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Meeting Abstracts

835-P: The Hepatoselective Glucokinase Activator (GKA) TTP399 Does Not Increase Risk of Ketoacidosis in Type 1 Diabetes (T1D)

KLARA KLEIN, SCHAFER C. BOEDER, JENNIFER L. FREEMAN, SUPRADEEP MADDURI, ERIN R. GIOVANNETTI, CARMEN VALCARCE, JOHN B. BUSE, JEREMY PETTUS

Diabetes 2022;71(Supplement_1):835-P

DOI: https://doi.org/10.2337/db22-835-P

Published: 01 June 2022

View article titled, 835-P: The Hepatoselective Glucokinase Activator (GKA) TTP399 Does Not Increase Risk of Ketoacidosis in Type 1 Diabetes (T1D)

Meeting Abstracts

532-P: Voluntary Exercise during Food Restriction Promotes a Sustained Increase in Hepatic Oxidative Metabolism

STANISLAW DEJA, BLANKA KUCEJOVA, ADRIANNA MAURER, MONIKA N. MIZERSKA, XIAORONG FU, JOHN P. THYFAULT, SHAWN C. BURGESS

Diabetes 2022;71(Supplement_1):532-P

DOI: https://doi.org/10.2337/db22-532-P

Published: 01 June 2022

View article titled, 532-P: Voluntary Exercise during Food Restriction Promotes a Sustained Increase in Hepatic Oxidative Metabolism

Meeting Abstracts

275-OR: Inhibition of Hepatic ACC Decreases Ketogenesis during Fasting due to Elevated Amino Acid Availability

STANISLAW DEJA, JUSTIN A. FLETCHER, BLANKA KUCEJOVA, MONIKA N. MIZERSKA, XIAORONG FU, CHAI-WAN KIM, JEFFREY BROWNING, JAMEY YOUNG, JAY D. HORTON, SHAWN C. BURGESS

Diabetes 2022;71(Supplement_1):275-OR

DOI: https://doi.org/10.2337/db22-275-OR

Published: 01 June 2022

View article titled, 275-OR: Inhibition of Hepatic ACC Decreases Ketogenesis during Fasting due to Elevated Amino Acid Availability

Meeting Abstracts

368-OR: Activation of Hepatic Gluconeogenesis Is Required to Suppress DNL and Stimulate Ketogenesis during Fasting

STANISLAW DEJA, JOAO DUARTE, JUSTIN A. FLETCHER, BLANKA KUCEJOVA, XIAORONG FU, GONÇALO VALE, JAMEY YOUNG, JEFFREY BROWNING, SHAWN C. BURGESS

Diabetes 2020;69(Supplement_1):368-OR

DOI: https://doi.org/10.2337/db20-368-OR

Published: 01 June 2020

View article titled, 368-OR: Activation of Hepatic Gluconeogenesis Is Required to Suppress DNL and Stimulate Ketogenesis during Fasting

Meeting Abstracts

128-LB: Effects of Glucagon Receptor Antagonism (GRA) on Ketone Body Formation during Insulinopenia in Type 1 Diabetes (T1D)

SCHAFER C. BOEDER, DANIEL G. INES, LESLIE CARTER, ERIN R. GIOVANNETTI, DEBRA ARMSTRONG, PAIVI BURKE, JEREMY PETTUS

Diabetes 2020;69(Supplement_1):128-LB

DOI: https://doi.org/10.2337/db20-128-LB

Published: 01 June 2020

View article titled, 128-LB: Effects of Glucagon Receptor Antagonism (GRA) on Ketone Body Formation during Insulinopenia in Type 1 Diabetes (T1D)

Journal Articles

The Limited Role of Glucagon for Ketogenesis During Fasting or in Response to SGLT2 Inhibition

Megan E. Capozzi, Reilly W. Coch, Jepchumba Koech, Inna I. Astapova, Jacob B. Wait, Sara E. Encisco, Jonathan D. Douros, Kimberly El, Brian Finan, Kyle W. Sloop, Mark A. Herman, David A. D’Alessio, Jonathan E. Campbell

Diabetes 2020;69(5):882–892

DOI: https://doi.org/10.2337/db19-1216

Published: 31 January 2020

View article titled, The Limited Role of Glucagon for Ketogenesis During Fasting or in Response to SGLT2 Inhibition

Includes: Supplementary data

Meeting Abstracts

Suppression of Ketogenesis in Type 1 Diabetes Is Not Delayed by SGLT2 Inhibitor Therapy

STEPHAN SIEBEL, NEHA S. PATEL, ALFONSO GALDERISI, LORI R. CARRIA, WILLIAM V. TAMBORLANE, JENNIFER SHERR

Diabetes 2018;67(Supplement_1):117-LB

DOI: https://doi.org/10.2337/db18-117-LB

Published: 01 July 2018

View article titled, Suppression of Ketogenesis in Type 1 Diabetes Is Not Delayed by SGLT2 Inhibitor Therapy

