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Journal Articles

Atf4 Protects Islet β-Cell Identity and Function Under Acute Glucose-Induced Stress but Promotes β-Cell Failure in the Presence of Free Fatty Acid

Mahircan Yagan, Sadia Najam, Ruiying Hu, Yu Wang, Mathew T. Dickerson, Prasanna K. Dadi, Yanwen Xu, Alan J. Simmons, Roland Stein, Christopher M. Adams, David A. Jacobson, Ken S. Lau, Qi Liu, Guoqiang Gu

Diabetes 2025;74(5):838–849

https://doi.org/10.2337/db24-0360

Published: 03 February 2025

View articletitled, Atf4 Protects Islet β-Cell Identity and Function Under Acute Glucose-Induced Stress but Promotes β-Cell Failure in the Presence of Free Fatty Acid

Journal Articles

Association of Serum Very-Long-Chain Saturated Fatty Acids With Changes in Insulin Sensitivity and β-Cell Function: The Prospective Metabolism and Islet Cell Evaluation (PROMISE) Cohort

Kira Zhi Hua Lai, Zhila Semnani-Azad, Beatrice A. Boucher, Ravi Retnakaran, Stewart B. Harris, Vasanti Malik, Richard P. Bazinet, Anthony J. Hanley

Diabetes 2023;72(11):1664–1670

https://doi.org/10.2337/db22-1050

Published: 16 August 2023

View articletitled, Association of Serum Very-Long-Chain Saturated Fatty Acids With Changes in Insulin Sensitivity and β-Cell Function: The Prospective Metabolism and Islet Cell Evaluation (PROMISE) Cohort

Journal Articles

Glucose Controls Glucagon Secretion by Regulating Fatty Acid Oxidation in Pancreatic α-Cells

Sarah L. Armour, Alexander Frueh, Margarita V. Chibalina, Haiqiang Dou, Lidia Argemi-Muntadas, Alexander Hamilton, Georgios Katzilieris-Petras, Peter Carmeliet, Benjamin Davies, Thomas Moritz, Lena Eliasson, Patrik Rorsman, Jakob G. Knudsen

Diabetes 2023;72(10):1446–1459

https://doi.org/10.2337/db23-0056

Published: 26 July 2023

View articletitled, Glucose Controls Glucagon Secretion by Regulating Fatty Acid Oxidation in Pancreatic α-Cells

Meeting Abstracts

1216-P: Effects of Aging after Age 65 on Glucose Tolerance, Insulin Sensitivity, and ß-Cell Function in Japanese—The Bunkyo Health Study

HITOSHI NAITO, HIDEYOSHI KAGA, YUKI SOMEYA, HIROKI TABATA, SAORI KAKEHI, YASUYO YOSHIZAWA, MAI KIYA, TSUBASA TAJIMA, NAOAKI ITO, MOTONORI SATO, SATOSHI KADOWAKI, TAKASHI FUNAYAMA, HIROTAKA WATADA, YOSHIFUMI TAMURA

Diabetes 2023;72(Supplement_1):1216-P

https://doi.org/10.2337/db23-1216-P

Published: 20 June 2023

View articletitled, 1216-P: Effects of Aging after Age 65 on Glucose Tolerance, Insulin Sensitivity, and ß-Cell Function in Japanese—The Bunkyo Health Study

Meeting Abstracts

1779-P: Lipotoxicity-Induced Beta-Cell Small Extracellular Vesicles Promote Beta-Cell Functional Failure through Activation of the TGFß/Smad3 Pathway

ABHISHEK ROY, ALEXANDRA HOFF, TRACY K. HER, KAMALNATH SANKARAN RAJAGOPALAN, DANIELA D. MALTAIS, ALEKSEY MATVEYENKO, NAUREEN JAVEED

Diabetes 2023;72(Supplement_1):1779-P

https://doi.org/10.2337/db23-1779-P

Published: 20 June 2023

View articletitled, 1779-P: Lipotoxicity-Induced Beta-Cell Small Extracellular Vesicles Promote Beta-Cell Functional Failure through Activation of the TGFß/Smad3 Pathway

Meeting Abstracts

1539-P: Effects of Free Fatty Acids (FFA) on Central Regulation of Glucose Metabolism

MONICA FABIOLA NOGUEIRA CORDEIRO, VANESSA H. ROUTH, ANJALI MANAVALAN, PRIYANKA M. MATHIAS, CAROLINE E. BOYLE, ANA C. RIOS CHEN, NANCY JIANG, NAOMI FRIEDMAN, YUNUS EMRE DEMIRHAN, MEREDITH HAWKINS, KEHAO ZHANG

