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Meeting Abstracts

1306-P: In Vivo Downregulation of Pancreatic Amylin in Diabetic Mice Improves Recognition Memory

VELMURUGAN GOPAL VISWANATHAN, NIRMAL VERMA, EDRIC D. WINFORD, DEEPAK KOTIYA, LAURA E. RADULESCU, NOAH LEIBOLD, KUEY C. CHEN, SANDA DESPA, DEMITRIUS A. HILL, MICHAEL MUEHLBAUER, JAMES R. BAIN, FLORIN DESPA

Diabetes 2022;71(Supplement_1):1306-P

DOI: https://doi.org/10.2337/db22-1306-P

Published: 01 June 2022

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Meeting Abstracts

824-P: Dual Amylin and Calcitonin Receptor Agonists Improve Insulin Sensitivity and Increase Tissue-Specific Glucose Uptake Independent of Weight Loss

ANNA T. LARSEN, NINA SONNE, EMMA-MARIE BREDTOFT, MORTEN A. KARSDAL, KIM HENRIKSEN

Diabetes 2022;71(Supplement_1):824-P

DOI: https://doi.org/10.2337/db22-824-P

Published: 01 June 2022

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Meeting Abstracts

823-P: The Long-Acting Dual Amylin and Calcitonin Receptor Agonist KBP Has Increased Efficacy on Weight Loss and Glucose Control Compared with Cagrilintide in Obese and Diabetic Rats

ANNA T. LARSEN, NINA SONNE, KHALED ELHADY MOHAMED, EMMA-MARIE BREDTOFT, FREDERIK ANDERSEN, MORTEN A. KARSDAL, KIM HENRIKSEN

Diabetes 2022;71(Supplement_1):823-P

DOI: https://doi.org/10.2337/db22-823-P

Published: 01 June 2022

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Journal Articles

Novel Human Insulin Isoforms and Cα-Peptide Product in Islets of Langerhans and Choroid Plexus

Qing-Rong Liu, Min Zhu, Pingbo Zhang, Caio H. Mazucanti, Nicholas S. Huang, Doyle L. Lang, Qinghua Chen, Pavan Auluck, Stefano Marenco, Jennifer F. O’Connell, Luigi Ferrucci, Chee W. Chia, Josephine M. Egan

Diabetes 2021;70(12):2947–2956

DOI: https://doi.org/10.2337/db21-0198

Published: 14 October 2021

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Meeting Abstracts

1238-P: The Proinflammatory but Not Cytotoxic Effect of Aggregated IAPP on Islet Endothelial Cells Requires TLR2/4 Signaling

JOSEPH J. CASTILLO, ALFRED APLIN, MEGHAN F. HOGAN, ANDREW T. TEMPLIN, NATHALIE ESSER, REHANA AKTER, REBECCA L. HULL

Diabetes 2021;70(Supplement_1):1238-P

DOI: https://doi.org/10.2337/db21-1238-P

Published: 01 June 2021

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Meeting Abstracts

1829-P: Aggravating Liver Lipid Accumulation and Fibrosis in Nonalcoholic Steatohepatitis Model of MS-NASH Mice by a Modified Amylin Diet

GUODONG ZHANG, KEEFE CHNG, YIXIN WANG

Diabetes 2020;69(Supplement_1):1829-P

DOI: https://doi.org/10.2337/db20-1829-P

Published: 01 June 2020

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Meeting Abstracts

2039-P: Plasmin-Mediated Cleavage of Human Islet Amyloid Polypeptide (hIAPP) Protects ß-Cells from Amyloid-Induced Toxicity

NATHALIE ESSER, MEGHAN F. HOGAN, ANDREW T. TEMPLIN, JOSEPH J. CASTILLO, DANIEL RALEIGH, JOHN S. EDGAR, SAKENEH ZRAIKA, REBECCA L. HULL, STEVEN E. KAHN

Diabetes 2020;69(Supplement_1):2039-P

DOI: https://doi.org/10.2337/db20-2039-P

Published: 01 June 2020

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Meeting Abstracts

2091-P: Effects of Caveolin-1 on the Synthesis and Decomposition of Islet ß-Cell IAPP and Its Mechanism

KUNYING LIU, WEN ZENG, SHUO LIN, CHUWEN LIN, FEN XU, NAN CAI, LONGYI ZENG

Diabetes 2020;69(Supplement_1):2091-P

DOI: https://doi.org/10.2337/db20-2091-P

Published: 01 June 2020

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Journal Articles

Amylin/Calcitonin Receptor–Mediated Signaling in POMC Neurons Influences Energy Balance and Locomotor Activity in Chow-Fed Male Mice

