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Journal Articles

Astrocyte glycogen is a major source of hypothalamic lactate in rats with recurrent hypoglycemia.

Gong Su, Rawad Farhat, Anil K. Laxman, Kimberly Chapman-Natewa, Irvane E. Nelson, Owen Chan

Diabetes db220902

DOI: https://doi.org/10.2337/db22-0902

Published: 22 May 2023

View article titled, Astrocyte glycogen is a major source of hypothalamic lactate in rats with recurrent hypoglycemia.

Journal Articles

AIFM2 Is Required for High-Intensity Aerobic Exercise in Promoting Glucose Utilization

Hai P. Nguyen, Sneha Damal Villivalam, Byung Chul Jung, Dongjoo You, Frances Lin, Danielle Yi, Anna Pi, Katherine Ma, Sunhee Jung, Sang-Hee Park, Cholsoon Jang, Hei Sook Sul, Sona Kang

Diabetes 2022;71(10):2084–2093

DOI: https://doi.org/10.2337/db21-1114

Published: 30 June 2022

View article titled, AIFM2 Is Required for High-Intensity Aerobic Exercise in Promoting Glucose Utilization

Meeting Abstracts

1342-P: Reduction of Glucokinase and Glucokinase Regulatory Protein Expression by siRNA Is Associated with the Reduction of Lactate and Pyruvate Export from Canine Hepatocytes

MORVARID KABIR, MARILYN ADER, RICHARD N. BERGMAN

Diabetes 2022;71(Supplement_1):1342-P

DOI: https://doi.org/10.2337/db22-1342-P

Published: 01 June 2022

View article titled, 1342-P: Reduction of Glucokinase and Glucokinase Regulatory Protein Expression by siRNA Is Associated with the Reduction of Lactate and Pyruvate Export from Canine Hepatocytes

Meeting Abstracts

242-OR: Bilateral Dorsolateral Prefrontal Cortex High-Definition Transcranial Direct-Current Stimulation (HD-tDCS) Improves Time-Trial Performance in Elite Cyclists with Type 1 Diabetes (T1D)

ROBERTO CODELLA, LUCA FILIPAS, GABRIELE GALLO, LIVIO LUZI

Diabetes 2022;71(Supplement_1):242-OR

DOI: https://doi.org/10.2337/db22-242-OR

Published: 01 June 2022

View article titled, 242-OR: Bilateral Dorsolateral Prefrontal Cortex High-Definition Transcranial Direct-Current Stimulation (HD-tDCS) Improves Time-Trial Performance in Elite Cyclists with Type 1 Diabetes (T1D)

Meeting Abstracts

227-LB: Elevated Plasma Lactate and the Risk for Metabolic Syndrome—Is Skeletal Muscle a Producer or Consumer?

NICHOLAS T. BROSKEY, TERRY E. JONES, CHUCK J. TANNER, DONGHAI ZHENG, FILIP JEVTOVIC, POLINA KRASSOVSKAIA, LAURA E. MATARESE, RONALD N. CORTRIGHT, ROBERT HICKNER, ERIC J. DEMARIA, WALTER J. PORIES, JOSEPH A. HOUMARD, LYNIS DOHM

Diabetes 2022;71(Supplement_1):227-LB

DOI: https://doi.org/10.2337/db22-227-LB

Published: 01 June 2022

View article titled, 227-LB: Elevated Plasma Lactate and the Risk for Metabolic Syndrome—Is Skeletal Muscle a Producer or Consumer?

Journal Articles

Lactate Is a Key Mediator That Links Obesity to Insulin Resistance via Modulating Cytokine Production From Adipose Tissue

Yijun Lin, Meijuan Bai, Shuo Wang, Lingling Chen, Zixuan Li, Chenchen Li, Peijuan Cao, Yan Chen

Diabetes 2022;71(4):637–652

DOI: https://doi.org/10.2337/db21-0535

Published: 19 January 2022

View article titled, Lactate Is a Key Mediator That Links Obesity to Insulin Resistance via Modulating Cytokine Production From Adipose Tissue

Meeting Abstracts

20-OR: A New Model to Assess Lactate Synthetic Rate during an Oral Glucose Tolerance Test

JACOPO BONET, BRITTANY GALUPPO, NICOLA SANTORO, CHIARA DALLA MAN

Diabetes 2021;70(Supplement_1):20-OR

DOI: https://doi.org/10.2337/db21-20-OR

Published: 01 June 2021

View article titled, 20-OR: A New Model to Assess Lactate Synthetic Rate during an Oral Glucose Tolerance Test

Meeting Abstracts

3-LB: Glutamate Metabolism Is Coupled to Lactate Production from Astrocytes under Low-Glucose Conditions

DANIEL A. APPADURAI, OWEN CHAN

Diabetes 2021;70(Supplement_1):3-LB

DOI: https://doi.org/10.2337/db21-3-LB

Published: 01 June 2021

View article titled, 3-LB: Glutamate Metabolism Is Coupled to Lactate Production from Astrocytes under Low-Glucose Conditions

Meeting Abstracts

229-LB: Plasma Lactate and Muscle Aerobic Substrate Oxidation: Does Elevated Lactate Precede Obesity?

