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Journal Articles

Empagliflozin Treatment Is Associated With Improvements in Cardiac Energetics and Function and Reductions in Myocardial Cellular Volume in Patients With Type 2 Diabetes

Sharmaine Thirunavukarasu, Nicholas Jex, Amrit Chowdhary, Imtiaz Ul Hassan, Sam Straw, Thomas P. Craven, Miroslawa Gorecka, David Broadbent, Peter Swoboda, Klaus K. Witte, Richard M. Cubbon, Hui Xue, Peter Kellman, John P. Greenwood, Sven Plein, Eylem Levelt

Diabetes 2021;70(12):2810–2822

DOI: https://doi.org/10.2337/db21-0270

Published: 05 October 2021

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Meeting Abstracts

323-OR: SGLT2 Inhibition Promotes Myocardial Ketone Utilization in the Normal and Failing Heart

LEIGH GOEDEKE, JI EUN LEE, YINA MA, XIAOYUE HU, JIASHENG ZHANG, JIANYING DONG, KATRINE D. GALSGAARD, NICOLE GUERRERA, SOFIE HAEDERSDAL, XIAN-MAN ZHANG, RACHEL J. PERRY, GARY CLINE, LAWRENCE H. YOUNG, GERALD I. SHULMAN

Diabetes 2021;70(Supplement_1):323-OR

DOI: https://doi.org/10.2337/db21-323-OR

Published: 01 June 2021

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Meeting Abstracts

377-P: Effect of Severe Hypoglycemia on Myocardial Cardiac Function in Type 1 Diabetes

ELKE R. FAHRMANN, LAURA J. ADKINS, RAJAN LAMICHHANE, HENRY DRISCOLL

Diabetes 2021;70(Supplement_1):377-P

DOI: https://doi.org/10.2337/db21-377-P

Published: 01 June 2021

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Meeting Abstracts

379-P: Aldose Reductase Inhibition by AT-001 Prevents Diabetic Cardiomyopathy via Reducing Myocardial Fatty Acid Oxidation Rates

KESHAV GOPAL, QUTUBA G. KARWI, SEYED AMIRHOSSEIN TABATABAEI DAKHILI, CORY S. WAGG, RICCARDO PERFETTI, RAVICHANDRAN RAMASAMY, JOHN R. USSHER, GARY LOPASCHUK

Diabetes 2021;70(Supplement_1):379-P

DOI: https://doi.org/10.2337/db21-379-P

Published: 01 June 2021

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Journal Articles

SGLT2 Inhibition Does Not Affect Myocardial Fatty Acid Oxidation or Uptake, but Reduces Myocardial Glucose Uptake and Blood Flow in Individuals With Type 2 Diabetes: A Randomized Double-Blind, Placebo-Controlled Crossover Trial

Katrine M. Lauritsen, Bent R.R. Nielsen, Lars P. Tolbod, Mogens Johannsen, Jakob Hansen, Troels K. Hansen, Henrik Wiggers, Niels Møller, Lars C. Gormsen, Esben Søndergaard

Diabetes 2021;70(3):800–808

DOI: https://doi.org/10.2337/db20-0921

Published: 17 December 2020

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Journal Articles

Dapagliflozin Suppresses ER Stress and Improves Subclinical Myocardial Function in Diabetes: From Bedside to Bench

Jhih-Yuan Shih, Yu-Wen Lin, Sudeshna Fisch, Juei-Tang Cheng, Nai-Wen Kang, Chon-Seng Hong, Zhih-Cherng Chen, Wei-Ting Chang

Diabetes 2021;70(1):262–267

DOI: https://doi.org/10.2337/db20-0840

Published: 28 October 2020

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Journal Articles

Cardiac Autophagy Deficiency Attenuates ANP Production and Disrupts Myocardial-Adipose Cross Talk, Leading to Increased Fat Accumulation and Metabolic Dysfunction

Erfei Song, Daniel Da Eira, Shailee Jani, Diane Sepa-Kishi, Vivian Vu, Howard Hunter, Mi Lai, Michael B. Wheeler, Rolando B. Ceddia, Gary Sweeney

Diabetes 2021;70(1):51–61

DOI: https://doi.org/10.2337/db19-0762

Published: 12 October 2020

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Journal Articles

Autophagy Inhibition Enables Nrf2 to Exaggerate the Progression of Diabetic Cardiomyopathy in Mice

Huimei Zang, Weiwei Wu, Lei Qi, Wenbin Tan, Prakash Nagarkatti, Mitzi Nagarkatti, Xuejun Wang, Taixing Cui

Diabetes 2020;69(12):2720–2734

DOI: https://doi.org/10.2337/db19-1176

Published: 18 September 2020

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Meeting Abstracts

422-P: Association between Nonalcoholic Fatty Liver Disease and Diastolic Myocardial Dysfunction and Myocardial Insulin Resistance in Patients with Type 2 Diabetes