Diabetes 2023;72(Supplement_1):1539-P

https://doi.org/10.2337/db23-1539-P

Published: 20 June 2023

View articletitled, 1539-P: Effects of Free Fatty Acids (FFA) on Central Regulation of Glucose Metabolism

Meeting Abstracts

1571-P: Plasma FGF5 Concentration Correlates Better with Hepatic Steatosis, Blood Glucose, and Specific Plasma Free Fatty Acids than with Other Tissue Fat Accumulation

DAE HO LEE, IE BYUNG PARK

Diabetes 2023;72(Supplement_1):1571-P

https://doi.org/10.2337/db23-1571-P

Published: 20 June 2023

View articletitled, 1571-P: Plasma FGF5 Concentration Correlates Better with Hepatic Steatosis, Blood Glucose, and Specific Plasma Free Fatty Acids than with Other Tissue Fat Accumulation

Meeting Abstracts

1516-P: Free Fatty Acid and Amino Acid Predictors of Response to Metformin in Polycystic Ovary Syndrome

ALICE Y. CHANG, ANEESH K. ASOKAN, DHANANJAY SAKRIKAR, ANTIGONI LALIA, IAN R. LANZA, MAI PETTERSON, K. SREEKUMARAN NAIR

Diabetes 2023;72(Supplement_1):1516-P

https://doi.org/10.2337/db23-1516-P

Published: 20 June 2023

View articletitled, 1516-P: Free Fatty Acid and Amino Acid Predictors of Response to Metformin in Polycystic Ovary Syndrome

Journal Articles

Total Postprandial Hepatic Nonesterified and Dietary Fatty Acid Uptake Is Increased and Insufficiently Curbed by Adipose Tissue Fatty Acid Trapping in Prediabetes With Overweight

Run Zhou Ye, Émilie Montastier, Christophe Noll, Frédérique Frisch, Mélanie Fortin, Lucie Bouffard, Serge Phoenix, Brigitte Guérin, Éric E. Turcotte, André C. Carpentier

Diabetes 2022;71(9):1891–1901

https://doi.org/10.2337/db21-1097

Published: 24 June 2022

View articletitled, Total Postprandial Hepatic Nonesterified and Dietary Fatty Acid Uptake Is Increased and Insufficiently Curbed by Adipose Tissue Fatty Acid Trapping in Prediabetes With Overweight

Meeting Abstracts

1325-P: Modulation of Overnight Free Fatty Acid and Glucose Concentrations and Their Effect on Postprandial Islet Function and Glucose Metabolism

ANDREW A. WELCH, DANIEL SCHEMBRI WISMAYER, AOIFE M. EGAN, RAHELE A. FARAHANI, MARCELLO C. LAURENTI, CLAUDIO COBELLI, CHIARA DALLA MAN, ADRIAN VELLA

Diabetes 2022;71(Supplement_1):1325-P

https://doi.org/10.2337/db22-1325-P

Published: 01 June 2022

View articletitled, 1325-P: Modulation of Overnight Free Fatty Acid and Glucose Concentrations and Their Effect on Postprandial Islet Function and Glucose Metabolism

Meeting Abstracts

1313-P: Short-Chain Fatty Acids Decrease Food Intake through Free Fatty Acid Receptors in the Brain

PEI LUO, PINGWEN XU, BING FENG, HUI YE, NIRALI PATEL, BRIAN T. LAYDEN, YANLIN HE, MAYA KOTA, DEVIN DIXIT, NIMISHA ANTONY, LESLIE CARRILLO-SÁENZ, VALERIA C. TORRES IRIZARRY, LUCAS IBRAHIMI, SARAH SCHAUL

Diabetes 2022;71(Supplement_1):1313-P

https://doi.org/10.2337/db22-1313-P

Published: 01 June 2022

View articletitled, 1313-P: Short-Chain Fatty Acids Decrease Food Intake through Free Fatty Acid Receptors in the Brain

Meeting Abstracts

1411-P: Increased 24-Hour Plasma Free Fatty Acids in People with Obesity and Prediabetes

MAX C. PETERSEN, SARAH S. FARABI, GORDON SMITH, SAMUEL KLEIN

Diabetes 2022;71(Supplement_1):1411-P

https://doi.org/10.2337/db22-1411-P

Published: 01 June 2022

View articletitled, 1411-P: Increased 24-Hour Plasma Free Fatty Acids in People with Obesity and Prediabetes