NICHOLAS T. BROSKEY, TERRY E. JONES, ZHEN YANG, NKAUJYI KHANG, DONGHAI ZHENG, CHUCK J. TANNER, RONALD N. CORTRIGHT, JOSEPH A. HOUMARD, LYNIS DOHM

Diabetes 2020;69(Supplement_1):229-LB

DOI: https://doi.org/10.2337/db20-229-LB

Published: 01 June 2020

View article titled, 229-LB: Plasma Lactate and Muscle Aerobic Substrate Oxidation: Does Elevated Lactate Precede Obesity?

Meeting Abstracts

139-LB: The Redox Balance Predicts Both Cardiovascular (CV) and Renal Outcomes in CANVAS

ELE FERRANNINI, SIMONA BALDI, TIZIANA SCOZZARO, FISSEHA TESFAYE, WAYNE SHAW, NORM ROSENTHAL, KENNETH W. MAHAFFEY, BRUCE NEAL, VLADO PERKOVIC, MICHAEL K. HANSEN

Diabetes 2020;69(Supplement_1):139-LB

DOI: https://doi.org/10.2337/db20-139-LB

Published: 01 June 2020

View article titled, 139-LB: The Redox Balance Predicts Both Cardiovascular (CV) and Renal Outcomes in CANVAS

Meeting Abstracts

1344-P: Metabolomics Reveals Broad Scale Metabolic Changes in Gestational Diabetes

YU LIU, ALAN KUANG, JAMES R. BAIN, TABITHA GEORGE, OLGA ILKAYEVA, ADAM MINCEY, MICHAEL MUEHLBAUER, LYNN P. LOWE, BOYD E. METZGER, CHRISTOPHER B. NEWGARD, DENISE SCHOLTENS, WILLIAM LOWE, JR.

Diabetes 2020;69(Supplement_1):1344-P

DOI: https://doi.org/10.2337/db20-1344-P

Published: 01 June 2020

View article titled, 1344-P: Metabolomics Reveals Broad Scale Metabolic Changes in Gestational Diabetes

Journal Articles

Mitochondrial Uncoupling Coordinated With PDH Activation Safely Ameliorates Hyperglycemia via Promoting Glucose Oxidation

Haowen Jiang, Jia Jin, Yanan Duan, Zhifu Xie, Yufeng Li, Anhui Gao, Min Gu, Xinwen Zhang, Chang Peng, Chunmei Xia, Tiancheng Dong, Hui Li, Lifang Yu, Jie Tang, Fan Yang, Jingya Li, Jia Li

Diabetes 2019;68(12):2197–2209

DOI: https://doi.org/10.2337/db19-0589

Published: 30 August 2019

View article titled, Mitochondrial Uncoupling Coordinated With PDH Activation Safely Ameliorates Hyperglycemia via Promoting Glucose Oxidation

Includes: Supplementary data

Meeting Abstracts

1923-P: Quantitative Measurement of Whole-Body Glycogen Metabolism and Gluconeogenic Flux

TARA TESLAA

Diabetes 2019;68(Supplement_1):1923-P

DOI: https://doi.org/10.2337/db19-1923-P

Published: 01 June 2019

View article titled, 1923-P: Quantitative Measurement of Whole-Body Glycogen Metabolism and Gluconeogenic Flux

Meeting Abstracts

738-P: Meta’omic Analysis of Elite Athletes Identifies a Performance-Enhancing Microbe that Functions via Lactate Metabolism

ALEKSANDAR KOSTIC

Diabetes 2019;68(Supplement_1):738-P

DOI: https://doi.org/10.2337/db19-738-P

Published: 01 June 2019

View article titled, 738-P: Meta’omic Analysis of Elite Athletes Identifies a Performance-Enhancing Microbe that Functions via Lactate Metabolism

Meeting Abstracts

1205-P: Baseline Lactate Level Is a Useful Predictor for Weight Loss after Long-Term SGLT2 Inhibitor Treatment

TOSHIAKI NOJIMA, YASUHIRO MATSUBAYASHI, AKIHIRO YOSHIDA, HIDEKI SUGANAMI, KOHEI KAKU, HIROHITO SONE

Diabetes 2019;68(Supplement_1):1205-P

DOI: https://doi.org/10.2337/db19-1205-P

Published: 01 June 2019

View article titled, 1205-P: Baseline Lactate Level Is a Useful Predictor for Weight Loss after Long-Term SGLT2 Inhibitor Treatment

Journal Articles

Absence of TXNIP in Humans Leads to Lactic Acidosis and Low Serum Methionine Linked to Deficient Respiration on Pyruvate

