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Meeting Abstracts

1580-P: Role of Hepatic Glycogen on Nocturnal Gluconeogenesis in Type 2 Diabetes

UMA UNNI, YOGESH YADAV, JOHN P. MUGLER, III, RICKEY CARTER, ANANDA BASU, RITA BASU
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1580-P
https://doi.org/10.2337/db23-1580-P
Published: 20 June 2023
View article titled, 1580-P: Role of Hepatic Glycogen on Nocturnal Gluconeogenesis in Type 2 Diabetes
Meeting Abstracts

1605-P: Hepatic Glycogen Directly Regulates Gluconeogenesis in Energy Shortage through AMPK

BICHEN ZHANG, MORGAN M. JOHNSON, TIMOTHY YUAN, TAMMY-NHU NGUYEN, ALAN SALTIEL
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1605-P
https://doi.org/10.2337/db23-1605-P
Published: 20 June 2023
View article titled, 1605-P: Hepatic Glycogen Directly Regulates Gluconeogenesis in Energy Shortage through AMPK
Meeting Abstracts

354-OR: Cotadutide (medi0382), a Dual Receptor Agonist with Glucagon-Like Peptide-1 and Glucagon Activity, Modulates Hepatic Glycogen and Fat Content

DARREN ROBERTSON, LARS HANSEN, PHILIP AMBERY, RUSSELL L. ESTERLINE, LUTZ JERMUTUS, YI-TING CHANG, MARCELLA PETRONE, EDVIN JOHANSSON, LARS JOHANSSON, FOLKE B. SJÖBERG, VICTORIA PARKER
Journal: Diabetes
Diabetes 2020;69(Supplement_1):354-OR
https://doi.org/10.2337/db20-354-OR
Published: 01 June 2020
View article titled, 354-OR: Cotadutide (medi0382), a Dual Receptor Agonist with Glucagon-Like Peptide-1 and Glucagon Activity, Modulates Hepatic Glycogen and Fat Content
Journal Articles

Liver ChREBP Protects Against Fructose-Induced Glycogenic Hepatotoxicity by Regulating L-Type Pyruvate Kinase

Jian-Hui Shi, Jun-Yu Lu, Heng-Yu Chen, Chun-Chun Wei, Xiongfei Xu, Hao Li, Qiufang Bai, Fang-Zhen Xia, Sin Man Lam, Hai Zhang, Ya-Nan Shi, Dongmei Cao, Liming Chen, Guanghou Shui, Xia Yang, Yingli Lu, Yu-Xia Chen, Weiping J. Zhang
Journal: Diabetes
Diabetes 2020;69(4):591–602
https://doi.org/10.2337/db19-0388
Published: 23 January 2020
View article titled, Liver ChREBP Protects Against Fructose-Induced Glycogenic Hepatotoxicity by Regulating L-Type Pyruvate Kinase
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Includes: Supplementary data
Meeting Abstracts

371-P: Hypoglycemia in the Brain Is Required to Augment Counterregulatory Responses to Hypoglycemia when Liver Glycogen Levels Are Enhanced

SHANA O. WARNER, MARTA S. SMITH, BEN FARMER, JASON J. WINNICK
Journal: Diabetes
Diabetes 2019;68(Supplement_1):371-P
https://doi.org/10.2337/db19-371-P
Published: 01 June 2019
View article titled, 371-P: Hypoglycemia in the Brain Is Required to Augment Counterregulatory Responses to Hypoglycemia when Liver Glycogen Levels Are Enhanced
Meeting Abstracts

Hypothalamic HSP10 Impacts Mitochondrial Dynamics, Insulin Signaling, and Liver Glycogen Content

KRISTINA WARDELMANN, JOSÉ PEDRO CASTRO, MICHAELA RATH, JÜRGEN WEIß, ANNETTE SCHUERMANN, ANDRE KLEINRIDDERS
Journal: Diabetes
Diabetes 2018;67(Supplement_1):1801-P
https://doi.org/10.2337/db18-1801-P
Published: 01 July 2018
View article titled, Hypothalamic HSP10 Impacts Mitochondrial Dynamics, Insulin Signaling, and Liver Glycogen Content
Journal Articles

Morning Hyperinsulinemia Primes the Liver for Glucose Uptake and Glycogen Storage Later in the Day

Mary Courtney Moore, Marta S. Smith, Ben Farmer, Katie C. Coate, Guillaume Kraft, Masakazu Shiota, Phillip E. Williams, Alan D. Cherrington
Journal: Diabetes
Diabetes 2018;67(7):1237–1245
https://doi.org/10.2337/db17-0979
Published: 17 April 2018
View article titled, Morning Hyperinsulinemia Primes the Liver for Glucose Uptake and Glycogen Storage Later in the Day
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Journal Articles

Liver Glycogen Reduces Food Intake and Attenuates Obesity in a High-Fat Diet–Fed Mouse Model

