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Meeting Abstracts

1855-PUB: Generation and Identification of Pik3r3 Gene Pancreatic Beta-Cell Knockout Mice Model

XIAO-RONG ZHU

Diabetes 2023;72(Supplement_1):1855-PUB

https://doi.org/10.2337/db23-1855-PUB

Published: 23 June 2023

View article titled, 1855-PUB: Generation and Identification of Pik3r3 Gene Pancreatic Beta-Cell Knockout Mice Model

Meeting Abstracts

68-LB: Early Pharmacological Intervention (EPIC) to Preserve Beta-Cell Function in Prediabetes (PreDM)

ALBERTO CHAVEZ, AURORA MEROVCI, SIVARAM NEPPALA, LUIS A. CRUZ MORENO, GOZDE BASKOY, FRANCISCA M. ACOSTA, ANDREA A. HANSIS-DIARTE, CURTISS L. PUCKETT, JR., JOHN M. ADAMS, III, MUHAMMAD ABDUL-GHANI, CURTIS L. TRIPLITT, EUGENIO CERSOSIMO, RALPH A. DEFRONZO

Diabetes 2023;72(Supplement_1):68-LB

https://doi.org/10.2337/db23-68-LB

Published: 20 June 2023

View article titled, 68-LB: Early Pharmacological Intervention (EPIC) to Preserve Beta-Cell Function in Prediabetes (PreDM)

Meeting Abstracts

375-OR: Epigenetic Control of Beta-Cell Stress Response and Senescence

SNEHA S. VARGHESE, NAZIA PARVEEN, JEAN K. WANG, ALESSANDRO G. HERNANDEZ-DE LA PENA, SANGEETA DHAWAN

Diabetes 2023;72(Supplement_1):375-OR

https://doi.org/10.2337/db23-375-OR

Published: 20 June 2023

View article titled, 375-OR: Epigenetic Control of Beta-Cell Stress Response and Senescence

Meeting Abstracts

349-OR: Selected DYRK1A Inhibitors Simultaneously Drive Both Human Beta-Cell Proliferation and Differentiation

PENG WANG, KUNAL KUMAR, HONGTAO LIU, OLIVIA WOOD, ESRA KARAKOSE, LAURYN CHOLEVA, LUCA LAMBERTINI, ADOLFO GARCIA-OCANA, ROBERT J. DEVITA, ANDREW F. STEWART

Diabetes 2023;72(Supplement_1):349-OR

https://doi.org/10.2337/db23-349-OR

Published: 20 June 2023

View article titled, 349-OR: Selected DYRK1A Inhibitors Simultaneously Drive Both Human Beta-Cell Proliferation and Differentiation

Meeting Abstracts

198-OR: Pancreatic Elastase Regulates Human Beta-Cell Viability by Impairing the PAR2 Pathway

GIORGIO BASILE, AMEDEO VETERE, JIANG HU, DARIO F. DE JESUS, AMIT CHOUDHARY, BRIDGET WAGNER, ROHIT KULKARNI

Diabetes 2023;72(Supplement_1):198-OR

https://doi.org/10.2337/db23-198-OR

Published: 20 June 2023

View article titled, 198-OR: Pancreatic Elastase Regulates Human Beta-Cell Viability by Impairing the PAR2 Pathway

Meeting Abstracts

1442-P: Composite Scores Using Fasting and Stimulated C-Peptide Are Equivalent and Can Track Beta-Cell Function in New-Onset Type 1 Diabetes

ALICE CARR, KIMBERLY S. COLLINS, STEPHEN KARPEN, ELNAZ ATABAKHSH, ANNA LAM, PETER TAYLOR, COLIN DAYAN, PETER A. SENIOR

Diabetes 2023;72(Supplement_1):1442-P

https://doi.org/10.2337/db23-1442-P

Published: 20 June 2023

View article titled, 1442-P: Composite Scores Using Fasting and Stimulated C-Peptide Are Equivalent and Can Track Beta-Cell Function in New-Onset Type 1 Diabetes

Meeting Abstracts

1779-P: Lipotoxicity-Induced Beta-Cell Small Extracellular Vesicles Promote Beta-Cell Functional Failure through Activation of the TGFß/Smad3 Pathway

