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Journal Articles

Astrocyte glycogen is a major source of hypothalamic lactate in rats with recurrent hypoglycemia.

Gong Su, Rawad Farhat, Anil K. Laxman, Kimberly Chapman-Natewa, Irvane E. Nelson, Owen Chan

Diabetes db220902

DOI: https://doi.org/10.2337/db22-0902

Published: 22 May 2023

View article titled, Astrocyte glycogen is a major source of hypothalamic lactate in rats with recurrent hypoglycemia.

Journal Articles

Prostaglandin PGE2 Receptor EP4 Regulates Microglial Phagocytosis and Increases Susceptibility to Diet-Induced Obesity

Anzela Niraula, Rachael D. Fasnacht, Kelly M. Ness, Jeremy M. Frey, Sophia A. Cuschieri, Mauricio D. Dorfman, Joshua P. Thaler

Diabetes 2023;72(2):233–244

DOI: https://doi.org/10.2337/db21-1072

Published: 01 November 2022

View article titled, Prostaglandin PGE2 Receptor EP4 Regulates Microglial Phagocytosis and Increases Susceptibility to Diet-Induced Obesity

Journal Articles

In This Issue of Diabetes

Max Bingham, PhD

Diabetes 2022;71(11):2235–2236

DOI: https://doi.org/10.2337/db22-ti11

Published: 13 October 2022

View article titled, In This Issue of Diabetes

Journal Articles

Exposure to Gestational Diabetes Mellitus Prior to 26 Weeks Is Related to the Presence of Mediobasal Hypothalamic Gliosis in Children

Suchitra Chandrasekaran, Susan Melhorn, Kelsey L.W. Olerich, Brendan Angelo, Ting Chow, Anny Xiang, Ellen A. Schur, Kathleen A. Page

Diabetes 2022;71(12):2552–2556

DOI: https://doi.org/10.2337/db22-0448

Published: 12 September 2022

View article titled, Exposure to Gestational Diabetes Mellitus Prior to 26 Weeks Is Related to the Presence of Mediobasal Hypothalamic Gliosis in Children

Journal Articles

MANF in POMC Neurons Promotes Brown Adipose Tissue Thermogenesis and Protects Against Diet-Induced Obesity

Qin Tang, Qinhui Liu, Jiahui Li, Jiamin Yan, Xiandan Jing, Jinhang Zhang, Yan Xia, Ying Xu, Yanping Li, Jinhan He

Diabetes 2022;71(11):2344–2359

DOI: https://doi.org/10.2337/db21-1128

Published: 12 August 2022

View article titled, MANF in POMC Neurons Promotes Brown Adipose Tissue Thermogenesis and Protects Against Diet-Induced Obesity

Meeting Abstracts

152-OR: Evidence Linking Loss of Hypothalamic Perineuronal Nets to Obesity Pathogenesis

KIMBERLY M. ALONGE, MAURICIO D. DORFMAN, JARRAD M. SCARLETT, SUSAN J. MELHORN, YUANCHAO YE, SHANNON J.W. HU, KENDRA L. FRANCIS, AARUN HENDRICKSON, KATHERINE CUI, GREGORY J. MORTON, ELLEN SCHUR, JOSHUA THALER, MICHAEL W. SCHWARTZ

Diabetes 2022;71(Supplement_1):152-OR

DOI: https://doi.org/10.2337/db22-152-OR

Published: 01 June 2022

View article titled, 152-OR: Evidence Linking Loss of Hypothalamic Perineuronal Nets to Obesity Pathogenesis

Meeting Abstracts

165-OR: Norepinephrine Acts on Glutamatergic Neurons in the Ventromedial Hypothalamus to Stimulate the Release of Counterregulatory Hormones

DANIEL A. APPADURAI, OWEN CHAN

Diabetes 2022;71(Supplement_1):165-OR

DOI: https://doi.org/10.2337/db22-165-OR

Published: 01 June 2022

View article titled, 165-OR: Norepinephrine Acts on Glutamatergic Neurons in the Ventromedial Hypothalamus to Stimulate the Release of Counterregulatory Hormones

Meeting Abstracts

343-OR: Maternal Diabetes Is Associated with Hypothalamic Gliosis in Offspring

LETICIA E. SEWAYBRICKER, KELSEY OLERICH, SARAH L. KEE, SUSAN J. MELHORN, SUCHITRA CHANDRASEKARAN, ELLEN SCHUR

Diabetes 2022;71(Supplement_1):343-OR

DOI: https://doi.org/10.2337/db22-343-OR

Published: 01 June 2022

View article titled, 343-OR: Maternal Diabetes Is Associated with Hypothalamic Gliosis in Offspring

Meeting Abstracts

158-OR: Perinatal Hypercaloric Diet Leads to Cardiometabolic Imbalance via Hypothalamic Methylation Events in Male Mice

MONA ELGAZZAZ, CLARA BERDASCO, ERIC D. LAZARTIGUES

Diabetes 2022;71(Supplement_1):158-OR

DOI: https://doi.org/10.2337/db22-158-OR

Published: 01 June 2022

View article titled, 158-OR: Perinatal Hypercaloric Diet Leads to Cardiometabolic Imbalance via Hypothalamic Methylation Events in Male Mice