Meeting Abstracts

Meal Intake Is Suppressive of Ketogenesis in Patients with Type 1 Diabetes

HUSAM GHANIM, KELLY GREEN, JEANNE M. HEJNA, NITESH D. KUHADIYA, MANAV BATRA, AJAY CHAUDHURI, PARESH DANDONA

Diabetes 2018;67(Supplement_1):1888-P

DOI: https://doi.org/10.2337/db18-1888-P

Published: 01 July 2018

View article titled, Meal Intake Is Suppressive of Ketogenesis in Patients with Type 1 Diabetes

Journal Articles

Inhibition of Pyruvate Dehydrogenase Kinase 2 Protects Against Hepatic Steatosis Through Modulation of Tricarboxylic Acid Cycle Anaplerosis and Ketogenesis

Younghoon Go, Ji Yun Jeong, Nam Ho Jeoung, Jae-Han Jeon, Bo-Yoon Park, Hyeon-Ji Kang, Chae-Myeong Ha, Young-Keun Choi, Sun Joo Lee, Hye Jin Ham, Byung-Gyu Kim, Keun-Gyu Park, So Young Park, Chul-Ho Lee, Cheol Soo Choi, Tae-Sik Park, W.N. Paul Lee, Robert A. Harris, In-Kyu Lee

Diabetes 2016;65(10):2876–2887

DOI: https://doi.org/10.2337/db16-0223

Published: 06 July 2016

View article titled, Inhibition of Pyruvate Dehydrogenase Kinase 2 Protects Against Hepatic Steatosis Through Modulation of Tricarboxylic Acid Cycle Anaplerosis and Ketogenesis

Includes: Supplementary data

Journal Articles

Cdc2-Like Kinase 2 Suppresses Hepatic Fatty Acid Oxidation and Ketogenesis Through Disruption of the PGC-1α and MED1 Complex

Mitsuhisa Tabata, Joseph T. Rodgers, Jessica A. Hall, Yoonjin Lee, Mark P. Jedrychowski, Steven P. Gygi, Pere Puigserver

Diabetes 2014;63(5):1519–1532

DOI: https://doi.org/10.2337/db13-1304

Published: 12 April 2014

View article titled, Cdc2-Like Kinase 2 Suppresses Hepatic Fatty Acid Oxidation and Ketogenesis Through Disruption of the PGC-1α and MED1 Complex

Includes: Supplementary data

Journal Articles

Partial Resistance to Peroxisome Proliferator–Activated Receptor-α Agonists in ZDF Rats Is Associated With Defective Hepatic Mitochondrial Metabolism

Santhosh Satapati, TianTeng He, Takeshi Inagaki, Matthew Potthoff, Matthew E. Merritt, Victoria Esser, David J. Mangelsdorf, Steven A. Kliewer, Jeffrey D. Browning, Shawn C. Burgess

Diabetes 2008;57(8):2012–2021

DOI: https://doi.org/10.2337/db08-0226

Published: 01 August 2008

View article titled, Partial Resistance to Peroxisome Proliferator–Activated Receptor-α Agonists in ZDF Rats Is Associated With Defective Hepatic Mitochondrial Metabolism

Includes: Supplementary data

Journal Articles

John Denis McGarry, PhD

Daniel W. Foster, MD

Diabetes 2002;51(5):1651

DOI: https://doi.org/10.2337/diabetes.51.5.1651

Published: 01 May 2002

View article titled, John Denis McGarry, PhD

Journal Articles

Responses of Leptin to Short-Term Fasting and Refeeding in Humans: A Link With Ketogenesis but Not Ketones Themselves

Jerzy W Kolaczynski, Robert V Considine, Joanna Ohannesian, Cheryl Marco, Irina Opentanova, Mark R Nyce, Michael Myint, Jasé F Caro

Diabetes 1996;45(11):1511–1515

DOI: https://doi.org/10.2337/diab.45.11.1511

Published: 01 November 1996

View article titled, Responses of Leptin to Short-Term Fasting and Refeeding in Humans: A Link With Ketogenesis but Not Ketones Themselves

Journal Articles

Exercise-Induced Rise in Glucagon and Ketogenesis During Prolonged Muscular Work

David H Wasserman, Jennifer A Spalding, Deanna Bracy, D Brooks Lacy, Alan D Cherrington

Diabetes 1989;38(6):799–807

DOI: https://doi.org/10.2337/diab.38.6.799

Published: 01 June 1989

View article titled, Exercise-Induced Rise in Glucagon and Ketogenesis During Prolonged Muscular Work

Journal Articles

Regulation of Ketogenesis, Gluconeogenesis, and Glycogen Synthesis by Insulin and Proinsulin in Rat Hepatocyte Monolayer Cultures

L Agius, M H Chowdhury, S N Davis, K G M M Alberti

Diabetes 1986;35(11):1286–1293

DOI: https://doi.org/10.2337/diab.35.11.1286

Published: 01 November 1986

View article titled, Regulation of Ketogenesis, Gluconeogenesis, and Glycogen Synthesis by Insulin and Proinsulin in Rat Hepatocyte Monolayer Cultures

