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Journal Articles

Leucine Suppresses α-Cell cAMP and Glucagon Secretion via a Combination of Cell-Intrinsic and Islet Paracrine Signaling

Emily R. Knuth, Hannah R. Foster, Erli Jin, Maia H. Ekstrand, Jakob G. Knudsen, Matthew J. Merrins
Journal: Diabetes
Diabetes 2024;73(9):1426–1439
https://doi.org/10.2337/db23-1013
Published: 13 June 2024
View article titled, Leucine Suppresses α-Cell cAMP and Glucagon Secretion via a Combination of Cell-Intrinsic and Islet Paracrine Signaling
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Journal Articles

Decoding the Mechanisms Behind Early Weaning–Driven Obesity and the Leucine “Solution”

M. Luisa Bonet, Joan Ribot, Catalina Picó
Journal: Diabetes
Diabetes 2023;72(10):1347–1349
https://doi.org/10.2337/dbi23-0011
Published: 20 September 2023
View article titled, Decoding the Mechanisms Behind Early Weaning–Driven Obesity and the Leucine “Solution”
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Journal Articles

Leucine Supplementation Ameliorates Early-Life Programming of Obesity in Rats

Yuchen Sun, Bo Sun, Xuesong Han, Anshan Shan, Qingquan Ma
Journal: Diabetes
Diabetes 2023;72(10):1409–1423
https://doi.org/10.2337/db22-0862
Published: 17 May 2023
View article titled, Leucine Supplementation Ameliorates Early-Life Programming of Obesity in Rats
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Journal Articles

Nutrient Sensor mTORC1 Regulates Insulin Secretion by Modulating β-Cell Autophagy

Tal Israeli, Yael Riahi, Perla Garzon, Ruy Andrade Louzada, Joao Pedro Werneck-de-Castro, Manuel Blandino-Rosano, Roni Yeroslaviz-Stolper, Liat Kadosh, Sharona Tornovsky-Babeay, Gilad Hacker, Nitzan Israeli, Orly Agmon, Boaz Tirosh, Erol Cerasi, Ernesto Bernal-Mizrachi, Gil Leibowitz
Journal: Diabetes
Diabetes 2022;71(3):453–469
https://doi.org/10.2337/db21-0281
Published: 03 December 2021
View article titled, Nutrient Sensor mTORC1 Regulates Insulin Secretion by Modulating β-Cell Autophagy
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Journal Articles

Intermittent Leucine Deprivation Produces Long-lasting Improvement in Insulin Sensitivity by Increasing Hepatic Gcn2 Expression

Hanrui Yin, Feixiang Yuan, Fuxin Jiao, Yuguo Niu, Xiaoxue Jiang, Jiali Deng, Yajie Guo, Shanghai Chen, Qiwei Zhai, Cheng Hu, Yiming Li, Feifan Guo
Journal: Diabetes
Diabetes 2022;71(2):206–218
https://doi.org/10.2337/db21-0336
Published: 05 November 2021
View article titled, Intermittent Leucine Deprivation Produces Long-lasting Improvement in Insulin Sensitivity by Increasing Hepatic <em>Gcn2</em> Expression
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Journal Articles

Pancreatic Differentiation of Stem Cells Reveals Pathogenesis of a Syndrome of Ketosis-Prone Diabetes

Diane Yang, Sanjeet Patel, Wojciech J. Szlachcic, Jolanta Chmielowiec, Diane Scaduto, Nagireddy Putluri, Arun Sreekumar, James Suliburk, Michael Metzker, Ashok Balasubramanyam, Malgorzata Borowiak
Journal: Diabetes
Diabetes 2021;70(10):2419–2429
https://doi.org/10.2337/db20-1293
Published: 03 August 2021
View article titled, Pancreatic Differentiation of Stem Cells Reveals Pathogenesis of a Syndrome of Ketosis-Prone Diabetes
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Journal Articles

A Multifunctional Role of Leucine-Rich α-2-Glycoprotein 1 in Cutaneous Wound Healing Under Normal and Diabetic Conditions

Chenghao Liu, Melissa Hui Yen Teo, Sharon Li Ting Pek, Xiaoting Wu, Mei Ling Leong, Hui Min Tay, Han Wei Hou, Christiane Ruedl, Stephen E. Moss, John Greenwood, Subramaniam Tavintharan, Wanjin Hong, Xiaomeng Wang
Journal: Diabetes
Diabetes 2020;69(11):2467–2480
https://doi.org/10.2337/db20-0585
Published: 04 September 2020
View article titled, A Multifunctional Role of Leucine-Rich α-2-Glycoprotein 1 in Cutaneous Wound Healing Under Normal and Diabetic Conditions
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Meeting Abstracts