ABHISHEK ROY, ALEXANDRA HOFF, TRACY K. HER, KAMALNATH SANKARAN RAJAGOPALAN, DANIELA D. MALTAIS, ALEKSEY MATVEYENKO, NAUREEN JAVEED

Diabetes 2023;72(Supplement_1):1779-P

https://doi.org/10.2337/db23-1779-P

Published: 20 June 2023

View article titled, 1779-P: Lipotoxicity-Induced Beta-Cell Small Extracellular Vesicles Promote Beta-Cell Functional Failure through Activation of the TGFß/Smad3 Pathway

Meeting Abstracts

1778-P: Endoplasmic Reticulum Stress Leads to Pancreatic Beta-Cell Failure by Suppressing cAMP Signaling via ATF4

JAEMIN LEE

Diabetes 2023;72(Supplement_1):1778-P

https://doi.org/10.2337/db23-1778-P

Published: 20 June 2023

View article titled, 1778-P: Endoplasmic Reticulum Stress Leads to Pancreatic Beta-Cell Failure by Suppressing cAMP Signaling via ATF4

Meeting Abstracts

227-LB: Kynurenine Pathway Is Associated with Preservation of Beta-Cell Function in Autoimmune Diabetes

ERNESTO MADDALONI, AMALIA GASTALDELLI, LUCA NAVARINI, ROCCO AMENDOLARA, SIMONA FENIZIA, SAMANTHA PEZZICA, MARTA TESI, LUCA D'ONOFRIO, EMANUELE BOSI, FRANCESCO DOTTA, PIERO MARCHETTI, RAFFAELLA BUZZETTI

Diabetes 2023;72(Supplement_1):227-LB

https://doi.org/10.2337/db23-227-LB

Published: 20 June 2023

View article titled, 227-LB: Kynurenine Pathway Is Associated with Preservation of Beta-Cell Function in Autoimmune Diabetes

Meeting Abstracts

1731-P: Determining the Mechanistic Relationship between Maternal Diet and Postnatal Beta-Cell Function

SIMONE NEVILLS, GUOQIANG GU

Diabetes 2023;72(Supplement_1):1731-P

https://doi.org/10.2337/db23-1731-P

Published: 20 June 2023

View article titled, 1731-P: Determining the Mechanistic Relationship between Maternal Diet and Postnatal Beta-Cell Function

Meeting Abstracts

283-OR: ADA Presidents' Select Abstract: An Isogenic hPSC-Based Platform for Functional Interrogation of the Role of Multiple T2D-Associated Genes in Pancreatic Beta-Cell Failure

DONGXIANG XUE, NARISU NARISU, TINGFEN YAN, MEILI ZHANG, CALEB GRENKO, XUMING TANG, JIAJUN ZHU, LORI L. BONNYCASTLE, MICHAEL ERDOS, J JEYA VANDANA, ANGIE CHONG, FRANCIS S. COLLINS, SHUIBING CHEN

Diabetes 2023;72(Supplement_1):283-OR

https://doi.org/10.2337/db23-283-OR

Published: 20 June 2023

View article titled, 283-OR: ADA Presidents' Select Abstract: An Isogenic hPSC-Based Platform for Functional Interrogation of the Role of Multiple T2D-Associated Genes in Pancreatic Beta-Cell Failure

Meeting Abstracts

1737-P: Novel Interaction between Nkx6.1 and Pdx1 Is Needed for Proper Beta-Cell Function

JEFFERY S. TESSEM, CONNOR C. LITTLEFIELD, JONATHON T. HILL

Diabetes 2023;72(Supplement_1):1737-P

https://doi.org/10.2337/db23-1737-P

Published: 20 June 2023

View article titled, 1737-P: Novel Interaction between Nkx6.1 and Pdx1 Is Needed for Proper Beta-Cell Function

Meeting Abstracts

1736-P: Effect of Glucokinase Haploinsufficiency on Pancreatic Beta-Cell Function and Mass in High-Fat, High-Sucrose Diet-Fed Mice