Meeting Abstracts

1379-P: Combination of FGF21 and ß3-Adrenergic Treatment in Obese Mice

PETR ZOUHAR

Diabetes 2022;71(Supplement_1):1379-P

https://doi.org/10.2337/db22-1379-P

Published: 01 June 2022

View articletitled, 1379-P: Combination of FGF21 and ß3-Adrenergic Treatment in Obese Mice

Meeting Abstracts

178-OR: Lipotoxicity Stimulates ß-Cell Extracellular Vesicle Secretion Which Induces ß-Cell Dysfunction and Perturbs ß-Cell Transcriptional Identity

TRACY K. HER, MATTHEW BROWN, ALEKSEY MATVEYENKO, NAUREEN JAVEED

Diabetes 2021;70(Supplement_1):178-OR

https://doi.org/10.2337/db21-178-OR

Published: 01 June 2021

View articletitled, 178-OR: Lipotoxicity Stimulates ß-Cell Extracellular Vesicle Secretion Which Induces ß-Cell Dysfunction and Perturbs ß-Cell Transcriptional Identity

Meeting Abstracts

1186-P: Mechanisms of Glucose Intolerance Induced by Excess Triglycerides and Free Fatty Acids

DOMENICO TRICO, BRENNO D. ASTIARRAGA, MARTA SEGHIERI, ALESSANDRO MENGOZZI, SIMONA BALDI, ANDREA MARI, ANDREA NATALI

Diabetes 2021;70(Supplement_1):1186-P

https://doi.org/10.2337/db21-1186-P

Published: 01 June 2021

View articletitled, 1186-P: Mechanisms of Glucose Intolerance Induced by Excess Triglycerides and Free Fatty Acids

Meeting Abstracts

440-P: Dual Long-Term Effects of Free Fatty Acid on Human Endothelial Barrier In Vitro Are Mediated by NO, Mitochondrial ROS, and Dicarbonyl Stress

MIKHAIL SAMSONOV, NIKITA PODKUYCHENKO, ASKER Y. KHAPCHAEV, TATIANA VLASIK, VADIM LANKIN, MAXIM SKULACHEV, IURII STAFEEV, ALEXANDER V. VOROTNIKOV, MARINA V. SHESTAKOVA, VLADIMIR P. SHIRINSKY

Diabetes 2021;70(Supplement_1):440-P

https://doi.org/10.2337/db21-440-P

Published: 01 June 2021

View articletitled, 440-P: Dual Long-Term Effects of Free Fatty Acid on Human Endothelial Barrier In Vitro Are Mediated by NO, Mitochondrial ROS, and Dicarbonyl Stress

Meeting Abstracts

107-OR: Six-Day Subcutaneous GIP Infusion Increases Circulating Free Fatty Acids without Altering the Adipose Tissue Transcriptome, Adipocyte GIP Receptor Levels, or Circulating Inflammation Markers in Patients with Type 1 Diabetes

SEBASTIAN M. NGUYEN HEIMBÜRGER, BJØRN HOE, CHRIS N. NIELSEN, BOLETTE HARTMANN, JENS J. HOLST, FLEMMING DELA, ANNE JULIE OVERGAARD, JOACHIM STØRLING, TINA VILSBØLL, THOMAS F. DEJGAARD, CHARLES PYKE, MIKKEL B. CHRISTENSEN, FILIP K. KNOP

Diabetes 2021;70(Supplement_1):107-OR

https://doi.org/10.2337/db21-107-OR

Published: 01 June 2021

View articletitled, 107-OR: Six-Day Subcutaneous GIP Infusion Increases Circulating Free Fatty Acids without Altering the Adipose Tissue Transcriptome, Adipocyte GIP Receptor Levels, or Circulating Inflammation Markers in Patients with Type 1 Diabetes

Meeting Abstracts

128-LB: Effects of Glucagon Receptor Antagonism (GRA) on Ketone Body Formation during Insulinopenia in Type 1 Diabetes (T1D)

SCHAFER C. BOEDER, DANIEL G. INES, LESLIE CARTER, ERIN R. GIOVANNETTI, DEBRA ARMSTRONG, PAIVI BURKE, JEREMY PETTUS

Diabetes 2020;69(Supplement_1):128-LB

https://doi.org/10.2337/db20-128-LB

Published: 01 June 2020

View articletitled, 128-LB: Effects of Glucagon Receptor Antagonism (GRA) on Ketone Body Formation during Insulinopenia in Type 1 Diabetes (T1D)

