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Meeting Abstracts

1808-PUB: Effective and Durable Stem-Cell-Enabled Therapy of Autoimmune T1DM in Rodents and Dogs Provides the Scientific Basis for the First-in-Human Trial Using I.P. Administered “Neo-Islets,” 3-D Organoids of Allogeneic Islet, and Mesenchymal Stromal Cells—The Omentum Becomes the New Endocrine Pancreas without the Need for Antirejection Drugs

ANNA GOOCH, CHRISTOF WESTENFELDER

Diabetes 2023;72(Supplement_1):1808-PUB

https://doi.org/10.2337/db23-1808-PUB

Published: 23 June 2023

View article titled, 1808-PUB: Effective and Durable Stem-Cell-Enabled Therapy of Autoimmune T1DM in Rodents and Dogs Provides the Scientific Basis for the First-in-Human Trial Using I.P. Administered “Neo-Islets,” 3-D Organoids of Allogeneic Islet, and Mesenchymal Stromal Cells—The Omentum Becomes the New Endocrine Pancreas without the Need for Antirejection Drugs

Meeting Abstracts

87-OR: Engineered Vasculature Induces Functional Maturation of Pluripotent Stem Cell–Derived Islet Organoids

KIM-VY NGUYEN-NGOC

Diabetes 2023;72(Supplement_1):87-OR

https://doi.org/10.2337/db23-87-OR

Published: 20 June 2023

View article titled, 87-OR: Engineered Vasculature Induces Functional Maturation of Pluripotent Stem Cell–Derived Islet Organoids

Meeting Abstracts

841-P: Scientific Basis for the First-in-Human Trial of “Neo-Islet”–Mediated Functional Cure of T1DM: The Intraperitoneal Administration of “Neo-Islets,” 3-D Organoids of Allogeneic Islet and Mesenchymal Stromal Cells from Rodents, Dogs, and Humans Durably Cures

CHRISTOF WESTENFELDER, SABIHA S. CHOWDHURY, ANNA GOOCH

Diabetes 2022;71(Supplement_1):841-P

https://doi.org/10.2337/db22-841-P

Published: 01 June 2022

View article titled, 841-P: Scientific Basis for the First-in-Human Trial of “Neo-Islet”–Mediated Functional Cure of T1DM: The Intraperitoneal Administration of “Neo-Islets,” 3-D Organoids of Allogeneic Islet and Mesenchymal Stromal Cells from Rodents, Dogs, and Humans Durably Cures

Meeting Abstracts

760-P: Allogeneic "Neo-Islets," Organoids Composed of Cultured Pancreatic Islet and Mesenchymal Stromal Cells from Diverse Donors, Afford a Marked Increase in the Global Availability of a Curative, Novel, Anti-Rejection-Drug-Independent Biotherapy of T1DM

CHRISTOF WESTENFELDER, SABIHA S. CHOWDHURY, ANNA GOOCH

Diabetes 2021;70(Supplement_1):760-P

https://doi.org/10.2337/db21-760-P

Published: 01 June 2021

View article titled, 760-P: Allogeneic "Neo-Islets," Organoids Composed of Cultured Pancreatic Islet and Mesenchymal Stromal Cells from Diverse Donors, Afford a Marked Increase in the Global Availability of a Curative, Novel, Anti-Rejection-Drug-Independent Biotherapy of T1DM

Journal Articles

Pancreatic Pseudoislets: An Organoid Archetype for Metabolism Research

Mollie S.H. Friedlander, Vy M. Nguyen, Seung K. Kim, Romina J. Bevacqua

Diabetes 2021;70(5):1051–1060

https://doi.org/10.2337/db20-1115

Published: 19 May 2021

View article titled, Pancreatic Pseudoislets: An Organoid Archetype for Metabolism Research

Journal Articles

Deciphering the Complex Communication Networks That Orchestrate Pancreatic Islet Function

Jonathan Weitz, Danusa Menegaz, Alejandro Caicedo

Diabetes 2021;70(1):17–26

https://doi.org/10.2337/dbi19-0033

Published: 15 December 2020

View article titled, Deciphering the Complex Communication Networks That Orchestrate Pancreatic Islet Function

Meeting Abstracts

256-OR: Using Human Induced Pluripotent Stem Cell Derived Organoids to Identify New Pathologies in Patients with Pdx1 Mutations

MANSA KRISHNAMURTHY, TAYLOR R. BRODA, DANIEL O. KECHELE, XINGHAO ZHANG, JOSEPH J. PALERMO, MARGARET H. COLLINS, INAS H. THOMAS, AMER HEIDER, ANDREW DAUBER, JAMES WELLS