Journal Articles

The Role of GIP Receptor in the CNS for the Pathogenesis of Obesity

Makoto Fukuda

Diabetes 2021;70(9):1929–1937

DOI: https://doi.org/10.2337/dbi21-0001

Published: 27 June 2021

View article titled, The Role of GIP Receptor in the CNS for the Pathogenesis of Obesity

Meeting Abstracts

170-OR: Hypothalamic Gliosis Predicts Decline in Insulin Sensitivity over One Year in People with Obesity

JENNIFER L. ROSENBAUM, STEFAN SCHOEN, SUSAN J. MELHORN, MARY ROSALYNN DE LEON, MARY WEBB, KRISTINA UTZSCHNEIDER, ELLEN SCHUR

Diabetes 2021;70(Supplement_1):170-OR

DOI: https://doi.org/10.2337/db21-170-OR

Published: 01 June 2021

View article titled, 170-OR: Hypothalamic Gliosis Predicts Decline in Insulin Sensitivity over One Year in People with Obesity

Meeting Abstracts

1153-P: Sodium-Glucose Cotransporter-2 Inhibitors Increase Food Intake via a Mechanism That Acts on the Central Nervous System Involving Phosphorylation of Adenosine Monophosphate-Activated Protein Kinase in the Lateral Hypothalamus

KENJI TAKEDA, HIRAKU ONO, TOMOHIRO OHNO, KOUTARO YOKOTE

Diabetes 2021;70(Supplement_1):1153-P

DOI: https://doi.org/10.2337/db21-1153-P

Published: 01 June 2021

View article titled, 1153-P: Sodium-Glucose Cotransporter-2 Inhibitors Increase Food Intake via a Mechanism That Acts on the Central Nervous System Involving Phosphorylation of Adenosine Monophosphate-Activated Protein Kinase in the Lateral Hypothalamus

Meeting Abstracts

1154-P: Mediobasal Hypothalamic PACAP Is Essential for Energy Balance by Stimulating Energy Expenditure

DAVID Q. JOHNSON, RASHMITA BASU, JONATHAN FLAK

Diabetes 2021;70(Supplement_1):1154-P

DOI: https://doi.org/10.2337/db21-1154-P

Published: 01 June 2021

View article titled, 1154-P: Mediobasal Hypothalamic PACAP Is Essential for Energy Balance by Stimulating Energy Expenditure

Meeting Abstracts

172-OR: Perinatal Exposure to a Western Diet Alters Hypothalamic Gene Expression and Predisposes to Diabetes in Adult Male Mice

MONA ELGAZZAZ, ERIC D. LAZARTIGUES, FRANCK MAUVAIS-JARVIS

Diabetes 2021;70(Supplement_1):172-OR

DOI: https://doi.org/10.2337/db21-172-OR

Published: 01 June 2021

View article titled, 172-OR: Perinatal Exposure to a Western Diet Alters Hypothalamic Gene Expression and Predisposes to Diabetes in Adult Male Mice

Journal Articles

Lack of Brain Insulin Receptor Substrate-1 Causes Growth Retardation, With Decreased Expression of Growth Hormone–Releasing Hormone in the Hypothalamus

Takanori Hayashi, Tetsuya Kubota, Inoue Mariko, Iseki Takamoto, Masakazu Aihara, Yoshitaka Sakurai, Nobuhiro Wada, Takashi Miki, Toshimasa Yamauchi, Naoto Kubota, Takashi Kadowaki

Diabetes 2021;70(8):1640–1653

DOI: https://doi.org/10.2337/db20-0482

Published: 12 May 2021

View article titled, Lack of Brain Insulin Receptor Substrate-1 Causes Growth Retardation, With Decreased Expression of Growth Hormone–Releasing Hormone in the Hypothalamus

Journal Articles

Effects of Gastric Bypass Surgery on the Brain: Simultaneous Assessment of Glucose Uptake, Blood Flow, Neural Activity, and Cognitive Function During Normo- and Hypoglycemia

Kristina E. Almby, Martin H. Lundqvist, Niclas Abrahamsson, Sofia Kvernby, Markus Fahlström, Maria J. Pereira, Malin Gingnell, F. Anders Karlsson, Giovanni Fanni, Magnus Sundbom, Urban Wiklund, Sven Haller, Mark Lubberink, Johan Wikström, Jan W. Eriksson

Diabetes 2021;70(6):1265–1277

DOI: https://doi.org/10.2337/db20-1172

Published: 04 March 2021

View article titled, Effects of Gastric Bypass Surgery on the Brain: Simultaneous Assessment of Glucose Uptake, Blood Flow, Neural Activity, and Cognitive Function During Normo- and Hypoglycemia

Journal Articles

Erratum. The Hypothalamic Arcuate Nucleus–Median Eminence Is a Target for Sustained Diabetes Remission Induced by Fibroblast Growth Factor 1. Diabetes 2019;68: 1054–1061

