimization of a Glucagon-Like Peptide 1 Receptor Antagonist Antibody for Treatment of Hyperinsulinism

Meeting Abstracts

1286-P: Hyperinsulinemia Is Common in Individuals with Normoglycemia in a Nationwide Working-Age Population

JUDY Z. LOUIE, DOV SHIFFMAN, JAMES B. MEIGS, MICHAEL J. MCPHAUL

Diabetes 2023;72(Supplement_1):1286-P

https://doi.org/10.2337/db23-1286-P

Published: 20 June 2023

View article titled, 1286-P: Hyperinsulinemia Is Common in Individuals with Normoglycemia in a Nationwide Working-Age Population

Meeting Abstracts

1600-P: Duration of Morning Hyperinsulinemia Is Key to the Enhancement of Hepatic Glucose Uptake Later in the Day

HANNAH L. WATERMAN, MARTA S. SMITH, BEN FARMER, GUILLAUME KRAFT, MELANIE SCOTT, DALE S. EDGERTON, ALAN D. CHERRINGTON, MARY C. MOORE

Diabetes 2023;72(Supplement_1):1600-P

https://doi.org/10.2337/db23-1600-P

Published: 20 June 2023

View article titled, 1600-P: Duration of Morning Hyperinsulinemia Is Key to the Enhancement of Hepatic Glucose Uptake Later in the Day

Meeting Abstracts

1637-P: Acute Hyperinsulinemia Alters Intramuscular 1,2-DAG Species across Metabolic Phenotypes

COLLEEN MCKENNA, KARIN ZEMSKI BERRY, SIMONA ZARINI, DARCY KAHN, LEIGH PERREAULT, SEAN A. NEWSOM, JANET K. SNELL-BERGEON, BRYAN C. BERGMAN

Diabetes 2023;72(Supplement_1):1637-P

https://doi.org/10.2337/db23-1637-P

Published: 20 June 2023

View article titled, 1637-P: Acute Hyperinsulinemia Alters Intramuscular 1,2-DAG Species across Metabolic Phenotypes

Meeting Abstracts

1590-P: Post-Oral Glucose Load Hyperinsulinemia in Individuals with Metabolic Syndrome and Metabolic-Associated Fatty Liver Disease—First Steps toward the Development of Type 2 Diabetes?

GABRIELLE TRÉPANIER, THEO GIGNAC, MARION PRADEAU, ARIANNE MORISSETTE, ANNE-LAURE AGRINIER, CLAUDIA GAGNON, MARIE-CLAUDE VOHL, ANDRE MARETTE, ANNE-MARIE CARREAU

Diabetes 2023;72(Supplement_1):1590-P

https://doi.org/10.2337/db23-1590-P

Published: 20 June 2023

View article titled, 1590-P: Post-Oral Glucose Load Hyperinsulinemia in Individuals with Metabolic Syndrome and Metabolic-Associated Fatty Liver Disease—First Steps toward the Development of Type 2 Diabetes?

Meeting Abstracts

1745-P: Voltage-Gated K+ Channel Kv7.1 Is an Important Regulator of Insulin Secretion in Normal and Hyperinsulinemic Islets

CHRISTINE JULIANA, DIVA DE LEON

Diabetes 2023;72(Supplement_1):1745-P

https://doi.org/10.2337/db23-1745-P

Published: 20 June 2023

View article titled, 1745-P: Voltage-Gated K+ Channel Kv7.1 Is an Important Regulator of Insulin Secretion in Normal and Hyperinsulinemic Islets

Meeting Abstracts

50-OR: First-Trimester Dietary Phenolic Compounds and Lipids Are Associated with Hyperinsulinism at Birth in Type 1 Diabetes Pregnancy

CLAIRE L. MEEK, ZOE A. STEWART, DENICE FEIG, ALBERT KOULMAN, HELEN R. MURPHY

Diabetes 2023;72(Supplement_1):50-OR

https://doi.org/10.2337/db23-50-OR

Published: 20 June 2023

View article titled, 50-OR: First-Trimester Dietary Phenolic Compounds and Lipids Are Associated with Hyperinsulinism at Birth in Type 1 Diabetes Pregnancy

Meeting Abstracts

1782-P: Perinatal Hypoxia Lowers the Glucose Threshold for Insulin Secretion Causing Hypoglycemia and Hyperinsulinism

CHRISTINE JULIANA, DIVA DE LEON

Diabetes 2023;72(Supplement_1):1782-P

https://doi.org/10.2337/db23-1782-P

Published: 20 June 2023

View article titled, 1782-P: Perinatal Hypoxia Lowers the Glucose Threshold for Insulin Secretion Causing Hypoglycemia and Hyperinsulinism

