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Journal Articles

Obesity Enables NLRP3 Activation and Induces Myocardial Fibrosis via Hyperacetylation of HADHa

Yan Deng, Xin Liu, Min Xie, Rui Zhao, Liwei Ji, Kuo Tang, Wei Yang, Wei Ou, Maodi Xie, Tao Li

Diabetes 2023;72(11):1597–1608

https://doi.org/10.2337/db23-0264

Published: 25 August 2023

View article titled, Obesity Enables NLRP3 Activation and Induces Myocardial Fibrosis via Hyperacetylation of HADHa

Meeting Abstracts

29-OR: Diabetic Wound Keratinocytes Induce Macrophage JMJD3–Mediated Nlrp3 Expression

SONYA WOLF-FORTUNE, JADIE MOON, AMRITA JOSHI, PURBA MAZUMDER, EMILY BARRETT, KEVIN D. MANGUM, KATHERINE GALLAGHER

Diabetes 2023;72(Supplement_1):29-OR

https://doi.org/10.2337/db23-29-OR

Published: 20 June 2023

View article titled, 29-OR: Diabetic Wound Keratinocytes Induce Macrophage JMJD3–Mediated Nlrp3 Expression

Meeting Abstracts

1482-P: Neutrophil Inflammasome Is Activated in Diabetes and Contributes to the Exacerbated NETosis

LIANG DE WANG, RINKOO DALAN, SIU LING WONG

Diabetes 2023;72(Supplement_1):1482-P

https://doi.org/10.2337/db23-1482-P

Published: 20 June 2023

View article titled, 1482-P: Neutrophil Inflammasome Is Activated in Diabetes and Contributes to the Exacerbated NETosis

Meeting Abstracts

1570-P: Myeloid-Specific Inactivation of Basp1 Protects Mice from Diet-Induced NASH through Attenuating NLRP3 Inflammasome Activation

ZIYI MENG, LINKANG ZHOU, SUNGKI HONG, TONGYU LIU, XIAOXUE QIU, ZHIMIN CHEN, SIMING LI, KEN INOKI, JIANDIE LIN

Diabetes 2023;72(Supplement_1):1570-P

https://doi.org/10.2337/db23-1570-P

Published: 20 June 2023

View article titled, 1570-P: Myeloid-Specific Inactivation of Basp1 Protects Mice from Diet-Induced NASH through Attenuating NLRP3 Inflammasome Activation

Journal Articles

Hematopoietic NLRP3 and AIM2 Inflammasomes Promote Diabetes-Accelerated Atherosclerosis, but Increased Necrosis Is Independent of Pyroptosis

Cheng-Chieh Hsu, Trevor P. Fidler, Jenny E. Kanter, Vishal Kothari, Farah Kramer, Jingjing Tang, Alan R. Tall, Karin E. Bornfeldt

Diabetes 2023;72(7):999–1011

https://doi.org/10.2337/db22-0962

Published: 21 April 2023

View article titled, Hematopoietic NLRP3 and AIM2 Inflammasomes Promote Diabetes-Accelerated Atherosclerosis, but Increased Necrosis Is Independent of Pyroptosis

Journal Articles

Targeting Pancreatic Islet NLRP3 Improves Islet Graft Revascularization

Selina Wrublewsky, Thimoteus Speer, Lisa Nalbach, Anne S. Boewe, Mandy Pack, Dalia Alansary, Leticia P. Roma, Markus D.A. Hoffmann, Beate M. Schmitt, Andrea Weinzierl, Michael D. Menger, Matthias W. Laschke, Emmanuel Ampofo

Diabetes 2022;71(8):1706–1720

https://doi.org/10.2337/db21-0851

Published: 21 August 2022

View article titled, Targeting Pancreatic Islet NLRP3 Improves Islet Graft Revascularization

Journal Articles

In This Issue of Diabetes

Max Bingham, PhD

Diabetes 2022;71(8):1599–1600

https://doi.org/10.2337/db22-ti08

Published: 21 August 2022

View article titled, In This Issue of <em>Diabetes</em>

Meeting Abstracts

77-OR: Native LDL Upregulate the NLRP3 Inflammasome in Human Adipose Tissue: A Mechanism for Higher Risk for Type 2 Diabetes in Subjects with HyperapoB

SIMON BISSONNETTE, VALÉRIE LAMANTIA, YANNICK CYR, MARIE DEVAUX, RÉMI RABASA-LHORET, MICHEL CHRETIEN, MAYA SALEH, MAY FARAJ

Diabetes 2022;71(Supplement_1):77-OR

https://doi.org/10.2337/db22-77-OR

Published: 01 June 2022

View article titled, 77-OR: Native LDL Upregulate the NLRP3 Inflammasome in Human Adipose Tissue: A Mechanism for Higher Risk for Type 2 Diabetes in Subjects with HyperapoB

