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Journal Articles

Cross-Ancestry DNA Methylation Marks of Insulin Resistance in Pregnancy: An Integrative Epigenome-Wide Association Study

Nicolas Fragoso-Bargas, Hannah R. Elliott, Sindre Lee-Ødegård, Julia O. Opsahl, Line Sletner, Anne Karen Jenum, Christian A. Drevon, Elisabeth Qvigstad, Gunn-Helen Moen, Kåre I. Birkeland, Rashmi B. Prasad, Christine Sommer
Journal: Diabetes
Diabetes 2023;72(3):415–426
DOI: https://doi.org/10.2337/db22-0504
Published: 19 December 2022
View article titled, Cross-Ancestry DNA Methylation Marks of Insulin Resistance in Pregnancy: An Integrative Epigenome-Wide Association Study
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Journal Articles

NRF2 and Diabetes: The Good, the Bad, and the Complex

Matthew Dodson, Aryatara Shakya, Annadurai Anandhan, Jinjing Chen, Joe G.N. Garcia, Donna D. Zhang
Journal: Diabetes
Diabetes 2022;71(12):2463–2476
DOI: https://doi.org/10.2337/db22-0623
Published: 21 November 2022
View article titled, NRF2 and Diabetes: The Good, the Bad, and the Complex
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Journal Articles

Prostaglandin PGE2 Receptor EP4 Regulates Microglial Phagocytosis and Increases Susceptibility to Diet-Induced Obesity

Anzela Niraula, Rachael D. Fasnacht, Kelly M. Ness, Jeremy M. Frey, Sophia A. Cuschieri, Mauricio D. Dorfman, Joshua P. Thaler
Journal: Diabetes
Diabetes 2023;72(2):233–244
DOI: https://doi.org/10.2337/db21-1072
Published: 01 November 2022
View article titled, Prostaglandin PGE2 Receptor EP4 Regulates Microglial Phagocytosis and Increases Susceptibility to Diet-Induced Obesity
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Journal Articles

Genetic Mapping of Multiple Traits Identifies Novel Genes for Adiposity, Lipids, and Insulin Secretory Capacity in Outbred Rats

Thu Hong-Le, Wesley L. Crouse, Gregory R. Keele, Katie Holl, Osborne Seshie, Michael Tschannen, Ann Craddock, Swapan K. Das, Alexandria M. Szalanczy, Bailey McDonald, Michael Grzybowski, Jason Klotz, Neeraj K. Sharma, Aron M. Geurts, Chia-Chi Chuang Key, Gregory Hawkins, William Valdar, Richard Mott, Leah C. Solberg Woods
Journal: Diabetes
Diabetes 2023;72(1):135–148
DOI: https://doi.org/10.2337/db22-0252
Published: 11 October 2022
View article titled, Genetic Mapping of Multiple Traits Identifies Novel Genes for Adiposity, Lipids, and Insulin Secretory Capacity in Outbred Rats
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Journal Articles

Disentangling Genetic Risks for Metabolic Syndrome

Eva S. van Walree, Iris E. Jansen, Nathaniel Y. Bell, Jeanne E. Savage, Christiaan de Leeuw, Max Nieuwdorp, Sophie van der Sluis, Danielle Posthuma
Journal: Diabetes
Diabetes 2022;71(11):2447–2457
DOI: https://doi.org/10.2337/db22-0478
Published: 19 August 2022
View article titled, Disentangling Genetic Risks for Metabolic Syndrome
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Journal Articles

Deficient Caveolin-1 Synthesis in Adipocytes Stimulates Systemic Insulin-Independent Glucose Uptake via Extracellular Vesicles

Clair Crewe, Shiuhwei Chen, Dawei Bu, Christy M. Gliniak, Ingrid Wernstedt Asterholm, Xin Xin Yu, Nolwenn Joffin, Camila O. de Souza, Jan-Bernd Funcke, Da Young Oh, Oleg Varlamov, Jacob J. Robino, Ruth Gordillo, Philipp E. Scherer
Journal: Diabetes
Diabetes 2022;71(12):2496–2512
DOI: https://doi.org/10.2337/db22-0035
Published: 26 July 2022
View article titled, Deficient Caveolin-1 Synthesis in Adipocytes Stimulates Systemic Insulin-Independent Glucose Uptake via Extracellular Vesicles
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Journal Articles

