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Journal Articles

Regulation of Monocyte Activation by PPARα Through Interaction With the cGAS-STING Pathway

Lijie Dong, Rui Cheng, Xiang Ma, Wentao Liang, Yaru Hong, Hui Li, Kelu Zhou, Yanhong Du, Yusuke Takahashi, Xiaomin Zhang, Xiao-rong Li, Jian-xing Ma

Diabetes 2023;72(7):958–972

https://doi.org/10.2337/db22-0654

Published: 14 April 2023

View article titled, Regulation of Monocyte Activation by PPARα Through Interaction With the cGAS-STING Pathway

Journal Articles

The Attenuation of Diabetic Nephropathy by Annexin A1 via Regulation of Lipid Metabolism Through the AMPK/PPARα/CPT1b Pathway

Liang Wu, Changjie Liu, Dong-Yuan Chang, Rui Zhan, Mingming Zhao, Sin Man Lam, Guanghou Shui, Ming-Hui Zhao, Lemin Zheng, Min Chen

Diabetes 2021;70(10):2192–2203

https://doi.org/10.2337/db21-0050

Published: 08 June 2021

View article titled, The Attenuation of Diabetic Nephropathy by Annexin A1 via Regulation of Lipid Metabolism Through the AMPK/PPARα/CPT1b Pathway

Journal Articles

Activation of dsRNA-Dependent Protein Kinase R by miR-378 Sustains Metabolic Inflammation in Hepatic Insulin Resistance

Hao Wang, Yongyan Song, Yuxin Wu, Virender Kumar, Ram I. Mahato, Qiaozhu Su

Diabetes 2021;70(3):710–719

https://doi.org/10.2337/db20-0181

Published: 07 January 2021

View article titled, Activation of dsRNA-Dependent Protein Kinase R by miR-378 Sustains Metabolic Inflammation in Hepatic Insulin Resistance

Journal Articles

CEPT1-Mediated Phospholipogenesis Regulates Endothelial Cell Function and Ischemia-Induced Angiogenesis Through PPARα

Mohamed A. Zayed, Xiaohua Jin, Chao Yang, Larisa Belaygorod, Connor Engel, Kshitij Desai, Nikolai Harroun, Omar Saffaf, Bruce W. Patterson, Fong-Fu Hsu, Clay F. Semenkovich

Diabetes 2021;70(2):549–561

https://doi.org/10.2337/db20-0635

Published: 19 December 2020

View article titled, CEPT1-Mediated Phospholipogenesis Regulates Endothelial Cell Function and Ischemia-Induced Angiogenesis Through PPARα

Journal Articles

Ncor2/PPARα-Dependent Upregulation of MCUb in the Type 2 Diabetic Heart Impacts Cardiac Metabolic Flexibility and Function

Federico Cividini, Brian T. Scott, Jorge Suarez, Darren E. Casteel, Sven Heinz, Anzhi Dai, Tanja Diemer, Jorge A. Suarez, Christopher W. Benner, Majid Ghassemian, Wolfgang H. Dillmann

Diabetes 2021;70(3):665–679

https://doi.org/10.2337/db20-0779

Published: 10 December 2020

View article titled, Ncor2/PPARα-Dependent Upregulation of MCUb in the Type 2 Diabetic Heart Impacts Cardiac Metabolic Flexibility and Function

Meeting Abstracts

370-OR: Hepatic FGF21 Expression Is Under the Regulation of the Canonical Wnt Signaling Pathway

YASAMAN BADAKHSHI, WEIJUAN SHAO, LILI TIAN, TIANRU JIN

Diabetes 2020;69(Supplement_1):370-OR

https://doi.org/10.2337/db20-370-OR

Published: 01 June 2020

View article titled, 370-OR: Hepatic FGF21 Expression Is Under the Regulation of the Canonical Wnt Signaling Pathway

Journal Articles

Pathogenic Role of PPARα Downregulation in Corneal Nerve Degeneration and Impaired Corneal Sensitivity in Diabetes

H. Greg Matlock, Fangfang Qiu, Volha Malechka, Kelu Zhou, Rui Cheng, Siribhinya Benyajati, Amy Whelchel, Dimitrios Karamichos, Jian-xing Ma

Diabetes 2020;69(6):1279–1291

https://doi.org/10.2337/db19-0898

Published: 25 March 2020

View article titled, Pathogenic Role of PPARα Downregulation in Corneal Nerve Degeneration and Impaired Corneal Sensitivity in Diabetes

Journal Articles

CTRP13 Preserves Endothelial Function by Targeting GTP Cyclohydrolase 1 in Diabetes

Cheng Wang, Yuelin Chao, Wenjing Xu, Minglu Liang, Shan Deng, Donghong Zhang, Kai Huang

Diabetes 2020;69(1):99–111

https://doi.org/10.2337/db19-0635

Published: 01 November 2019

View article titled, CTRP13 Preserves Endothelial Function by Targeting GTP Cyclohydrolase 1 in Diabetes