Bernd Coester, Christina Koester-Hegmann, Thomas A. Lutz, Christelle Le Foll

Diabetes 2020;69(6):1110–1125

DOI: https://doi.org/10.2337/db19-0849

Published: 09 March 2020

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Includes: Supplementary data

Meeting Abstracts

1993-P: Deconstruction of the Role of the Amylin and Calcitonin Receptors in the Regulation of Body Weight and Glucose Tolerance

ANNA T. LARSEN, NINA SONNE, KIM V. ANDREASSEN, MORTEN ASSER KARSDAL, KIM HENRIKSEN

Diabetes 2019;68(Supplement_1):1993-P

DOI: https://doi.org/10.2337/db19-1993-P

Published: 01 June 2019

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Meeting Abstracts

1995-P: Optimization of DACRA Dosing Frequency—The Balance between Efficacy and Tolerability

ANNA T. LARSEN, KIM V. ANDREASSEN, NINA SONNE, MORTEN ASSER KARSDAL, KIM HENRIKSEN

Diabetes 2019;68(Supplement_1):1995-P

DOI: https://doi.org/10.2337/db19-1995-P

Published: 01 June 2019

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Meeting Abstracts

2189-P: Human IAPP Destabilizes IRF1 Protein to Reduce PD-L1 Expression in INS1 Cells

SHUHEI MORITA, TATSUYA ISHIBASHI, HIROYUKI ARIYASU, HIROSHI IWAKURA, MASAHIRO NISHI, HIROTO FURUTA, TAKASHI AKAMIZU

Diabetes 2019;68(Supplement_1):2189-P

DOI: https://doi.org/10.2337/db19-2189-P

Published: 01 June 2019

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Meeting Abstracts

2143-P: GLP-1 Conjugation Enhances the Activity of Antisense Oligonucleotides Targeting Islet Amyloid Polypeptide (IAPP) or Kelch-Like ECH Associated Protein 1 (Keap1) in Isolated Pancreatic Islets

WUXIA FU, RICHARD LEE, ELAINE C. PIRIE, THAZHA PRAKASH, SUE MURRAY, ANDREW F. POWERS, ROSANNE M. CROOKE

Diabetes 2019;68(Supplement_1):2143-P

DOI: https://doi.org/10.2337/db19-2143-P

Published: 01 June 2019

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Meeting Abstracts

2126-P: Physiological Concentrations of IL-1 Beta Promote Islet Amyloid Deposition by Increasing Beta-Cell Secretion of Human Islet Amyloid Polypeptide

ANDREW T. TEMPLIN, MAHNAZ MELLATI, DANIEL ZEMAN-MEIER, MEGHAN F. HOGAN, NATHALIE ESSER, SAKENEH ZRAIKA, REBECCA L. HULL, STEVEN E. KAHN

Diabetes 2019;68(Supplement_1):2126-P

DOI: https://doi.org/10.2337/db19-2126-P

Published: 01 June 2019

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Meeting Abstracts

2124-P: The Tissue Plasminogen Activator (tPA)/Plasmin System Reduces Amyloid Formation by Cleaving Human Islet Amyloid Polypeptide (hIAPP)

NATHALIE ESSER, MEGHAN F. HOGAN, ALFRED APLIN, ANDREW T. TEMPLIN, SAM EL-OSTA, DANIEL RALEIGH, JOHN S. EDGAR, SAKENEH ZRAIKA, REBECCA L. HULL, STEVEN E. KAHN

Diabetes 2019;68(Supplement_1):2124-P

DOI: https://doi.org/10.2337/db19-2124-P

Published: 01 June 2019

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Meeting Abstracts

2037-P: Characterization of Novel Unimolecular Amylin-Adrenomedullin Dual Agonists

LOUISE S. DALBOEGE, PAOLA MAGOTTI, NINA BUCH-MÅNSON, ESBEN M. BECH, LISBETH N. FINK, SØREN LJUNGBERG PEDERSEN, KELD FOSGERAU

Diabetes 2019;68(Supplement_1):2037-P

DOI: https://doi.org/10.2337/db19-2037-P

Published: 01 June 2019

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Meeting Abstracts

2035-P: Treatment with a Dual Amylin and Calcitonin Receptor Agonist Improves Metabolic Health in a Rat Model of Elderly Menopausal Women

