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Journal Articles

Improved Specificity of Glutamate Decarboxylase 65 Autoantibody Measurement Using Luciferase-Based Immunoprecipitation System Assays

Rebecca C. Wyatt, Sian L. Grace, Cristina Brigatti, Ilaria Marzinotto, Ben T. Gillard, Deborah K. Shoemark, Kyla Chandler, Peter Achenbach, Lorenzo Piemonti, Anna E. Long, Kathleen M. Gillespie, Vito Lampasona, Alistair J.K. Williams, BOX Study Group, Isabel Wilson, Rachel Aitken, Ilana Kelland, Clare Megson, Chitrabhanu Ballav, Atanu Dutta, Michelle Russell-Taylor, Rachel Besser, James Bursell, Shanthi Chandran, Sejal Patel, Anne Smith, Manohara Kenchaiah, Gomathi Margabanthu, Foteini Kavvoura, Chandan Yaliwal
Journal: Diabetes
Diabetes 2024;73(4):565–571
https://doi.org/10.2337/db23-0550
Published: 17 January 2024
View article titled, Improved Specificity of Glutamate Decarboxylase 65 Autoantibody Measurement Using Luciferase-Based Immunoprecipitation System Assays
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Journal Articles

Activation of METTL3 Promotes White Adipose Tissue Beiging and Combats Obesity

Renxiang Xie, Sujun Yan, Xiaoling Zhou, Yunyi Gao, Yu Qian, Jingyu Hou, Zhanghui Chen, Kairan Lai, Xiangwei Gao, Saisai Wei
Journal: Diabetes
Diabetes 2023;72(8):1083–1094
https://doi.org/10.2337/db22-0775
Published: 24 May 2023
View article titled, Activation of METTL3 Promotes White Adipose Tissue Beiging and Combats Obesity
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Meeting Abstracts

298-OR: Variant-to-Gene Mapping at the Childhood Obesity Locus on chr12q13 and Subsequent Luciferase Assay Analyses Implicate rs71329as a Causal Variant within the 3’ UTR of FAIM2

SHERIDAN H. LITTLETON, JONATHAN BRADFIELD, JAMES A. PIPPIN, CHUN SU, ALESSANDRA CHESI, ANDREW D. WELLS, ROBERT I. BERKOWITZ, MATTHEW C. PAHL, STRUAN F. GRANT
Journal: Diabetes
Diabetes 2022;71(Supplement_1):298-OR
https://doi.org/10.2337/db22-298-OR
Published: 01 June 2022
View article titled, 298-OR: Variant-to-Gene Mapping at the Childhood Obesity Locus on chr12q13 and Subsequent Luciferase Assay Analyses Implicate rs71329as a Causal Variant within the 3’ UTR of FAIM2
Meeting Abstracts

183-OR: Overcoming Immunological Barriers for “Off-the-Shelf” iPSC-Derived Islets

XIAOMENG HU, KATHY WHITE, ARI G. OLROYD, ROWENA DEJESUS, ANTONIA DOMINGUEZ, WILLIAM E. DOWDLE, ELAINE Y.L. CHU, ANNABELLE FRIERA, CHI YOUNG, FRANK WELLS, TREVOR MCGILL, MICHAEL RUKSTALIS, CORIE GATTIS, RONALD BASCO, JEFFREY R. MILLMAN, SONJA SCHREPFER
Journal: Diabetes
Diabetes 2022;71(Supplement_1):183-OR
https://doi.org/10.2337/db22-183-OR
Published: 01 June 2022
View article titled, 183-OR: Overcoming Immunological Barriers for “Off-the-Shelf” iPSC-Derived Islets
Journal Articles

Obesity-Induced miR-455 Upregulation Promotes Adaptive Pancreatic β-Cell Proliferation Through the CPEB1/CDKN1B Pathway

Qianxing Hu, Jinming Mu, Yuhong Liu, Yue Yang, Yue Liu, Yi Pan, Yanfeng Zhang, Ling Li, Dechen Liu, Jianqiu Chen, Fangfang Zhang, Liang Jin
Journal: Diabetes
Diabetes 2022;71(3):394–411
https://doi.org/10.2337/db21-0134
Published: 14 January 2022
View article titled, Obesity-Induced <em>miR-455</em> Upregulation Promotes Adaptive Pancreatic β-Cell Proliferation Through the CPEB1/CDKN1B Pathway
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Journal Articles

Inhibition of lncRNA TCONS_00077866 Ameliorates the High Stearic Acid Diet-Induced Mouse Pancreatic β-Cell Inflammatory Response by Increasing miR-297b-5p to Downregulate SAA3 Expression