Insulin Response to Oral Glucose and Cardiometabolic Disease: A Mendelian Randomization Study to Assess Potential Causality

Anthony Nguyen, Rana Khafagy, Ameena Meerasa, Delnaz Roshandel, Andrew D. Paterson, Satya Dash
Journal: Diabetes
Diabetes 2022;71(9):1880–1890
DOI: https://doi.org/10.2337/db22-0138
Published: 24 June 2022
View article titled, Insulin Response to Oral Glucose and Cardiometabolic Disease: A Mendelian Randomization Study to Assess Potential Causality
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Meeting Abstracts

305-OR: Quiescence Abrogates Stress-Induced Senescence-Associated Secretion Phenotype in Adipose-Derived Stem Cells and May Enhance Their Therapeutic Effects on Diabetic Complications

MAKOTO FUNAKI, AKIKO HATA, MITSUTERU YOSHIDA, NAOKI MIYAMOTO, TAKAHISA IKUTA, YUTA UEMURA, MINATO AKIZUKI, AKIRA TANGOKU, HIROMICHI YUMOTO, HIROHISA OGAWA, TAKESHI OYA
Journal: Diabetes
Diabetes 2022;71(Supplement_1):305-OR
DOI: https://doi.org/10.2337/db22-305-OR
Published: 01 June 2022
View article titled, 305-OR: Quiescence Abrogates Stress-Induced Senescence-Associated Secretion Phenotype in Adipose-Derived Stem Cells and May Enhance Their Therapeutic Effects on Diabetic Complications
Meeting Abstracts

1201-P: Glycemic Response Phenotypes on Metformin Monotherapy in Real-World Diabetes Care

SRIDHARAN RAGHAVAN, WENHUI LIU, THEODORE WARSAVAGE, LAWRENCE S. PHILLIPS, JANE E. REUSCH, LIRON CAPLAN
Journal: Diabetes
Diabetes 2022;71(Supplement_1):1201-P
DOI: https://doi.org/10.2337/db22-1201-P
Published: 01 June 2022
View article titled, 1201-P: Glycemic Response Phenotypes on Metformin Monotherapy in Real-World Diabetes Care
Meeting Abstracts

18-LB: Hypertriglyceridemic-Waist Phenotype in Relation to Carotid Artery Atherosclerosis in Patients with Type 2 Diabetes

LEI ZHANG, YUXIU YANG, JUN WANG, YANHU DONG
Journal: Diabetes
Diabetes 2022;71(Supplement_1):18-LB
DOI: https://doi.org/10.2337/db22-18-LB
Published: 01 June 2022
View article titled, 18-LB: Hypertriglyceridemic-Waist Phenotype in Relation to Carotid Artery Atherosclerosis in Patients with Type 2 Diabetes
Meeting Abstracts

255-LB: Defining Functional Phenotype in Human Islets across Endocrine Cell Composition, Donor Age, Sex, and Ancestry

MARCELA BRISSOVA, HEATHER H. DURAI, SHAOJUN MEI, ANASTASIA COLDREN, COREY DAVIS, CONRAD REIHSMANN, ALEXANDER L. HOPKIRK, DANNIELLE GIBSON, RADHIKA ARAMANDLA, GREG POFFENBERGER, DIANE C. SAUNDERS, ALVIN C. POWERS, JOYCE C. NILAND, CARMELLA EVANS-MOLINA
Journal: Diabetes
Diabetes 2022;71(Supplement_1):255-LB
DOI: https://doi.org/10.2337/db22-255-LB
Published: 01 June 2022
View article titled, 255-LB: Defining Functional Phenotype in Human Islets across Endocrine Cell Composition, Donor Age, Sex, and Ancestry
Meeting Abstracts

1262-P: Developing a Computable Phenotype Algorithm for Identification of Children and Adolescents with Diabetes Using Electronic Health Records

