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Meeting Abstracts

1334-P: Hepatocyte D-ß-Hydroxybutyrate Dehydrogenase Deficiency Improves Glucose Homeostasis and Prevents Diet-Induced Liver Fibrosis

DAVID B. STAGG, ALISHA R. SEAY, ALISA B. NELSON, DANA ANDRE A. D’AVIGNON, CURTIS C. HUGHEY, PATRYCJA PUCHALSKA, PETER A. CRAWFORD
Journal: Diabetes
Diabetes 2022;71(Supplement_1):1334-P
https://doi.org/10.2337/db22-1334-P
Published: 01 June 2022
View article titled, 1334-P: Hepatocyte D-ß-Hydroxybutyrate Dehydrogenase Deficiency Improves Glucose Homeostasis and Prevents Diet-Induced Liver Fibrosis
Meeting Abstracts

191-OR: Hepatic Expression of the Branched-Chain Keto Acid Dehydrogenase Kinase Is Sufficient to Cause Glucose Intolerance in Lean Mice

JACQUELYN WALEJKO, ROBERT W. MCGARRAH, III, PHILLIP J. WHITE
Journal: Diabetes
Diabetes 2022;71(Supplement_1):191-OR
https://doi.org/10.2337/db22-191-OR
Published: 01 June 2022
View article titled, 191-OR: Hepatic Expression of the Branched-Chain Keto Acid Dehydrogenase Kinase Is Sufficient to Cause Glucose Intolerance in Lean Mice
Journal Articles

Metformin’s Therapeutic Efficacy in the Treatment of Diabetes Does Not Involve Inhibition of Mitochondrial Glycerol Phosphate Dehydrogenase

Michael J. MacDonald, Israr-ul H. Ansari, Melissa J. Longacre, Scott W. Stoker
Journal: Diabetes
Diabetes 2021;70(7):1575–1580
https://doi.org/10.2337/db20-1143
Published: 13 April 2021
View article titled, Metformin’s Therapeutic Efficacy in the Treatment of Diabetes Does Not Involve Inhibition of Mitochondrial Glycerol Phosphate Dehydrogenase
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Meeting Abstracts

308-OR: Deficiency of Mitochondrial Glycerol 3-Phosphate Dehydrogenase Accelerates the Progression of Diabetic Glomerular Pathology

HUA QU, YI ZHENG
Journal: Diabetes
Diabetes 2020;69(Supplement_1):308-OR
https://doi.org/10.2337/db20-308-OR
Published: 01 June 2020
View article titled, 308-OR: Deficiency of Mitochondrial Glycerol 3-Phosphate Dehydrogenase Accelerates the Progression of Diabetic Glomerular Pathology
Meeting Abstracts

2292-PUB: Luminescent Assays Quantitate the Biology of Peptide Hormones

JOLANTA VIDUGIRIENE, DONNA M. LEIPPE, MICHAEL VALLEY
Journal: Diabetes
Diabetes 2020;69(Supplement_1):2292-PUB
https://doi.org/10.2337/db20-2292-PUB
Published: 01 June 2020
View article titled, 2292-PUB: Luminescent Assays Quantitate the Biology of Peptide Hormones
Meeting Abstracts

2031-P: Adipose-Specific Lack of Hexose-6-Phosphate Dehydrogenase Causes Inactivation of Adipose Glucocorticoids and Improves Metabolic Phenotype in Male Mice

JIAN WANG, XINXIANG WANG, KABIRULLAH LUTFY, THEODORE FRIEDMAN, MEISHENG JIANG, YANJUN LIU
Journal: Diabetes
Diabetes 2019;68(Supplement_1):2031-P
https://doi.org/10.2337/db19-2031-P
Published: 01 June 2019
View article titled, 2031-P: Adipose-Specific Lack of Hexose-6-Phosphate Dehydrogenase Causes Inactivation of Adipose Glucocorticoids and Improves Metabolic Phenotype in Male Mice
Meeting Abstracts

97-OR: Leptin's Hunger-Suppressing Effects Are Mediated by the Hypothalamic-Pituitary-Adrenocortical Axis

