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Meeting Abstracts

152-OR: Evidence Linking Loss of Hypothalamic Perineuronal Nets to Obesity Pathogenesis

KIMBERLY M. ALONGE, MAURICIO D. DORFMAN, JARRAD M. SCARLETT, SUSAN J. MELHORN, YUANCHAO YE, SHANNON J.W. HU, KENDRA L. FRANCIS, AARUN HENDRICKSON, KATHERINE CUI, GREGORY J. MORTON, ELLEN SCHUR, JOSHUA THALER, MICHAEL W. SCHWARTZ

Diabetes 2022;71(Supplement_1):152-OR

DOI: https://doi.org/10.2337/db22-152-OR

Published: 01 June 2022

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Meeting Abstracts

165-OR: Norepinephrine Acts on Glutamatergic Neurons in the Ventromedial Hypothalamus to Stimulate the Release of Counterregulatory Hormones

DANIEL A. APPADURAI, OWEN CHAN

Diabetes 2022;71(Supplement_1):165-OR

DOI: https://doi.org/10.2337/db22-165-OR

Published: 01 June 2022

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Meeting Abstracts

343-OR: Maternal Diabetes Is Associated with Hypothalamic Gliosis in Offspring

LETICIA E. SEWAYBRICKER, KELSEY OLERICH, SARAH L. KEE, SUSAN J. MELHORN, SUCHITRA CHANDRASEKARAN, ELLEN SCHUR

Diabetes 2022;71(Supplement_1):343-OR

DOI: https://doi.org/10.2337/db22-343-OR

Published: 01 June 2022

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Meeting Abstracts

158-OR: Perinatal Hypercaloric Diet Leads to Cardiometabolic Imbalance via Hypothalamic Methylation Events in Male Mice

MONA ELGAZZAZ, CLARA BERDASCO, ERIC D. LAZARTIGUES

Diabetes 2022;71(Supplement_1):158-OR

DOI: https://doi.org/10.2337/db22-158-OR

Published: 01 June 2022

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Journal Articles

The Role of GIP Receptor in the CNS for the Pathogenesis of Obesity

Makoto Fukuda

Diabetes 2021;70(9):1929–1937

DOI: https://doi.org/10.2337/dbi21-0001

Published: 27 June 2021

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Meeting Abstracts

170-OR: Hypothalamic Gliosis Predicts Decline in Insulin Sensitivity over One Year in People with Obesity

JENNIFER L. ROSENBAUM, STEFAN SCHOEN, SUSAN J. MELHORN, MARY ROSALYNN DE LEON, MARY WEBB, KRISTINA UTZSCHNEIDER, ELLEN SCHUR

Diabetes 2021;70(Supplement_1):170-OR

DOI: https://doi.org/10.2337/db21-170-OR

Published: 01 June 2021

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Meeting Abstracts

1153-P: Sodium-Glucose Cotransporter-2 Inhibitors Increase Food Intake via a Mechanism That Acts on the Central Nervous System Involving Phosphorylation of Adenosine Monophosphate-Activated Protein Kinase in the Lateral Hypothalamus

KENJI TAKEDA, HIRAKU ONO, TOMOHIRO OHNO, KOUTARO YOKOTE

Diabetes 2021;70(Supplement_1):1153-P

DOI: https://doi.org/10.2337/db21-1153-P

Published: 01 June 2021

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Meeting Abstracts

1154-P: Mediobasal Hypothalamic PACAP Is Essential for Energy Balance by Stimulating Energy Expenditure

DAVID Q. JOHNSON, RASHMITA BASU, JONATHAN FLAK

Diabetes 2021;70(Supplement_1):1154-P

DOI: https://doi.org/10.2337/db21-1154-P

Published: 01 June 2021

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Meeting Abstracts

172-OR: Perinatal Exposure to a Western Diet Alters Hypothalamic Gene Expression and Predisposes to Diabetes in Adult Male Mice

MONA ELGAZZAZ, ERIC D. LAZARTIGUES, FRANCK MAUVAIS-JARVIS

Diabetes 2021;70(Supplement_1):172-OR

DOI: https://doi.org/10.2337/db21-172-OR

Published: 01 June 2021

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Journal Articles

Lack of Brain Insulin Receptor Substrate-1 Causes Growth Retardation, With Decreased Expression of Growth Hormone–Releasing Hormone in the Hypothalamus

Takanori Hayashi, Tetsuya Kubota, Inoue Mariko, Iseki Takamoto, Masakazu Aihara, Yoshitaka Sakurai, Nobuhiro Wada, Takashi Miki, Toshimasa Yamauchi, Naoto Kubota, Takashi Kadowaki

