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Journal Articles

Reduced Expression Level of Protein Phosphatase PPM1E Serves to Maintain Insulin Secretion in Type 2 Diabetes

Sevda Gheibi, Luis Rodrigo Cataldo, Alexander Hamilton, Mi Huang, Sebastian Kalamajski, Malin Fex, Hindrik Mulder

Diabetes 2023;72(4):455–466

DOI: https://doi.org/10.2337/db22-0472

Published: 20 January 2023

View article titled, Reduced Expression Level of Protein Phosphatase PPM1E Serves to Maintain Insulin Secretion in Type 2 Diabetes

Meeting Abstracts

299-OR: Molecular and Physiological Consequences of the Diabetes-Related PGC1A Gly482Ser Polymorphism

MARIA GALIPEAU, NATHALIE JOUVET, EMILIE COURTY, ROXANNE VANDENBEEK, NAVEEN P. KHAN, KHALIL BOUYAKDAN, CUILAN NIAN, CATERINA IORIO, DANIEL D. SCOTT, MAY FARAJ, MARLENE OEFFINGER, FRANCIS C. LYNN, ROBERT A. SCREATON, THIERRY ALQUIER, JENNIFER L. ESTALL

Diabetes 2022;71(Supplement_1):299-OR

DOI: https://doi.org/10.2337/db22-299-OR

Published: 01 June 2022

View article titled, 299-OR: Molecular and Physiological Consequences of the Diabetes-Related PGC1A Gly482Ser Polymorphism

Meeting Abstracts

441-P: Oleate Prevents Palmitate-Induced Abnormalities in Insulin Signaling in Human Cardiac Progenitor Cells by Inhibiting p38 MAPK and c-Jun Phosphorylation

ROSSELLA DORIA, ISABELLA CALDERONI, CRISTINA CACCIOPPOLI, VALENTINA ANNAMARIA GENCHI, GIUSEPPE SANTARPINO, ANNA LEONARDINI, ANNALISA NATALICCHIO, SEBASTIO PERRINI, ANGELO CIGNARELLI, FRANCESCO GIORGINO, LUIGI LAVIOLA

Diabetes 2022;71(Supplement_1):441-P

DOI: https://doi.org/10.2337/db22-441-P

Published: 01 June 2022

View article titled, 441-P: Oleate Prevents Palmitate-Induced Abnormalities in Insulin Signaling in Human Cardiac Progenitor Cells by Inhibiting p38 MAPK and c-Jun Phosphorylation

Journal Articles

Hepatic GSK3β-Dependent CRY1 Degradation Contributes to Diabetic Hyperglycemia

Ye Young Kim, Hagoon Jang, Gung Lee, Yong Geun Jeon, Jee Hyung Sohn, Ji Seul Han, Won Taek Lee, Jeu Park, Jin Young Huh, Hahn Nahmgoong, Sang Mun Han, Jeesoo Kim, Minwoo Pak, Sun Kim, Jong-Seo Kim, Jae Bum Kim

Diabetes 2022;71(7):1373–1387

DOI: https://doi.org/10.2337/db21-0649

Published: 27 April 2022

View article titled, Hepatic GSK3β-Dependent CRY1 Degradation Contributes to Diabetic Hyperglycemia

Journal Articles

DOC2b Enhances β-Cell Function via a Novel Tyrosine Phosphorylation-Dependent Mechanism

Diti Chatterjee Bhowmick, Arianne Aslamy, Supriyo Bhattacharya, Eunjin Oh, Miwon Ahn, Debbie C. Thurmond

Diabetes 2022;71(6):1246–1260

DOI: https://doi.org/10.2337/db21-0681

Published: 04 April 2022

View article titled, DOC2b Enhances β-Cell Function via a Novel Tyrosine Phosphorylation-Dependent Mechanism

Journal Articles

Illumination of the Endogenous Insulin-Regulated TBC1D4 Interactome in Human Skeletal Muscle

Jeppe K. Larsen, Magnus R. Larsen, Jesper B. Birk, Dorte E. Steenberg, Janne R. Hingst, Kurt Højlund, Alexandra Chadt, Hadi Al-Hasani, Atul S. Deshmukh, Jørgen F.P. Wojtaszewski, Rasmus Kjøbsted

