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Meeting Abstracts

106-OR: Degludec-Like Insulin Analog Improves Peripheral Neuropathy More than Control Insulin Independent of Glycemic Control in a Rat Model of Type 2 Diabetes

THORBJÖRN C.A. ÅKERSTRÖM, LAURA JUL ANDREASEN, ERICA NISHIMURA, MARK A. YOREK

Diabetes 2023;72(Supplement_1):106-OR

https://doi.org/10.2337/db23-106-OR

Published: 20 June 2023

View article titled, 106-OR: Degludec-Like Insulin Analog Improves Peripheral Neuropathy More than Control Insulin Independent of Glycemic Control in a Rat Model of Type 2 Diabetes

Journal Articles

In This Issue of Diabetes

Max Bingham, PhD

Diabetes 2023;72(6):675–676

https://doi.org/10.2337/db23-ti06

Published: 19 May 2023

View article titled, In This Issue of Diabetes

Journal Articles

Glucose-Activated Switch Regulating Insulin Analog Secretion Enables Long-term Precise Glucose Control in Mice With Type 1 Diabetes

Lifang Xie, Wanling Lu, Yanhan Zhang, Lu Deng, Ming Liu, Hong Gao, Chunguang Xie, Gang Wang

Diabetes 2023;72(6):703–714

https://doi.org/10.2337/db22-0860

Published: 13 March 2023

View article titled, Glucose-Activated Switch Regulating Insulin Analog Secretion Enables Long-term Precise Glucose Control in Mice With Type 1 Diabetes

Meeting Abstracts

236-OR: Molecular and Biological Properties of Insulin Icodec, a New Insulin Analog Designed to Give a Long Half-Life Suitable for Once-Weekly Dosing

ERICA NISHIMURA, THOMAS KJELDSEN, FRANTISEK HUBALEK, TINE GLENDORF, CARSTEN E. STIDSEN, BO F. HANSEN, THOMAS A. PEDERSEN, ANNE LUETZEN, LONE PRIDAL, PETER MADSEN

Diabetes 2020;69(Supplement_1):236-OR

https://doi.org/10.2337/db20-236-OR

Published: 01 June 2020

View article titled, 236-OR: Molecular and Biological Properties of Insulin Icodec, a New Insulin Analog Designed to Give a Long Half-Life Suitable for Once-Weekly Dosing

Meeting Abstracts

237-OR: Insulin Icodec: An Insulin Analog Suited for Once-Weekly Dosing in Type 2 Diabetes

ULRIKE HÖVELMANN, LISE BRØNDSTED, NIELS R. KRISTENSEN, RASMUS RIBEL-MADSEN, J. HANS DEVRIES, TIM HEISE, HANNE HAAHR

Diabetes 2020;69(Supplement_1):237-OR

https://doi.org/10.2337/db20-237-OR

Published: 01 June 2020

View article titled, 237-OR: Insulin Icodec: An Insulin Analog Suited for Once-Weekly Dosing in Type 2 Diabetes

Meeting Abstracts

1024-P: Technosphere Insulin Added to Basal Insulin Is Associated with Less Weight Gain than Basal Insulin plus Insulin Aspart or Insulin Analog (Aspart) 70/30 Mixture in Type 2 DM

JONATHAN MANOUKIAN, DAVID M. KENDALL, PATRICK M. MOREY, BYRON J. HOOGWERF

Diabetes 2020;69(Supplement_1):1024-P

https://doi.org/10.2337/db20-1024-P

Published: 01 June 2020

View article titled, 1024-P: Technosphere Insulin Added to Basal Insulin Is Associated with Less Weight Gain than Basal Insulin plus Insulin Aspart or Insulin Analog (Aspart) 70/30 Mixture in Type 2 DM