169-OR: Differential Effects of Amount, Intensity, and Mode of Exercise Training on the Diabetes Risk Index

LEANNA M. ROSS, CRIS A. SLENTZ, IRINA Y. SHALAUROVA, JAMES D. OTVOS, MARGERY A. CONNELLY, CONNIE W. BALES, JOSEPH A. HOUMARD, WILLIAM E. KRAUS
Journal: Diabetes
Diabetes 2020;69(Supplement_1):169-OR
https://doi.org/10.2337/db20-169-OR
Published: 01 June 2020
View article titled, 169-OR: Differential Effects of Amount, Intensity, and Mode of Exercise Training on the Diabetes Risk Index
Meeting Abstracts

418-P: The Branched-Chain Amino Acids Valine and Leucine Predict All-Cause Mortality in Cardiovascular Disease Patients Independently from the Presence of Type 2 Diabetes Mellitus

AXEL MUENDLEIN, ANDREAS LEIHERER, CHRISTOPH H. SAELY, ALEXANDER VONBANK, BARBARA LARCHER, ARTHUR MADER, PETER FRAUNBERGER, HEINZ DREXEL
Journal: Diabetes
Diabetes 2019;68(Supplement_1):418-P
https://doi.org/10.2337/db19-418-P
Published: 01 June 2019
View article titled, 418-P: The Branched-Chain Amino Acids Valine and Leucine Predict All-Cause Mortality in Cardiovascular Disease Patients Independently from the Presence of Type 2 Diabetes Mellitus
Meeting Abstracts

2046-P: NS-0200 (Leucine-Metformin-Sildenafil) Reduces Weight in Obese Subjects: A 24-Week Randomized Trial

MICHAEL B. ZEMEL, ORVILLE G. KOLTERMAN, OMAR FLORES, GILBERT ALEXANDER FLEMING, FRANK L. GREENWAY
Journal: Diabetes
Diabetes 2019;68(Supplement_1):2046-P
https://doi.org/10.2337/db19-2046-P
Published: 01 June 2019
View article titled, 2046-P: NS-0200 (Leucine-Metformin-Sildenafil) Reduces Weight in Obese Subjects: A 24-Week Randomized Trial
Journal Articles

Nine Amino Acids Are Associated With Decreased Insulin Secretion and Elevated Glucose Levels in a 7.4-Year Follow-up Study of 5,181 Finnish Men

Jagadish Vangipurapu, Alena Stancáková, Ulf Smith, Johanna Kuusisto, Markku Laakso
Journal: Diabetes
Diabetes 2019;68(6):1353–1358
https://doi.org/10.2337/db18-1076
Published: 18 March 2019
View article titled, Nine Amino Acids Are Associated With Decreased Insulin Secretion and Elevated Glucose Levels in a 7.4-Year Follow-up Study of 5,181 Finnish Men
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Includes: Supplementary data
Meeting Abstracts

Functional Roles of Proline/Arginine-Rich End Leucine-Rich Repeat Protein (PRELP) in Adipocytes

JUN EGUCHI, JUN WADA
Journal: Diabetes
Diabetes 2018;67(Supplement_1):33-OR
https://doi.org/10.2337/db18-33-OR
Published: 01 July 2018
View article titled, Functional Roles of Proline/Arginine-Rich End Leucine-Rich Repeat Protein (PRELP) in Adipocytes
Meeting Abstracts

Functional Maturation of Pancreatic ß Cells during Development

DIANA E. STANESCU, CHANGHONG LI, JUXIANG YANG, DAPHNE YAU, CHARLES A. STANLEY
Journal: Diabetes
Diabetes 2018;67(Supplement_1):2131-P
https://doi.org/10.2337/db18-2131-P
Published: 01 July 2018
View article titled, Functional Maturation of Pancreatic ß Cells during Development
Journal Articles

Glutamine-Elicited Secretion of Glucagon-Like Peptide 1 Is Governed by an Activated Glutamate Dehydrogenase