Journal Articles

Specific NLRP3 Inhibition Protects Against Diabetes-Associated Atherosclerosis

Arpeeta Sharma, Judy S.Y. Choi, Nada Stefanovic, Annas Al-Sharea, Daniel S. Simpson, Nigora Mukhamedova, Karin Jandeleit-Dahm, Andrew J. Murphy, Dmitri Sviridov, James E. Vince, Rebecca H. Ritchie, Judy B. de Haan

Diabetes 2021;70(3):772–787

https://doi.org/10.2337/db20-0357

Published: 15 December 2020

View article titled, Specific NLRP3 Inhibition Protects Against Diabetes-Associated Atherosclerosis

Meeting Abstracts

566-P: Sulodexide Suppresses NLRP3 Inflammasome Activation via NOX4/ROS Signaling in the Retinal Microvasculature

TING LI, XUEMIN HE, RONGDONG PENG, XIANAN FU, GUOJUN SHI, YANMING CHEN

Diabetes 2020;69(Supplement_1):566-P

https://doi.org/10.2337/db20-566-P

Published: 01 June 2020

View article titled, 566-P: Sulodexide Suppresses NLRP3 Inflammasome Activation via NOX4/ROS Signaling in the Retinal Microvasculature

Meeting Abstracts

568-P: ATF4 Regulates the Inflammatory Responses via the Modulation of NLRP3 Inflammasome in Diabetic Retinopathy

TING LI, XUEMIN HE, RONGDONG PENG, RONG GAO, GUOJUN SHI, YANMING CHEN

Diabetes 2020;69(Supplement_1):568-P

https://doi.org/10.2337/db20-568-P

Published: 01 June 2020

View article titled, 568-P: ATF4 Regulates the Inflammatory Responses via the Modulation of NLRP3 Inflammasome in Diabetic Retinopathy

Meeting Abstracts

479-P: Inhibition of the NLRP3 Inflammasome by MCC950 Accelerates Renal Injury in Diabetes Model

JAKOB A. ØSTERGAARD, JAY C. JHA, ARPEETA SHARMA, AOZHI DAI, MARK E. COOPER, JUDY B. DE HAAN, KARIN JANDELEIT-DAHM

Diabetes 2020;69(Supplement_1):479-P

https://doi.org/10.2337/db20-479-P

Published: 01 June 2020

View article titled, 479-P: Inhibition of the NLRP3 Inflammasome by MCC950 Accelerates Renal Injury in Diabetes Model

Meeting Abstracts

514-P: Adaptive Downregulation of NLRP3 Inflammasome Expression in Human Renal Tubular Epithelia in the Hyperglycemic and Hyperuricemic Culture

CHEN CIYING, JIANMIN RAN, CHUPING CHEN, PING ZHU, RONGSHAO TAN, YAN LIU

Diabetes 2020;69(Supplement_1):514-P

https://doi.org/10.2337/db20-514-P

Published: 01 June 2020

View article titled, 514-P: Adaptive Downregulation of NLRP3 Inflammasome Expression in Human Renal Tubular Epithelia in the Hyperglycemic and Hyperuricemic Culture

Meeting Abstracts

365-OR: The NLRP3 Inflammasome Mediates Early Beta-Cell Dysfunction Triggered by Islet Amyloid

HEATHER C. DENROCHE, NAHAE KIM, KIANA YAU, DOMINIKA NACKIEWICZ, PAUL C. ORBAN, IMELDA SUEN, CAMERON B. VERCHERE

Diabetes 2019;68(Supplement_1):365-OR

https://doi.org/10.2337/db19-365-OR

Published: 01 June 2019

View article titled, 365-OR: The NLRP3 Inflammasome Mediates Early Beta-Cell Dysfunction Triggered by Islet Amyloid

Meeting Abstracts

508-P: Gemigliptin Ameliorates Renal Fibrosis by Attenuating NLRP3-Mediated Inflammation in a Murine Model

GWONSOO JUNG, YEON-KYUNG CHOI, JUNG BEOM SEO, SUNG DON PARK, NAYOUNG KIM, MIN-JI KIM, JUNG-GUK KIM, IN-KYU LEE, KEUN-GYU PARK

Diabetes 2019;68(Supplement_1):508-P

https://doi.org/10.2337/db19-508-P

Published: 01 June 2019

View article titled, 508-P: Gemigliptin Ameliorates Renal Fibrosis by Attenuating NLRP3-Mediated Inflammation in a Murine Model

Meeting Abstracts

603-P: Circulating Inflammatory Cells and Inflammasome Activation in Diabetics with Diabetic Retinopathy (DR)

MARIANA D. DUPONT, ANA LEDA LONGHINI, GOPALKRISHNA SREEJIT, RAM PRASAD, PRABHAKARA NAGAREDDY, MARIA B. GRANT

Diabetes 2019;68(Supplement_1):603-P

https://doi.org/10.2337/db19-603-P

Published: 01 June 2019

View article titled, 603-P: Circulating Inflammatory Cells and Inflammasome Activation in Diabetics with Diabetic Retinopathy (DR)

