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Journal Articles

Metformin’s Therapeutic Efficacy in the Treatment of Diabetes Does Not Involve Inhibition of Mitochondrial Glycerol Phosphate Dehydrogenase

Michael J. MacDonald, Israr-ul H. Ansari, Melissa J. Longacre, Scott W. Stoker
Journal: Diabetes
Diabetes 2021;70(7):1575–1580
https://doi.org/10.2337/db20-1143
Published: 13 April 2021
View article titled, Metformin’s Therapeutic Efficacy in the Treatment of Diabetes Does Not Involve Inhibition of Mitochondrial Glycerol Phosphate Dehydrogenase
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Journal Articles

Defective Hydroxylation of Phenformin as a Determinant of Drug Toxicity

E Bosisio, M Galli Kienle, G Galli, M Ciconali, A Negri, A Sessa, S Morosati, C R Sirtori
Journal: Diabetes
Diabetes 1981;30(8):644–649
https://doi.org/10.2337/diab.30.8.644
Published: 01 August 1981
View article titled, Defective Hydroxylation of Phenformin as a Determinant of Drug Toxicity
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Journal Articles

Phenformin Increases Insulin Binding to Human Cultured Breast Cancer Cells

D Cohen, V Pezzino, R Vigneri, R Avola, R D'agata, P Polosa
Journal: Diabetes
Diabetes 1980;29(4):329–331
https://doi.org/10.2337/diab.29.4.329
Published: 01 April 1980
View article titled, Phenformin Increases Insulin Binding to Human Cultured Breast Cancer Cells
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Journal Articles

Enhancement of the Mitochondrial Ca2+ Uptake Rate by Phenethylbiguanide and Other Organic Cations with Hypoglycemic Activity

F Davidoff, M.D., D Bertolini, Ph.D., Haas D, Ph.D.
Journal: Diabetes
Diabetes 1978;27(7):757–765
https://doi.org/10.2337/diab.27.7.757
Published: 01 July 1978
View article titled, Enhancement of the Mitochondrial Ca<sup>2+</sup> Uptake Rate by Phenethylbiguanide and Other Organic Cations with Hypoglycemic Activity
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Journal Articles

Serum Phenformin Concentrations in Patients with Phenformin-associated Lactic Acidosis

L A Conlay, BS, J H Karam, MD, S B Matin, PhD, J E Loewenstein, MD
Journal: Diabetes
Diabetes 1977;26(7):628–631
https://doi.org/10.2337/diab.26.7.628
Published: 01 July 1977
View article titled, Serum Phenformin Concentrations in Patients with Phenformin-associated Lactic Acidosis
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Journal Articles

Potentiation of Hypoglycemic Effect of Chlorpropamide and Phenformin by Halofenate

David J Kudzma, MD, Samuel J Friedberg, MD
Journal: Diabetes
Diabetes 1977;26(4):291–295
https://doi.org/10.2337/diab.26.4.291
Published: 01 April 1977
View article titled, Potentiation of Hypoglycemic Effect of Chlorpropamide and Phenformin by Halofenate
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Journal Articles

Phenformin-associated Metabolic Acidosis

Milford Fulop, M.D., Hemry D Hoberman, Ph.D., M.D.
Journal: Diabetes
Diabetes 1976;25(4):292–296
https://doi.org/10.2337/diab.25.4.292
Published: 01 April 1976
View article titled, Phenformin-associated Metabolic Acidosis
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Journal Articles

Phenformin-induced Lactic Acidosis in Diabetic Patients

Roger Assan, M.D., Christine Heuclin, Jean Raymond Girard, Ph.D., Francois LeMaire, M.D., Jean Raymond Attali, M.D.
Journal: Diabetes
Diabetes 1975;24(9):791–800
https://doi.org/10.2337/diab.24.9.791
Published: 01 September 1975
View article titled, Phenformin-induced Lactic Acidosis in Diabetic Patients
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Journal Articles

Lactic Acidosis Associated with Phenformin Therapy: Evidence that Inhibited Lactate Oxidation is the Causative Factor

G L Searle, PhD, M D Siperstein, MD, PhD
Journal: Diabetes
Diabetes 1975;24(8):741–745
https://doi.org/10.2337/diab.24.8.741
Published: 01 August 1975
View article titled, Lactic Acidosis Associated with Phenformin Therapy: Evidence that Inhibited Lactate Oxidation is the Causative Factor
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Journal Articles

Effect of Phenformin on Gluconeogenesis from Lactate and Intracellular pH in the Isolated Perfused Guinea Pig Liver

M H Lloyd, MB, MRCP, R A Iles, PhD, B Walton, MB, FFARCS, C A Hamilton, BSc, R D Cohen, MD, FRCP
Journal: Diabetes
Diabetes 1975;24(7):618–624
https://doi.org/10.2337/diab.24.7.618
Published: 01 July 1975
View article titled, Effect of Phenformin on Gluconeogenesis from Lactate and Intracellular pH in the Isolated Perfused Guinea Pig Liver
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Journal Articles