Diabetes 2022;71(5):906–920

DOI: https://doi.org/10.2337/db21-0855

Published: 22 February 2022

View article titled, Illumination of the Endogenous Insulin-Regulated TBC1D4 Interactome in Human Skeletal Muscle

Meeting Abstracts

29-LB: Exercise Effects on ?3-AMPK Activity, Akt Substrate of 160 kDa Phosphorylation, and Glucose Uptake in Muscle of Normal and Insulin-Resistant Female Rats

HAIYAN WANG, EDWARD B. ARIAS, AMY ZHENG, SEONGEUN KWAK, JIAHUI ZHAO, GENGFU DONG, GREGORY D. CARTEE

Diabetes 2021;70(Supplement_1):29-LB

DOI: https://doi.org/10.2337/db21-29-LB

Published: 01 June 2021

View article titled, 29-LB: Exercise Effects on ?3-AMPK Activity, Akt Substrate of 160 kDa Phosphorylation, and Glucose Uptake in Muscle of Normal and Insulin-Resistant Female Rats

Meeting Abstracts

1153-P: Sodium-Glucose Cotransporter-2 Inhibitors Increase Food Intake via a Mechanism That Acts on the Central Nervous System Involving Phosphorylation of Adenosine Monophosphate-Activated Protein Kinase in the Lateral Hypothalamus

KENJI TAKEDA, HIRAKU ONO, TOMOHIRO OHNO, KOUTARO YOKOTE

Diabetes 2021;70(Supplement_1):1153-P

DOI: https://doi.org/10.2337/db21-1153-P

Published: 01 June 2021

View article titled, 1153-P: Sodium-Glucose Cotransporter-2 Inhibitors Increase Food Intake via a Mechanism That Acts on the Central Nervous System Involving Phosphorylation of Adenosine Monophosphate-Activated Protein Kinase in the Lateral Hypothalamus

Meeting Abstracts

1244-P: The Protein Phosphatase PPm1k Regulates Ribosomal Protein S6 Phosphorylation in Beta Cells

YANN DELEYE, JACOB HERRING, KAVAN H. HESS, BRENNAN LEININGER, ROBERT W. MCGARRAH, III, JEFFERY S. TESSEM, PHILLIP J. WHITE

Diabetes 2021;70(Supplement_1):1244-P

DOI: https://doi.org/10.2337/db21-1244-P

Published: 01 June 2021

View article titled, 1244-P: The Protein Phosphatase PPm1k Regulates Ribosomal Protein S6 Phosphorylation in Beta Cells

Meeting Abstracts

334-OR: Sex Differences in Protein Phosphorylation in Insulin Resistance in Humans at the Cellular Level

NIDA HAIDER, JASMIN LEBASTCHI, THIAGO M. BATISTA, HUI PAN, JONATHAN DREYFUSS, IVAN CARCAMO-ORIVE, JOSH KNOWLES, C. RONALD KAHN

Diabetes 2021;70(Supplement_1):334-OR

DOI: https://doi.org/10.2337/db21-334-OR

Published: 01 June 2021

View article titled, 334-OR: Sex Differences in Protein Phosphorylation in Insulin Resistance in Humans at the Cellular Level

Meeting Abstracts

121-OR: Activation of FoxO1 Induces Akt Phosphorylation and Mimics the Metabolic Functions of Insulin without Proliferative Effects on 3T3-L1 Adipocytes

TOMOHIRO OHNO, HIRAKU ONO, KENJI TAKEDA, KOUTARO YOKOTE

Diabetes 2021;70(Supplement_1):121-OR

DOI: https://doi.org/10.2337/db21-121-OR

Published: 01 June 2021

View article titled, 121-OR: Activation of FoxO1 Induces Akt Phosphorylation and Mimics the Metabolic Functions of Insulin without Proliferative Effects on 3T3-L1 Adipocytes

Journal Articles

Vascular Expression of Permeability-Resistant Occludin Mutant Preserves Visual Function in Diabetes

Andreia Goncalves, Alyssa Dreffs, Cheng-mao Lin, Sarah Sheskey, Natalie Hudson, Jason Keil, Matthew Campbell, David A. Antonetti

Diabetes 2021;70(7):1549–1560

DOI: https://doi.org/10.2337/db20-1220

Published: 21 April 2021

View article titled, Vascular Expression of Permeability-Resistant Occludin Mutant Preserves Visual Function in Diabetes