RACHEL J. PERRY, JON RESCH, AMELIA M. DOUGLASS, JOSEPH MADARA, JOONGYU D. SONG, CHEN WU, BRADFORD LOWELL, GERALD I. SHULMAN
Journal: Diabetes
Diabetes 2019;68(Supplement_1):97-OR
https://doi.org/10.2337/db19-97-OR
Published: 01 June 2019
View article titled, 97-OR: Leptin's Hunger-Suppressing Effects Are Mediated by the Hypothalamic-Pituitary-Adrenocortical Axis
Meeting Abstracts

1922-P: Branched-Chain Ketoacid Dehydrogenase Kinase Inhibition Acutely Improves Glycemia and Alters the Response to Feeding in Mice

ELIZA BOLLINGER, CHARLES PARKER SIDDALL, TIMOTHY GREIZER, JENNA L. LIBERA, GHAZAL HARIRI, EVANTHIA E. PASHOS, ARUN SHIPSTONE, ANGELA HADJIPANAYIS, ZHONGYUAN SUN, GANG XING, MICHELLE F. CLASQUIN, BEI B. ZHANG, RUSSELL A. MILLER, RACHEL ROTH FLACH
Journal: Diabetes
Diabetes 2019;68(Supplement_1):1922-P
https://doi.org/10.2337/db19-1922-P
Published: 01 June 2019
View article titled, 1922-P: Branched-Chain Ketoacid Dehydrogenase Kinase Inhibition Acutely Improves Glycemia and Alters the Response to Feeding in Mice
Meeting Abstracts

Mitochondrial Glycerol 3-Phosphate Dehydrogenase Improves Skeletal Muscle Regeneration in Obesity and Diabetes

HUA QU, YI ZHENG
Journal: Diabetes
Diabetes 2018;67(Supplement_1):155-OR
https://doi.org/10.2337/db18-155-OR
Published: 01 July 2018
View article titled, Mitochondrial Glycerol 3-Phosphate Dehydrogenase Improves Skeletal Muscle Regeneration in Obesity and Diabetes
Journal Articles

The Hypoglycemic Phenotype Is Islet Cell–Autonomous in Short-Chain Hydroxyacyl-CoA Dehydrogenase–Deficient Mice

Anders Molven, Jennifer Hollister-Lock, Jiang Hu, Rachael Martinez, Pål R. Njølstad, Chong Wee Liew, Gordon Weir, Rohit N. Kulkarni
Journal: Diabetes
Diabetes 2016;65(6):1672–1678
https://doi.org/10.2337/db15-1475
Published: 07 March 2016
View article titled, The Hypoglycemic Phenotype Is Islet Cell–Autonomous in Short-Chain Hydroxyacyl-CoA Dehydrogenase–Deficient Mice
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Journal Articles

5α-Reductase Type 1 Deficiency or Inhibition Predisposes to Insulin Resistance, Hepatic Steatosis, and Liver Fibrosis in Rodents

Dawn E.W. Livingstone, Pascal Barat, Emma M. Di Rollo, Georgina A. Rees, Benjamin A. Weldin, Eva A. Rog-Zielinska, David P. MacFarlane, Brian R. Walker, Ruth Andrew
Journal: Diabetes
Diabetes 2015;64(2):447–458
https://doi.org/10.2337/db14-0249
Published: 19 September 2014
View article titled, 5α-Reductase Type 1 Deficiency or Inhibition Predisposes to Insulin Resistance, Hepatic Steatosis, and Liver Fibrosis in Rodents
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Includes: Supplementary data
Journal Articles

Comment on: Turban et al. Optimal Elevation of β-Cell 11β-Hydroxysteroid Dehydrogenase Type 1 Is a Compensatory Mechanism That Prevents High-Fat Diet–Induced β-Cell Failure. Diabetes 2012;61:642–652

