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Meeting Abstracts

271-OR: Capillary Blood Ketone Level and Future Ketoacidosis Risk in Type 1 Diabetes Using Sodium–Glucose Linked Transporter Inhibitors

PRIYA BAPAT, SHARON DHALIWAL, CIMON SONG, DALTON R. BUDHRAM, ABDULMOHSEN M.K. BAKHSH, DANIEL SCARR, ALANNA WEISMAN, MICHAEL FRALICK, NOAH IVERS, DAVID CHERNEY, DOUG MUMFORD, GEORGE TOMLINSON, LEIF ERIK LOVBLOM, BRUCE A. PERKINS

Diabetes 2023;72(Supplement_1):271-OR

https://doi.org/10.2337/db23-271-OR

Published: 20 June 2023

View article titled, 271-OR: Capillary Blood Ketone Level and Future Ketoacidosis Risk in Type 1 Diabetes Using Sodium–Glucose Linked Transporter Inhibitors

Meeting Abstracts

286-LB: A Trailblazing Approach to Target Mitochondrial Dysfunction in Diabetic Beta Cells

STANISLOVAS JANKAUSKAS, URNA KANSAKAR, CRYSTAL NIEVES GARCIA, JESSICA GAMBARDELLA, PASQUALE MONE, YARON TOMER, GAETANO SANTULLI, ANGELA LOMBARDI

Diabetes 2023;72(Supplement_1):286-LB

https://doi.org/10.2337/db23-286-LB

Published: 20 June 2023

View article titled, 286-LB: A Trailblazing Approach to Target Mitochondrial Dysfunction in Diabetic Beta Cells

Meeting Abstracts

530-P: Capillary Blood Ketone Level and the Prediction of Future Diabetic Ketoacidosis Risk in Type 1 Diabetes

CIMON SONG, SHARON DHALIWAL, PRIYA BAPAT, ABDULMOHSEN M.K. BAKHSH, DALTON R. BUDHRAM, DANIEL SCARR, ALANNA WEISMAN, MICHAEL FRALICK, NOAH IVERS, DAVID CHERNEY, DOUG MUMFORD, GEORGE TOMLINSON, LEIF ERIK LOVBLOM, BRUCE A. PERKINS

Diabetes 2023;72(Supplement_1):530-P

https://doi.org/10.2337/db23-530-P

Published: 20 June 2023

View article titled, 530-P: Capillary Blood Ketone Level and the Prediction of Future Diabetic Ketoacidosis Risk in Type 1 Diabetes

Meeting Abstracts

99-LB: Myocardial Blood Flow in Association with Baseline Ejection Fraction after Elevation in Plasma Ketones in Patients with T2DM and Heart Failure

CAROLINA SOLIS-HERRERA, YUEJUAN QIN, HENRI HONKA, FRANCISCA M. ACOSTA, ALEXANDER MOODY, ALBERTO CHAVEZ, CURTIS L. TRIPLITT, GEOFFREY D. CLARKE, EUGENIO CERSOSIMO, RALPH A. DEFRONZO

Diabetes 2023;72(Supplement_1):99-LB

https://doi.org/10.2337/db23-99-LB

Published: 20 June 2023

View article titled, 99-LB: Myocardial Blood Flow in Association with Baseline Ejection Fraction after Elevation in Plasma Ketones in Patients with T2DM and Heart Failure

Meeting Abstracts

54-LB: Distinct Mechanisms Are Responsible for the Increase in Endogenous Glucose Production and Ketone Formation following Empagliflozin in T2DM Patients

SIHAM ABDELGANI, JOHN M. ADAMS, III, GIUSEPPE DANIELE, FAHD ALMULLA, RALPH A. DEFRONZO, MUHAMMAD ABDUL-GHANI, MOHAMED ABU-FARHA, STEFANO DEL PRATO

Diabetes 2022;71(Supplement_1):54-LB

https://doi.org/10.2337/db22-54-LB

Published: 01 June 2022

View article titled, 54-LB: Distinct Mechanisms Are Responsible for the Increase in Endogenous Glucose Production and Ketone Formation following Empagliflozin in T2DM Patients

Meeting Abstracts

153-OR: Ventromedial Hypothalamic Nucleus Controls Glucose Metabolism through Adipose Tissue Lipolysis

ALISON AFFINATI, JONATHAN FLAK, NANDAN KODUR, ABDULLAH HASHSHAM, ABIGAIL J. TOMLINSON, NADEJDA BOZADJIEVA KRAMER, CHIEN LI, MARTIN G. MYERS, JR.