Meeting Abstracts

1714-P: Regulation of Phosphorylation Status in Insulin Signaling via a4 Is Necessary for Adipocyte Maintenance and Lipid Dynamics

MASAJI SAKAGUCHI, SHOTA OKAGAWA, YUMA OKUBO, SAYAKA KITANO, MOTOYUKI IGATA, TATSUYA KONDO, EIICHI ARAKI

Diabetes 2020;69(Supplement_1):1714-P

DOI: https://doi.org/10.2337/db20-1714-P

Published: 01 June 2020

View article titled, 1714-P: Regulation of Phosphorylation Status in Insulin Signaling via a4 Is Necessary for Adipocyte Maintenance and Lipid Dynamics

Meeting Abstracts

1757-P: Tyrosine Phosphorylation of Phospholipase C in Human Skeletal Muscle Insulin Resistance

XIANGMIN ZHANG, AKTHAM H. MESTAREEHI, BERHANE SEYOUM, ZHENGPING YI

Diabetes 2020;69(Supplement_1):1757-P

DOI: https://doi.org/10.2337/db20-1757-P

Published: 01 June 2020

View article titled, 1757-P: Tyrosine Phosphorylation of Phospholipase C in Human Skeletal Muscle Insulin Resistance

Meeting Abstracts

298-OR: Disruption of Multiple Cell-Autonomous Protein Phosphorylation Networks Underlies Muscle Insulin Resistance in Type 2 Diabetes

THIAGO M. BATISTA, NICOLAI J. WEWER ALBRECHTSEN, JULEEN R. ZIERATH, MATTHIAS MANN, C. RONALD KAHN

Diabetes 2020;69(Supplement_1):298-OR

DOI: https://doi.org/10.2337/db20-298-OR

Published: 01 June 2020

View article titled, 298-OR: Disruption of Multiple Cell-Autonomous Protein Phosphorylation Networks Underlies Muscle Insulin Resistance in Type 2 Diabetes

Meeting Abstracts

455-P: Pan-ErbB Inhibition Attenuates Diabetes-Induced Vascular Dysfunction in an Experimental Model of Diabetes

SAGHIR AKHTAR, BINDU CHANDRASEKHAR, IBRAHIM BENTER, SR.

Diabetes 2020;69(Supplement_1):455-P

DOI: https://doi.org/10.2337/db20-455-P

Published: 01 June 2020

View article titled, 455-P: Pan-ErbB Inhibition Attenuates Diabetes-Induced Vascular Dysfunction in an Experimental Model of Diabetes

Meeting Abstracts

410-P: Effects of Palmitate and Oleate on Apoptosis, Autophagy, Stress, Kinase Phosphorylation, and Enzymes of Fatty Acid Oxidation in Human Cardiac Progenitor Cells from Control and Diabetic Subjects

LUIGI LAVIOLA, ROSSELLA SCHIPANI, ROSSELLA DORIA, CRISTINA CACCIOPPOLI, ANNA LEONARDINI, ANNALISA NATALICCHIO, SEBASTIO PERRINI, ANGELO CIGNARELLI, FRANCESCO GIORGINO

Diabetes 2020;69(Supplement_1):410-P

DOI: https://doi.org/10.2337/db20-410-P

Published: 01 June 2020

View article titled, 410-P: Effects of Palmitate and Oleate on Apoptosis, Autophagy, Stress, Kinase Phosphorylation, and Enzymes of Fatty Acid Oxidation in Human Cardiac Progenitor Cells from Control and Diabetic Subjects

Meeting Abstracts

2119-P: Deep Profiling of Phosphorylation Dynamics in Human Islets in Response to Inflammatory Cytokines

ADAM C. SWENSEN, YINYIN YE, ERCUMENT DIRICE, ROHIT KULKARNI, WEIJUN QIAN

Diabetes 2020;69(Supplement_1):2119-P

DOI: https://doi.org/10.2337/db20-2119-P

Published: 01 June 2020

View article titled, 2119-P: Deep Profiling of Phosphorylation Dynamics in Human Islets in Response to Inflammatory Cytokines

Journal Articles

TBC1D4 Is Necessary for Enhancing Muscle Insulin Sensitivity in Response to AICAR and Contraction

Rasmus Kjøbsted, Alexandra Chadt, Nicolas O. Jørgensen, Kohei Kido, Jeppe K. Larsen, Christian de Wendt, Hadi Al-Hasani, Jørgen F.P. Wojtaszewski