Huimin Lu, Rui Guo, Yunjin Zhang, Shenghan Su, Qingrui Zhao, Yue Yu, Hongbo Shi, Haoran Sun, Yongjian Zhang, Shenglong Li, Dan Shi, Xia Chu, Changhao Sun
Journal: Diabetes
Diabetes 2021;70(10):2275–2288
https://doi.org/10.2337/db20-1079
Published: 14 July 2021
View article titled, Inhibition of lncRNA TCONS_00077866 Ameliorates the High Stearic Acid Diet-Induced Mouse Pancreatic β-Cell Inflammatory Response by Increasing miR-297b-5p to Downregulate SAA3 Expression
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Journal Articles

ETV5 Regulates Hepatic Fatty Acid Metabolism Through PPAR Signaling Pathway

Zhuo Mao, Mingji Feng, Zhuoran Li, Minsi Zhou, Langning Xu, Ke Pan, Shaoxiang Wang, Wen Su, Weizhen Zhang
Journal: Diabetes
Diabetes 2021;70(1):214–226
https://doi.org/10.2337/db20-0619
Published: 22 October 2020
View article titled, ETV5 Regulates Hepatic Fatty Acid Metabolism Through PPAR Signaling Pathway
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Meeting Abstracts

1638-P: Functional Characterization of HNF1B Variants Can Enhance Diabetes Precision Medicine

BENTE B. JOHANSSON, AISHWARYA PAVITHRAM, HAICHEN ZHANG, KRISTIN A. MALONEY, MONIKA RINGDAL, ALBA KACI, JORN V. SAGEN, JEFFREY KLEINBERGER, LINDA JENG, PÅL RASMUS NJØLSTAD, TONI I. POLLIN, JANNE MOLNES
Journal: Diabetes
Diabetes 2020;69(Supplement_1):1638-P
https://doi.org/10.2337/db20-1638-P
Published: 01 June 2020
View article titled, 1638-P: Functional Characterization of HNF1B Variants Can Enhance Diabetes Precision Medicine
Meeting Abstracts

370-OR: Hepatic FGF21 Expression Is Under the Regulation of the Canonical Wnt Signaling Pathway

YASAMAN BADAKHSHI, WEIJUAN SHAO, LILI TIAN, TIANRU JIN
Journal: Diabetes
Diabetes 2020;69(Supplement_1):370-OR
https://doi.org/10.2337/db20-370-OR
Published: 01 June 2020
View article titled, 370-OR: Hepatic FGF21 Expression Is Under the Regulation of the Canonical Wnt Signaling Pathway
Meeting Abstracts

1801-P: Novel De Novo INS P.T97P Variant Presenting with Severe Neonatal DKA

RAYHAN LAL, HANNAH P. MOELLER, RAQUEL FREEMAN, PRIYA PRAHALAD, JUSTIN P. ANNES
Journal: Diabetes
Diabetes 2020;69(Supplement_1):1801-P
https://doi.org/10.2337/db20-1801-P
Published: 01 June 2020
View article titled, 1801-P: Novel De Novo INS P.T97P Variant Presenting with Severe Neonatal DKA
Journal Articles

β-Cell Stress Shapes CTL Immune Recognition of Preproinsulin Signal Peptide by Posttranscriptional Regulation of Endoplasmic Reticulum Aminopeptidase 1

Sofia Thomaidou, Maria J.L. Kracht, Arno van der Slik, Sandra Laban, Eelco J. de Koning, Francoise Carlotti, Rob C. Hoeben, Bart O. Roep, Arnaud Zaldumbide
Journal: Diabetes
Diabetes 2020;69(4):670–680
https://doi.org/10.2337/db19-0984
Published: 02 January 2020
View article titled, β-Cell Stress Shapes CTL Immune Recognition of Preproinsulin Signal Peptide by Posttranscriptional Regulation of Endoplasmic Reticulum Aminopeptidase 1
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Includes: Supplementary data
Journal Articles

Glucolipotoxicity Alters Insulin Secretion via Epigenetic Changes in Human Islets

Elin Hall, Josefine Jönsson, Jones K. Ofori, Petr Volkov, Alexander Perfilyev, Marloes Dekker Nitert, Lena Eliasson, Charlotte Ling, Karl Bacos
Journal: Diabetes
Diabetes 2019;68(10):1965–1974
https://doi.org/10.2337/db18-0900
Published: 16 August 2019
View article titled, Glucolipotoxicity Alters Insulin Secretion via Epigenetic Changes in Human Islets
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Includes: Supplementary data
Journal Articles

Elevated Thrombospondin 2 Contributes to Delayed Wound Healing in Diabetes

Britta Kunkemoeller, Tara Bancroft, Hao Xing, Aaron H. Morris, Amelia K. Luciano, Jason Wu, Carlos Fernandez-Hernando, Themis R. Kyriakides
Journal: Diabetes
Diabetes 2019;68(10):2016–2023
https://doi.org/10.2337/db18-1001
Published: 07 August 2019
View article titled, Elevated Thrombospondin 2 Contributes to Delayed Wound Healing in Diabetes
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Includes: Supplementary data
Meeting Abstracts

481-P: KCNMA1 Transcriptional Regulation by Nrf2 in Diabetic Vessels

HON-CHI LEE, XIAOJING SUN, XIAO-LI WANG, TONG LU
Journal: Diabetes
Diabetes 2019;68(Supplement_1):481-P
https://doi.org/10.2337/db19-481-P
Published: 01 June 2019
View article titled, 481-P: KCNMA1 Transcriptional Regulation by Nrf2 in Diabetic Vessels
Journal Articles

Ameliorating Methylglyoxal-Induced Progenitor Cell Dysfunction for Tissue Repair in Diabetes

Hainan Li, Megan O’Meara, Xiang Zhang, Kezhong Zhang, Berhane Seyoum, Zhengping Yi, Randal J. Kaufman, Terrence J. Monks, Jie-Mei Wang
Journal: Diabetes
Diabetes 2019;68(6):1287–1302
https://doi.org/10.2337/db18-0933
Published: 18 March 2019
View article titled, Ameliorating Methylglyoxal-Induced Progenitor Cell Dysfunction for Tissue Repair in Diabetes
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Includes: Supplementary data
Journal Articles

Obesity-Associated miR-199a/214 Cluster Inhibits Adipose Browning via PRDM16–PGC-1α Transcriptional Network

Linyun He, Mowei Tang, Ting Xiao, Hailan Liu, Wei Liu, Guangdi Li, Feng Zhang, Yalun Xiao, Zhiguang Zhou, Feng Liu, Fang Hu
Journal: Diabetes
Diabetes 2018;67(12):2585–2600
https://doi.org/10.2337/db18-0626
Published: 02 October 2018
View article titled, Obesity-Associated miR-199a/214 Cluster Inhibits Adipose Browning via PRDM16–PGC-1α Transcriptional Network
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Includes: Supplementary data
Journal Articles

Glucolipotoxicity-Inhibited miR-299-5p Regulates Pancreatic β-Cell Function and Survival

Qiqing Huang, Weiyan You, Yating Li, Yi Sun, Yuncai Zhou, Yan Zhang, Dechen Liu, Shanshan Zhan, Yunxia Zhu, Xiao Han
Journal: Diabetes
Diabetes 2018;67(11):2280–2292
https://doi.org/10.2337/db18-0223
Published: 21 August 2018
View article titled, Glucolipotoxicity-Inhibited <em>miR-299-5p</em> Regulates Pancreatic β-Cell Function and Survival
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Includes: Multimedia, Supplementary data
Journal Articles

Contribution of the Long Noncoding RNA H19 to β-Cell Mass Expansion in Neonatal and Adult Rodents

Clara Sanchez-Parra, Cécile Jacovetti, Olivier Dumortier, Kailun Lee, Marie-Line Peyot, Claudiane Guay, Marc Prentki, D. Ross Laybutt, Emmanuel Van Obberghen, Romano Regazzi
Journal: Diabetes
Diabetes 2018;67(11):2254–2267
https://doi.org/10.2337/db18-0201
Published: 16 August 2018
View article titled, Contribution of the Long Noncoding RNA H19 to β-Cell Mass Expansion in Neonatal and Adult Rodents
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Includes: Supplementary data
Meeting Abstracts

Lunapark, a Novel Target to miR-126—Its Potential Role in Maintenance of ER and Glucose Homeostasis

JULIANA DE A. FARIA, DANIELLA DUQUE GUIMARAES, LUCAS PANTALEAO, THOMAS P. ONG, SR., AUSAN OZANNE
Journal: Diabetes
Diabetes 2018;67(Supplement_1):238-LB
https://doi.org/10.2337/db18-238-LB
Published: 01 July 2018
View article titled, Lunapark, a Novel Target to miR-126—Its Potential Role in Maintenance of ER and Glucose Homeostasis
Meeting Abstracts

Assessment of Proinflammatory Mediators of Beta-Cell Circadian Clock Dysfunction in Diabetes

NAUREEN JAVEED, KUNTOL RAKSHIT, ALEKSEY MATVEYENKO
Journal: Diabetes
Diabetes 2018;67(Supplement_1):193-OR
https://doi.org/10.2337/db18-193-OR
Published: 01 July 2018
View article titled, Assessment of Proinflammatory Mediators of Beta-Cell Circadian Clock Dysfunction in Diabetes