Meeting Abstracts

248-LB: Deficiency of APPL1 in Macrophages Triggers Adipose Tissue Inflammation and Insulin Resistance by Potentiating NLRP3 Inflammasome Activation

KELVIN K.L. WU, AIMIN XU, KENNETH K. CHENG

Diabetes 2019;68(Supplement_1):248-LB

https://doi.org/10.2337/db19-248-LB

Published: 01 June 2019

View article titled, 248-LB: Deficiency of APPL1 in Macrophages Triggers Adipose Tissue Inflammation and Insulin Resistance by Potentiating NLRP3 Inflammasome Activation

Journal Articles

Monosodium Urate Contributes to Retinal Inflammation and Progression of Diabetic Retinopathy

Menaka C. Thounaojam, Annalisa Montemari, Folami L. Powell, Prerana Malla, Diana R. Gutsaeva, Alessandra Bachettoni, Guido Ripandelli, Andrea Repossi, Amany Tawfik, Pamela M. Martin, Francesco Facchiano, Manuela Bartoli

Diabetes 2019;68(5):1014–1025

https://doi.org/10.2337/db18-0912

Published: 06 February 2019

View article titled, Monosodium Urate Contributes to Retinal Inflammation and Progression of Diabetic Retinopathy

Includes: Supplementary data

Journal Articles

NLRP3 Promotes Diabetic Bladder Dysfunction and Changes in Symptom-Specific Bladder Innervation

Francis M. Hughes, Jr., Nathan A. Hirshman, Brian M. Inouye, Huixia Jin, Eloise W. Stanton, Chloe E. Yun, Leah G. Davis, Jonathan C. Routh, J. Todd Purves

Diabetes 2019;68(2):430–440

https://doi.org/10.2337/db18-0845

Published: 13 November 2018

View article titled, NLRP3 Promotes Diabetic Bladder Dysfunction and Changes in Symptom-Specific Bladder Innervation

Meeting Abstracts

Sweet-Taste Receptors Mediated ROS-NLRP3 Inflammasome Signaling Activation—Implications for Diabetic Nephropathy

LUPING ZHOU, WEI HUANG, YONG XU, CHENLIN GAO

Diabetes 2018;67(Supplement_1):499-P

https://doi.org/10.2337/db18-499-P

Published: 01 July 2018

View article titled, Sweet-Taste Receptors Mediated ROS-NLRP3 Inflammasome Signaling Activation—Implications for Diabetic Nephropathy

NARROW

Obesity Enables NLRP3 Activation and Induces Myocardial Fibrosis via Hyperacetylation of HADHa

29-OR: Diabetic Wound Keratinocytes Induce Macrophage JMJD3–Mediated Nlrp3 Expression

1482-P: Neutrophil Inflammasome Is Activated in Diabetes and Contributes to the Exacerbated NETosis

1570-P: Myeloid-Specific Inactivation of Basp1 Protects Mice from Diet-Induced NASH through Attenuating NLRP3 Inflammasome Activation

Hematopoietic NLRP3 and AIM2 Inflammasomes Promote Diabetes-Accelerated Atherosclerosis, but Increased Necrosis Is Independent of Pyroptosis

Targeting Pancreatic Islet NLRP3 Improves Islet Graft Revascularization

In This Issue of Diabetes

77-OR: Native LDL Upregulate the NLRP3 Inflammasome in Human Adipose Tissue: A Mechanism for Higher Risk for Type 2 Diabetes in Subjects with HyperapoB

Specific NLRP3 Inhibition Protects Against Diabetes-Associated Atherosclerosis

566-P: Sulodexide Suppresses NLRP3 Inflammasome Activation via NOX4/ROS Signaling in the Retinal Microvasculature

568-P: ATF4 Regulates the Inflammatory Responses via the Modulation of NLRP3 Inflammasome in Diabetic Retinopathy

479-P: Inhibition of the NLRP3 Inflammasome by MCC950 Accelerates Renal Injury in Diabetes Model

514-P: Adaptive Downregulation of NLRP3 Inflammasome Expression in Human Renal Tubular Epithelia in the Hyperglycemic and Hyperuricemic Culture

365-OR: The NLRP3 Inflammasome Mediates Early Beta-Cell Dysfunction Triggered by Islet Amyloid

508-P: Gemigliptin Ameliorates Renal Fibrosis by Attenuating NLRP3-Mediated Inflammation in a Murine Model

603-P: Circulating Inflammatory Cells and Inflammasome Activation in Diabetics with Diabetic Retinopathy (DR)

248-LB: Deficiency of APPL1 in Macrophages Triggers Adipose Tissue Inflammation and Insulin Resistance by Potentiating NLRP3 Inflammasome Activation

Monosodium Urate Contributes to Retinal Inflammation and Progression of Diabetic Retinopathy

NLRP3 Promotes Diabetic Bladder Dysfunction and Changes in Symptom-Specific Bladder Innervation

Sweet-Taste Receptors Mediated ROS-NLRP3 Inflammasome Signaling Activation—Implications for Diabetic Nephropathy

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