Jun-Li Liu, Coimbatore B. Srikant, Subrata Chowdhury
Journal: Diabetes
Diabetes 2012;61(9):e13
https://doi.org/10.2337/db12-0556
Published: 17 August 2012
View article titled, Comment on: Turban et al. Optimal Elevation of β-Cell 11β-Hydroxysteroid Dehydrogenase Type 1 Is a Compensatory Mechanism That Prevents High-Fat Diet–Induced β-Cell Failure. Diabetes 2012;61:642–652
Open the PDF for Comment on: Turban et al. Optimal Elevation of β-Cell 11β-Hydroxysteroid Dehydrogenase Type 1 Is a Compensatory Mechanism That Prevents High-Fat Diet–Induced β-Cell Failure. Diabetes 2012;61:642–652 in another window
Journal Articles

Comment on: Gögebakan et al. Glucose-Dependent Insulinotropic Polypeptide Reduces Fat-Specific Expression and Activity of 11β-Hydroxysteroid Dehydrogenase Type 1 and Inhibits Release of Free Fatty Acids. Diabetes 2012;61:292–300

Filip K. Knop, Mikkel Christensen
Journal: Diabetes
Diabetes 2012;61(9):e12
https://doi.org/10.2337/db12-0219
Published: 17 August 2012
View article titled, Comment on: Gögebakan et al. Glucose-Dependent Insulinotropic Polypeptide Reduces Fat-Specific Expression and Activity of 11β-Hydroxysteroid Dehydrogenase Type 1 and Inhibits Release of Free Fatty Acids. Diabetes 2012;61:292–300
Open the PDF for Comment on: Gögebakan et al. Glucose-Dependent Insulinotropic Polypeptide Reduces Fat-Specific Expression and Activity of 11β-Hydroxysteroid Dehydrogenase Type 1 and Inhibits Release of Free Fatty Acids. Diabetes 2012;61:292–300 in another window
Journal Articles

Response to Comment on: Turban et al. Optimal Elevation of β-Cell 11β-Hydroxysteroid Dehydrogenase Type 1 Is a Compensatory Mechanism That Prevents High-Fat Diet–Induced β-Cell Failure. Diabetes 2012;61:642–652

Sophie Turban, Jonathan R. Seckl, Nicholas M. Morton
Journal: Diabetes
Diabetes 2012;61(9):e14
https://doi.org/10.2337/db12-0583
Published: 17 August 2012
View article titled, Response to Comment on: Turban et al. Optimal Elevation of β-Cell 11β-Hydroxysteroid Dehydrogenase Type 1 Is a Compensatory Mechanism That Prevents High-Fat Diet–Induced β-Cell Failure. Diabetes 2012;61:642–652
Open the PDF for Response to Comment on: Turban et al. Optimal Elevation of β-Cell 11β-Hydroxysteroid Dehydrogenase Type 1 Is a Compensatory Mechanism That Prevents High-Fat Diet–Induced β-Cell Failure. Diabetes 2012;61:642–652 in another window
Journal Articles

Ubiquitin-Specific Protease 2 Regulates Hepatic Gluconeogenesis and Diurnal Glucose Metabolism Through 11β-Hydroxysteroid Dehydrogenase 1

Matthew M. Molusky, Siming Li, Di Ma, Lei Yu, Jiandie D. Lin
Journal: Diabetes
Diabetes 2012;61(5):1025–1035
https://doi.org/10.2337/db11-0970
Published: 13 April 2012
View article titled, Ubiquitin-Specific Protease 2 Regulates Hepatic Gluconeogenesis and Diurnal Glucose Metabolism Through 11β-Hydroxysteroid Dehydrogenase 1
Open the PDF for Ubiquitin-Specific Protease 2 Regulates Hepatic Gluconeogenesis and Diurnal Glucose Metabolism Through 11β-Hydroxysteroid Dehydrogenase 1 in another window
Includes: Supplementary data
Journal Articles

Optimal Elevation of β-Cell 11β-Hydroxysteroid Dehydrogenase Type 1 Is a Compensatory Mechanism That Prevents High-Fat Diet–Induced β-Cell Failure