IKUMI SHIGESAWA, AKINOBU NAKAMURA, YUKI YAMAUCHI, SHINICHIRO KAWATA, ASUKA MIYAZAKI, HIROSHI NOMOTO, HIRAKU KAMEDA, HIDEAKI MIYOSHI, YASUO TERAUCHI, TATSUYA ATSUMI

Diabetes 2023;72(Supplement_1):1736-P

https://doi.org/10.2337/db23-1736-P

Published: 20 June 2023

View article titled, 1736-P: Effect of Glucokinase Haploinsufficiency on Pancreatic Beta-Cell Function and Mass in High-Fat, High-Sucrose Diet-Fed Mice

Meeting Abstracts

1735-P: The Dichotomic and Timely Regulation of SerpinB13 Plays a Role in Beta-Cell Neogenesis and Pancreatic Islet Expansion

YURY KRYVALAP, SHAWN Z. MENG, RIM HABTE, JAN CZYZYK

Diabetes 2023;72(Supplement_1):1735-P

https://doi.org/10.2337/db23-1735-P

Published: 20 June 2023

View article titled, 1735-P: The Dichotomic and Timely Regulation of SerpinB13 Plays a Role in Beta-Cell Neogenesis and Pancreatic Islet Expansion

Meeting Abstracts

1732-P: Correlation of Cyclin D2 with Cell Proliferation in Human Pancreatic Beta Cells and Possible Regulation by CCND2-AS1

SHO OSONOI, TAKANORI SASAKI, YUKI TAKEUCHI, HIROKI MIZUKAMI

Diabetes 2023;72(Supplement_1):1732-P

https://doi.org/10.2337/db23-1732-P

Published: 20 June 2023

View article titled, 1732-P: Correlation of Cyclin D2 with Cell Proliferation in Human Pancreatic Beta Cells and Possible Regulation by CCND2-AS1

Meeting Abstracts

771-P: Tirzepatide Reduces HbA1c and Body Weight Significantly More than Placebo or Semaglutide Irrespective of Baseline Beta-Cell Function—Post Hoc Analysis from SURPASS-1 and SURPASS-2

JUAN M. MALDONADO, CHRISTOPHE DE BLOCK, JUAN P. FRIAS, CLARE LEE, KATELYN BROWN, HUI WANG, MELISSA K. THOMAS

Diabetes 2023;72(Supplement_1):771-P

https://doi.org/10.2337/db23-771-P

Published: 20 June 2023

View article titled, 771-P: Tirzepatide Reduces HbA1c and Body Weight Significantly More than Placebo or Semaglutide Irrespective of Baseline Beta-Cell Function—Post Hoc Analysis from SURPASS-1 and SURPASS-2

Meeting Abstracts

1755-P: EndoC-ßH5 Is a Storable and Ready-to-Use Human Pancreatic Beta Cell That Can Model Type 1 and 2 Diabetes

HAMZA OLLEIK, BRUNO BLANCHI

Diabetes 2023;72(Supplement_1):1755-P

https://doi.org/10.2337/db23-1755-P

Published: 20 June 2023

View article titled, 1755-P: EndoC-ßH5 Is a Storable and Ready-to-Use Human Pancreatic Beta Cell That Can Model Type 1 and 2 Diabetes

Meeting Abstracts

84-OR: Structure–Function Analysis of p57KIP2 in the Human Pancreatic Beta Cell Reveals a Canonical Bipartite Nuclear Localization Sequence (NLS)

LAURYN CHOLEVA, PENG WANG, HONGTAO LIU, OLIVIA WOOD, LUCA LAMBERTINI, ESRA KARAKOSE, ANDREW F. STEWART

Diabetes 2023;72(Supplement_1):84-OR

https://doi.org/10.2337/db23-84-OR

Published: 20 June 2023

View article titled, 84-OR: Structure–Function Analysis of p57KIP2 in the Human Pancreatic Beta Cell Reveals a Canonical Bipartite Nuclear Localization Sequence (NLS)

Meeting Abstracts

1168-P: Time-Limited Eating in Youth with Newly Diagnosed Type 1 Diabetes—Feasibility and Impact on Beta-Cell Function