PIAOPIAO LI, ELIOT SPECTOR, KHALID ALKHUZAM, RAHUL S. PATEL, WILLIAM T. DONAHOO, SARAH BOST, TIANCHEN LYU, YONGHUI WU, WILLIAM HOGAN, MATTIA PROSPERI, BRIAN E. DIXON, DANA DABELEA, LEVON H. UTIDJIAN, TESSA L. CRUME, LORNA THORPE, ANGELA D. LIESE, DESMOND SCHATZ, MARK A. ATKINSON, MICHAEL J. HALLER, ELIZABETH SHENKMAN, JIANG BIAN, YI GUO, HUI SHAO, MARK A. ATKINSON
Journal: Diabetes
Diabetes 2022;71(Supplement_1):1262-P
DOI: https://doi.org/10.2337/db22-1262-P
Published: 01 June 2022
View article titled, 1262-P: Developing a Computable Phenotype Algorithm for Identification of Children and Adolescents with Diabetes Using Electronic Health Records
Meeting Abstracts

1451-P: Peri-Islet Fibrosis in Cystic Fibrosis Is Associated with Altered Alpha-Cell Phenotype

NICOLE KATTNER, YARA AL-SELWI, DINA TINIAKOS, GÜNTER KLÖPPEL, JAMES A. SHAW
Journal: Diabetes
Diabetes 2022;71(Supplement_1):1451-P
DOI: https://doi.org/10.2337/db22-1451-P
Published: 01 June 2022
View article titled, 1451-P: Peri-Islet Fibrosis in Cystic Fibrosis Is Associated with Altered Alpha-Cell Phenotype
Meeting Abstracts

1292-P: Differential Glycaemic Effects of Recombinant IL-9 across Species Highlight Translational Challenges for Immunometabolic Phenotypes

TINGQING GUO, ELLEN MARIE STRAARUP, JOSEFINE LINDROOS CHRISTENSEN, GERT BOLT, PEDER LISBY NØRBY, WANG ZHE, THOMAS A. PEDERSEN, MERCEDES FERRERAS, KRISTIAN SASS-ØRUM, KLAUS S. FREDERIKSEN
Journal: Diabetes
Diabetes 2022;71(Supplement_1):1292-P
DOI: https://doi.org/10.2337/db22-1292-P
Published: 01 June 2022
View article titled, 1292-P: Differential Glycaemic Effects of Recombinant IL-9 across Species Highlight Translational Challenges for Immunometabolic Phenotypes
Meeting Abstracts

1065-P: The Use of OGTT and Phenotypic Characteristics to Identify GDM Subtypes in Mexican Women, an Approach towards Precision Medicine

HECTOR GALLARDO-RINCÓN, JANINNE ORTEGA-MONTIEL, LUIS ALBERTO MARTINEZ-JUAREZ, JULIETA LOMELIN-GASCON, ALEJANDRA MONTOYA, ENRIQUE REYES-MUÑOZ, VICTORIA GALICIA-HERNANDEZ, ROSANGELA AVILA-DOMINGUEZ, LUCIA V. PEREZ-TORRES, NATALI GARCIA-GONZALEZ, AZUCENA H. PEREZ-HERNANDEZ, BRENDA PEREZ-ROMERO, CYNDY G. GRANILLO-RAMIREZ, ROBERTO TAPIA-CONYER
Journal: Diabetes
Diabetes 2022;71(Supplement_1):1065-P
DOI: https://doi.org/10.2337/db22-1065-P
Published: 01 June 2022
View article titled, 1065-P: The Use of OGTT and Phenotypic Characteristics to Identify GDM Subtypes in Mexican Women, an Approach towards Precision Medicine
Meeting Abstracts

78-OR: LRH-1/NR5A2 Agonism Triggers an Anti-Inflammatory Phenotypic Switch of Immune Cells from Patients with Type 1 Diabetes and Improves Islet Engraftment/Function