Journal Articles

Effect of Norepinephrine on Ketogenesis, Fatty Acid Oxidation, and Esterification in Isolated Rat Hepatocytes

Rolf D Oberhaensli, Rita Schwendimann, Ulrich Keller

Diabetes 1985;34(8):774–779

DOI: https://doi.org/10.2337/diab.34.8.774

Published: 01 August 1985

View article titled, Effect of Norepinephrine on Ketogenesis, Fatty Acid Oxidation, and Esterification in Isolated Rat Hepatocytes

Journal Articles

Regulation of Ketogenesis by Epinephrine and Norepinephrine in the Overnight-fasted, Conscious Dog

Kurt E Steiner, Howard Fuchs, Phillip E Williams, Ralph W Stevenson, Alan D Cherrington, K G M M Alberti

Diabetes 1985;34(5):425–432

DOI: https://doi.org/10.2337/diab.34.5.425

Published: 01 May 1985

View article titled, Regulation of Ketogenesis by Epinephrine and Norepinephrine in the Overnight-fasted, Conscious Dog

Journal Articles

Lilly Lecture 1978: New Perspectives in the Regulation of Ketogenesis

J Denis Mcgarry

Diabetes 1979;28(5):517–523

DOI: https://doi.org/10.2337/diab.28.5.517

Published: 01 May 1979

View article titled, Lilly Lecture 1978: New Perspectives in the Regulation of Ketogenesis

Journal Articles

The Roles of Insulin, Glucagon, and Free Fatty Acids in the Regulation of Ketogenesis in Dogs

Ulrich Keller, MD, Jean-Louis Chiasson, MD, John E Liljenquist, MD, Alan D Cherrington, PhD, Anthony S Jennings, MD, Oscar B Crofford, MD

Diabetes 1977;26(11):1040–1051

DOI: https://doi.org/10.2337/diab.26.11.1040

Published: 01 November 1977

View article titled, The Roles of Insulin, Glucagon, and Free Fatty Acids in the Regulation of Ketogenesis in Dogs

Journal Articles

Physiologic Mechanisms in the Development of Starvation Ketosis in Man

Neil J Grey, M.D., Irene Karl, Ph.D., David M Kipnis, M.D.

Diabetes 1975;24(1):10–16

DOI: https://doi.org/10.2337/diab.24.1.10

Published: 01 January 1975

View article titled, Physiologic Mechanisms in the Development of Starvation Ketosis in Man

NARROW

835-P: The Hepatoselective Glucokinase Activator (GKA) TTP399 Does Not Increase Risk of Ketoacidosis in Type 1 Diabetes (T1D)

532-P: Voluntary Exercise during Food Restriction Promotes a Sustained Increase in Hepatic Oxidative Metabolism

275-OR: Inhibition of Hepatic ACC Decreases Ketogenesis during Fasting due to Elevated Amino Acid Availability

368-OR: Activation of Hepatic Gluconeogenesis Is Required to Suppress DNL and Stimulate Ketogenesis during Fasting

128-LB: Effects of Glucagon Receptor Antagonism (GRA) on Ketone Body Formation during Insulinopenia in Type 1 Diabetes (T1D)

The Limited Role of Glucagon for Ketogenesis During Fasting or in Response to SGLT2 Inhibition

Suppression of Ketogenesis in Type 1 Diabetes Is Not Delayed by SGLT2 Inhibitor Therapy

Meal Intake Is Suppressive of Ketogenesis in Patients with Type 1 Diabetes

Inhibition of Pyruvate Dehydrogenase Kinase 2 Protects Against Hepatic Steatosis Through Modulation of Tricarboxylic Acid Cycle Anaplerosis and Ketogenesis

Cdc2-Like Kinase 2 Suppresses Hepatic Fatty Acid Oxidation and Ketogenesis Through Disruption of the PGC-1α and MED1 Complex

Partial Resistance to Peroxisome Proliferator–Activated Receptor-α Agonists in ZDF Rats Is Associated With Defective Hepatic Mitochondrial Metabolism

John Denis McGarry, PhD

Responses of Leptin to Short-Term Fasting and Refeeding in Humans: A Link With Ketogenesis but Not Ketones Themselves

Exercise-Induced Rise in Glucagon and Ketogenesis During Prolonged Muscular Work

Regulation of Ketogenesis, Gluconeogenesis, and Glycogen Synthesis by Insulin and Proinsulin in Rat Hepatocyte Monolayer Cultures

Effect of Norepinephrine on Ketogenesis, Fatty Acid Oxidation, and Esterification in Isolated Rat Hepatocytes

Regulation of Ketogenesis by Epinephrine and Norepinephrine in the Overnight-fasted, Conscious Dog

Lilly Lecture 1978: New Perspectives in the Regulation of Ketogenesis

The Roles of Insulin, Glucagon, and Free Fatty Acids in the Regulation of Ketogenesis in Dogs

Physiologic Mechanisms in the Development of Starvation Ketosis in Man

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