Journal Articles

Role of Proinsulin Self-Association in Mutant INS Gene–Induced Diabetes of Youth

Jinhong Sun, Yi Xiong, Xin Li, Leena Haataja, Wei Chen, Saiful A. Mir, Li Lv, Rachel Madley, Dennis Larkin, Arfah Anjum, Balamurugan Dhayalan, Nischay Rege, Nalinda P. Wickramasinghe, Michael A. Weiss, Pamela Itkin-Ansari, Randal J. Kaufman, David A. Ostrov, Peter Arvan, Ming Liu

Diabetes 2020;69(5):954–964

https://doi.org/10.2337/db19-1106

Published: 05 March 2020

View article titled, Role of Proinsulin Self-Association in Mutant INS Gene–Induced Diabetes of Youth

Includes: Supplementary data

Meeting Abstracts

1112-P: Ultra Rapid Lispro (URLi) Lowers Postprandial Glucose (PPG) and More Closely Matches Normal Physiological Glucose Response Compared with Other Rapid Insulin Analogs

TIM HEISE, HELLE LINNEBJERG, DACHUANG CAO, DAVID E. COUTANT, ELIZABETH S. LABELL, SHOBHA REDDY, ERIC ZIJLSTRA, CHRISTOPH KAPITZA, JULIANA M. BUE-VALLESKEY, QIANYI ZHANG, JENNIFER LEOHR

Diabetes 2019;68(Supplement_1):1112-P

https://doi.org/10.2337/db19-1112-P

Published: 01 June 2019

View article titled, 1112-P: Ultra Rapid Lispro (URLi) Lowers Postprandial Glucose (PPG) and More Closely Matches Normal Physiological Glucose Response Compared with Other Rapid Insulin Analogs

Meeting Abstracts

Intensive Metabolic Control of T1D Pregnant Women in CSII vs. MDI—A Retrospective Analysis

SARA PARRETTINI, IRENE GIARDINA, FRANCESCA CARDINI, ELISABETTA TORLONE

Diabetes 2018;67(Supplement_1):1457-P

https://doi.org/10.2337/db18-1457-P

Published: 01 July 2018

View article titled, Intensive Metabolic Control of T1D Pregnant Women in CSII vs. MDI—A Retrospective Analysis

Meeting Abstracts

Differential Impacts of Insulin Analogs Lispro and Glulisine on Glucose and Lipid Homeostasis during Hyperinsulinemic Euglycemic Clamp in Streptozotocin-Induced Diabetic Rats

FRANÇOIS BRIAND, EMMANUEL BROUSSEAU, RÉMY BURCELIN, THIERRY SULPICE

Diabetes 2018;67(Supplement_1):1773-P

https://doi.org/10.2337/db18-1773-P

Published: 01 July 2018

View article titled, Differential Impacts of Insulin Analogs Lispro and Glulisine on Glucose and Lipid Homeostasis during Hyperinsulinemic Euglycemic Clamp in Streptozotocin-Induced Diabetic Rats

Meeting Abstracts

Basal Oral Insulin Analog I338 Enhances Meal-Related Hepatic Glucose Disposal

MARY C. MOORE, ERICA NISHIMURA, CHRISTIAN L. BRAND, THOMAS KJELDSEN, PETER MADSEN, HANNE H. REFSGAARD, KARSTEN WASSERMANN, SANNE GRAM-NIELSEN, MARTA S. SMITH, L. MERKLE MOORE, BEN FARMER, JON R. HASTINGS, PHILLIP E. WILLIAMS, ALAN D. CHERRINGTON

Diabetes 2018;67(Supplement_1):347-OR

https://doi.org/10.2337/db18-347-OR

Published: 01 July 2018

View article titled, Basal Oral Insulin Analog I338 Enhances Meal-Related Hepatic Glucose Disposal

Journal Articles

Superior Glycemic Control With a Glucose-Responsive Insulin Analog: Hepatic and Nonhepatic Impacts

Mary Courtney Moore, David E. Kelley, Raul C. Camacho, Peter Zafian, Tian Ye, Songnian Lin, Niels C. Kaarsholm, Ravi Nargund, Terri M. Kelly, Margaret Van Heek, Stephen F. Previs, Christopher Moyes, Marta S. Smith, Ben Farmer, Phil Williams, Alan D. Cherrington