CASEY BERMAN, ALAINA VIDMAR, JAQUELIN J. FLORES GARCIA, JENNIFER RAYMOND

Diabetes 2023;72(Supplement_1):1168-P

https://doi.org/10.2337/db23-1168-P

Published: 20 June 2023

View article titled, 1168-P: Time-Limited Eating in Youth with Newly Diagnosed Type 1 Diabetes—Feasibility and Impact on Beta-Cell Function

Meeting Abstracts

1754-P: Reduced Incretin Effect Predicts Diabetes Appearance in a Cohort of Nondiabetic Subjects after Acute Beta-Cell Mass Reduction

GIANFRANCO DI GIUSEPPE, CHIARA MARIA ASSUNTA CEFALO, SIMONA MOFFA, GEA CICCARELLI, LAURA SOLDOVIERI, FRANCESCA CINTI, UMBERTO CAPECE, FLAVIA IMPRONTA, ANDREA MARI, JENS J. HOLST, ANDREA GIACCARI, TERESA MEZZA

Diabetes 2023;72(Supplement_1):1754-P

https://doi.org/10.2337/db23-1754-P

Published: 20 June 2023

View article titled, 1754-P: Reduced Incretin Effect Predicts Diabetes Appearance in a Cohort of Nondiabetic Subjects after Acute Beta-Cell Mass Reduction

NARROW

1855-PUB: Generation and Identification of Pik3r3 Gene Pancreatic Beta-Cell Knockout Mice Model

68-LB: Early Pharmacological Intervention (EPIC) to Preserve Beta-Cell Function in Prediabetes (PreDM)

375-OR: Epigenetic Control of Beta-Cell Stress Response and Senescence

349-OR: Selected DYRK1A Inhibitors Simultaneously Drive Both Human Beta-Cell Proliferation and Differentiation

198-OR: Pancreatic Elastase Regulates Human Beta-Cell Viability by Impairing the PAR2 Pathway

1442-P: Composite Scores Using Fasting and Stimulated C-Peptide Are Equivalent and Can Track Beta-Cell Function in New-Onset Type 1 Diabetes

1779-P: Lipotoxicity-Induced Beta-Cell Small Extracellular Vesicles Promote Beta-Cell Functional Failure through Activation of the TGFß/Smad3 Pathway

1778-P: Endoplasmic Reticulum Stress Leads to Pancreatic Beta-Cell Failure by Suppressing cAMP Signaling via ATF4

227-LB: Kynurenine Pathway Is Associated with Preservation of Beta-Cell Function in Autoimmune Diabetes

1731-P: Determining the Mechanistic Relationship between Maternal Diet and Postnatal Beta-Cell Function

283-OR: ADA Presidents' Select Abstract: An Isogenic hPSC-Based Platform for Functional Interrogation of the Role of Multiple T2D-Associated Genes in Pancreatic Beta-Cell Failure

1737-P: Novel Interaction between Nkx6.1 and Pdx1 Is Needed for Proper Beta-Cell Function

1736-P: Effect of Glucokinase Haploinsufficiency on Pancreatic Beta-Cell Function and Mass in High-Fat, High-Sucrose Diet-Fed Mice

1735-P: The Dichotomic and Timely Regulation of SerpinB13 Plays a Role in Beta-Cell Neogenesis and Pancreatic Islet Expansion

1732-P: Correlation of Cyclin D2 with Cell Proliferation in Human Pancreatic Beta Cells and Possible Regulation by CCND2-AS1

771-P: Tirzepatide Reduces HbA1c and Body Weight Significantly More than Placebo or Semaglutide Irrespective of Baseline Beta-Cell Function—Post Hoc Analysis from SURPASS-1 and SURPASS-2

1755-P: EndoC-ßH5 Is a Storable and Ready-to-Use Human Pancreatic Beta Cell That Can Model Type 1 and 2 Diabetes

84-OR: Structure–Function Analysis of p57KIP2 in the Human Pancreatic Beta Cell Reveals a Canonical Bipartite Nuclear Localization Sequence (NLS)

1168-P: Time-Limited Eating in Youth with Newly Diagnosed Type 1 Diabetes—Feasibility and Impact on Beta-Cell Function

1754-P: Reduced Incretin Effect Predicts Diabetes Appearance in a Cohort of Nondiabetic Subjects after Acute Beta-Cell Mass Reduction

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