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Meeting Abstracts

1727-P: Mice Deficient in Myeloid Cell-Derived Interleukin-1a Are Protected from Diet-Induced Obesity and Insulin Resistance

SUJIN SUK, RANDALL H. FRIEDLINE, HYE LIM NOH, XIAODI HU, DUY A. TRAN, LAUREN A. TAUER, ALLISON M. KIM, LAUREN H. KIM, JASON K. KIM

Diabetes 2020;69(Supplement_1):1727-P

DOI: https://doi.org/10.2337/db20-1727-P

Published: 01 June 2020

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Meeting Abstracts

278-OR: Efficacy and Safety of Anti-interleukin (IL)-21 in Combination with Liraglutide in Adults Recently Diagnosed with Type 1 Diabetes

MATTHIAS G. VON HERRATH, STEPHEN C. BAIN, BRUCE W. BODE, JESPER OLE CLAUSEN, KEN COPPIETERS, LEYLYA GAYSINA, JANUSZ GUMPRECHT, TROELS K. HANSEN, CHANTAL MATHIEU, CRISTOBAL MORALES PORTILLO, OFRI MOSENZON, STINE SEGEL, GEORGE M. TSOUKAS, THOMAS PIEBER

Diabetes 2020;69(Supplement_1):278-OR

DOI: https://doi.org/10.2337/db20-278-OR

Published: 01 June 2020

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Meeting Abstracts

1887-P: Intermittent Hypoxia Increased the Expressions of Interleukin (IL)-8, Osteonectin, and Myonectin via OCT1 and Nrf2 Binding to the Promoters in Muscle Cells

SHIN TAKASAWA, RYOGO SHOBATAKE, ASAKO ITAYA-HIRONAKA, MAI MAKINO, SUMIYO SAKURAMOTO-TSUCHIDA, TOMOKO UCHIYAMA, HIROYO OTA, AKIYO YAMAUCHI

Diabetes 2020;69(Supplement_1):1887-P

DOI: https://doi.org/10.2337/db20-1887-P

Published: 01 June 2020

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Meeting Abstracts

1955-P: Interleukin-1ß Orchestrates Non–Glucose Dependent Cephalic Phase Insulin Release in Health and Obesity

SOPHIA J. WIEDEMANN, EREZ DROR, DANIEL T. MEIER, KELLY TRIMIGLIOZZI, JOSE ALBERTO MOLINA-TIJERAS, FRIEDERIKE SCHULZE, LEILA RACHID, STÉPHANIE P. HÄUSELMANN, THERESA V. ROHM, HELENE MEREAU, CHRISTOPHE MAGNAN, MARIANNE BOENI-SCHNETZLER, MARC Y. DONATH

Diabetes 2020;69(Supplement_1):1955-P

DOI: https://doi.org/10.2337/db20-1955-P

Published: 01 June 2020

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Journal Articles

Statement of Retraction. Kathrin Maedler, Desiree M. Schumann, Nadine Sauter, Helga Ellingsgaard, Domenico Bosco, Reto Baertschiger, Yoichiro Iwakura, José Oberholzer, Claes B. Wollheim, Benoit R. Gauthier, and Marc Y. Donath. Low Concentration of Interleukin-1β Induces FLICE-Inhibitory Protein–Mediated β-Cell Proliferation in Human Pancreatic Islets. Diabetes 2006;55: 2713–2722 . DOI: 10.2337/db05-1430. PMID: 17003335

American Diabetes Association

Diabetes 2020;69(3):493

DOI: https://doi.org/10.2337/db20-rt03a

Published: 13 January 2020

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Journal Articles

Update to Expression of Concern. Kathrin Maedler, Desiree M. Schumann, Nadine Sauter, Helga Ellingsgaard, Domenico Bosco, Reto Baertschiger, Yoichiro Iwakura, José Oberholzer, Claes B. Wollheim, Benoit R. Gauthier, and Marc Y. Donath. Low Concentration of Interleukin-1β Induces FLICE-Inhibitory Protein–Mediated β-Cell Proliferation in Human Pancreatic Islets. Diabetes 2006;55: 2713-2722 . DOI: 10.2337/db05-1430 . PMID: 17003335

American Diabetes Association

Diabetes 2018;67(11):2479–2480

DOI: https://doi.org/10.2337/db18-ec2018b

Published: 11 October 2018

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Journal Articles

Expression of Concern. Low Concentration of Interleukin-1β Induces FLICE-Inhibitory Protein–Mediated β-Cell Proliferation in Human Pancreatic Islets. Diabetes 2006;55:2713–2722; DOI: 10.2337/db05-1430

Kathrin Maedler, Desiree M. Schumann, Nadine Sauter, Helga Ellingsgaard, Domenico Bosco, Reto Baertschiger, Yoichiro Iwakura, José Oberholzer, Claes B. Wollheim, Benoit R. Gauthier, Marc Y. Donath