Diabetes 2022;71(Supplement_1):153-OR

https://doi.org/10.2337/db22-153-OR

Published: 01 June 2022

View article titled, 153-OR: Ventromedial Hypothalamic Nucleus Controls Glucose Metabolism through Adipose Tissue Lipolysis

Meeting Abstracts

123-LB: Extended Fasting Reveals Effect of Canagliflozin to Mobilize Ketones in Canines

MARILYN ADER, RASHIN SEDIGHI, MORVARID KABIR, RICHARD N. BERGMAN

Diabetes 2022;71(Supplement_1):123-LB

https://doi.org/10.2337/db22-123-LB

Published: 01 June 2022

View article titled, 123-LB: Extended Fasting Reveals Effect of Canagliflozin to Mobilize Ketones in Canines

Meeting Abstracts

323-OR: SGLT2 Inhibition Promotes Myocardial Ketone Utilization in the Normal and Failing Heart

LEIGH GOEDEKE, JI EUN LEE, YINA MA, XIAOYUE HU, JIASHENG ZHANG, JIANYING DONG, KATRINE D. GALSGAARD, NICOLE GUERRERA, SOFIE HAEDERSDAL, XIAN-MAN ZHANG, RACHEL J. PERRY, GARY CLINE, LAWRENCE H. YOUNG, GERALD I. SHULMAN

Diabetes 2021;70(Supplement_1):323-OR

https://doi.org/10.2337/db21-323-OR

Published: 01 June 2021

View article titled, 323-OR: SGLT2 Inhibition Promotes Myocardial Ketone Utilization in the Normal and Failing Heart

Meeting Abstracts

676-P: Ideal Ketone Test Training among Type 1 Patients in Context of Risk Associated with SGLT2 Inhibitors

JONATHAN B. ROST, SARA SUHL, KEATON C. STONER, CATERINA FLORISSI, REBECCA GOWEN, RICHARD WOOD

Diabetes 2020;69(Supplement_1):676-P

https://doi.org/10.2337/db20-676-P

Published: 01 June 2020

View article titled, 676-P: Ideal Ketone Test Training among Type 1 Patients in Context of Risk Associated with SGLT2 Inhibitors

Meeting Abstracts

128-LB: Effects of Glucagon Receptor Antagonism (GRA) on Ketone Body Formation during Insulinopenia in Type 1 Diabetes (T1D)

SCHAFER C. BOEDER, DANIEL G. INES, LESLIE CARTER, ERIN R. GIOVANNETTI, DEBRA ARMSTRONG, PAIVI BURKE, JEREMY PETTUS

Diabetes 2020;69(Supplement_1):128-LB

https://doi.org/10.2337/db20-128-LB

Published: 01 June 2020

View article titled, 128-LB: Effects of Glucagon Receptor Antagonism (GRA) on Ketone Body Formation during Insulinopenia in Type 1 Diabetes (T1D)

Meeting Abstracts

651-P: Validation of a Clinically Relevant Knowledge Assessment in Pediatric Type 1 Diabetes

ALBANESE-O'NEILL ANASTASIA, JANN W. MACINNES, NICOLE T. THOMAS, MICHAEL J. HALLER, DESMOND SCHATZ, JANET SILVERSTEIN, JANEY ADAMS, REBECCA OYETORO, BRITTANY A. KERSHAW, KIRA ANDERSON, ANGELINA BERNIER

Diabetes 2019;68(Supplement_1):651-P

https://doi.org/10.2337/db19-651-P

Published: 01 June 2019

View article titled, 651-P: Validation of a Clinically Relevant Knowledge Assessment in Pediatric Type 1 Diabetes

Meeting Abstracts

1010-P: Effects of MEDI0382, an Oxyntomodulin-Like Peptide with Targeted GLP-1/Glucagon Receptor Activity, on Amino Acids, Ketones, and Free Fatty Acids