Yurika Katsu-Jiménez, Carmela Vázquez-Calvo, Camilla Maffezzini, Maria Halldin, Xiaoxiao Peng, Christoph Freyer, Anna Wredenberg, Alfredo Giménez-Cassina, Anna Wedell, Elias S.J. Arnér

Diabetes 2019;68(4):709–723

DOI: https://doi.org/10.2337/db18-0557

Published: 12 February 2019

View article titled, Absence of TXNIP in Humans Leads to Lactic Acidosis and Low Serum Methionine Linked to Deficient Respiration on Pyruvate

Includes: Supplementary data

Meeting Abstracts

The Hyperinsulinemic Isoglycemic Hyperlactemic Clamp

DMITRY ZARETSKY, ANDREW A. YOUNG

Diabetes 2018;67(Supplement_1):1959-P

DOI: https://doi.org/10.2337/db18-1959-P

Published: 01 July 2018

View article titled, The Hyperinsulinemic Isoglycemic Hyperlactemic Clamp

Meeting Abstracts

Metagenomic and Functional Analysis of Athletes Identify an Exercise-Promoting Microbiome

ALEKSANDAR KOSTIC

Diabetes 2018;67(Supplement_1):2251-PUB

DOI: https://doi.org/10.2337/db18-2251-PUB

Published: 01 July 2018

View article titled, Metagenomic and Functional Analysis of Athletes Identify an Exercise-Promoting Microbiome

Meeting Abstracts

The Impact of Metformin Exposure on Lactate Level in Tibetan Type 2 Diabetes Living at High-Altitude Area

YINGYING LUO, YANYAN GENG, QIAN REN, LINGLI ZHOU, XUEMEI LV, SHUYOU MENG, LIHUI YANG

Diabetes 2018;67(Supplement_1):1197-P

DOI: https://doi.org/10.2337/db18-1197-P

Published: 01 July 2018

View article titled, The Impact of Metformin Exposure on Lactate Level in Tibetan Type 2 Diabetes Living at High-Altitude Area

Meeting Abstracts

Assessment and Expansion of Models for ¹³C-Metabolic Flux Analysis (MFA) In Vivo

CLINTON HASENOUR, MOHSIN RAHIM, JAMEY YOUNG

Diabetes 2018;67(Supplement_1):258-LB

DOI: https://doi.org/10.2337/db18-258-LB

Published: 01 July 2018

View article titled, Assessment and Expansion of Models for <sup>13</sup>C-Metabolic Flux Analysis (MFA) In Vivo

NARROW

Astrocyte glycogen is a major source of hypothalamic lactate in rats with recurrent hypoglycemia.

AIFM2 Is Required for High-Intensity Aerobic Exercise in Promoting Glucose Utilization

1342-P: Reduction of Glucokinase and Glucokinase Regulatory Protein Expression by siRNA Is Associated with the Reduction of Lactate and Pyruvate Export from Canine Hepatocytes

242-OR: Bilateral Dorsolateral Prefrontal Cortex High-Definition Transcranial Direct-Current Stimulation (HD-tDCS) Improves Time-Trial Performance in Elite Cyclists with Type 1 Diabetes (T1D)

227-LB: Elevated Plasma Lactate and the Risk for Metabolic Syndrome—Is Skeletal Muscle a Producer or Consumer?

Lactate Is a Key Mediator That Links Obesity to Insulin Resistance via Modulating Cytokine Production From Adipose Tissue

20-OR: A New Model to Assess Lactate Synthetic Rate during an Oral Glucose Tolerance Test

3-LB: Glutamate Metabolism Is Coupled to Lactate Production from Astrocytes under Low-Glucose Conditions

229-LB: Plasma Lactate and Muscle Aerobic Substrate Oxidation: Does Elevated Lactate Precede Obesity?

139-LB: The Redox Balance Predicts Both Cardiovascular (CV) and Renal Outcomes in CANVAS

1344-P: Metabolomics Reveals Broad Scale Metabolic Changes in Gestational Diabetes

Mitochondrial Uncoupling Coordinated With PDH Activation Safely Ameliorates Hyperglycemia via Promoting Glucose Oxidation

1923-P: Quantitative Measurement of Whole-Body Glycogen Metabolism and Gluconeogenic Flux

738-P: Meta’omic Analysis of Elite Athletes Identifies a Performance-Enhancing Microbe that Functions via Lactate Metabolism

1205-P: Baseline Lactate Level Is a Useful Predictor for Weight Loss after Long-Term SGLT2 Inhibitor Treatment

Absence of TXNIP in Humans Leads to Lactic Acidosis and Low Serum Methionine Linked to Deficient Respiration on Pyruvate

The Hyperinsulinemic Isoglycemic Hyperlactemic Clamp

Metagenomic and Functional Analysis of Athletes Identify an Exercise-Promoting Microbiome

The Impact of Metformin Exposure on Lactate Level in Tibetan Type 2 Diabetes Living at High-Altitude Area

Assessment and Expansion of Models for ¹³C-Metabolic Flux Analysis (MFA) In Vivo

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