Journal Articles

Insulin Response to Oral Glucose and Cardiometabolic Disease: A Mendelian Randomization Study to Assess Potential Causality

Anthony Nguyen, Rana Khafagy, Ameena Meerasa, Delnaz Roshandel, Andrew D. Paterson, Satya Dash

Diabetes 2022;71(9):1880–1890

https://doi.org/10.2337/db22-0138

Published: 24 June 2022

View article titled, Insulin Response to Oral Glucose and Cardiometabolic Disease: A Mendelian Randomization Study to Assess Potential Causality

Journal Articles

Hyperinsulinemia Is Highly Associated With Markers of Hepatocytic Senescence in Two Independent Cohorts

Diabetes 2022;71(9):1929–1936

https://doi.org/10.2337/db21-1076

Published: 17 June 2022

View article titled, Hyperinsulinemia Is Highly Associated With Markers of Hepatocytic Senescence in Two Independent Cohorts

Meeting Abstracts

995-P: LRG1 Mediates Diet-Induced Hyperinsulinemia by Enhancing Glucose-Stimulated Insulin Secretion

DESIRAE MORALES, JIYOON RYU, JANE L. LYNCH, RAVINDRANATH DUGGIRALA, LILY Q. DONG

Diabetes 2022;71(Supplement_1):995-P

https://doi.org/10.2337/db22-995-P

Published: 01 June 2022

View article titled, 995-P: LRG1 Mediates Diet-Induced Hyperinsulinemia by Enhancing Glucose-Stimulated Insulin Secretion

Journal Articles

ATP-Sensitive Potassium Channels in Hyperinsulinism and Type 2 Diabetes: Inconvenient Paradox or New Paradigm?

Colin G. Nichols, Nathaniel W. York, Maria S. Remedi

Diabetes 2022;71(3):367–375

https://doi.org/10.2337/db21-0755

Published: 23 February 2022

View article titled, ATP-Sensitive Potassium Channels in Hyperinsulinism and Type 2 Diabetes: Inconvenient Paradox or New Paradigm?

Journal Articles

Possible Involvement of Adipose Tissue in Patients With Older Age, Obesity, and Diabetes With SARS-CoV-2 Infection (COVID-19) via GRP78 (BIP/HSPA5): Significance of Hyperinsulinemia Management in COVID-19

Jihoon Shin, Shinichiro Toyoda, Shigeki Nishitani, Atsunori Fukuhara, Shunbun Kita, Michio Otsuki, Iichiro Shimomura

Diabetes 2021;70(12):2745–2755

https://doi.org/10.2337/db20-1094

Published: 22 October 2021

View article titled, Possible Involvement of Adipose Tissue in Patients With Older Age, Obesity, and Diabetes With SARS-CoV-2 Infection (COVID-19) via GRP78 (BIP/HSPA5): Significance of Hyperinsulinemia Management in COVID-19

Journal Articles

Specific Deletion of CASK in Pancreatic β-Cells Affects Glucose Homeostasis and Improves Insulin Sensitivity in Obese Mice by Reducing Hyperinsulinemia

Xingjing Liu, Peng Sun, Qingzhao Yuan, Jinyang Xie, Ting Xiao, Kai Zhang, Xiu Chen, Yao Wang, Li Yuan, Xiao Han

Diabetes 2022;71(1):104–115

https://doi.org/10.2337/db20-1208

Published: 21 October 2021

View article titled, Specific Deletion of CASK in Pancreatic β-Cells Affects Glucose Homeostasis and Improves Insulin Sensitivity in Obese Mice by Reducing Hyperinsulinemia

Journal Articles

What Regulates Basal Insulin Secretion and Causes Hyperinsulinemia?

Barbara E. Corkey, Jude T. Deeney, Matthew J. Merrins

Diabetes 2021;70(10):2174–2182

https://doi.org/10.2337/dbi21-0009

Published: 27 September 2021

View article titled, What Regulates Basal Insulin Secretion and Causes Hyperinsulinemia?

Journal Articles

Insulin Resistance in Skeletal Muscle Selectively Protects the Heart in Response to Metabolic Stress

Dandan Jia, Jun Zhang, Xueling Liu, John-Paul Andersen, Zhenjun Tian, Jia Nie, Yuguang Shi

Diabetes 2021;70(10):2333–2343

https://doi.org/10.2337/db20-1212

Published: 08 July 2021

View article titled, Insulin Resistance in Skeletal Muscle Selectively Protects the Heart in Response to Metabolic Stress

Meeting Abstracts

94-OR: Reappearance of C-Peptide during the Third Trimester in Type 1 Diabetes Pregnancy: Pancreatic Regeneration or Fetal Hyperinsulinism?