YOUNG-EUN KIM, MINYOUNG LEE, SEJEONG LEE, BONG-SOO CHA, EUN SEOK KANG

Diabetes 2020;69(Supplement_1):422-P

DOI: https://doi.org/10.2337/db20-422-P

Published: 01 June 2020

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Meeting Abstracts

87-OR: NF Kappa B Expression Is Related to Diabetes and Impaired Respiratory Capacity of Human Ventricular Myocardium

ELRIC ZWECK, DANIEL SCHEIBER, TOMAS JELENIK, PATRICK HORN, DOMINIK PESTA, DIRK LASSNER, HEINZ-PETER SCHULTHEISS, UDO BOEKEN, PAYAM AKHYARI, ARTUR LICHTENBERG, MALTE KELM, MICHAEL RODEN, RALF WESTENFELD, JULIA SZENDROEDI

Diabetes 2020;69(Supplement_1):87-OR

DOI: https://doi.org/10.2337/db20-87-OR

Published: 01 June 2020

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Meeting Abstracts

1888-P: Activation of Myocardial Mitochondrial Akt1 Remotely Modulated Body Composition and Adiposity through LXR/RXR Signaling

YU-HAN CHEN, ALBERT TA, EMILY TOM, YUMAY CHEN, PING H. WANG

Diabetes 2020;69(Supplement_1):1888-P

DOI: https://doi.org/10.2337/db20-1888-P

Published: 01 June 2020

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Meeting Abstracts

1279-P: Early Myocardial Structural Alterations in Youth with Type 1 Diabetes: Preliminary Results from the Cardea Study

SOREN HARNOIS-LEBLANC, VANESSA MCNEALIS, MATTHIAS G. FRIEDRICH, ANDRAEA VAN HULST, ANNE MONIQUE NUYT, JEAN-LUC BIGRAS, TRACIE A. BARNETT, ANDREA BENEDETTI, VICKY DRAPEAU, MÉLANIE HENDERSON

Diabetes 2020;69(Supplement_1):1279-P

DOI: https://doi.org/10.2337/db20-1279-P

Published: 01 June 2020

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Journal Articles

Maintaining Myocardial Glucose Utilization in Diabetic Cardiomyopathy Accelerates Mitochondrial Dysfunction

Adam R. Wende, John C. Schell, Chae-Myeong Ha, Mark E. Pepin, Oleh Khalimonchuk, Hansjörg Schwertz, Renata O. Pereira, Manoja K. Brahma, Joseph Tuinei, Ariel Contreras-Ferrat, Li Wang, Chase A. Andrizzi, Curtis D. Olsen, Wayne E. Bradley, Louis J. Dell’Italia, Wolfgang H. Dillmann, Sheldon E. Litwin, E. Dale Abel

Diabetes 2020;69(10):2094–2111

DOI: https://doi.org/10.2337/db19-1057

Published: 04 May 2020

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Journal Articles

Cardiac Magnetic Resonance Myocardial Feature Tracking for Optimized Risk Assessment After Acute Myocardial Infarction in Patients With Type 2 Diabetes

Sören J. Backhaus, Johannes T. Kowallick, Thomas Stiermaier, Torben Lange, Jenny-Lou Navarra, Alexander Koschalka, Ruben Evertz, Joachim Lotz, Shelby Kutty, Gerd Hasenfuß, Matthias Gutberlet, Holger Thiele, Ingo Eitel, Andreas Schuster

Diabetes 2020;69(7):1540–1548

DOI: https://doi.org/10.2337/db20-0001

Published: 24 April 2020

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Journal Articles

Empagliflozin Ameliorates Obesity-Related Cardiac Dysfunction by Regulating Sestrin2-Mediated AMPK-mTOR Signaling and Redox Homeostasis in High-Fat Diet–Induced Obese Mice

Xiaodong Sun, Fang Han, Qingguo Lu, Xuan Li, Di Ren, Jingwen Zhang, Ying Han, Yang K. Xiang, Ji Li

Diabetes 2020;69(6):1292–1305

DOI: https://doi.org/10.2337/db19-0991

Published: 31 March 2020

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Journal Articles

Disturbed Fatty Acid Oxidation, Endoplasmic Reticulum Stress, and Apoptosis in Left Ventricle of Patients With Type 2 Diabetes

Marko Ljubkovic, Melanie Gressette, Cristijan Bulat, Marija Cavar, Darija Bakovic, Damir Fabijanic, Ivica Grkovic, Christophe Lemaire, Jasna Marinovic

Diabetes 2019;68(10):1924–1933

DOI: https://doi.org/10.2337/db19-0423

Published: 07 August 2019

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Includes: Supplementary data

Meeting Abstracts

414-P: Insulin Secretion Capacity Relates to Human Ventricular Myocardial Mitochondrial Function

ELRIC ZWECK, DANIEL SCHEIBER, SOPHIE ALBERMANN, JULIUS BORGER, TOMAS JELENIK, DOMINIK PESTA, PATRICK HORN, UDO BOEKEN, PAYAM AKHYARI, MALTE KELM, MICHAEL RODEN, RALF WESTENFELD, JULIA SZENDROEDI