Iliana López-Soldado, Delia Zafra, Jordi Duran, Anna Adrover, Joaquim Calbó, Joan J. Guinovart
Journal: Diabetes
Diabetes 2015;64(3):796–807
https://doi.org/10.2337/db14-0728
Published: 02 October 2014
View article titled, Liver Glycogen Reduces Food Intake and Attenuates Obesity in a High-Fat Diet–Fed Mouse Model
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Journal Articles

Glucose-6-Phosphate–Mediated Activation of Liver Glycogen Synthase Plays a Key Role in Hepatic Glycogen Synthesis

Alexander von Wilamowitz-Moellendorff, Roger W. Hunter, Mar García-Rocha, Li Kang, Iliana López-Soldado, Louise Lantier, Kashyap Patel, Mark W. Peggie, Carlos Martínez-Pons, Martin Voss, Joaquim Calbó, Patricia T.W. Cohen, David H. Wasserman, Joan J. Guinovart, Kei Sakamoto
Journal: Diabetes
Diabetes 2013;62(12):4070–4082
https://doi.org/10.2337/db13-0880
Published: 16 November 2013
View article titled, Glucose-6-Phosphate–Mediated Activation of Liver Glycogen Synthase Plays a Key Role in Hepatic Glycogen Synthesis
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Includes: Supplementary data
Journal Articles

Hepatic Glucose Metabolism in Late Pregnancy: Normal Versus High-Fat and -Fructose Diet

Katie C. Coate, Marta S. Smith, Masakazu Shiota, Jose M. Irimia, Peter J. Roach, Ben Farmer, Phillip E. Williams, Mary Courtney Moore
Journal: Diabetes
Diabetes 2013;62(3):753–761
https://doi.org/10.2337/db12-0875
Published: 14 February 2013
View article titled, Hepatic Glucose Metabolism in Late Pregnancy: <subtitle>Normal Versus High-Fat and -Fructose Diet</subtitle>
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Journal Articles

Liver Glycogen Loading Dampens Glycogen Synthesis Seen in Response to Either Hyperinsulinemia or Intraportal Glucose Infusion

Jason J. Winnick, Zhibo An, Guillaume Kraft, Christopher J. Ramnanan, Jose M. Irimia, Marta Smith, Margaret Lautz, Peter J. Roach, Alan D. Cherrington
Journal: Diabetes
Diabetes 2013;62(1):96–101
https://doi.org/10.2337/db11-1773
Published: 13 December 2012
View article titled, Liver Glycogen Loading Dampens Glycogen Synthesis Seen in Response to Either Hyperinsulinemia or Intraportal Glucose Infusion
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Journal Articles

A Novel Mechanism for Regulating Hepatic Glycogen Synthesis Involving Serotonin and Cyclin-Dependent Kinase-5

Susan J. Tudhope, Chung-Chi Wang, John L. Petrie, Lloyd Potts, Fiona Malcomson, Julius Kieswich, Muhammad M. Yaqoob, Catherine Arden, Laura J. Hampson, Loranne Agius
Journal: Diabetes
Diabetes 2012;61(1):49–60
https://doi.org/10.2337/db11-0870
Published: 12 December 2011
View article titled, A Novel Mechanism for Regulating Hepatic Glycogen Synthesis Involving Serotonin and Cyclin-Dependent Kinase-5
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Journal Articles

Postprandial and Fasting Hepatic Glucose Fluxes in Long-Standing Type 1 Diabetes

Michaela Kacerovsky, John Jones, Albrecht I. Schmid, Cristina Barosa, Angelika Lettner, Gertrud Kacerovsky-Bielesz, Julia Szendroedi, Marek Chmelik, Peter Nowotny, Visvanathan Chandramouli, Michael Wolzt, Michael Roden
Journal: Diabetes
Diabetes 2011;60(6):1752–1758
https://doi.org/10.2337/db10-1001
Published: 21 May 2011
View article titled, Postprandial and Fasting Hepatic Glucose Fluxes in Long-Standing Type 1 Diabetes
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Includes: Supplementary data
Journal Articles

Fasting-Induced Protein Phosphatase 1 Regulatory Subunit Contributes to Postprandial Blood Glucose Homeostasis via Regulation of Hepatic Glycogenesis

Xiaolin Luo, Yongxian Zhang, Xiangbo Ruan, Xiaomeng Jiang, Lu Zhu, Xiao Wang, Qiurong Ding, Weizhong Liu, Yi Pan, Zhenzhen Wang, Yan Chen
Journal: Diabetes
Diabetes 2011;60(5):1435–1445
https://doi.org/10.2337/db10-1663
Published: 23 April 2011
View article titled, Fasting-Induced Protein Phosphatase 1 Regulatory Subunit Contributes to Postprandial Blood Glucose Homeostasis via Regulation of Hepatic Glycogenesis
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Includes: Supplementary data
Journal Articles

Hepatic Glycogen Supercompensation Activates AMP-Activated Protein Kinase, Impairs Insulin Signaling, and Reduces Glycogen Deposition in the Liver

