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Meeting Abstracts

2126-P: Physiological Concentrations of IL-1 Beta Promote Islet Amyloid Deposition by Increasing Beta-Cell Secretion of Human Islet Amyloid Polypeptide

ANDREW T. TEMPLIN, MAHNAZ MELLATI, DANIEL ZEMAN-MEIER, MEGHAN F. HOGAN, NATHALIE ESSER, SAKENEH ZRAIKA, REBECCA L. HULL, STEVEN E. KAHN
Journal: Diabetes
Diabetes 2019;68(Supplement_1):2126-P
https://doi.org/10.2337/db19-2126-P
Published: 01 June 2019
View article titled, 2126-P: Physiological Concentrations of IL-1 Beta Promote Islet Amyloid Deposition by Increasing Beta-Cell Secretion of Human Islet Amyloid Polypeptide
Meeting Abstracts

Alpha-1 Antitrypsin (AAT) Promotes Islets Graft Survival by Modulating Macrophage Activation

WENYU GOU, JINGJING WANG, DO-SUNG KIM, LILI SONG, CHARLIE STRANGE, DAVID ADAMS, KATHERINE MORGAN, HONGJUN WANG
Journal: Diabetes
Diabetes 2018;67(Supplement_1):1741-P
https://doi.org/10.2337/db18-1741-P
Published: 01 July 2018
View article titled, Alpha-1 Antitrypsin (AAT) Promotes Islets Graft Survival by Modulating Macrophage Activation
Journal Articles

How to Make Mice Tell the Truth

Helen E. Thomas, Thomas C. Brodnicki, Thomas W.H. Kay
Journal: Diabetes
Diabetes 2016;65(5):1161–1163
https://doi.org/10.2337/dbi16-0001
Published: 15 April 2016
View article titled, How to Make Mice Tell the Truth
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Journal Articles

A Preclinical Consortium Approach for Assessing the Efficacy of Combined Anti-CD3 Plus IL-1 Blockade in Reversing New-Onset Autoimmune Diabetes in NOD Mice

Ronald G. Gill, Philippe P. Pagni, Tinalyn Kupfer, Clive H. Wasserfall, Songyan Deng, Amanda Posgai, Yulia Manenkova, Amira Bel Hani, Laura Straub, Philip Bernstein, Mark A. Atkinson, Kevan C. Herold, Matthias von Herrath, Teodora Staeva, Mario R. Ehlers, Gerald T. Nepom
Journal: Diabetes
Diabetes 2016;65(5):1310–1316
https://doi.org/10.2337/db15-0492
Published: 31 December 2015
View article titled, A Preclinical Consortium Approach for Assessing the Efficacy of Combined Anti-CD3 Plus IL-1 Blockade in Reversing New-Onset Autoimmune Diabetes in NOD Mice
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Includes: Supplementary data
Journal Articles

Niche-Dependent Regulations of Metabolic Balance in High-Fat Diet–Induced Diabetic Mice by Mesenchymal Stromal Cells

Andrea Tung-Qian Ji, Yun-Chuang Chang, Yun-Ju Fu, Oscar K. Lee, Jennifer H. Ho
Journal: Diabetes
Diabetes 2015;64(3):926–936
https://doi.org/10.2337/db14-1042
Published: 01 October 2014
View article titled, Niche-Dependent Regulations of Metabolic Balance in High-Fat Diet–Induced Diabetic Mice by Mesenchymal Stromal Cells
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Journal Articles

Interleukin-1 Antagonism: A Sturdy Companion for Immune Tolerance Induction in Type 1 Diabetes?

Thomas Mandrup-Poulsen
Journal: Diabetes
Diabetes 2014;63(6):1833–1835
https://doi.org/10.2337/db14-0371
Published: 15 May 2014
View article titled, Interleukin-1 Antagonism: A Sturdy Companion for Immune Tolerance Induction in Type 1 Diabetes?
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Journal Articles

Amyloid and the Macrophage: It’s All About Local Production of IL-1β

Katarzyna A. Broniowska, John A. Corbett
Journal: Diabetes
Diabetes 2014;63(5):1448–1450
https://doi.org/10.2337/db14-0003
Published: 12 April 2014
View article titled, Amyloid and the Macrophage: It’s All About Local Production of IL-1β
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Journal Articles

Resident Macrophages Mediate Islet Amyloid Polypeptide–Induced Islet IL-1β Production and β-Cell Dysfunction