VICTORIA E. PARKER, DARREN ROBERTSON, TAO WANG, DAVID C. HORNIGOLD, MAXIMILIAN G. POSCH, LEONA PLUM-MOERSCHEL, JURIS J. MEIER, HEIKE SCHLICHTHAAR, BEATE M. KLAUS, LUTZ JERMUTUS, PHILIP AMBERY, BOAZ HIRSHBERG

Diabetes 2019;68(Supplement_1):1010-P

https://doi.org/10.2337/db19-1010-P

Published: 01 June 2019

View article titled, 1010-P: Effects of MEDI0382, an Oxyntomodulin-Like Peptide with Targeted GLP-1/Glucagon Receptor Activity, on Amino Acids, Ketones, and Free Fatty Acids

Meeting Abstracts

1204-P: The Effects of Insulin Treatment on Circulating Ketone Levels in Patients with Type 2 Diabetes on Sodium-Glucose Cotransporter 2 Inhibitors

CHI HO LEE, JOANNE K. LAM, ALAN C. LEE, DAVID T.W. LUI, HO YI CAROL FONG, YU CHO WOO, KAREN S. LAM, KATHRYN C. TAN

Diabetes 2019;68(Supplement_1):1204-P

https://doi.org/10.2337/db19-1204-P

Published: 01 June 2019

View article titled, 1204-P: The Effects of Insulin Treatment on Circulating Ketone Levels in Patients with Type 2 Diabetes on Sodium-Glucose Cotransporter 2 Inhibitors

Meeting Abstracts

1219-P: Enhanced Response in Serum Ketone Level in Men Compared with Women by Administration of SGLT2 Inhibitor

AKIHIRO YOSHIDA, YASUHIRO MATSUBAYASHI, TOSHIAKI NOJIMA, HIDEKI SUGANAMI, KOHEI KAKU, HIROHITO SONE

Diabetes 2019;68(Supplement_1):1219-P

https://doi.org/10.2337/db19-1219-P

Published: 01 June 2019

View article titled, 1219-P: Enhanced Response in Serum Ketone Level in Men Compared with Women by Administration of SGLT2 Inhibitor

Meeting Abstracts

SGLT2 Inhibitors Suppress NLRP3 Inflammasome Activity via Changes in Ketones and Insulin in Type 2 Diabetes and Cardiovascular Diseases

YONG-HO LEE, SO RA KIM, JAEHYUN BAE, BYUNG-WAN LEE, EUN SEOK KANG, CHUL WOO AHN, BONG-SOO CHA

Diabetes 2018;67(Supplement_1):164-OR

https://doi.org/10.2337/db18-164-OR

Published: 01 July 2018

View article titled, SGLT2 Inhibitors Suppress NLRP3 Inflammasome Activity via Changes in Ketones and Insulin in Type 2 Diabetes and Cardiovascular Diseases

Meeting Abstracts

Regulation of Systemic Energy Metabolism by a Human-Specific Long Noncoding RNA In Vivo

XIANGBO RUAN, PING LI, HAIMING CAO

Diabetes 2018;67(Supplement_1):256-LB

https://doi.org/10.2337/db18-256-LB

Published: 01 July 2018

View article titled, Regulation of Systemic Energy Metabolism by a Human-Specific Long Noncoding RNA In Vivo

Meeting Abstracts

Effects of NAFLD on Acetyl-CoA Partitioning and Ketone Kinetics in Response to a 24-Hour Fast

JUSTIN A. FLETCHER, STANISLAW DEJA, SHAWN C. BURGESS, JEFFREY BROWNING

Diabetes 2018;67(Supplement_1):47-OR

https://doi.org/10.2337/db18-47-OR

Published: 01 July 2018

View article titled, Effects of NAFLD on Acetyl-CoA Partitioning and Ketone Kinetics in Response to a 24-Hour Fast

Meeting Abstracts

Ketones to Success—Does NICH Involvement Influence DKA Discharge Presentation?