Diabetes 2021;70(8):1640–1653

DOI: https://doi.org/10.2337/db20-0482

Published: 12 May 2021

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Journal Articles

Effects of Gastric Bypass Surgery on the Brain: Simultaneous Assessment of Glucose Uptake, Blood Flow, Neural Activity, and Cognitive Function During Normo- and Hypoglycemia

Kristina E. Almby, Martin H. Lundqvist, Niclas Abrahamsson, Sofia Kvernby, Markus Fahlström, Maria J. Pereira, Malin Gingnell, F. Anders Karlsson, Giovanni Fanni, Magnus Sundbom, Urban Wiklund, Sven Haller, Mark Lubberink, Johan Wikström, Jan W. Eriksson

Diabetes 2021;70(6):1265–1277

DOI: https://doi.org/10.2337/db20-1172

Published: 04 March 2021

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Journal Articles

Erratum. The Hypothalamic Arcuate Nucleus–Median Eminence Is a Target for Sustained Diabetes Remission Induced by Fibroblast Growth Factor 1. Diabetes 2019;68: 1054–1061

Jenny M. Brown, Jarrad M. Scarlett, Miles E. Matsen, Hong T. Nguyen, Anna Secher, Rasmus Jorgensen, Gregory J. Morton, Michael W. Schwartz

Diabetes 2021;70(3):817

DOI: https://doi.org/10.2337/db21-er03a

Published: 18 December 2020

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Journal Articles

Central Regulation of Branched-Chain Amino Acids Is Mediated by AgRP Neurons

Ritchel B. Gannaban, Cherl NamKoong, Henry H. Ruiz, Hyung Jin Choi, Andrew C. Shin

Diabetes 2021;70(1):62–75

DOI: https://doi.org/10.2337/db20-0510

Published: 28 October 2020

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Meeting Abstracts

1760-P: Brain Sh2b1 Protects against Obesity and Insulin Resistance through Multiple Hypothalamic Neural Circuits

YUAN LI, MIN-HYUN KIM, LIN JIANG, MARTIN G. MYERS, JR., LIANGYOU RUI

Diabetes 2020;69(Supplement_1):1760-P

DOI: https://doi.org/10.2337/db20-1760-P

Published: 01 June 2020

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Meeting Abstracts

1768-P: The Role of Hypothalamic Growth Hormone Receptor–Expressing Neurons in Glucose Metabolism and Energy Homeostasis

JULIANA LIMA, LUCAS K. DEBARBA, IVEN T. AYYAR, CHIDERA UBAH, MANAL KHAN, HAWRAA ALROMDHAN, MOHAMMED ALYSOFI, MARIANNA SADAGURSKI

Diabetes 2020;69(Supplement_1):1768-P

DOI: https://doi.org/10.2337/db20-1768-P

Published: 01 June 2020

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Meeting Abstracts

1766-P: Androgen Action in Hypothalamic Arcuate Nucleus Neurons Increases Hepatic Glucose Production in Female Mice

JAMIE MORFORD, FRANCK MAUVAIS-JARVIS

Diabetes 2020;69(Supplement_1):1766-P

DOI: https://doi.org/10.2337/db20-1766-P

Published: 01 June 2020

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Meeting Abstracts

1771-P: Hypothalamic Perineuronal Net Assembly Is Required for Sustained Diabetes Remission Induced by FGF1

KIMBERLY M. ALONGE, ZAMAN MIRZADEH, JARRAD SCARLETT, ARIC LOGSDON, JENNY M. BROWN, ELAINE CABRALES, CHRISTINA K. CHAN, KARL KAIYALA, MARIE A. BENTSEN, WILLIAM A. BANKS, MIKLOS GUTTMAN, THOMAS N. WIGHT, GREGORY J. MORTON, MICHAEL W. SCHWARTZ

Diabetes 2020;69(Supplement_1):1771-P

DOI: https://doi.org/10.2337/db20-1771-P

Published: 01 June 2020

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Meeting Abstracts

245-OR: CIS-Regulatory Architecture of Human ESC-Derived Hypothalamic Neuron Differentiation Aids in Variant-to-Gene Mapping of Type 2 Diabetes Related Traits