Clara Y. Westwell-Roper, Jan A. Ehses, C. Bruce Verchere
Journal: Diabetes
Diabetes 2014;63(5):1698–1711
https://doi.org/10.2337/db13-0863
Published: 12 April 2014
View article titled, Resident Macrophages Mediate Islet Amyloid Polypeptide–Induced Islet IL-1β Production and β-Cell Dysfunction
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Includes: Supplementary data
Journal Articles

Synergistic Reversal of Type 1 Diabetes in NOD Mice With Anti-CD3 and Interleukin-1 Blockade: Evidence of Improved Immune Regulation

Vitaly Ablamunits, Octavian Henegariu, Jakob Bondo Hansen, Lynn Opare-Addo, Paula Preston-Hurlburt, Pere Santamaria, Thomas Mandrup-Poulsen, Kevan C. Herold
Journal: Diabetes
Diabetes 2012;61(1):145–154
https://doi.org/10.2337/db11-1033
Published: 12 December 2011
View article titled, Synergistic Reversal of Type 1 Diabetes in NOD Mice With Anti-CD3 and Interleukin-1 Blockade: <subtitle>Evidence of Improved Immune Regulation</subtitle>
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Includes: Supplementary data
Journal Articles

Lack of Interleukin-1 Receptor I (IL-1RI) Protects Mice From High-Fat Diet–Induced Adipose Tissue Inflammation Coincident With Improved Glucose Homeostasis

Fiona C. McGillicuddy, Karen A. Harford, Clare M. Reynolds, Elizabeth Oliver, Mandy Claessens, Kingston H.G. Mills, Helen M. Roche
Journal: Diabetes
Diabetes 2011;60(6):1688–1698
https://doi.org/10.2337/db10-1278
Published: 21 May 2011
View article titled, Lack of Interleukin-1 Receptor I (IL-1RI) Protects Mice From High-Fat Diet–Induced Adipose Tissue Inflammation Coincident With Improved Glucose Homeostasis
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Includes: Supplementary data
Journal Articles

Interleukin-1β Produced in Response to Islet Autoantigen Presentation Differentiates T-Helper 17 Cells at the Expense of Regulatory T-Cells: Implications for the Timing of Tolerizing Immunotherapy

Sebastien Bertin-Maghit, Dimeng Pang, Brendan O'Sullivan, Shannon Best, Emily Duggan, Sanjoy Paul, Helen Thomas, Thomas W.H. Kay, Leonard C. Harrison, Raymond Steptoe, Ranjeny Thomas
Journal: Diabetes
Diabetes 2011;60(1):248–257
https://doi.org/10.2337/db10-0104
Published: 27 October 2010
View article titled, Interleukin-1β Produced in Response to Islet Autoantigen Presentation Differentiates T-Helper 17 Cells at the Expense of Regulatory T-Cells: <subtitle>Implications for the Timing of Tolerizing Immunotherapy</subtitle>
Open the PDF for Interleukin-1β Produced in Response to Islet Autoantigen Presentation Differentiates T-Helper 17 Cells at the Expense of Regulatory T-Cells: <subtitle>Implications for the Timing of Tolerizing Immunotherapy</subtitle> in another window
Includes: Supplementary data
Journal Articles

Identification of a Serum-Induced Transcriptional Signature Associated With Type 1 Diabetes in the BioBreeding Rat

Mary Kaldunski, Shuang Jia, Rhonda Geoffrey, Joel Basken, Simon Prosser, Sanjay Kansra, John P. Mordes, Åke Lernmark, Xujing Wang, Martin J. Hessner
Journal: Diabetes
Diabetes 2010;59(10):2375–2385
https://doi.org/10.2337/db10-0372
Published: 03 August 2010
View article titled, Identification of a Serum-Induced Transcriptional Signature Associated With Type 1 Diabetes in the BioBreeding Rat
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Includes: Supplementary data
Journal Articles

The Role of Nitric Oxide and the Unfolded Protein Response in Cytokine-Induced β-Cell Death

Kari T. Chambers, Julie A. Unverferth, Sarah M. Weber, Ronald C. Wek, Fumihiko Urano, John A. Corbett
Journal: Diabetes
Diabetes 2008;57(1):124–132
https://doi.org/10.2337/db07-0944
Published: 01 January 2008
View article titled, The Role of Nitric Oxide and the Unfolded Protein Response in Cytokine-Induced β-Cell Death
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Journal Articles

Cardioprotective and Anti-Inflammatory Effects of Interleukin Converting Enzyme Inhibition in Experimental Diabetic Cardiomyopathy

