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Journal Articles

Regulation of Monocyte Activation by PPARα Through Interaction With the cGAS-STING Pathway

Lijie Dong, Rui Cheng, Xiang Ma, Wentao Liang, Yaru Hong, Hui Li, Kelu Zhou, Yanhong Du, Yusuke Takahashi, Xiaomin Zhang, Xiao-rong Li, Jian-xing Ma
Journal: Diabetes
Diabetes 2023;72(7):958–972
https://doi.org/10.2337/db22-0654
Published: 14 April 2023
View article titled, Regulation of Monocyte Activation by PPARα Through Interaction With the cGAS-STING Pathway
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Meeting Abstracts

830-P: The Pan-PPAR Agonist Lanifibranor Improves Nonalcoholic Steatohepatitis (NASH) and Glycemic Control

MICHAEL P. COOREMAN, SVEN FRANCQUE, LUCILE DZEN, PHILIPPE HUOT-MARCHAND, JEAN L. JUNIEN, PIERRE BROQUA, MANAL F. ABDELMALEK
Journal: Diabetes
Diabetes 2022;71(Supplement_1):830-P
https://doi.org/10.2337/db22-830-P
Published: 01 June 2022
View article titled, 830-P: The Pan-PPAR Agonist Lanifibranor Improves Nonalcoholic Steatohepatitis (NASH) and Glycemic Control
Meeting Abstracts

1139-P: CD36/FABP4/PPAR-d Axis-Induced Inflammation Is Dependent on ACSL1 under the Influence of Acute High-Fat Feeding

FATEMA ALRASHED, ASHRAF AL MADHOUN, SARDAR T. SINDHU, AMNAH AL-SAYYAR, FAHD ALMULLA, RASHEED AHMAD
Journal: Diabetes
Diabetes 2021;70(Supplement_1):1139-P
https://doi.org/10.2337/db21-1139-P
Published: 01 June 2021
View article titled, 1139-P: CD36/FABP4/PPAR-d Axis-Induced Inflammation Is Dependent on ACSL1 under the Influence of Acute High-Fat Feeding
Meeting Abstracts

198-LB: A Novel Heterozygous Mutation in Peroxisome Proliferator-Activated Receptor Gamma (PPAR-γ) Gene in a Woman with Familial Partial Lipodystrophy

PATRÍCIA V. WANDERLEY, JOAO C. DIAS, MARTA W. VIEIRA, GIANE GARCIA, ITUO T. FILHO, RAYSSA F. CHAMMA, LILIAN S. GUGONI, RAFAEL B. GIORGI, CRISTIANO R.G. BARCELLOS
Journal: Diabetes
Diabetes 2021;70(Supplement_1):198-LB
https://doi.org/10.2337/db21-198-LB
Published: 01 June 2021
View article titled, 198-LB: A Novel Heterozygous Mutation in Peroxisome Proliferator-Activated Receptor Gamma (PPAR-γ) Gene in a Woman with Familial Partial Lipodystrophy
Journal Articles

ETV5 Regulates Hepatic Fatty Acid Metabolism Through PPAR Signaling Pathway

Zhuo Mao, Mingji Feng, Zhuoran Li, Minsi Zhou, Langning Xu, Ke Pan, Shaoxiang Wang, Wen Su, Weizhen Zhang
Journal: Diabetes
Diabetes 2021;70(1):214–226
https://doi.org/10.2337/db20-0619
Published: 22 October 2020
View article titled, ETV5 Regulates Hepatic Fatty Acid Metabolism Through PPAR Signaling Pathway
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Meeting Abstracts

167-OR: Exercise Training Alters Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1 Alpha (PGC-1 Alpha) DNA Methylation in Human Skeletal Muscle

SUNG LEE, LUIS GARCIA, ALMA D. LEON, ROCIO ZAPATA BUSTOS, BALTAZAR CAMPOS, JUDY A. KRENTZEL, LAWRENCE MANDARINO, DAWN K. COLETTA
Journal: Diabetes
Diabetes 2020;69(Supplement_1):167-OR
https://doi.org/10.2337/db20-167-OR
Published: 01 June 2020
View article titled, 167-OR: Exercise Training Alters Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1 Alpha (PGC-1 Alpha) DNA Methylation in Human Skeletal Muscle
Journal Articles

Pharmacologic PPAR-γ Activation Reprograms Bone Marrow Macrophages and Partially Rescues HSPC Mobilization in Human and Murine Diabetes

Serena Tedesco, Stefano Ciciliot, Lisa Menegazzo, Marianna D’Anna, Valentina Scattolini, Roberta Cappellari, Andrea Cignarella, Angelo Avogaro, Mattia Albiero, Gian Paolo Fadini
Journal: Diabetes
Diabetes 2020;69(7):1562–1572
https://doi.org/10.2337/db19-0640
Published: 28 April 2020
View article titled, Pharmacologic PPAR-γ Activation Reprograms Bone Marrow Macrophages and Partially Rescues HSPC Mobilization in Human and Murine Diabetes
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Journal Articles