Diabetes 2016;65(8):2462

DOI: https://doi.org/10.2337/db16-ec08a

Published: 12 July 2016

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Journal Articles

Antidiabetic Effect of Interleukin-1β Antibody Therapy Through β-Cell Protection in the Cohen Diabetes-Sensitive Rat

Genya Aharon-Hananel, Anne Jörns, Sigurd Lenzen, Itamar Raz, Sarah Weksler-Zangen

Diabetes 2015;64(5):1780–1785

DOI: https://doi.org/10.2337/db14-1018

Published: 08 December 2014

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Journal Articles

Dysregulated Toll-Like Receptor–Induced Interleukin-1β and Interleukin-6 Responses in Subjects at Risk for the Development of Type 1 Diabetes

Aimon K. Alkanani, Marian Rewers, Fran Dong, Kathleen Waugh, Peter A. Gottlieb, Danny Zipris

Diabetes 2012;61(10):2525–2533

DOI: https://doi.org/10.2337/db12-0099

Published: 13 September 2012

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Includes: Supplementary data

Journal Articles

Prevention of Autoimmune Diabetes by Ectopic Pancreatic β-Cell Expression of Interleukin-35

Maria Bettini, Ashley H. Castellaw, Greig P. Lennon, Amanda R. Burton, Dario A.A. Vignali

Diabetes 2012;61(6):1519–1526

DOI: https://doi.org/10.2337/db11-0784

Published: 14 May 2012

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Includes: Supplementary data

Journal Articles

Interleukin-1β Produced in Response to Islet Autoantigen Presentation Differentiates T-Helper 17 Cells at the Expense of Regulatory T-Cells: Implications for the Timing of Tolerizing Immunotherapy

Sebastien Bertin-Maghit, Dimeng Pang, Brendan O'Sullivan, Shannon Best, Emily Duggan, Sanjoy Paul, Helen Thomas, Thomas W.H. Kay, Leonard C. Harrison, Raymond Steptoe, Ranjeny Thomas

Diabetes 2011;60(1):248–257

DOI: https://doi.org/10.2337/db10-0104

Published: 27 October 2010

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Includes: Supplementary data

Journal Articles

Exendin-4 Protects β-Cells From Interleukin-1β–Induced Apoptosis by Interfering With the c-Jun NH₂-Terminal Kinase Pathway

Mourad Ferdaoussi, Saida Abdelli, Jiang-Yan Yang, Marion Cornu, Guy Niederhauser, Dimitri Favre, Christian Widmann, Romano Regazzi, Bernard Thorens, Gérard Waeber, Amar Abderrahmani

Diabetes 2008;57(5):1205–1215

DOI: https://doi.org/10.2337/db07-1214

Published: 01 May 2008

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Journal Articles

Cardioprotective and Anti-Inflammatory Effects of Interleukin Converting Enzyme Inhibition in Experimental Diabetic Cardiomyopathy

Dirk Westermann, Sophie Van Linthout, Sameer Dhayat, Nasser Dhayat, Felicitas Escher, Carola Bücker-Gärtner, Frank Spillmann, Michel Noutsias, Alexander Riad, Heinz-Peter Schultheiss, Carsten Tschöpe

Diabetes 2007;56(7):1834–1841

DOI: https://doi.org/10.2337/db06-1662

Published: 01 July 2007

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Journal Articles

Inhibition of Caspase-1/Interleukin-1β Signaling Prevents Degeneration of Retinal Capillaries in Diabetes and Galactosemia

Jason A. Vincent, Susanne Mohr

Diabetes 2007;56(1):224–230

DOI: https://doi.org/10.2337/db06-0427

Published: 01 January 2007

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Journal Articles

Low Concentration of Interleukin-1β Induces FLICE-Inhibitory Protein–Mediated β-Cell Proliferation in Human Pancreatic Islets

Kathrin Maedler, Desiree M. Schumann, Nadine Sauter, Helga Ellingsgaard, Domenico Bosco, Reto Baertschiger, Yoichiro Iwakura, José Oberholzer, Claes B. Wollheim, Benoit R. Gauthier, Marc Y. Donath

Diabetes 2006;55(10):2713–2722

DOI: https://doi.org/10.2337/db05-1430

Published: 01 October 2006

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Journal Articles

Complete Protection Against Interleukin-1β–Induced Functional Suppression and Cytokine-Mediated Cytotoxicity in Rat Pancreatic Islets In Vitro Using an Interleukin-1 Cytokine Trap

Tobias Rydgren, Daniel Bengtsson, Stellan Sandler

Diabetes 2006;55(5):1407–1412

DOI: https://doi.org/10.2337/db05-1273

Published: 01 May 2006

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Journal Articles

Transforming Growth Factor-β and Natural Killer T-Cells Are Involved in the Protective Effect of a Bacterial Extract on Type 1 Diabetes

