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Meeting Abstracts

207-LB: Simultaneous 2H/13C Assessment of Liver and Kidney Metabolic Fluxes Reveals Reciprocal Upregulation of Renal Gluconeogenesis in Hepatic PEPCK-C Knockout Mice

MOHSIN RAHIM, CLINTON M. HASENOUR, TOMASZ BEDNARSKI, CURTIS C. HUGHEY, DAVID WASSERMAN, JAMEY YOUNG
Journal: Diabetes
Diabetes 2021;70(Supplement_1):207-LB
https://doi.org/10.2337/db21-207-LB
Published: 01 June 2021
View article titled, 207-LB: Simultaneous 2H/13C Assessment of Liver and Kidney Metabolic Fluxes Reveals Reciprocal Upregulation of Renal Gluconeogenesis in Hepatic PEPCK-C Knockout Mice
Meeting Abstracts

Regulation of Hepatic Insulin Sensitivity and Hepatic Steatosis by ULK1

YOUNGDO KOO, MICHAEL P. GARNEAU, QUANJIANG ZHANG, E. DALE ABEL
Journal: Diabetes
Diabetes 2018;67(Supplement_1):1863-P
https://doi.org/10.2337/db18-1863-P
Published: 01 July 2018
View article titled, Regulation of Hepatic Insulin Sensitivity and Hepatic Steatosis by ULK1
Meeting Abstracts

T3 and Glucose Increase Expression of ChREBPß to Induce Expression of Phosphoenolpyruvate Carboxykinase (Pck1) Leading to Increased ß-Cell Proliferation

LIORA S. KATZ, DONALD SCOTT
Journal: Diabetes
Diabetes 2018;67(Supplement_1):2137-P
https://doi.org/10.2337/db18-2137-P
Published: 01 July 2018
View article titled, T3 and Glucose Increase Expression of ChREBPß to Induce Expression of Phosphoenolpyruvate Carboxykinase (Pck1) Leading to Increased ß-Cell Proliferation
Meeting Abstracts

Assessment and Expansion of Models for 13C-Metabolic Flux Analysis (MFA) In Vivo

CLINTON HASENOUR, MOHSIN RAHIM, JAMEY YOUNG
Journal: Diabetes
Diabetes 2018;67(Supplement_1):258-LB
https://doi.org/10.2337/db18-258-LB
Published: 01 July 2018
View article titled, Assessment and Expansion of Models for <sup>13</sup>C-Metabolic Flux Analysis (MFA) In Vivo
Journal Articles

Aberrant Expression of FBXO2 Disrupts Glucose Homeostasis Through Ubiquitin-Mediated Degradation of Insulin Receptor in Obese Mice

Bin Liu, Han Lu, Duanzhuo Li, Xuelian Xiong, Lu Gao, Zhixiang Wu, Yan Lu
Journal: Diabetes
Diabetes 2017;66(3):689–698
https://doi.org/10.2337/db16-1104
Published: 08 December 2016
View article titled, Aberrant Expression of FBXO2 Disrupts Glucose Homeostasis Through Ubiquitin-Mediated Degradation of Insulin Receptor in Obese Mice
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Includes: Supplementary data
Journal Articles

MicroRNA-451 Negatively Regulates Hepatic Glucose Production and Glucose Homeostasis by Targeting Glycerol Kinase–Mediated Gluconeogenesis

Shu Zhuo, Mengmei Yang, Yanan Zhao, Xiaofang Chen, Feifei Zhang, Na Li, Pengle Yao, Tengfei Zhu, Hong Mei, Shanshan Wang, Yu Li, Shiting Chen, Yingying Le
Journal: Diabetes
Diabetes 2016;65(11):3276–3288
https://doi.org/10.2337/db16-0166
Published: 05 August 2016
View article titled, MicroRNA-451 Negatively Regulates Hepatic Glucose Production and Glucose Homeostasis by Targeting Glycerol Kinase–Mediated Gluconeogenesis
Open the PDF for MicroRNA-451 Negatively Regulates Hepatic Glucose Production and Glucose Homeostasis by Targeting Glycerol Kinase–Mediated Gluconeogenesis in another window
Includes: Supplementary data
Journal Articles

O-GlcNAcylation of Orphan Nuclear Receptor Estrogen-Related Receptor γ Promotes Hepatic Gluconeogenesis

Jagannath Misra, Don-Kyu Kim, Yoon Seok Jung, Han Byeol Kim, Yong-Hoon Kim, Eun-Kyung Yoo, Byung Gyu Kim, Sunghoon Kim, In-Kyu Lee, Robert A. Harris, Jeong-Sun Kim, Chul-Ho Lee, Jin Won Cho, Hueng-Sik Choi
Journal: Diabetes
Diabetes 2016;65(10):2835–2848
https://doi.org/10.2337/db15-1523
Published: 22 June 2016
View article titled, O-GlcNAcylation of Orphan Nuclear Receptor Estrogen-Related Receptor γ Promotes Hepatic Gluconeogenesis
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Includes: Supplementary data
Journal Articles