Meeting Abstracts

1881-P: Separate Free Fatty Acid (FFA) Pools Are Involved in Muscle Lipid Utilization

LISA S. CHOW, DOUGLAS G. MASHEK, MICHAEL D. JENSEN

Diabetes 2020;69(Supplement_1):1881-P

https://doi.org/10.2337/db20-1881-P

Published: 01 June 2020

View articletitled, 1881-P: Separate Free Fatty Acid (FFA) Pools Are Involved in Muscle Lipid Utilization

Meeting Abstracts

195-LB: Metabolomic Characterization of Laron and Guevara-Rosenbloom Syndromes Using UHPLC-HRMS

VANESSA RUBIO, CASEY A. CHAMBERLAIN, CLIVE WASSERFALL, JAIME GUEVARA-AGUIRRE, ALEXANDRA GUEVARA, ARLAN L. ROSENBLOOM, MARK A. ATKINSON, RICHARD A. YOST, TIMOTHY J. GARRETT

Diabetes 2020;69(Supplement_1):195-LB

https://doi.org/10.2337/db20-195-LB

Published: 01 June 2020

View articletitled, 195-LB: Metabolomic Characterization of Laron and Guevara-Rosenbloom Syndromes Using UHPLC-HRMS

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Atf4 Protects Islet β-Cell Identity and Function Under Acute Glucose-Induced Stress but Promotes β-Cell Failure in the Presence of Free Fatty Acid

Association of Serum Very-Long-Chain Saturated Fatty Acids With Changes in Insulin Sensitivity and β-Cell Function: The Prospective Metabolism and Islet Cell Evaluation (PROMISE) Cohort

Glucose Controls Glucagon Secretion by Regulating Fatty Acid Oxidation in Pancreatic α-Cells

1216-P: Effects of Aging after Age 65 on Glucose Tolerance, Insulin Sensitivity, and ß-Cell Function in Japanese—The Bunkyo Health Study

1779-P: Lipotoxicity-Induced Beta-Cell Small Extracellular Vesicles Promote Beta-Cell Functional Failure through Activation of the TGFß/Smad3 Pathway

1539-P: Effects of Free Fatty Acids (FFA) on Central Regulation of Glucose Metabolism

1571-P: Plasma FGF5 Concentration Correlates Better with Hepatic Steatosis, Blood Glucose, and Specific Plasma Free Fatty Acids than with Other Tissue Fat Accumulation

1516-P: Free Fatty Acid and Amino Acid Predictors of Response to Metformin in Polycystic Ovary Syndrome

Total Postprandial Hepatic Nonesterified and Dietary Fatty Acid Uptake Is Increased and Insufficiently Curbed by Adipose Tissue Fatty Acid Trapping in Prediabetes With Overweight

1325-P: Modulation of Overnight Free Fatty Acid and Glucose Concentrations and Their Effect on Postprandial Islet Function and Glucose Metabolism

1313-P: Short-Chain Fatty Acids Decrease Food Intake through Free Fatty Acid Receptors in the Brain

1411-P: Increased 24-Hour Plasma Free Fatty Acids in People with Obesity and Prediabetes

1379-P: Combination of FGF21 and ß3-Adrenergic Treatment in Obese Mice

178-OR: Lipotoxicity Stimulates ß-Cell Extracellular Vesicle Secretion Which Induces ß-Cell Dysfunction and Perturbs ß-Cell Transcriptional Identity

1186-P: Mechanisms of Glucose Intolerance Induced by Excess Triglycerides and Free Fatty Acids

440-P: Dual Long-Term Effects of Free Fatty Acid on Human Endothelial Barrier In Vitro Are Mediated by NO, Mitochondrial ROS, and Dicarbonyl Stress

107-OR: Six-Day Subcutaneous GIP Infusion Increases Circulating Free Fatty Acids without Altering the Adipose Tissue Transcriptome, Adipocyte GIP Receptor Levels, or Circulating Inflammation Markers in Patients with Type 1 Diabetes

128-LB: Effects of Glucagon Receptor Antagonism (GRA) on Ketone Body Formation during Insulinopenia in Type 1 Diabetes (T1D)

1881-P: Separate Free Fatty Acid (FFA) Pools Are Involved in Muscle Lipid Utilization

195-LB: Metabolomic Characterization of Laron and Guevara-Rosenbloom Syndromes Using UHPLC-HRMS

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