Marie-Alexandra Alyanakian, Françoise Grela, Aude Aumeunier, Carlo Chiavaroli, Christine Gouarin, Emilie Bardel, Gérard Normier, Lucienne Chatenoud, Nathalie Thieblemont, Jean-François Bach

Diabetes 2006;55(1):179–185

DOI: https://doi.org/10.2337/diabetes.55.01.06.db05-0189

Published: 01 January 2006

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Journal Articles

Mechanisms of β-Cell Death in Type 2 Diabetes

Marc Y. Donath, Jan A. Ehses, Kathrin Maedler, Desiree M. Schumann, Helga Ellingsgaard, Elisabeth Eppler, Manfred Reinecke

Diabetes 2005;54(suppl_2):S108–S113

DOI: https://doi.org/10.2337/diabetes.54.suppl_2.S108

Published: 01 December 2005

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Journal Articles

Essential Role for Membrane Lipid Rafts in Interleukin-1β−Induced Nitric Oxide Release From Insulin-Secreting Cells: Potential Regulation by Caveolin-1⁺

Rajakrishnan Veluthakal, Irina Chvyrkova, Marie Tannous, Phillip McDonald, Rajesh Amin, Timothy Hadden, Debbie C. Thurmond, Michael J. Quon, Anjaneyulu Kowluru

Diabetes 2005;54(9):2576–2585

DOI: https://doi.org/10.2337/diabetes.54.9.2576

Published: 01 September 2005

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Journal Articles

The Potential Role of SOCS-3 in the Interleukin-1β-Induced Desensitization of Insulin Signaling in Pancreatic Beta-Cells

Brice Emanuelli, Murielle Glondu, Chantal Filloux, Pascal Peraldi, Emmanuel Van Obberghen

Diabetes 2004;53(suppl_3):S97–S103

DOI: https://doi.org/10.2337/diabetes.53.suppl_3.S97

Published: 01 December 2004

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NARROW

1727-P: Mice Deficient in Myeloid Cell-Derived Interleukin-1a Are Protected from Diet-Induced Obesity and Insulin Resistance

278-OR: Efficacy and Safety of Anti-interleukin (IL)-21 in Combination with Liraglutide in Adults Recently Diagnosed with Type 1 Diabetes

1887-P: Intermittent Hypoxia Increased the Expressions of Interleukin (IL)-8, Osteonectin, and Myonectin via OCT1 and Nrf2 Binding to the Promoters in Muscle Cells

1955-P: Interleukin-1ß Orchestrates Non–Glucose Dependent Cephalic Phase Insulin Release in Health and Obesity

Expression of Concern. Low Concentration of Interleukin-1β Induces FLICE-Inhibitory Protein–Mediated β-Cell Proliferation in Human Pancreatic Islets. Diabetes 2006;55:2713–2722; DOI: 10.2337/db05-1430

Antidiabetic Effect of Interleukin-1β Antibody Therapy Through β-Cell Protection in the Cohen Diabetes-Sensitive Rat

Dysregulated Toll-Like Receptor–Induced Interleukin-1β and Interleukin-6 Responses in Subjects at Risk for the Development of Type 1 Diabetes

Prevention of Autoimmune Diabetes by Ectopic Pancreatic β-Cell Expression of Interleukin-35

Interleukin-1β Produced in Response to Islet Autoantigen Presentation Differentiates T-Helper 17 Cells at the Expense of Regulatory T-Cells: Implications for the Timing of Tolerizing Immunotherapy

Exendin-4 Protects β-Cells From Interleukin-1β–Induced Apoptosis by Interfering With the c-Jun NH₂-Terminal Kinase Pathway

Cardioprotective and Anti-Inflammatory Effects of Interleukin Converting Enzyme Inhibition in Experimental Diabetic Cardiomyopathy

Inhibition of Caspase-1/Interleukin-1β Signaling Prevents Degeneration of Retinal Capillaries in Diabetes and Galactosemia

Low Concentration of Interleukin-1β Induces FLICE-Inhibitory Protein–Mediated β-Cell Proliferation in Human Pancreatic Islets

Complete Protection Against Interleukin-1β–Induced Functional Suppression and Cytokine-Mediated Cytotoxicity in Rat Pancreatic Islets In Vitro Using an Interleukin-1 Cytokine Trap

Transforming Growth Factor-β and Natural Killer T-Cells Are Involved in the Protective Effect of a Bacterial Extract on Type 1 Diabetes

Mechanisms of β-Cell Death in Type 2 Diabetes

Essential Role for Membrane Lipid Rafts in Interleukin-1β−Induced Nitric Oxide Release From Insulin-Secreting Cells: Potential Regulation by Caveolin-1⁺

The Potential Role of SOCS-3 in the Interleukin-1β-Induced Desensitization of Insulin Signaling in Pancreatic Beta-Cells

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