Diabetes 2019;68(9):1756–1766

DOI: https://doi.org/10.2337/db18-0769

Published: 07 June 2019

View article titled, TBC1D4 Is Necessary for Enhancing Muscle Insulin Sensitivity in Response to AICAR and Contraction

Includes: Supplementary data

Meeting Abstracts

718-P: Post-exercise Enhancement of Insulin-Stimulated Glucose Uptake in Insulin-Resistant Rat Skeletal Muscle Concomitant with Greater γ3-AMPK Activity and Insulin-Stimulated AS160 Phosphorylation on Key Regulatory Phosphosites

MARK W. PATAKY, EDWARD B. ARIAS, XIAOHUA ZHENG, HAIYAN WANG, GREGORY D. CARTEE

Diabetes 2019;68(Supplement_1):718-P

DOI: https://doi.org/10.2337/db19-718-P

Published: 01 June 2019

View article titled, 718-P: Post-exercise Enhancement of Insulin-Stimulated Glucose Uptake in Insulin-Resistant Rat Skeletal Muscle Concomitant with Greater γ3-AMPK Activity and Insulin-Stimulated AS160 Phosphorylation on Key Regulatory Phosphosites

NARROW

Reduced Expression Level of Protein Phosphatase PPM1E Serves to Maintain Insulin Secretion in Type 2 Diabetes

299-OR: Molecular and Physiological Consequences of the Diabetes-Related PGC1A Gly482Ser Polymorphism

441-P: Oleate Prevents Palmitate-Induced Abnormalities in Insulin Signaling in Human Cardiac Progenitor Cells by Inhibiting p38 MAPK and c-Jun Phosphorylation

Hepatic GSK3β-Dependent CRY1 Degradation Contributes to Diabetic Hyperglycemia

DOC2b Enhances β-Cell Function via a Novel Tyrosine Phosphorylation-Dependent Mechanism

Illumination of the Endogenous Insulin-Regulated TBC1D4 Interactome in Human Skeletal Muscle

29-LB: Exercise Effects on ?3-AMPK Activity, Akt Substrate of 160 kDa Phosphorylation, and Glucose Uptake in Muscle of Normal and Insulin-Resistant Female Rats

1153-P: Sodium-Glucose Cotransporter-2 Inhibitors Increase Food Intake via a Mechanism That Acts on the Central Nervous System Involving Phosphorylation of Adenosine Monophosphate-Activated Protein Kinase in the Lateral Hypothalamus

1244-P: The Protein Phosphatase PPm1k Regulates Ribosomal Protein S6 Phosphorylation in Beta Cells

334-OR: Sex Differences in Protein Phosphorylation in Insulin Resistance in Humans at the Cellular Level

121-OR: Activation of FoxO1 Induces Akt Phosphorylation and Mimics the Metabolic Functions of Insulin without Proliferative Effects on 3T3-L1 Adipocytes

Vascular Expression of Permeability-Resistant Occludin Mutant Preserves Visual Function in Diabetes

1714-P: Regulation of Phosphorylation Status in Insulin Signaling via a4 Is Necessary for Adipocyte Maintenance and Lipid Dynamics

1757-P: Tyrosine Phosphorylation of Phospholipase C in Human Skeletal Muscle Insulin Resistance

298-OR: Disruption of Multiple Cell-Autonomous Protein Phosphorylation Networks Underlies Muscle Insulin Resistance in Type 2 Diabetes

455-P: Pan-ErbB Inhibition Attenuates Diabetes-Induced Vascular Dysfunction in an Experimental Model of Diabetes

410-P: Effects of Palmitate and Oleate on Apoptosis, Autophagy, Stress, Kinase Phosphorylation, and Enzymes of Fatty Acid Oxidation in Human Cardiac Progenitor Cells from Control and Diabetic Subjects

2119-P: Deep Profiling of Phosphorylation Dynamics in Human Islets in Response to Inflammatory Cytokines

TBC1D4 Is Necessary for Enhancing Muscle Insulin Sensitivity in Response to AICAR and Contraction

718-P: Post-exercise Enhancement of Insulin-Stimulated Glucose Uptake in Insulin-Resistant Rat Skeletal Muscle Concomitant with Greater γ3-AMPK Activity and Insulin-Stimulated AS160 Phosphorylation on Key Regulatory Phosphosites

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