Jenny M. Brown, Jarrad M. Scarlett, Miles E. Matsen, Hong T. Nguyen, Anna Secher, Rasmus Jorgensen, Gregory J. Morton, Michael W. Schwartz

Diabetes 2021;70(3):817

DOI: https://doi.org/10.2337/db21-er03a

Published: 18 December 2020

View article titled, Erratum. The Hypothalamic Arcuate Nucleus–Median Eminence Is a Target for Sustained Diabetes Remission Induced by Fibroblast Growth Factor 1. Diabetes 2019;68: 1054–1061

Journal Articles

Central Regulation of Branched-Chain Amino Acids Is Mediated by AgRP Neurons

Ritchel B. Gannaban, Cherl NamKoong, Henry H. Ruiz, Hyung Jin Choi, Andrew C. Shin

Diabetes 2021;70(1):62–75

DOI: https://doi.org/10.2337/db20-0510

Published: 28 October 2020

View article titled, Central Regulation of Branched-Chain Amino Acids Is Mediated by AgRP Neurons

Meeting Abstracts

1760-P: Brain Sh2b1 Protects against Obesity and Insulin Resistance through Multiple Hypothalamic Neural Circuits

YUAN LI, MIN-HYUN KIM, LIN JIANG, MARTIN G. MYERS, JR., LIANGYOU RUI

Diabetes 2020;69(Supplement_1):1760-P

DOI: https://doi.org/10.2337/db20-1760-P

Published: 01 June 2020

View article titled, 1760-P: Brain Sh2b1 Protects against Obesity and Insulin Resistance through Multiple Hypothalamic Neural Circuits

Meeting Abstracts

1768-P: The Role of Hypothalamic Growth Hormone Receptor–Expressing Neurons in Glucose Metabolism and Energy Homeostasis

JULIANA LIMA, LUCAS K. DEBARBA, IVEN T. AYYAR, CHIDERA UBAH, MANAL KHAN, HAWRAA ALROMDHAN, MOHAMMED ALYSOFI, MARIANNA SADAGURSKI

Diabetes 2020;69(Supplement_1):1768-P

DOI: https://doi.org/10.2337/db20-1768-P

Published: 01 June 2020

View article titled, 1768-P: The Role of Hypothalamic Growth Hormone Receptor–Expressing Neurons in Glucose Metabolism and Energy Homeostasis

NARROW

Astrocyte glycogen is a major source of hypothalamic lactate in rats with recurrent hypoglycemia.

Prostaglandin PGE2 Receptor EP4 Regulates Microglial Phagocytosis and Increases Susceptibility to Diet-Induced Obesity

In This Issue of Diabetes

Exposure to Gestational Diabetes Mellitus Prior to 26 Weeks Is Related to the Presence of Mediobasal Hypothalamic Gliosis in Children

MANF in POMC Neurons Promotes Brown Adipose Tissue Thermogenesis and Protects Against Diet-Induced Obesity

152-OR: Evidence Linking Loss of Hypothalamic Perineuronal Nets to Obesity Pathogenesis

165-OR: Norepinephrine Acts on Glutamatergic Neurons in the Ventromedial Hypothalamus to Stimulate the Release of Counterregulatory Hormones

343-OR: Maternal Diabetes Is Associated with Hypothalamic Gliosis in Offspring

158-OR: Perinatal Hypercaloric Diet Leads to Cardiometabolic Imbalance via Hypothalamic Methylation Events in Male Mice

The Role of GIP Receptor in the CNS for the Pathogenesis of Obesity

170-OR: Hypothalamic Gliosis Predicts Decline in Insulin Sensitivity over One Year in People with Obesity

1153-P: Sodium-Glucose Cotransporter-2 Inhibitors Increase Food Intake via a Mechanism That Acts on the Central Nervous System Involving Phosphorylation of Adenosine Monophosphate-Activated Protein Kinase in the Lateral Hypothalamus

1154-P: Mediobasal Hypothalamic PACAP Is Essential for Energy Balance by Stimulating Energy Expenditure

172-OR: Perinatal Exposure to a Western Diet Alters Hypothalamic Gene Expression and Predisposes to Diabetes in Adult Male Mice

Lack of Brain Insulin Receptor Substrate-1 Causes Growth Retardation, With Decreased Expression of Growth Hormone–Releasing Hormone in the Hypothalamus

Effects of Gastric Bypass Surgery on the Brain: Simultaneous Assessment of Glucose Uptake, Blood Flow, Neural Activity, and Cognitive Function During Normo- and Hypoglycemia

Erratum. The Hypothalamic Arcuate Nucleus–Median Eminence Is a Target for Sustained Diabetes Remission Induced by Fibroblast Growth Factor 1. Diabetes 2019;68: 1054–1061

Central Regulation of Branched-Chain Amino Acids Is Mediated by AgRP Neurons

1760-P: Brain Sh2b1 Protects against Obesity and Insulin Resistance through Multiple Hypothalamic Neural Circuits

1768-P: The Role of Hypothalamic Growth Hormone Receptor–Expressing Neurons in Glucose Metabolism and Energy Homeostasis

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