MATTHEW C. PAHL, SHERIDAN H. LITTLETON, CLAUDIA DOEGE, KENYAITA M. HODGE, MICHELLE LEONARD, SUMEI LU, REZA HAMMOND, KEITH BOEHM, CHIARA LASCONI, CHUN SU, ALESSANDRA CHESI, JAMES A. PIPPIN, MATTHEW JOHNSON, ANDREW D. WELLS, BENJAMIN F. VOIGHT, RUDOLPH LEIBEL, STRUAN F. GRANT, DIANA L. COUSMINER

Diabetes 2020;69(Supplement_1):245-OR

DOI: https://doi.org/10.2337/db20-245-OR

Published: 01 June 2020

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Meeting Abstracts

1776-P: ROCK1 Deletion in Sim1-Expressing Neurons of the Hypothalamus Leads to Obesity Despite Hypophagia

HYON LEE, JUNG SUK HAN, AYKUT G. UNER, SOO J. CHOI, RODRIGO M. PEREIRA, XIAOFANG SUN, HYUN JEONG KIM, YOUNG-BUM KIM

Diabetes 2020;69(Supplement_1):1776-P

DOI: https://doi.org/10.2337/db20-1776-P

Published: 01 June 2020

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Meeting Abstracts

211-OR: Hypothalamic Slug Couples Overnutrition States to Epigenetic Reprogramming of Leptin Neural Circuits, Obesity, and Type 2 Diabetes

MIN-HYUN KIM, LIN JIANG, MARTIN G. MYERS, JR., LIANGYOU RUI

Diabetes 2020;69(Supplement_1):211-OR

DOI: https://doi.org/10.2337/db20-211-OR

Published: 01 June 2020

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2 3 4 5

NARROW

152-OR: Evidence Linking Loss of Hypothalamic Perineuronal Nets to Obesity Pathogenesis

165-OR: Norepinephrine Acts on Glutamatergic Neurons in the Ventromedial Hypothalamus to Stimulate the Release of Counterregulatory Hormones

343-OR: Maternal Diabetes Is Associated with Hypothalamic Gliosis in Offspring

158-OR: Perinatal Hypercaloric Diet Leads to Cardiometabolic Imbalance via Hypothalamic Methylation Events in Male Mice

The Role of GIP Receptor in the CNS for the Pathogenesis of Obesity

170-OR: Hypothalamic Gliosis Predicts Decline in Insulin Sensitivity over One Year in People with Obesity

1153-P: Sodium-Glucose Cotransporter-2 Inhibitors Increase Food Intake via a Mechanism That Acts on the Central Nervous System Involving Phosphorylation of Adenosine Monophosphate-Activated Protein Kinase in the Lateral Hypothalamus

1154-P: Mediobasal Hypothalamic PACAP Is Essential for Energy Balance by Stimulating Energy Expenditure

172-OR: Perinatal Exposure to a Western Diet Alters Hypothalamic Gene Expression and Predisposes to Diabetes in Adult Male Mice

Lack of Brain Insulin Receptor Substrate-1 Causes Growth Retardation, With Decreased Expression of Growth Hormone–Releasing Hormone in the Hypothalamus

Effects of Gastric Bypass Surgery on the Brain: Simultaneous Assessment of Glucose Uptake, Blood Flow, Neural Activity, and Cognitive Function During Normo- and Hypoglycemia

Erratum. The Hypothalamic Arcuate Nucleus–Median Eminence Is a Target for Sustained Diabetes Remission Induced by Fibroblast Growth Factor 1. Diabetes 2019;68: 1054–1061

Central Regulation of Branched-Chain Amino Acids Is Mediated by AgRP Neurons

1760-P: Brain Sh2b1 Protects against Obesity and Insulin Resistance through Multiple Hypothalamic Neural Circuits

1768-P: The Role of Hypothalamic Growth Hormone Receptor–Expressing Neurons in Glucose Metabolism and Energy Homeostasis

1766-P: Androgen Action in Hypothalamic Arcuate Nucleus Neurons Increases Hepatic Glucose Production in Female Mice

1771-P: Hypothalamic Perineuronal Net Assembly Is Required for Sustained Diabetes Remission Induced by FGF1

245-OR: CIS-Regulatory Architecture of Human ESC-Derived Hypothalamic Neuron Differentiation Aids in Variant-to-Gene Mapping of Type 2 Diabetes Related Traits

1776-P: ROCK1 Deletion in Sim1-Expressing Neurons of the Hypothalamus Leads to Obesity Despite Hypophagia

211-OR: Hypothalamic Slug Couples Overnutrition States to Epigenetic Reprogramming of Leptin Neural Circuits, Obesity, and Type 2 Diabetes

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