Lotta E. Andersson, Liliya Shcherbina, Mahmoud Al-Majdoub, Neelanjan Vishnu, Claudia Balderas Arroyo, Jonathan Aste Carrara, Claes B. Wollheim, Malin Fex, Hindrik Mulder, Nils Wierup, Peter Spégel
Journal: Diabetes
Diabetes 2018;67(3):372–384
https://doi.org/10.2337/db16-1441
Published: 11 December 2017
View article titled, Glutamine-Elicited Secretion of Glucagon-Like Peptide 1 Is Governed by an Activated Glutamate Dehydrogenase
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Includes: Supplementary data
Journal Articles

Alterations in 3-Hydroxyisobutyrate and FGF21 Metabolism Are Associated With Protein Ingestion–Induced Insulin Resistance

Lydia-Ann L.S. Harris, Gordon I. Smith, Bruce W. Patterson, Raja S. Ramaswamy, Adewole L. Okunade, Shannon C. Kelly, Lane C. Porter, Samuel Klein, Jun Yoshino, Bettina Mittendorfer
Journal: Diabetes
Diabetes 2017;66(7):1871–1878
https://doi.org/10.2337/db16-1475
Published: 04 May 2017
View article titled, Alterations in 3-Hydroxyisobutyrate and FGF21 Metabolism Are Associated With Protein Ingestion–Induced Insulin Resistance
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Includes: Supplementary data
Journal Articles

Comment on Smith et al. Protein Ingestion Induces Muscle Insulin Resistance Independent of Leucine-Mediated mTOR Activation. Diabetes 2015;64:1555–1563

Francesco S. Dioguardi
Journal: Diabetes
Diabetes 2015;64(6):e10
https://doi.org/10.2337/db15-0149
Published: 16 May 2015
View article titled, Comment on Smith et al. Protein Ingestion Induces Muscle Insulin Resistance Independent of Leucine-Mediated mTOR Activation. Diabetes 2015;64:1555–1563
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Journal Articles

Response to Comment on Smith et al. Protein Ingestion Induces Muscle Insulin Resistance Independent of Leucine-Mediated mTOR Activation. Diabetes 2015;64:1555–1563

Gordon I. Smith, Bettina Mittendorfer
Journal: Diabetes
Diabetes 2015;64(6):e11
https://doi.org/10.2337/db15-0225
Published: 16 May 2015
View article titled, Response to Comment on Smith et al. Protein Ingestion Induces Muscle Insulin Resistance Independent of Leucine-Mediated mTOR Activation. Diabetes 2015;64:1555–1563
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Journal Articles

Protein Ingestion Induces Muscle Insulin Resistance Independent of Leucine-Mediated mTOR Activation

Gordon I. Smith, Jun Yoshino, Kelly L. Stromsdorfer, Seth J. Klein, Faidon Magkos, Dominic N. Reeds, Samuel Klein, Bettina Mittendorfer
Journal: Diabetes
Diabetes 2015;64(5):1555–1563
https://doi.org/10.2337/db14-1279
Published: 04 December 2014
View article titled, Protein Ingestion Induces Muscle Insulin Resistance Independent of Leucine-Mediated mTOR Activation
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Journal Articles

Mitochondrial GTP Insensitivity Contributes to Hypoglycemia in Hyperinsulinemia Hyperammonemia by Inhibiting Glucagon Release

Richard G. Kibbey, Cheol Soo Choi, Hui-Young Lee, Over Cabrera, Rebecca L. Pongratz, Xiaojian Zhao, Andreas L. Birkenfeld, Changhong Li, Per-Olof Berggren, Charles Stanley, Gerald I. Shulman
Journal: Diabetes
Diabetes 2014;63(12):4218–4229
https://doi.org/10.2337/db14-0783
Published: 13 November 2014
View article titled, Mitochondrial GTP Insensitivity Contributes to Hypoglycemia in Hyperinsulinemia Hyperammonemia by Inhibiting Glucagon Release
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Journal Articles

Interaction of Islet α-Cell and β-Cell in the Regulation of Glucose Homeostasis in HI/HA Syndrome Patients With the GDHH454Y Mutation

Guanghong Jia, James R. Sowers
Journal: Diabetes
Diabetes 2014;63(12):4008–4010
https://doi.org/10.2337/db14-1243
Published: 13 November 2014
View article titled, Interaction of Islet α-Cell and β-Cell in the Regulation of Glucose Homeostasis in HI/HA Syndrome Patients With the GDH<sup>H454Y</sup> Mutation
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