NADIA COBO-VUILLEUMIER, SILVIA RODRIGUEZ-FERNANDEZ, PETRA I. LORENZO, LIVIA LOPEZ, AKAITZ DORRONSORO, CHRISTIAN C. LACHAUD, LIDIA ALMENARA-FUENTES, MIREIA RAMOS-RODRÍGUEZ, ISABEL MERIDA, MANUEL AGUILAR-DIOSDADO, RITA NANO, SR., LORENZO PIEMONTI, LORENZO PASQUALI, FRANZ MARTIN, ISABEL GARCIA-SANCHEZ, MARIA ASUNCION MARTINEZ-BROCCA, MARTA VIVES-PI, BENOIT R. GAUTHIER
Journal: Diabetes
Diabetes 2022;71(Supplement_1):78-OR
DOI: https://doi.org/10.2337/db22-78-OR
Published: 01 June 2022
View article titled, 78-OR: LRH-1/NR5A2 Agonism Triggers an Anti-Inflammatory Phenotypic Switch of Immune Cells from Patients with Type 1 Diabetes and Improves Islet Engraftment/Function
Meeting Abstracts

1166-P: Distinct Phenotypes of Multiorgan Abnormalities in Long COVID and Type 2 Diabetes Identified by Multiparametric Magnetic Resonance Imaging

NICOLE EICHERT, ALISON TELFORD, ADRIANA ROCA-FERNANDEZ, AZLINDA HAMID, HELENA B. THOMAIDES-BREARS, ANDREA DENNIS, RAJARSHI BANERJEE, SARAH ALI, GAYA THANABALASINGHAM, GRAHAM KEMP, DANIEL CUTHBERTSON, AMITAVA BANERJEE
Journal: Diabetes
Diabetes 2022;71(Supplement_1):1166-P
DOI: https://doi.org/10.2337/db22-1166-P
Published: 01 June 2022
View article titled, 1166-P: Distinct Phenotypes of Multiorgan Abnormalities in Long COVID and Type 2 Diabetes Identified by Multiparametric Magnetic Resonance Imaging
Journal Articles

Systematic Heritability and Heritability Enrichment Analysis for Diabetes Complications in UK Biobank and ACCORD Studies

Juhyun Kim, Aubrey Jensen, Seyoon Ko, Sridharan Raghavan, Lawrence S. Phillips, Adriana Hung, Yan Sun, Hua Zhou, Peter Reaven, Jin J. Zhou
Journal: Diabetes
Diabetes 2022;71(5):1137–1148
DOI: https://doi.org/10.2337/db21-0839
Published: 08 February 2022
View article titled, Systematic Heritability and Heritability Enrichment Analysis for Diabetes Complications in UK Biobank and ACCORD Studies
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Journal Articles

pdx1 Knockout Leads to a Diabetic Nephropathy– Like Phenotype in Zebrafish and Identifies Phosphatidylethanolamine as Metabolite Promoting Early Diabetic Kidney Damage

Lucas M. Wiggenhauser, Lena Metzger, Katrin Bennewitz, Silas Soleymani, Mike Boger, Christoph T. Tabler, Ingrid Hausser, Carsten Sticht, Paulus Wohlfart, Nadine Volk, Elena Heidenreich, Michael Buettner, Hans-Peter Hammes, Jens Kroll
Journal: Diabetes
Diabetes 2022;71(5):1073–1080
DOI: https://doi.org/10.2337/db21-0645
Published: 31 January 2022
View article titled, pdx1 Knockout Leads to a Diabetic Nephropathy– Like Phenotype in Zebrafish and Identifies Phosphatidylethanolamine as Metabolite Promoting Early Diabetic Kidney Damage
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Journal Articles

Single-Cell Transcriptomics Reveals Novel Role of Microglia in Fibrovascular Membrane of Proliferative Diabetic Retinopathy

Zizhong Hu, Xiying Mao, Mingkang Chen, Xinjing Wu, Tianye Zhu, Yu Liu, Zhengyu Zhang, Wen Fan, Ping Xie, Songtao Yuan, Qinghuai Liu
Journal: Diabetes
Diabetes 2022;71(4):762–773
DOI: https://doi.org/10.2337/db21-0551
Published: 21 January 2022
View article titled, Single-Cell Transcriptomics Reveals Novel Role of Microglia in Fibrovascular Membrane of Proliferative Diabetic Retinopathy
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