Dirk Westermann, Sophie Van Linthout, Sameer Dhayat, Nasser Dhayat, Felicitas Escher, Carola Bücker-Gärtner, Frank Spillmann, Michel Noutsias, Alexander Riad, Heinz-Peter Schultheiss, Carsten Tschöpe
Journal: Diabetes
Diabetes 2007;56(7):1834–1841
https://doi.org/10.2337/db06-1662
Published: 01 July 2007
View article titled, Cardioprotective and Anti-Inflammatory Effects of Interleukin Converting Enzyme Inhibition in Experimental Diabetic Cardiomyopathy
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Journal Articles

Low Concentration of Interleukin-1β Induces FLICE-Inhibitory Protein–Mediated β-Cell Proliferation in Human Pancreatic Islets

Kathrin Maedler, Desiree M. Schumann, Nadine Sauter, Helga Ellingsgaard, Domenico Bosco, Reto Baertschiger, Yoichiro Iwakura, José Oberholzer, Claes B. Wollheim, Benoit R. Gauthier, Marc Y. Donath
Journal: Diabetes
Diabetes 2006;55(10):2713–2722
https://doi.org/10.2337/db05-1430
Published: 01 October 2006
View article titled, Low Concentration of Interleukin-1β Induces FLICE-Inhibitory Protein–Mediated β-Cell Proliferation in Human Pancreatic Islets
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Journal Articles

Mature-Onset Obesity in Interleukin-1 Receptor I Knockout Mice

Maria C. García, Ingrid Wernstedt, Anna Berndtsson, Maria Enge, Michal Bell, Olof Hultgren, Michael Horn, Bo Ahrén, Sven Enerback, Claes Ohlsson, Ville Wallenius, John-Olov Jansson
Journal: Diabetes
Diabetes 2006;55(5):1205–1213
https://doi.org/10.2337/db05-1304
Published: 01 May 2006
View article titled, Mature-Onset Obesity in Interleukin-1 Receptor I Knockout Mice
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Journal Articles

Complete Protection Against Interleukin-1β–Induced Functional Suppression and Cytokine-Mediated Cytotoxicity in Rat Pancreatic Islets In Vitro Using an Interleukin-1 Cytokine Trap

Tobias Rydgren, Daniel Bengtsson, Stellan Sandler
Journal: Diabetes
Diabetes 2006;55(5):1407–1412
https://doi.org/10.2337/db05-1273
Published: 01 May 2006
View article titled, Complete Protection Against Interleukin-1β–Induced Functional Suppression and Cytokine-Mediated Cytotoxicity in Rat Pancreatic Islets In Vitro Using an Interleukin-1 Cytokine Trap
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Journal Articles

Combined Interleukin-6 and Interleukin-1 Deficiency Causes Obesity in Young Mice

Dai Chida, Toshimasa Osaka, Okito Hashimoto, Yoichiro Iwakura
Journal: Diabetes
Diabetes 2006;55(4):971–977
https://doi.org/10.2337/diabetes.55.04.06.db05-1250
Published: 01 April 2006
View article titled, Combined Interleukin-6 and Interleukin-1 Deficiency Causes Obesity in Young Mice
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Journal Articles

Is There a Role for Locally Produced Interleukin-1 in the Deleterious Effects of High Glucose or the Type 2 Diabetes Milieu to Human Pancreatic Islets?

Nils Welsh, Miriam Cnop, Ilham Kharroubi, Marco Bugliani, Roberto Lupi, Piero Marchetti, Décio L. Eizirik
Journal: Diabetes
Diabetes 2005;54(11):3238–3244
https://doi.org/10.2337/diabetes.54.11.3238
Published: 01 November 2005
View article titled, Is There a Role for Locally Produced Interleukin-1 in the Deleterious Effects of High Glucose or the Type 2 Diabetes Milieu to Human Pancreatic Islets?
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Journal Articles

IL-1 Receptor Deficiency Slows Progression to Diabetes in the NOD Mouse

Helen E. Thomas, Windy Irawaty, Rima Darwiche, Thomas C. Brodnicki, Pere Santamaria, Janette Allison, Thomas W.H. Kay
Journal: Diabetes
Diabetes 2004;53(1):113–121
https://doi.org/10.2337/diabetes.53.1.113
Published: 01 January 2004
View article titled, IL-1 Receptor Deficiency Slows Progression to Diabetes in the NOD Mouse
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