Diabetes 2019;68(Supplement_1):414-P

DOI: https://doi.org/10.2337/db19-414-P

Published: 01 June 2019

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Meeting Abstracts

1934-P: Acute Hyperglycemia Increases Perfusion of Skeletal and Cardiac Muscle in Healthy Subjects

WILLIAM B. HORTON, LINDA JAHN, LEE HARTLINE, JAMES T. PATRIE, EUGENE BARRETT

Diabetes 2019;68(Supplement_1):1934-P

DOI: https://doi.org/10.2337/db19-1934-P

Published: 01 June 2019

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Journal Articles

Insulin Resistance and Vulnerability to Cardiac Ischemia

Tomas Jelenik, Ulrich Flögel, Elisa Álvarez-Hernández, Daniel Scheiber, Elric Zweck, Zhaoping Ding, Maik Rothe, Lucia Mastrototaro, Vivien Kohlhaas, Jörg Kotzka, Birgit Knebel, Dirk Müller-Wieland, Sarah Moellendorf, Axel Gödecke, Malte Kelm, Ralf Westenfeld, Michael Roden, Julia Szendroedi

Diabetes 2018;67(12):2695–2702

DOI: https://doi.org/10.2337/db18-0449

Published: 26 September 2018

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Includes: Supplementary data

Meeting Abstracts

Both Diabetes Duration and Cumulative Hyperglycemic Exposure Promote Myocardial Fibrosis and Increase Coronary Microvascular Resistance Evaluated by Comprehensive Myocardial CT Perfusion

SHENGPU CHOU, MIKIKO HARAGUCHI, YUSUKE FUJINO, NOBUO TOMIZAWA, TAKESHI NOJO, SUNAO NAKAMURA

Diabetes 2018;67(Supplement_1):163-OR

DOI: https://doi.org/10.2337/db18-163-OR

Published: 01 July 2018

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NARROW

Empagliflozin Treatment Is Associated With Improvements in Cardiac Energetics and Function and Reductions in Myocardial Cellular Volume in Patients With Type 2 Diabetes

323-OR: SGLT2 Inhibition Promotes Myocardial Ketone Utilization in the Normal and Failing Heart

377-P: Effect of Severe Hypoglycemia on Myocardial Cardiac Function in Type 1 Diabetes

379-P: Aldose Reductase Inhibition by AT-001 Prevents Diabetic Cardiomyopathy via Reducing Myocardial Fatty Acid Oxidation Rates

SGLT2 Inhibition Does Not Affect Myocardial Fatty Acid Oxidation or Uptake, but Reduces Myocardial Glucose Uptake and Blood Flow in Individuals With Type 2 Diabetes: A Randomized Double-Blind, Placebo-Controlled Crossover Trial

Dapagliflozin Suppresses ER Stress and Improves Subclinical Myocardial Function in Diabetes: From Bedside to Bench

Cardiac Autophagy Deficiency Attenuates ANP Production and Disrupts Myocardial-Adipose Cross Talk, Leading to Increased Fat Accumulation and Metabolic Dysfunction

Autophagy Inhibition Enables Nrf2 to Exaggerate the Progression of Diabetic Cardiomyopathy in Mice

422-P: Association between Nonalcoholic Fatty Liver Disease and Diastolic Myocardial Dysfunction and Myocardial Insulin Resistance in Patients with Type 2 Diabetes

87-OR: NF Kappa B Expression Is Related to Diabetes and Impaired Respiratory Capacity of Human Ventricular Myocardium

1888-P: Activation of Myocardial Mitochondrial Akt1 Remotely Modulated Body Composition and Adiposity through LXR/RXR Signaling

1279-P: Early Myocardial Structural Alterations in Youth with Type 1 Diabetes: Preliminary Results from the Cardea Study

Maintaining Myocardial Glucose Utilization in Diabetic Cardiomyopathy Accelerates Mitochondrial Dysfunction

Cardiac Magnetic Resonance Myocardial Feature Tracking for Optimized Risk Assessment After Acute Myocardial Infarction in Patients With Type 2 Diabetes

Empagliflozin Ameliorates Obesity-Related Cardiac Dysfunction by Regulating Sestrin2-Mediated AMPK-mTOR Signaling and Redox Homeostasis in High-Fat Diet–Induced Obese Mice

Disturbed Fatty Acid Oxidation, Endoplasmic Reticulum Stress, and Apoptosis in Left Ventricle of Patients With Type 2 Diabetes

414-P: Insulin Secretion Capacity Relates to Human Ventricular Myocardial Mitochondrial Function

1934-P: Acute Hyperglycemia Increases Perfusion of Skeletal and Cardiac Muscle in Healthy Subjects

Insulin Resistance and Vulnerability to Cardiac Ischemia

Both Diabetes Duration and Cumulative Hyperglycemic Exposure Promote Myocardial Fibrosis and Increase Coronary Microvascular Resistance Evaluated by Comprehensive Myocardial CT Perfusion

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