DAVID V. WAGNER, ROSE CHUONG, NATALIE C. KOSKELA, HANNAH LUZOD, ERYNN BEESON, INES GUTTMANN-BAUMAN, MICHAEL A. HARRIS

Diabetes 2018;67(Supplement_1):805-P

https://doi.org/10.2337/db18-805-P

Published: 01 July 2018

View article titled, Ketones to Success—Does NICH Involvement Influence DKA Discharge Presentation?

Journal Articles

Regulation of Hypothalamic Neuronal Sensing and Food Intake by Ketone Bodies and Fatty Acids

Christelle Le Foll, Ambrose A. Dunn-Meynell, Henri M. Miziorko, Barry E. Levin

Diabetes 2014;63(4):1259–1269

https://doi.org/10.2337/db13-1090

Published: 13 March 2014

View article titled, Regulation of Hypothalamic Neuronal Sensing and Food Intake by Ketone Bodies and Fatty Acids

Includes: Supplementary data

Journal Articles

Pathogenesis of A⁻β⁺ Ketosis-Prone Diabetes

Sanjeet G. Patel, Jean W. Hsu, Farook Jahoor, Ivonne Coraza, James R. Bain, Robert D. Stevens, Dinakar Iyer, Ramaswami Nalini, Kerem Ozer, Christiane S. Hampe, Christopher B. Newgard, Ashok Balasubramanyam

Diabetes 2013;62(3):912–922

https://doi.org/10.2337/db12-0624

Published: 14 February 2013

View article titled, Pathogenesis of A<sup>−</sup>β<sup>+</sup> Ketosis-Prone Diabetes

NARROW

271-OR: Capillary Blood Ketone Level and Future Ketoacidosis Risk in Type 1 Diabetes Using Sodium–Glucose Linked Transporter Inhibitors

286-LB: A Trailblazing Approach to Target Mitochondrial Dysfunction in Diabetic Beta Cells

530-P: Capillary Blood Ketone Level and the Prediction of Future Diabetic Ketoacidosis Risk in Type 1 Diabetes

99-LB: Myocardial Blood Flow in Association with Baseline Ejection Fraction after Elevation in Plasma Ketones in Patients with T2DM and Heart Failure

54-LB: Distinct Mechanisms Are Responsible for the Increase in Endogenous Glucose Production and Ketone Formation following Empagliflozin in T2DM Patients

153-OR: Ventromedial Hypothalamic Nucleus Controls Glucose Metabolism through Adipose Tissue Lipolysis

123-LB: Extended Fasting Reveals Effect of Canagliflozin to Mobilize Ketones in Canines

323-OR: SGLT2 Inhibition Promotes Myocardial Ketone Utilization in the Normal and Failing Heart

676-P: Ideal Ketone Test Training among Type 1 Patients in Context of Risk Associated with SGLT2 Inhibitors

128-LB: Effects of Glucagon Receptor Antagonism (GRA) on Ketone Body Formation during Insulinopenia in Type 1 Diabetes (T1D)

651-P: Validation of a Clinically Relevant Knowledge Assessment in Pediatric Type 1 Diabetes

1010-P: Effects of MEDI0382, an Oxyntomodulin-Like Peptide with Targeted GLP-1/Glucagon Receptor Activity, on Amino Acids, Ketones, and Free Fatty Acids

1204-P: The Effects of Insulin Treatment on Circulating Ketone Levels in Patients with Type 2 Diabetes on Sodium-Glucose Cotransporter 2 Inhibitors

1219-P: Enhanced Response in Serum Ketone Level in Men Compared with Women by Administration of SGLT2 Inhibitor

SGLT2 Inhibitors Suppress NLRP3 Inflammasome Activity via Changes in Ketones and Insulin in Type 2 Diabetes and Cardiovascular Diseases

Regulation of Systemic Energy Metabolism by a Human-Specific Long Noncoding RNA In Vivo

Effects of NAFLD on Acetyl-CoA Partitioning and Ketone Kinetics in Response to a 24-Hour Fast

Ketones to Success—Does NICH Involvement Influence DKA Discharge Presentation?

Regulation of Hypothalamic Neuronal Sensing and Food Intake by Ketone Bodies and Fatty Acids

Pathogenesis of A⁻β⁺ Ketosis-Prone Diabetes

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