CLAIRE L. MEEK, RICHARD A. ORAM, TIMOTHY J. MCDONALD, DENICE FEIG, ANDREW T. HATTERSLEY, HELEN R. MURPHY

Diabetes 2021;70(Supplement_1):94-OR

https://doi.org/10.2337/db21-94-OR

Published: 01 June 2021

View article titled, 94-OR: Reappearance of C-Peptide during the Third Trimester in Type 1 Diabetes Pregnancy: Pancreatic Regeneration or Fetal Hyperinsulinism?

Meeting Abstracts

95-LB: Control-IQ Technology in the Real World: The First 30 Days

LARS MUELLER, ALEXANDRA CONSTANTIN, HARSIMRAN SINGH, STEPHANIE HABIF

Diabetes 2020;69(Supplement_1):95-LB

https://doi.org/10.2337/db20-95-LB

Published: 01 June 2020

View article titled, 95-LB: Control-IQ Technology in the Real World: The First 30 Days

Meeting Abstracts

1844-P: Agpat5 Promotes Obesity-Associated Hyperinsulinemia

SAMANTHA L. ST. CLAIR, SABRINA L. BELISLE, SYDNEY BRUGGEMAN, FERNANDA B. LEYVA JAIMES, BOBBI A. BURGESS, ZHONGGANG LI, BRIAN PARKS

Diabetes 2020;69(Supplement_1):1844-P

https://doi.org/10.2337/db20-1844-P

Published: 01 June 2020

View article titled, 1844-P: Agpat5 Promotes Obesity-Associated Hyperinsulinemia

NARROW

Dual Tracer Test to measure tissue-specific insulin action in individual mice identifies in vivo insulin resistance without fasting hyperinsulinemia

Optimization of a Glucagon-Like Peptide 1 Receptor Antagonist Antibody for Treatment of Hyperinsulinism

1286-P: Hyperinsulinemia Is Common in Individuals with Normoglycemia in a Nationwide Working-Age Population

1600-P: Duration of Morning Hyperinsulinemia Is Key to the Enhancement of Hepatic Glucose Uptake Later in the Day

1637-P: Acute Hyperinsulinemia Alters Intramuscular 1,2-DAG Species across Metabolic Phenotypes

1590-P: Post-Oral Glucose Load Hyperinsulinemia in Individuals with Metabolic Syndrome and Metabolic-Associated Fatty Liver Disease—First Steps toward the Development of Type 2 Diabetes?

1745-P: Voltage-Gated K+ Channel Kv7.1 Is an Important Regulator of Insulin Secretion in Normal and Hyperinsulinemic Islets

50-OR: First-Trimester Dietary Phenolic Compounds and Lipids Are Associated with Hyperinsulinism at Birth in Type 1 Diabetes Pregnancy

1782-P: Perinatal Hypoxia Lowers the Glucose Threshold for Insulin Secretion Causing Hypoglycemia and Hyperinsulinism

Insulin Response to Oral Glucose and Cardiometabolic Disease: A Mendelian Randomization Study to Assess Potential Causality

Hyperinsulinemia Is Highly Associated With Markers of Hepatocytic Senescence in Two Independent Cohorts

995-P: LRG1 Mediates Diet-Induced Hyperinsulinemia by Enhancing Glucose-Stimulated Insulin Secretion

ATP-Sensitive Potassium Channels in Hyperinsulinism and Type 2 Diabetes: Inconvenient Paradox or New Paradigm?

Possible Involvement of Adipose Tissue in Patients With Older Age, Obesity, and Diabetes With SARS-CoV-2 Infection (COVID-19) via GRP78 (BIP/HSPA5): Significance of Hyperinsulinemia Management in COVID-19

Specific Deletion of CASK in Pancreatic β-Cells Affects Glucose Homeostasis and Improves Insulin Sensitivity in Obese Mice by Reducing Hyperinsulinemia

What Regulates Basal Insulin Secretion and Causes Hyperinsulinemia?

Insulin Resistance in Skeletal Muscle Selectively Protects the Heart in Response to Metabolic Stress

94-OR: Reappearance of C-Peptide during the Third Trimester in Type 1 Diabetes Pregnancy: Pancreatic Regeneration or Fetal Hyperinsulinism?

95-LB: Control-IQ Technology in the Real World: The First 30 Days

1844-P: Agpat5 Promotes Obesity-Associated Hyperinsulinemia

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