Osteoprotegerin Promotes Liver Steatosis by Targeting the ERK–PPAR-γ–CD36 Pathway

Cheng Zhang, Xiaohe Luo, Jianrong Chen, Baoyong Zhou, Mengliu Yang, Rui Liu, Dongfang Liu, Harvest F. Gu, Zhiming Zhu, Hongting Zheng, Ling Li, Gangyi Yang
Journal: Diabetes
Diabetes 2019;68(10):1902–1914
https://doi.org/10.2337/db18-1055
Published: 10 July 2019
View article titled, Osteoprotegerin Promotes Liver Steatosis by Targeting the ERK–PPAR-γ–CD36 Pathway
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Includes: Supplementary data
Meeting Abstracts

189-LB: Maternal Pharmacological Activation of PPAR-gamma or PPAR-alpha Differentially Affects Adiposity and Energy Metabolism in the Offspring of Rats Born to Mothers Subjected to Caloric Restriction during Pregnancy

VANESSA B. VERONESI, JUNIA C. SANTOS-SILVA, DAILSON N. SOUZA, CAIO JORDÃO TEIXEIRA, FERNANDA B. HECHT, NATALIA TOBAR, MARIANA RODRIGUES PIOLI, GABRIEL F. ANHE
Journal: Diabetes
Diabetes 2019;68(Supplement_1):189-LB
https://doi.org/10.2337/db19-189-LB
Published: 01 June 2019
View article titled, 189-LB: Maternal Pharmacological Activation of PPAR-gamma or PPAR-alpha Differentially Affects Adiposity and Energy Metabolism in the Offspring of Rats Born to Mothers Subjected to Caloric Restriction during Pregnancy
Meeting Abstracts

1880-P: The Protein-Tyrosine Phosphatase Shp1 Interacts with PPAR Gamma and Regulates Its Transcriptional Activity through Dephosphorylation of Selected Tyrosine Sites

AMIT KUMAR, MARIE-HELENE LAVALLEE-BOURGET, MARIE-PIER FOREST, MICHAEL SCHWAB, KERSTIN BELLMANN, VANESSA HOUDE, HALIM MAAROUFI, NICOLE BEAUCHEMIN, ANDRE MARETTE
Journal: Diabetes
Diabetes 2019;68(Supplement_1):1880-P
https://doi.org/10.2337/db19-1880-P
Published: 01 June 2019
View article titled, 1880-P: The Protein-Tyrosine Phosphatase Shp1 Interacts with PPAR Gamma and Regulates Its Transcriptional Activity through Dephosphorylation of Selected Tyrosine Sites
Meeting Abstracts

1744-P: DBI-500 Significantly Increases Adipose Tissue Expression of PPAR-gamma and Adiponectin in DIO Mice and Significantly Decreases Markers of Fibrosis in Two Murine NASH Models

ANTON LEIGHTON
Journal: Diabetes
Diabetes 2019;68(Supplement_1):1744-P
https://doi.org/10.2337/db19-1744-P
Published: 01 June 2019
View article titled, 1744-P: DBI-500 Significantly Increases Adipose Tissue Expression of PPAR-gamma and Adiponectin in DIO Mice and Significantly Decreases Markers of Fibrosis in Two Murine NASH Models
Meeting Abstracts

135-OR: A Novel Thiazolidinedione (TZD) with Minimal PPAR-γ Activity Maximized for Mitochondrial Pyruvate Carrier (MPC) Modulation: Six-Month Analysis of Glycemia in a 12-Month Nonalcoholic Steatohepatitis (NASH) Study

KENNETH CUSI, ORVILLE G. KOLTERMAN, STEPHEN A. HARRISON, HOWARD C. DITTRICH
Journal: Diabetes
Diabetes 2019;68(Supplement_1):135-OR
https://doi.org/10.2337/db19-135-OR
Published: 01 June 2019
View article titled, 135-OR: A Novel Thiazolidinedione (TZD) with Minimal PPAR-γ Activity Maximized for Mitochondrial Pyruvate Carrier (MPC) Modulation: Six-Month Analysis of Glycemia in a 12-Month Nonalcoholic Steatohepatitis (NASH) Study
Meeting Abstracts

Inhibition of PPAR Gamma, Adipogenesis, and Insulin Sensitivity by MAGED1

QINGHUA WANG, JING TANG, XIANG GAO, HAI-BIN RUAN
Journal: Diabetes
Diabetes 2018;67(Supplement_1):1750-P
https://doi.org/10.2337/db18-1750-P
Published: 01 July 2018
View article titled, Inhibition of PPAR Gamma, Adipogenesis, and Insulin Sensitivity by MAGED1
Meeting Abstracts