Diabetes 2020;69(Supplement_1):256-OR

https://doi.org/10.2337/db20-256-OR

Published: 01 June 2020

View article titled, 256-OR: Using Human Induced Pluripotent Stem Cell Derived Organoids to Identify New Pathologies in Patients with Pdx1 Mutations

Journal Articles

L-Cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin Signaling

Mari Lilith Lund, Giovanni Sorrentino, Kristoffer Lihme Egerod, Chantal Kroone, Brynjulf Mortensen, Filip Krag Knop, Frank Reimann, Fiona M. Gribble, Daniel J. Drucker, Eelco J.P. de Koning, Kristina Schoonjans, Fredrik Bäckhed, Thue W. Schwartz, Natalia Petersen

Diabetes 2020;69(4):614–623

https://doi.org/10.2337/db19-0764

Published: 10 February 2020

View article titled, L-Cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin Signaling

Includes: Supplementary data

Meeting Abstracts

330-LB: Using Human Induced Pluripotent Stem Cell-Derived Organoids to Identify New Pathologies in Patients with PDX1 Mutations

MANSA KRISHNAMURTHY, TAYLOR R. BRODA, XINGHAO ZHANG, JOSEPH J. PALERMO, INAS H. THOMAS, AMER HEIDER, DANA B. STEIEN, ANDREW DAUBER, JAMES WELLS

Diabetes 2019;68(Supplement_1):330-LB

https://doi.org/10.2337/db19-330-LB

Published: 01 June 2019

View article titled, 330-LB: Using Human Induced Pluripotent Stem Cell-Derived Organoids to Identify New Pathologies in Patients with PDX1 Mutations

Journal Articles

Generation of L Cells in Mouse and Human Small Intestine Organoids

Natalia Petersen, Frank Reimann, Sina Bartfeld, Henner F. Farin, Femke C. Ringnalda, Robert G.J. Vries, Stieneke van den Brink, Hans Clevers, Fiona M. Gribble, Eelco J.P. de Koning

Diabetes 2014;63(2):410–420

https://doi.org/10.2337/db13-0991

Published: 16 January 2014

View article titled, Generation of L Cells in Mouse and Human Small Intestine Organoids

Includes: Supplementary data

Journal Articles

Copper Transporter ATP7A Protects Against Endothelial Dysfunction in Type 1 Diabetic Mice by Regulating Extracellular Superoxide Dismutase

Varadarajan Sudhahar, Norifumi Urao, Jin Oshikawa, Ronald D. McKinney, Roxana M. Llanos, Julian F.B. Mercer, Masuko Ushio-Fukai, Tohru Fukai

Diabetes 2013;62(11):3839–3850

https://doi.org/10.2337/db12-1228

Published: 18 October 2013

View article titled, Copper Transporter ATP7A Protects Against Endothelial Dysfunction in Type 1 Diabetic Mice by Regulating Extracellular Superoxide Dismutase

Includes: Supplementary data

NARROW

87-OR: Engineered Vasculature Induces Functional Maturation of Pluripotent Stem Cell–Derived Islet Organoids

841-P: Scientific Basis for the First-in-Human Trial of “Neo-Islet”–Mediated Functional Cure of T1DM: The Intraperitoneal Administration of “Neo-Islets,” 3-D Organoids of Allogeneic Islet and Mesenchymal Stromal Cells from Rodents, Dogs, and Humans Durably Cures

760-P: Allogeneic "Neo-Islets," Organoids Composed of Cultured Pancreatic Islet and Mesenchymal Stromal Cells from Diverse Donors, Afford a Marked Increase in the Global Availability of a Curative, Novel, Anti-Rejection-Drug-Independent Biotherapy of T1DM

Pancreatic Pseudoislets: An Organoid Archetype for Metabolism Research

Deciphering the Complex Communication Networks That Orchestrate Pancreatic Islet Function

256-OR: Using Human Induced Pluripotent Stem Cell Derived Organoids to Identify New Pathologies in Patients with Pdx1 Mutations

L-Cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin Signaling

330-LB: Using Human Induced Pluripotent Stem Cell-Derived Organoids to Identify New Pathologies in Patients with PDX1 Mutations

Generation of L Cells in Mouse and Human Small Intestine Organoids

Copper Transporter ATP7A Protects Against Endothelial Dysfunction in Type 1 Diabetic Mice by Regulating Extracellular Superoxide Dismutase

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