The Metabolic Regulator Histone Deacetylase 9 Contributes to Glucose Homeostasis Abnormality Induced by Hepatitis C Virus Infection

Jizheng Chen, Ning Wang, Mei Dong, Min Guo, Yang Zhao, Zhiyong Zhuo, Chao Zhang, Xiumei Chi, Yu Pan, Jing Jiang, Hong Tang, Junqi Niu, Dongliang Yang, Zhong Li, Xiao Han, Qian Wang, Xinwen Chen
Journal: Diabetes
Diabetes 2015;64(12):4088–4098
https://doi.org/10.2337/db15-0197
Published: 29 September 2015
View article titled, The Metabolic Regulator Histone Deacetylase 9 Contributes to Glucose Homeostasis Abnormality Induced by Hepatitis C Virus Infection
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Includes: Supplementary data
Journal Articles

Dietary Iron Controls Circadian Hepatic Glucose Metabolism Through Heme Synthesis

Judith A. Simcox, Thomas Creighton Mitchell, Yan Gao, Steven F. Just, Robert Cooksey, James Cox, Richard Ajioka, Deborah Jones, Soh-hyun Lee, Daniel King, Jingyu Huang, Donald A. McClain
Journal: Diabetes
Diabetes 2015;64(4):1108–1119
https://doi.org/10.2337/db14-0646
Published: 14 October 2014
View article titled, Dietary Iron Controls Circadian Hepatic Glucose Metabolism Through Heme Synthesis
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Includes: Supplementary data
Journal Articles

The Proliferative Gene Cyclin D1 and Gluconeogenesis—Could Suppressing Glucose Production Also Promote Cancer?

Sofianos Andrikopoulos
Journal: Diabetes
Diabetes 2014;63(10):3177–3179
https://doi.org/10.2337/db14-0857
Published: 15 September 2014
View article titled, The Proliferative Gene Cyclin D1 and Gluconeogenesis—Could Suppressing Glucose Production Also Promote Cancer?
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Journal Articles

Cyclin D1 Represses Gluconeogenesis via Inhibition of the Transcriptional Coactivator PGC1α

Kavita Bhalla, Wan-Ju Liu, Keyata Thompson, Lars Anders, Srikripa Devarakonda, Ruby Dewi, Stephanie Buckley, Bor-Jang Hwang, Brian Polster, Susan G. Dorsey, Yezhou Sun, Piotr Sicinski, Geoffrey D. Girnun
Journal: Diabetes
Diabetes 2014;63(10):3266–3278
https://doi.org/10.2337/db13-1283
Published: 15 September 2014
View article titled, Cyclin D1 Represses Gluconeogenesis via Inhibition of the Transcriptional Coactivator PGC1α
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Includes: Supplementary data
Journal Articles

Hypothalamic Nesfatin-1/NUCB2 Knockdown Augments Hepatic Gluconeogenesis That Is Correlated With Inhibition of mTOR-STAT3 Signaling Pathway in Rats

Dandong Wu, Mengliu Yang, Yang Chen, Yanjun Jia, Zhongmin Alex Ma, Guenther Boden, Ling Li, Gangyi Yang
Journal: Diabetes
Diabetes 2014;63(4):1234–1247
https://doi.org/10.2337/db13-0899
Published: 13 March 2014
View article titled, Hypothalamic Nesfatin-1/NUCB2 Knockdown Augments Hepatic Gluconeogenesis That Is Correlated With Inhibition of mTOR-STAT3 Signaling Pathway in Rats
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Includes: Supplementary data
Journal Articles

Yin Yang 1 Promotes Hepatic Gluconeogenesis Through Upregulation of Glucocorticoid Receptor

Yan Lu, Xuelian Xiong, Xiaolin Wang, Zhijian Zhang, Jin Li, Guojun Shi, Jian Yang, Huijie Zhang, Guang Ning, Xiaoying Li
Journal: Diabetes
Diabetes 2013;62(4):1064–1073
https://doi.org/10.2337/db12-0744
Published: 14 March 2013
View article titled, Yin Yang 1 Promotes Hepatic Gluconeogenesis Through Upregulation of Glucocorticoid Receptor
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Includes: Supplementary data
Journal Articles

Nesfatin-1 Action in the Brain Increases Insulin Sensitivity Through Akt/AMPK/TORC2 Pathway in Diet-Induced Insulin Resistance

Mengliu Yang, Zhihong Zhang, Chong Wang, Ke Li, Shengbing Li, Guenther Boden, Ling Li, Gangyi Yang
Journal: Diabetes
Diabetes 2012;61(8):1959–1968
https://doi.org/10.2337/db11-1755
Published: 17 July 2012
View article titled, Nesfatin-1 Action in the Brain Increases Insulin Sensitivity Through Akt/AMPK/TORC2 Pathway in Diet-Induced Insulin Resistance
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Includes: Supplementary data
Journal Articles

Ubiquitin-Specific Protease 2 Regulates Hepatic Gluconeogenesis and Diurnal Glucose Metabolism Through 11β-Hydroxysteroid Dehydrogenase 1

Matthew M. Molusky, Siming Li, Di Ma, Lei Yu, Jiandie D. Lin
Journal: Diabetes
Diabetes 2012;61(5):1025–1035
https://doi.org/10.2337/db11-0970
Published: 13 April 2012
View article titled, Ubiquitin-Specific Protease 2 Regulates Hepatic Gluconeogenesis and Diurnal Glucose Metabolism Through 11β-Hydroxysteroid Dehydrogenase 1
Open the PDF for Ubiquitin-Specific Protease 2 Regulates Hepatic Gluconeogenesis and Diurnal Glucose Metabolism Through 11β-Hydroxysteroid Dehydrogenase 1 in another window
Includes: Supplementary data
Journal Articles

Central Nervous System Delivery of the Antipsychotic Olanzapine Induces Hepatic Insulin Resistance

Paulo J.F. Martins, Michael Haas, Silvana Obici
Journal: Diabetes
Diabetes 2010;59(10):2418–2425
https://doi.org/10.2337/db10-0449
Published: 03 August 2010
View article titled, Central Nervous System Delivery of the Antipsychotic Olanzapine Induces Hepatic Insulin Resistance
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Includes: Supplementary data
Journal Articles

Role of KLF15 in Regulation of Hepatic Gluconeogenesis and Metformin Action

Mototsugu Takashima, Wataru Ogawa, Kumiko Hayashi, Hiroshi Inoue, Shinichi Kinoshita, Yasuo Okamoto, Hiroshi Sakaue, Yu Wataoka, Aki Emi, Yoko Senga, Yasushi Matsuki, Eijiro Watanabe, Ryuji Hiramatsu, Masato Kasuga
Journal: Diabetes
Diabetes 2010;59(7):1608–1615
https://doi.org/10.2337/db09-1679
Published: 14 April 2010
View article titled, Role of KLF15 in Regulation of Hepatic Gluconeogenesis and Metformin Action
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Includes: Supplementary data
Journal Articles

Molecular Characterization of Insulin-Mediated Suppression of Hepatic Glucose Production In Vivo

Christopher J. Ramnanan, Dale S. Edgerton, Noelia Rivera, Jose Irimia-Dominguez, Ben Farmer, Doss W. Neal, Margaret Lautz, E. Patrick Donahue, Catalina M. Meyer, Peter J. Roach, Alan D. Cherrington
Journal: Diabetes
Diabetes 2010;59(6):1302–1311
https://doi.org/10.2337/db09-1625
Published: 25 February 2010
View article titled, Molecular Characterization of Insulin-Mediated Suppression of Hepatic Glucose Production In Vivo
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Includes: Supplementary data
Journal Articles

Pck1 Gene Silencing in the Liver Improves Glycemia Control, Insulin Sensitivity, and Dyslipidemia in db/db Mice

Alicia G. Gómez-Valadés, Andrés Méndez-Lucas, Anna Vidal-Alabró, Francese X. Blasco, Miguel Chillon, Ramon Bartrons, Jordi Bermúdez, José C. Perales
Journal: Diabetes
Diabetes 2008;57(8):2199–2210
https://doi.org/10.2337/db07-1087
Published: 01 August 2008
View article titled, <em>Pck1</em> Gene Silencing in the Liver Improves Glycemia Control, Insulin Sensitivity, and Dyslipidemia in <em>db/db</em> Mice
Open the PDF for <em>Pck1</em> Gene Silencing in the Liver Improves Glycemia Control, Insulin Sensitivity, and Dyslipidemia in <em>db/db</em> Mice in another window
Includes: Supplementary data
Journal Articles

Metformin Inhibits Hepatic Gluconeogenesis Through AMP-Activated Protein Kinase–Dependent Regulation of the Orphan Nuclear Receptor SHP

Yong Deuk Kim, Keun-Gyu Park, Yong-Soo Lee, Yun-Yong Park, Don-Kyu Kim, Balachandar Nedumaran, Won Gu Jang, Won-Jea Cho, Joohun Ha, In-Kyu Lee, Chul-Ho Lee, Hueng-Sik Choi
Journal: Diabetes
Diabetes 2008;57(2):306–314
https://doi.org/10.2337/db07-0381
Published: 01 February 2008
View article titled, Metformin Inhibits Hepatic Gluconeogenesis Through AMP-Activated Protein Kinase–Dependent Regulation of the Orphan Nuclear Receptor SHP
Open the PDF for Metformin Inhibits Hepatic Gluconeogenesis Through AMP-Activated Protein Kinase–Dependent Regulation of the Orphan Nuclear Receptor SHP in another window
Includes: Supplementary data