Sophie Turban, Xiaoxia Liu, Lynne Ramage, Scott P. Webster, Brian R. Walker, Donald R. Dunbar, John J. Mullins, Jonathan R. Seckl, Nicholas M. Morton
Journal: Diabetes
Diabetes 2012;61(3):642–652
https://doi.org/10.2337/db11-1054
Published: 13 February 2012
View article titled, Optimal Elevation of β-Cell 11β-Hydroxysteroid Dehydrogenase Type 1 Is a Compensatory Mechanism That Prevents High-Fat Diet–Induced β-Cell Failure
Open the PDF for Optimal Elevation of β-Cell 11β-Hydroxysteroid Dehydrogenase Type 1 Is a Compensatory Mechanism That Prevents High-Fat Diet–Induced β-Cell Failure in another window
Includes: Supplementary data
Journal Articles

Glucose-Dependent Insulinotropic Polypeptide Reduces Fat-Specific Expression and Activity of 11β-Hydroxysteroid Dehydrogenase Type 1 and Inhibits Release of Free Fatty Acids

Özlem Gögebakan, Janin Andres, Katrin Biedasek, Knut Mai, Peter Kühnen, Heiko Krude, Frank Isken, Natalia Rudovich, Martin A. Osterhoff, Ulrich Kintscher, Michael Nauck, Andreas F.H. Pfeiffer, Joachim Spranger
Journal: Diabetes
Diabetes 2012;61(2):292–300
https://doi.org/10.2337/db10-0902
Published: 17 January 2012
View article titled, Glucose-Dependent Insulinotropic Polypeptide Reduces Fat-Specific Expression and Activity of 11β-Hydroxysteroid Dehydrogenase Type 1 and Inhibits Release of Free Fatty Acids
Open the PDF for Glucose-Dependent Insulinotropic Polypeptide Reduces Fat-Specific Expression and Activity of 11β-Hydroxysteroid Dehydrogenase Type 1 and Inhibits Release of Free Fatty Acids in another window
Includes: Supplementary data
Journal Articles

The Complex Mechanism of Glutamate Dehydrogenase in Insulin Secretion

Leonard A. Fahien, Michael J. MacDonald
Journal: Diabetes
Diabetes 2011;60(10):2450–2454
https://doi.org/10.2337/db10-1150
Published: 16 September 2011
View article titled, The Complex Mechanism of Glutamate Dehydrogenase in Insulin Secretion
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Journal Articles

Increased Whole-Body and Sustained Liver Cortisol Regeneration by 11β-Hydroxysteroid Dehydrogenase Type 1 in Obese Men With Type 2 Diabetes Provides a Target for Enzyme Inhibition

Roland H. Stimson, Ruth Andrew, Norma C. McAvoy, Dhiraj Tripathi, Peter C. Hayes, Brian R. Walker
Journal: Diabetes
Diabetes 2011;60(3):720–725
https://doi.org/10.2337/db10-0726
Published: 21 February 2011
View article titled, Increased Whole-Body and Sustained Liver Cortisol Regeneration by 11β-Hydroxysteroid Dehydrogenase Type 1 in Obese Men With Type 2 Diabetes Provides a Target for Enzyme Inhibition
Open the PDF for Increased Whole-Body and Sustained Liver Cortisol Regeneration by 11β-Hydroxysteroid Dehydrogenase Type 1 in Obese Men With Type 2 Diabetes Provides a Target for Enzyme Inhibition in another window
Journal Articles

Prenatal Programming of Metabolic Syndrome in the Common Marmoset Is Associated With Increased Expression of 11β-Hydroxysteroid Dehydrogenase Type 1

Moffat J. Nyirenda, Roderick Carter, Justin I. Tang, Annick de Vries, Christina Schlumbohm, Stephen G. Hillier, Frank Streit, Michael Oellerich, Victor W. Armstrong, Eberhard Fuchs, Jonathan R. Seckl
Journal: Diabetes
Diabetes 2009;58(12):2873–2879
https://doi.org/10.2337/db09-0873
Published: 31 August 2009
View article titled, Prenatal Programming of Metabolic Syndrome in the Common Marmoset Is Associated With Increased Expression of 11β-Hydroxysteroid Dehydrogenase Type 1
Open the PDF for Prenatal Programming of Metabolic Syndrome in the Common Marmoset Is Associated With Increased Expression of 11β-Hydroxysteroid Dehydrogenase Type 1 in another window