Includes: Supplementary data

Journal Articles

A Protective Effect of PPARα in Endothelial Progenitor Cells Through Regulating Metabolism

Yan Shao, Jianglei Chen, Li-jie Dong, Xuemin He, Rui Cheng, Kelu Zhou, Juping Liu, Fangfang Qiu, Xiao-rong Li, Jian-xing Ma

Diabetes 2019;68(11):2131–2142

https://doi.org/10.2337/db18-1278

Published: 26 August 2019

View article titled, A Protective Effect of PPARα in Endothelial Progenitor Cells Through Regulating Metabolism

Includes: Supplementary data

Meeting Abstracts

17-OR: Efficacy and Safety of Chiglitazar, a Novel PPARα/γ/d Pan-Agonist, in Patients with Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Phase 3 Superiority Trial (CMAP)

Diabetes 2019;68(Supplement_1):17-OR

https://doi.org/10.2337/db19-17-OR

Published: 01 June 2019

View article titled, 17-OR: Efficacy and Safety of Chiglitazar, a Novel PPARα/γ/d Pan-Agonist, in Patients with Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Phase 3 Superiority Trial (CMAP)

Meeting Abstracts

476-P: Pemafibrate, a PPAR Alpha Agonist, Attenuates Neointima Formation after Vascular Injury in Nondiabetic and Diabetic Mice

TSUYOSHI HORIKAWA, TAKASHI NOMIYAMA, HIROYUKI TAKAHASHI, TAKAKO KAWANAMI, YURIKO HAMAGUCHI, TOMOKO TANAKA, TOSHIHIKO YANASE

Diabetes 2019;68(Supplement_1):476-P

https://doi.org/10.2337/db19-476-P

Published: 01 June 2019

View article titled, 476-P: Pemafibrate, a PPAR Alpha Agonist, Attenuates Neointima Formation after Vascular Injury in Nondiabetic and Diabetic Mice

Meeting Abstracts

180-OR: Tissue-Specific Functions of PPARα Overexpression in Liver, Adipose, and Pancreatic ß Cells

RISHENG YE, PHILIPP E. SCHERER

Diabetes 2019;68(Supplement_1):180-OR

https://doi.org/10.2337/db19-180-OR

Published: 01 June 2019

View article titled, 180-OR: Tissue-Specific Functions of PPARα Overexpression in Liver, Adipose, and Pancreatic ß Cells

Meeting Abstracts

189-LB: Maternal Pharmacological Activation of PPAR-gamma or PPAR-alpha Differentially Affects Adiposity and Energy Metabolism in the Offspring of Rats Born to Mothers Subjected to Caloric Restriction during Pregnancy

VANESSA B. VERONESI, JUNIA C. SANTOS-SILVA, DAILSON N. SOUZA, CAIO JORDÃO TEIXEIRA, FERNANDA B. HECHT, NATALIA TOBAR, MARIANA RODRIGUES PIOLI, GABRIEL F. ANHE

Diabetes 2019;68(Supplement_1):189-LB

https://doi.org/10.2337/db19-189-LB

Published: 01 June 2019

View article titled, 189-LB: Maternal Pharmacological Activation of PPAR-gamma or PPAR-alpha Differentially Affects Adiposity and Energy Metabolism in the Offspring of Rats Born to Mothers Subjected to Caloric Restriction during Pregnancy

Meeting Abstracts

1953-P: PPARγ Agonism and FGF-21 Synergize to Robustly Induce Browning of White Fat

TOBIAS KROON, MATTHEW J. HARMS, DANIEL NILSSON, ANNA LINDBLOM, PETER GENNEMARK, GAVIN O'MAHONY, VICTORIA OSINSKI, COLEEN A. MCNAMARA, JEREMIE BOUCHER

Diabetes 2019;68(Supplement_1):1953-P

https://doi.org/10.2337/db19-1953-P

Published: 01 June 2019

View article titled, 1953-P: PPARγ Agonism and FGF-21 Synergize to Robustly Induce Browning of White Fat

Meeting Abstracts

1894-P: HIF-2α Induced by Hypoxia Exacerbates Nonalcoholic Fatty Liver Disease Progression via Suppressing PPARα

JIANDI CHEN, JIANXU CHEN, HUIRONG FU, YUN LI, SHUNKUI LUO, LINGLING WANG, HONGYUN LU

Diabetes 2019;68(Supplement_1):1894-P

https://doi.org/10.2337/db19-1894-P

Published: 01 June 2019

View article titled, 1894-P: HIF-2α Induced by Hypoxia Exacerbates Nonalcoholic Fatty Liver Disease Progression via Suppressing PPARα

Journal Articles

Fenofibrate Rescues Diabetes-Related Impairment of Ischemia-Mediated Angiogenesis by PPARα-Independent Modulation of Thioredoxin-Interacting Protein

Jun Yuan, Joanne T.M. Tan, Kushwin Rajamani, Emma L. Solly, Emily J. King, Laura Lecce, Philippa J.L. Simpson, Yuen Ting Lam, Alicia J. Jenkins, Christina A. Bursill, