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Journal Articles

Reversal of experimental autoimmune diabetes with a sCD39/anti-CD3 treatment

Carmen Fotino, R. Damaris Molano, Moufida Ben Nasr, Oliver Umland, Christopher A. Fraker, Ulisse Ulissi, Hari Baskar Balasubramanian, Maria Elena Lunati, Vera Usuelli, Andy Joe Seelam, Salma Ayman Khalefa, Christian La Sala, Jennifer Gimeno, Armando J. Mendez, Camillo Ricordi, Allison L. Bayer, Paolo Fiorina, Antonello Pileggi

Diabetes db230178

https://doi.org/10.2337/db23-0178

Published: 25 August 2023

View article titled, Reversal of experimental autoimmune diabetes with a sCD39/anti-CD3 treatment

Journal Articles

Unveiling Novel Markers and Modeling Clinical Prediction of Treatment Effects Are Equally Important for Implementing Precision Therapeutics

Vincenzo Trischitta, Claudia Menzaghi, Massimiliano Copetti

Diabetes 2023;72(8):1057–1059

https://doi.org/10.2337/dbi22-0039

Published: 20 July 2023

View article titled, Unveiling Novel Markers and Modeling Clinical Prediction of Treatment Effects Are Equally Important for Implementing Precision Therapeutics

Meeting Abstracts

1650-P: Characterizing the Mechanism of Action of the Lipokine 12,13-diHOME

JARED I. SENFELD, MATTHEW LYNES, SEAN KODANI, KIN SING STEPHEN LEE, YU-HUA TSENG

Diabetes 2023;72(Supplement_1):1650-P

https://doi.org/10.2337/db23-1650-P

Published: 20 June 2023

View article titled, 1650-P: Characterizing the Mechanism of Action of the Lipokine 12,13-diHOME

Meeting Abstracts

475-P: Intermittent Hypoxia Increased the Expression of Intercellular Adhesion Molecule-1 and Endothelial Cell–Specific Molecule-1 in Vascular Endothelial Cells via the Downregulation of MicroRNA-181a1

SHIN TAKASAWA, MAI MAKINO, AKIYO YAMAUCHI, SUMIYO SAKURAMOTO-TSUCHIDA, YOSHINORI TAKEDA, TOMOKO UCHIYAMA, RYOGO SHOBATAKE

Diabetes 2023;72(Supplement_1):475-P

https://doi.org/10.2337/db23-475-P

Published: 20 June 2023

View article titled, 475-P: Intermittent Hypoxia Increased the Expression of Intercellular Adhesion Molecule-1 and Endothelial Cell–Specific Molecule-1 in Vascular Endothelial Cells via the Downregulation of MicroRNA-181a1

Meeting Abstracts

76-OR: Axon Guidance Molecule Slit3 Is Essential for Cold-Induced Remodeling of BAT Neurovasculature and Thermogenesis

TAMIRES DUARTE AFONSO SERDAN, HEIDI E. CERVANTES, FELIPPE M. NETO, YU-HUA TSENG, FARNAZ SHAMSI

Diabetes 2023;72(Supplement_1):76-OR

https://doi.org/10.2337/db23-76-OR

Published: 20 June 2023

View article titled, 76-OR: Axon Guidance Molecule Slit3 Is Essential for Cold-Induced Remodeling of BAT Neurovasculature and Thermogenesis

Meeting Abstracts

223-OR: Identification of Novel Therapies for Monogenic Diabetes Using Connectivity Map (CMap)

RAYMOND J. KREIENKAMP, CHRISTOPHER BRYAN, JOSE C. FLOREZ, MIRIAM UDLER

Diabetes 2023;72(Supplement_1):223-OR

https://doi.org/10.2337/db23-223-OR

Published: 20 June 2023

View article titled, 223-OR: Identification of Novel Therapies for Monogenic Diabetes Using Connectivity Map (CMap)

Meeting Abstracts

1588-P: Translatable Modeling of Glucagon Actions in Human iPSC-Derived Hepatocytes Uniquely Predicts Differential Clinical Responses to Glucagon Analog Agonist Molecules

WILLIAM ROELL, AJIT REGMI, CHARLES T. BENSON, TAMER COSKUN, JULIE S. MOYERS, JORGE ALSINA-FERNANDEZ, MELISSA K. THOMAS

Diabetes 2023;72(Supplement_1):1588-P

https://doi.org/10.2337/db23-1588-P

Published: 20 June 2023

View article titled, 1588-P: Translatable Modeling of Glucagon Actions in Human iPSC-Derived Hepatocytes Uniquely Predicts Differential Clinical Responses to Glucagon Analog Agonist Molecules

Meeting Abstracts

1622-P: Complex Mechanisms Underlie the Antidiabetic Effect of Tempol in Experimentally Induced Diabetes Mellitus

YAHYA NAGUIB

Diabetes 2023;72(Supplement_1):1622-P

https://doi.org/10.2337/db23-1622-P

Published: 20 June 2023

View article titled, 1622-P: Complex Mechanisms Underlie the Antidiabetic Effect of Tempol in Experimentally Induced Diabetes Mellitus

Journal Articles

Probing β-Cell Biology in Space and Time

Rafael Arrojo e Drigo

Diabetes 2021;70(10):2163–2173

https://doi.org/10.2337/dbi21-0008

Published: 27 September 2021

View article titled, Probing β-Cell Biology in Space and Time

Journal Articles

From Pancreatic β-Cell Gene Networks to Novel Therapies for Type 1 Diabetes

Decio L. Eizirik, Florian Szymczak, Maria Inês Alvelos, Frank Martin

Diabetes 2021;70(9):1915–1925

https://doi.org/10.2337/dbi20-0046

Published: 07 September 2021

View article titled, From Pancreatic β-Cell Gene Networks to Novel Therapies for Type 1 Diabetes

Meeting Abstracts

185-OR: Longitudinal Changes in KidneyIntelX and Association with Progressive Decline in Kidney Function in the CANVAS Trial

DAVID W. LAM, GIRISH N. NADKARNI, BRUCE NEAL, KENNETH W. MAHAFFEY, NORM ROSENTHAL, MICHAEL K. HANSEN, HIDDO L. HEERSPINK, STEVEN COCA

Diabetes 2021;70(Supplement_1):185-OR

https://doi.org/10.2337/db21-185-OR

Published: 01 June 2021

View article titled, 185-OR: Longitudinal Changes in KidneyIntelX and Association with Progressive Decline in Kidney Function in the CANVAS Trial

Meeting Abstracts

1258-P: Il-1ß-Induced Transcription of Nf-kB Target Genes Is Repressed by Bet Bromodomain Inhibitors in Pancreatic ß-Cells

JOSHUA NORD, SARAH WYNIA-SMITH, BRIAN C. SMITH, RACHEL JONES LIPINSKI

Diabetes 2021;70(Supplement_1):1258-P

https://doi.org/10.2337/db21-1258-P

Published: 01 June 2021

View article titled, 1258-P: Il-1ß-Induced Transcription of Nf-kB Target Genes Is Repressed by Bet Bromodomain Inhibitors in Pancreatic ß-Cells

Journal Articles

Single Molecule–Based fliFISH Validates Radial and Heterogeneous Gene Expression Patterns in Pancreatic Islet β-Cells

Fangjia Li, Dehong Hu, Cailin Dieter, Charles Ansong, Lori Sussel, Galya Orr

Diabetes 2021;70(5):1117–1122

https://doi.org/10.2337/db20-0802

Published: 08 March 2021

View article titled, Single Molecule–Based fliFISH Validates Radial and Heterogeneous Gene Expression Patterns in Pancreatic Islet β-Cells

Journal Articles

Activation of dsRNA-Dependent Protein Kinase R by miR-378 Sustains Metabolic Inflammation in Hepatic Insulin Resistance

Hao Wang, Yongyan Song, Yuxin Wu, Virender Kumar, Ram I. Mahato, Qiaozhu Su

Diabetes 2021;70(3):710–719

https://doi.org/10.2337/db20-0181

Published: 07 January 2021

View article titled, Activation of dsRNA-Dependent Protein Kinase R by miR-378 Sustains Metabolic Inflammation in Hepatic Insulin Resistance

Journal Articles

Next-Generation HLA Sequence Analysis Uncovers Seven HLA-DQ Amino Acid Residues and Six Motifs Resistant to Childhood Type 1 Diabetes

Lue Ping Zhao, George K. Papadopoulos, William W. Kwok, Antonis K. Moustakas, George P. Bondinas, Annelie Carlsson, Helena Elding Larsson, Johnny Ludvigsson, Claude Marcus, Ulf Samuelsson, Ruihan Wang, Chul-Woo Pyo, Wyatt C. Nelson, Daniel E. Geraghty, Åke Lernmark

Diabetes 2020;69(11):2523–2535

https://doi.org/10.2337/db20-0374

Published: 31 August 2020

View article titled, Next-Generation HLA Sequence Analysis Uncovers Seven HLA-DQ Amino Acid Residues and Six Motifs Resistant to Childhood Type 1 Diabetes

Meeting Abstracts

1670-P: Enalapril Maleate, Angiotensin-Converting Enzyme Inhibitor, Suppresses the Expression of the MHC Molecules in Mucosal Cells of the Small Intestine Leading to the Delayed Onset of Autoimmune Type 1 Diabetes Mellitus in NOD Mice

MASAKAZU HATTORI, AIKO UEDA, RYUICHI KATOH, MASATAKA HIRAI, AKIHIRO NODA, KAZUYA MAYANAGI, YOSHITO FURUICHI, KIMIE HATTORI, TORBEN LUND, KENJI KOBAYASHI, YASUYUKI NAKAMURA

Diabetes 2020;69(Supplement_1):1670-P

https://doi.org/10.2337/db20-1670-P

Published: 01 June 2020

View article titled, 1670-P: Enalapril Maleate, Angiotensin-Converting Enzyme Inhibitor, Suppresses the Expression of the MHC Molecules in Mucosal Cells of the Small Intestine Leading to the Delayed Onset of Autoimmune Type 1 Diabetes Mellitus in NOD Mice

Meeting Abstracts

489-P: Energy Status Could Modulate Autophagy through Colocalizations of Fyn, P53, and Tgm2 in the Renal Tubules In Vivo

RYOTA UEHARA, EIJIRO YAMADA, YASUYO NAKAJIMA, KAZUHIKO HORIGUCHI, EMI ISHIDA, SHUNICHI MATSUMOTO, SHUICHI OKADA, CLAIRE C. BASTIE, MASANOBU YAMADA

Diabetes 2020;69(Supplement_1):489-P

https://doi.org/10.2337/db20-489-P

Published: 01 June 2020

View article titled, 489-P: Energy Status Could Modulate Autophagy through Colocalizations of Fyn, P53, and Tgm2 in the Renal Tubules In Vivo

Meeting Abstracts

2131-P: BET Bromodomain Inhibition Upregulates SIRT1 In Pancreatic ß-Cells

RACHEL A. JONES LIPINSKI, SARAH WYNIA-SMITH, JOSHUA NORD, BRIAN C. SMITH

Diabetes 2020;69(Supplement_1):2131-P

https://doi.org/10.2337/db20-2131-P

Published: 01 June 2020

View article titled, 2131-P: BET Bromodomain Inhibition Upregulates SIRT1 In Pancreatic ß-Cells

Journal Articles

The Local Paracrine Actions of the Pancreatic α-Cell

Rayner Rodriguez-Diaz, Alejandro Tamayo, Manami Hara, Alejandro Caicedo

Diabetes 2020;69(4):550–558

https://doi.org/10.2337/dbi19-0002

Published: 27 December 2019

View article titled, The Local Paracrine Actions of the Pancreatic α-Cell

Journal Articles

Single-Cell Analysis of CD4 T Cells in Type 1 Diabetes: From Mouse to Man, How to Perform Mechanistic Studies

Siddhartha Sharma, Jeremy Pettus, Michael Gottschalk, Brian Abe, Peter Gottlieb, Luc Teyton

Diabetes 2019;68(10):1886–1891

https://doi.org/10.2337/dbi18-0064

Published: 16 September 2019

View article titled, Single-Cell Analysis of CD4 T Cells in Type 1 Diabetes: From Mouse to Man, How to Perform Mechanistic Studies

NARROW

Reversal of experimental autoimmune diabetes with a sCD39/anti-CD3 treatment

Unveiling Novel Markers and Modeling Clinical Prediction of Treatment Effects Are Equally Important for Implementing Precision Therapeutics

1650-P: Characterizing the Mechanism of Action of the Lipokine 12,13-diHOME

475-P: Intermittent Hypoxia Increased the Expression of Intercellular Adhesion Molecule-1 and Endothelial Cell–Specific Molecule-1 in Vascular Endothelial Cells via the Downregulation of MicroRNA-181a1

76-OR: Axon Guidance Molecule Slit3 Is Essential for Cold-Induced Remodeling of BAT Neurovasculature and Thermogenesis

223-OR: Identification of Novel Therapies for Monogenic Diabetes Using Connectivity Map (CMap)

1588-P: Translatable Modeling of Glucagon Actions in Human iPSC-Derived Hepatocytes Uniquely Predicts Differential Clinical Responses to Glucagon Analog Agonist Molecules

1622-P: Complex Mechanisms Underlie the Antidiabetic Effect of Tempol in Experimentally Induced Diabetes Mellitus

Probing β-Cell Biology in Space and Time

From Pancreatic β-Cell Gene Networks to Novel Therapies for Type 1 Diabetes

185-OR: Longitudinal Changes in KidneyIntelX and Association with Progressive Decline in Kidney Function in the CANVAS Trial

1258-P: Il-1ß-Induced Transcription of Nf-kB Target Genes Is Repressed by Bet Bromodomain Inhibitors in Pancreatic ß-Cells

Single Molecule–Based fliFISH Validates Radial and Heterogeneous Gene Expression Patterns in Pancreatic Islet β-Cells

Activation of dsRNA-Dependent Protein Kinase R by miR-378 Sustains Metabolic Inflammation in Hepatic Insulin Resistance

Next-Generation HLA Sequence Analysis Uncovers Seven HLA-DQ Amino Acid Residues and Six Motifs Resistant to Childhood Type 1 Diabetes

1670-P: Enalapril Maleate, Angiotensin-Converting Enzyme Inhibitor, Suppresses the Expression of the MHC Molecules in Mucosal Cells of the Small Intestine Leading to the Delayed Onset of Autoimmune Type 1 Diabetes Mellitus in NOD Mice

489-P: Energy Status Could Modulate Autophagy through Colocalizations of Fyn, P53, and Tgm2 in the Renal Tubules In Vivo

2131-P: BET Bromodomain Inhibition Upregulates SIRT1 In Pancreatic ß-Cells

The Local Paracrine Actions of the Pancreatic α-Cell

Single-Cell Analysis of CD4 T Cells in Type 1 Diabetes: From Mouse to Man, How to Perform Mechanistic Studies

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