Regulation of Systemic Energy Metabolism by a Human-Specific Long Noncoding RNA In Vivo

XIANGBO RUAN, PING LI, HAIMING CAO
Journal: Diabetes
Diabetes 2018;67(Supplement_1):256-LB
https://doi.org/10.2337/db18-256-LB
Published: 01 July 2018
View article titled, Regulation of Systemic Energy Metabolism by a Human-Specific Long Noncoding RNA In Vivo
Journal Articles

Mesenchymal Stem Cells From Infants Born to Obese Mothers Exhibit Greater Potential for Adipogenesis: The Healthy Start BabyBUMP Project

Kristen E. Boyle, Zachary W. Patinkin, Allison L.B. Shapiro, Peter R. Baker, II, Dana Dabelea, Jacob E. Friedman
Journal: Diabetes
Diabetes 2016;65(3):647–659
https://doi.org/10.2337/db15-0849
Published: 02 December 2015
View article titled, Mesenchymal Stem Cells From Infants Born to Obese Mothers Exhibit Greater Potential for Adipogenesis: The Healthy Start BabyBUMP Project
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Includes: Supplementary data
Journal Articles

ATGL-Catalyzed Lipolysis Regulates SIRT1 to Control PGC-1α/PPAR-α Signaling

Salmaan Ahmed Khan, Aishwarya Sathyanarayan, Mara T. Mashek, Kuok Teong Ong, Edith E. Wollaston-Hayden, Douglas G. Mashek
Journal: Diabetes
Diabetes 2015;64(2):418–426
https://doi.org/10.2337/db14-0325
Published: 13 January 2015
View article titled, ATGL-Catalyzed Lipolysis Regulates SIRT1 to Control PGC-1α/PPAR-α Signaling
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Journal Articles

Increase of Palmitic Acid Concentration Impairs Endothelial Progenitor Cell and Bone Marrow–Derived Progenitor Cell Bioavailability: Role of the STAT5/PPARγ Transcriptional Complex

Antonella Trombetta, Gabriele Togliatto, Arturo Rosso, Patrizia Dentelli, Cristina Olgasi, Paolo Cotogni, Maria Felice Brizzi
Journal: Diabetes
Diabetes 2013;62(4):1245–1257
https://doi.org/10.2337/db12-0646
Published: 14 March 2013
View article titled, Increase of Palmitic Acid Concentration Impairs Endothelial Progenitor Cell and Bone Marrow–Derived Progenitor Cell Bioavailability: <subtitle>Role of the STAT5/PPARγ Transcriptional Complex</subtitle>
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Includes: Supplementary data
Journal Articles

Inverse Regulation of Inflammation and Mitochondrial Function in Adipose Tissue Defines Extreme Insulin Sensitivity in Morbidly Obese Patients

Mohammed Qatanani, Yejun Tan, Radu Dobrin, Danielle M. Greenawalt, Guanghui Hu, Wenqing Zhao, Jerrold M. Olefsky, Dorothy D. Sears, Lee M. Kaplan, Daniel M. Kemp
Journal: Diabetes
Diabetes 2013;62(3):855–863
https://doi.org/10.2337/db12-0399
Published: 14 February 2013
View article titled, Inverse Regulation of Inflammation and Mitochondrial Function in Adipose Tissue Defines Extreme Insulin Sensitivity in Morbidly Obese Patients
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Includes: Supplementary data
Journal Articles

Activin Receptor-Like Kinase 7 Suppresses Lipolysis to Accumulate Fat in Obesity Through Downregulation of Peroxisome Proliferator–Activated Receptor γ and C/EBPα

Satomi Yogosawa, Shin Mizutani, Yoshihiro Ogawa, Tetsuro Izumi
Journal: Diabetes
Diabetes 2013;62(1):115–123
https://doi.org/10.2337/db12-0295
Published: 13 December 2012
View article titled, Activin Receptor-Like Kinase 7 Suppresses Lipolysis to Accumulate Fat in Obesity Through Downregulation of Peroxisome Proliferator–Activated Receptor γ and C/EBPα
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Includes: Supplementary data
Journal Articles

Alterations in Lipid Signaling Underlie Lipodystrophy Secondary to AGPAT2 Mutations

Angela R. Subauste, Arun K. Das, Xiangquan Li, Brandon Elliot, Charles Evans, Mahmoud El Azzouny, Mary Treutelaar, Elif Oral, Todd Leff, Charles F. Burant
Journal: Diabetes
Diabetes 2012;61(11):2922–2931
https://doi.org/10.2337/db12-0004
Published: 16 October 2012
View article titled, Alterations in Lipid Signaling Underlie Lipodystrophy Secondary to AGPAT2 Mutations
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Includes: Supplementary data