Jason J. Winnick, Zhibo An, Christopher J. Ramnanan, Marta Smith, Jose M. Irimia, Doss W. Neal, Mary Courtney Moore, Peter J. Roach, Alan D. Cherrington
Journal: Diabetes
Diabetes 2011;60(2):398–407
https://doi.org/10.2337/db10-0592
Published: 21 January 2011
View article titled, Hepatic Glycogen Supercompensation Activates AMP-Activated Protein Kinase, Impairs Insulin Signaling, and Reduces Glycogen Deposition in the Liver
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Journal Articles

Normalization of Prandial Blood Glucose and Improvement of Glucose Tolerance by Liver-Specific Inhibition of SH2 Domain–Containing Inositol Phosphatase 2 (SHIP2) in Diabetic KKAy Mice : SHIP2 Inhibition Causes Insulin-Mimetic Effects on Glycogen Metabolism, Gluconeogenesis, and Glycolysis

Rolf Grempler, Darya Zibrova, Corinna Schoelch, André van Marle, Joerg F. Rippmann, Norbert Redemann
Journal: Diabetes
Diabetes 2007;56(9):2235–2241
https://doi.org/10.2337/db06-1660
Published: 01 September 2007
View article titled, Normalization of Prandial Blood Glucose and Improvement of Glucose Tolerance by Liver-Specific Inhibition of SH2 Domain–Containing Inositol Phosphatase 2 (SHIP2) in Diabetic KKA<sup>y</sup> Mice : <subtitle>SHIP2 Inhibition Causes Insulin-Mimetic Effects on Glycogen Metabolism, Gluconeogenesis, and Glycolysis</subtitle>
Open the PDF for Normalization of Prandial Blood Glucose and Improvement of Glucose Tolerance by Liver-Specific Inhibition of SH2 Domain–Containing Inositol Phosphatase 2 (SHIP2) in Diabetic KKA<sup>y</sup> Mice : <subtitle>SHIP2 Inhibition Causes Insulin-Mimetic Effects on Glycogen Metabolism, Gluconeogenesis, and Glycolysis</subtitle> in another window
Includes: Supplementary data
Journal Articles

Role of Excess Glycogenolysis in Fasting Hyperglycemia Among Pre-Diabetic and Diabetic Zucker (fa/fa) Rats

Eunsook S. Jin, Byung-Hyun Park, A. Dean Sherry, Craig R. Malloy
Journal: Diabetes
Diabetes 2007;56(3):777–785
https://doi.org/10.2337/db06-0717
Published: 01 March 2007
View article titled, Role of Excess Glycogenolysis in Fasting Hyperglycemia Among Pre-Diabetic and Diabetic Zucker (<em>fa/fa</em>) Rats
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Journal Articles

Noninvasive Analysis of Hepatic Glycogen Kinetics Before and After Breakfast with Deuterated Water and Acetaminophen

John G. Jones, Ana Fagulha, Cristina Barosa, Margarida Bastos, Luisa Barros, Carla Baptista, M. Madalena Caldeira, Manuela Carvalheiro
Journal: Diabetes
Diabetes 2006;55(8):2294–2300
https://doi.org/10.2337/db06-0304
Published: 01 August 2006
View article titled, Noninvasive Analysis of Hepatic Glycogen Kinetics Before and After Breakfast with Deuterated Water and Acetaminophen
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Journal Articles

Role of Hepatic Glycogen Breakdown in Defective Counterregulation of Hypoglycemia in Intensively Treated Type 1 Diabetes

Preeti Kishore, Ilan Gabriely, Min-Hui Cui, Joseph Di Vito, Srikanth Gajavelli, Jong-Hee Hwang, Harry Shamoon
Journal: Diabetes
Diabetes 2006;55(3):659–666
https://doi.org/10.2337/diabetes.55.03.06.db05-0849
Published: 01 March 2006
View article titled, Role of Hepatic Glycogen Breakdown in Defective Counterregulation of Hypoglycemia in Intensively Treated Type 1 Diabetes
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Journal Articles

5-Aminoimidazole-4-Carboxamide-1-β-d-Ribofuranoside Causes Acute Hepatic Insulin Resistance In Vivo

R. Richard Pencek, Jane Shearer, Raul C. Camacho, Freyja D. James, D. Brooks Lacy, Patrick T. Fueger, E. Patrick Donahue, Wanda Snead, David H. Wasserman
Journal: Diabetes
Diabetes 2005;54(2):355–360
https://doi.org/10.2337/diabetes.54.2.355
Published: 01 February 2005
View article titled, 5-Aminoimidazole-4-Carboxamide-1-β-<sc>d</sc>-Ribofuranoside Causes Acute Hepatic Insulin Resistance In Vivo
Open the PDF for 5-Aminoimidazole-4-Carboxamide-1-β-<sc>d</sc>-Ribofuranoside Causes Acute Hepatic Insulin Resistance In Vivo in another window