Diabetes 2018;67(6):1173–1181

https://doi.org/10.2337/db18-0099

Published: 14 March 2018

View article titled, Superior Glycemic Control With a Glucose-Responsive Insulin Analog: Hepatic and Nonhepatic Impacts

Includes: Supplementary data

Journal Articles

Changes in Glucose and Fat Metabolism in Response to the Administration of a Hepato-Preferential Insulin Analog

Dale S. Edgerton, Mary C. Moore, Jason J. Winnick, Melanie Scott, Ben Farmer, Helle Naver, Claus B. Jeppesen, Peter Madsen, Thomas B. Kjeldsen, Erica Nishimura, Christian L. Brand, Alan D. Cherrington

Diabetes 2014;63(11):3946–3954

https://doi.org/10.2337/db14-0266

Published: 13 October 2014

View article titled, Changes in Glucose and Fat Metabolism in Response to the Administration of a Hepato-Preferential Insulin Analog

Journal Articles

In This Issue of Diabetes

Diabetes 2014;63(5):1431–1432

https://doi.org/10.2337/db14-ti05

Published: 12 April 2014

View article titled, In This Issue of Diabetes

Journal Articles

LY2605541—A Preferential Hepato-Specific Insulin Analogue

Sten Madsbad

Diabetes 2014;63(2):390–392

https://doi.org/10.2337/db13-1646

Published: 16 January 2014

View article titled, LY2605541—A Preferential Hepato-Specific Insulin Analogue

Journal Articles

Insulin Receptor Phosphorylation by Endogenous Insulin or the Insulin Analog AspB10 Promotes Mammary Tumor Growth Independent of the IGF-I Receptor

Emily Jane Gallagher, Nyosha Alikhani, Aviva Tobin-Hess, Jeffrey Blank, Nicholas J. Buffin, Zara Zelenko, Norbert Tennagels, Ulrich Werner, Derek LeRoith

Diabetes 2013;62(10):3553–3560

https://doi.org/10.2337/db13-0249

Published: 17 September 2013

View article titled, Insulin Receptor Phosphorylation by Endogenous Insulin or the Insulin Analog AspB10 Promotes Mammary Tumor Growth Independent of the IGF-I Receptor

Journal Articles

A Novel Insulin Analog With Unique Properties: Lys^B3,Glu^B29 Insulin Induces Prominent Activation of Insulin Receptor Substrate 2, but Marginal Phosphorylation of Insulin Receptor Substrate 1

Irini Rakatzi, Stefanie Ramrath, Daniela Ledwig, Olaf Dransfeld, Thomas Bartels, Gerhard Seipke, Jürgen Eckel

Diabetes 2003;52(9):2227–2238

https://doi.org/10.2337/diabetes.52.9.2227

Published: 01 September 2003

View article titled, A Novel Insulin Analog With Unique Properties: <subtitle>LysB3,GluB29 Insulin Induces Prominent Activation of Insulin Receptor Substrate 2, but Marginal Phosphorylation of Insulin Receptor Substrate 1</subtitle>

Journal Articles

Mode of Transcapillary Transport of Insulin and Insulin Analog NN304 in Dog Hindlimb: Evidence for Passive Diffusion

Marianthe Hamilton-Wessler, Marilyn Ader, Melvin K. Dea, Donna Moore, Mette Loftager, Jan Markussen, Richard N. Bergman

Diabetes 2002;51(3):574–582

https://doi.org/10.2337/diabetes.51.3.574

Published: 01 March 2002

View article titled, Mode of Transcapillary Transport of Insulin and Insulin Analog NN304 in Dog Hindlimb: <subtitle>Evidence for Passive Diffusion</subtitle>

Meeting Abstracts

Pharmacokinetics and pharmacodynamics of subcutaneous injection of long-acting human insulin analog glargine, NPH insulin, and ultralente human insulin and continuous subcutaneous infusion of insulin lispro.