ANNA KATRI, MORTEN ASSER KARSDAL, KIM HENRIKSEN

Diabetes 2019;68(Supplement_1):2035-P

DOI: https://doi.org/10.2337/db19-2035-P

Published: 01 June 2019

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Journal Articles

Amylin Selectively Signals Onto POMC Neurons in the Arcuate Nucleus of the Hypothalamus

Thomas A. Lutz, Bernd Coester, Lynda Whiting, Ambrose A. Dunn-Meynell, Christina N. Boyle, Sebastien G. Bouret, Barry E. Levin, Christelle Le Foll

Diabetes 2018;67(5):805–817

DOI: https://doi.org/10.2337/db17-1347

Published: 21 February 2018

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Includes: Supplementary data

Journal Articles

Hyperamylinemia Increases IL-1β Synthesis in the Heart via Peroxidative Sarcolemmal Injury

Miao Liu, Nirmal Verma, Xiaoli Peng, Sarah Srodulski, Andrew Morris, Martin Chow, Louis B. Hersh, Jing Chen, Haining Zhu, Mihai G. Netea, Kenneth B. Margulies, Sanda Despa, Florin Despa

Diabetes 2016;65(9):2772–2783

DOI: https://doi.org/10.2337/db16-0044

Published: 22 June 2016

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Includes: Supplementary data

Journal Articles

Brain IL-6—Where Amylin and GLP-1 Antiobesity Signaling Congregate

John-Olov Jansson, Vilborg Palsdottir

Diabetes 2015;64(5):1498–1499

DOI: https://doi.org/10.2337/db14-1910

Published: 16 April 2015

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2 3 4 5

NARROW

1306-P: In Vivo Downregulation of Pancreatic Amylin in Diabetic Mice Improves Recognition Memory

824-P: Dual Amylin and Calcitonin Receptor Agonists Improve Insulin Sensitivity and Increase Tissue-Specific Glucose Uptake Independent of Weight Loss

823-P: The Long-Acting Dual Amylin and Calcitonin Receptor Agonist KBP Has Increased Efficacy on Weight Loss and Glucose Control Compared with Cagrilintide in Obese and Diabetic Rats

Novel Human Insulin Isoforms and Cα-Peptide Product in Islets of Langerhans and Choroid Plexus

1238-P: The Proinflammatory but Not Cytotoxic Effect of Aggregated IAPP on Islet Endothelial Cells Requires TLR2/4 Signaling

1829-P: Aggravating Liver Lipid Accumulation and Fibrosis in Nonalcoholic Steatohepatitis Model of MS-NASH Mice by a Modified Amylin Diet

2039-P: Plasmin-Mediated Cleavage of Human Islet Amyloid Polypeptide (hIAPP) Protects ß-Cells from Amyloid-Induced Toxicity

2091-P: Effects of Caveolin-1 on the Synthesis and Decomposition of Islet ß-Cell IAPP and Its Mechanism

Amylin/Calcitonin Receptor–Mediated Signaling in POMC Neurons Influences Energy Balance and Locomotor Activity in Chow-Fed Male Mice

1993-P: Deconstruction of the Role of the Amylin and Calcitonin Receptors in the Regulation of Body Weight and Glucose Tolerance

1995-P: Optimization of DACRA Dosing Frequency—The Balance between Efficacy and Tolerability

2189-P: Human IAPP Destabilizes IRF1 Protein to Reduce PD-L1 Expression in INS1 Cells

2143-P: GLP-1 Conjugation Enhances the Activity of Antisense Oligonucleotides Targeting Islet Amyloid Polypeptide (IAPP) or Kelch-Like ECH Associated Protein 1 (Keap1) in Isolated Pancreatic Islets

2126-P: Physiological Concentrations of IL-1 Beta Promote Islet Amyloid Deposition by Increasing Beta-Cell Secretion of Human Islet Amyloid Polypeptide

2124-P: The Tissue Plasminogen Activator (tPA)/Plasmin System Reduces Amyloid Formation by Cleaving Human Islet Amyloid Polypeptide (hIAPP)

2037-P: Characterization of Novel Unimolecular Amylin-Adrenomedullin Dual Agonists

2035-P: Treatment with a Dual Amylin and Calcitonin Receptor Agonist Improves Metabolic Health in a Rat Model of Elderly Menopausal Women

Amylin Selectively Signals Onto POMC Neurons in the Arcuate Nucleus of the Hypothalamus

Hyperamylinemia Increases IL-1β Synthesis in the Heart via Peroxidative Sarcolemmal Injury

Brain IL-6—Where Amylin and GLP-1 Antiobesity Signaling Congregate

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