Insulin Therapy in Phenformin-Associated Lactic Acidosis: A Case Report, Biochemical Considerations and Review of the Literature

Alon J Dembo, M.B., B.Ch., Errol B Marliss, M.D., F.R.C.P.(C), Mitchell L Halperin, M.D., F.R.C.P.(C)
Journal: Diabetes
Diabetes 1975;24(1):28–35
https://doi.org/10.2337/diab.24.1.28
Published: 01 January 1975
View article titled, Insulin Therapy in Phenformin-Associated Lactic Acidosis: A Case Report, Biochemical Considerations and Review of the Literature
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Journal Articles

Effect of Phenformin on Carbohydrate Absorption in Man

Ward A Olsen, M.D., Howard K Rasmussen, B.S.
Journal: Diabetes
Diabetes 1974;23(8):716–718
https://doi.org/10.2337/diab.23.8.716
Published: 01 August 1974
View article titled, Effect of Phenformin on Carbohydrate Absorption in Man
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Journal Articles

Effect of Phenformin on Glucose-Insulin Interrelationships

R W Stout, M.D., M.R.C.P., J D Brunzell, M.D., E L Bierman, M.D., D Porte, Jr, M.D.
Journal: Diabetes
Diabetes 1974;23(7):624–630
https://doi.org/10.2337/diab.23.7.624
Published: 01 July 1974
View article titled, Effect of Phenformin on Glucose-Insulin Interrelationships
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Journal Articles

Effect of Phenformin in Hyperglycemic Rats

I Polacek, Ph.D., J Quart
Journal: Diabetes
Diabetes 1974;23(1):25–28
https://doi.org/10.2337/diab.23.1.25
Published: 01 January 1974
View article titled, Effect of Phenformin in Hyperglycemic Rats
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Journal Articles

Effect of Phenformin on the Exocrine Function of the Pancreas and on Insulin Secretion after Intraduodenal Infusion of HCL and Intravenous Injection of Secretin

Artur Czyzyk, M.D., Ph.D., Marian Szadkowski, M.D., Henryk Rogala, M.D., January Lawecki, M.D., Ph.D.
Journal: Diabetes
Diabetes 1973;22(12):932–937
https://doi.org/10.2337/diab.22.12.932
Published: 01 December 1973
View article titled, Effect of Phenformin on the Exocrine Function of the Pancreas and on Insulin Secretion after Intraduodenal Infusion of HCL and Intravenous Injection of Secretin
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Journal Articles

Effect of Phenformin on Water and Glucose Transport Across Isolated Human Ileum

D L Wingate, B.M., M.R.C.P., G D Hadley, M.D., F.R.C.P.
Journal: Diabetes
Diabetes 1973;22(3):175–180
https://doi.org/10.2337/diab.22.3.175
Published: 01 March 1973
View article titled, Effect of Phenformin on Water and Glucose Transport Across Isolated Human Ileum
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Journal Articles

Gluconeogenesis in Renal Cortical Tubules: Effect of Phenformin

Edwin E Gordon, M.D., Maria de Hartog
Journal: Diabetes
Diabetes 1973;22(1):50–57
https://doi.org/10.2337/diab.22.1.50
Published: 01 January 1973
View article titled, Gluconeogenesis in Renal Cortical Tubules: Effect of Phenformin
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Journal Articles

Carbohydrate-induced Hypertriglyceridemia: Inhibition by Phenformin

W Crawford Owen, M.D., Robert A Kreisberg, M.D., Alan M Siegal, M.D.
Journal: Diabetes
Diabetes 1971;20(11):739–744
https://doi.org/10.2337/diab.20.11.739
Published: 01 November 1971
View article titled, Carbohydrate-induced Hypertriglyceridemia: Inhibition by Phenformin
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Journal Articles

Lactate Turnover and Gluconeogenesis in Obesity: Effect of Phenformin

R A Kreisberg, M.D., L F Pennington, M.D., B R Boshell, M.D.
Journal: Diabetes
Diabetes 1970;19(1):64–69
https://doi.org/10.2337/diab.19.1.64
Published: 01 January 1970
View article titled, Lactate Turnover and Gluconeogenesis in Obesity: Effect of Phenformin
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Journal Articles

Studies on the Site and Mechanism of Action of Phenformin: I. Evidence for Significant “Nonperipheral” Effects of Phenformin on Glucose Metabolism in Normal Subjects

Samuel L Hollobaugh, M.D., M Bhaskar Rao, M.D., Fred A Kruger, M.D.
Journal: Diabetes
Diabetes 1970;19(1):45–49
https://doi.org/10.2337/diab.19.1.45
Published: 01 January 1970
View article titled, Studies on the Site and Mechanism of Action of Phenformin: I. Evidence for Significant “Nonperipheral” Effects of Phenformin on Glucose Metabolism in Normal Subjects
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