M Lepore, S Pampanelli, C Fanelli, F Porcellati, L Bartocci, A Di Vincenzo, C Cordoni, E Costa, P Brunetti, G B Bolli

Diabetes 2000;49(12):2142–2148

https://doi.org/10.2337/diabetes.49.12.2142

Published: 01 December 2000

View article titled, Pharmacokinetics and pharmacodynamics of subcutaneous injection of long-acting human insulin analog glargine, NPH insulin, and ultralente human insulin and continuous subcutaneous infusion of insulin lispro.

Meeting Abstracts

Correlations of receptor binding and metabolic and mitogenic potencies of insulin analogs designed for clinical use.

P Kurtzhals, L Schäffer, A Sørensen, C Kristensen, I Jonassen, C Schmid, T Trüb

Diabetes 2000;49(6):999–1005

https://doi.org/10.2337/diabetes.49.6.999

Published: 01 June 2000

View article titled, Correlations of receptor binding and metabolic and mitogenic potencies of insulin analogs designed for clinical use.

NARROW

106-OR: Degludec-Like Insulin Analog Improves Peripheral Neuropathy More than Control Insulin Independent of Glycemic Control in a Rat Model of Type 2 Diabetes

In This Issue of Diabetes

Glucose-Activated Switch Regulating Insulin Analog Secretion Enables Long-term Precise Glucose Control in Mice With Type 1 Diabetes

236-OR: Molecular and Biological Properties of Insulin Icodec, a New Insulin Analog Designed to Give a Long Half-Life Suitable for Once-Weekly Dosing

237-OR: Insulin Icodec: An Insulin Analog Suited for Once-Weekly Dosing in Type 2 Diabetes

1024-P: Technosphere Insulin Added to Basal Insulin Is Associated with Less Weight Gain than Basal Insulin plus Insulin Aspart or Insulin Analog (Aspart) 70/30 Mixture in Type 2 DM

Role of Proinsulin Self-Association in Mutant INS Gene–Induced Diabetes of Youth

1112-P: Ultra Rapid Lispro (URLi) Lowers Postprandial Glucose (PPG) and More Closely Matches Normal Physiological Glucose Response Compared with Other Rapid Insulin Analogs

Intensive Metabolic Control of T1D Pregnant Women in CSII vs. MDI—A Retrospective Analysis

Differential Impacts of Insulin Analogs Lispro and Glulisine on Glucose and Lipid Homeostasis during Hyperinsulinemic Euglycemic Clamp in Streptozotocin-Induced Diabetic Rats

Basal Oral Insulin Analog I338 Enhances Meal-Related Hepatic Glucose Disposal

Superior Glycemic Control With a Glucose-Responsive Insulin Analog: Hepatic and Nonhepatic Impacts

Changes in Glucose and Fat Metabolism in Response to the Administration of a Hepato-Preferential Insulin Analog

In This Issue of Diabetes

LY2605541—A Preferential Hepato-Specific Insulin Analogue

Insulin Receptor Phosphorylation by Endogenous Insulin or the Insulin Analog AspB10 Promotes Mammary Tumor Growth Independent of the IGF-I Receptor

A Novel Insulin Analog With Unique Properties: Lys^B3,Glu^B29 Insulin Induces Prominent Activation of Insulin Receptor Substrate 2, but Marginal Phosphorylation of Insulin Receptor Substrate 1

Mode of Transcapillary Transport of Insulin and Insulin Analog NN304 in Dog Hindlimb: Evidence for Passive Diffusion

Pharmacokinetics and pharmacodynamics of subcutaneous injection of long-acting human insulin analog glargine, NPH insulin, and ultralente human insulin and continuous subcutaneous infusion of insulin lispro.

Correlations of receptor binding and metabolic and mitogenic potencies of insulin analogs designed for clinical use.

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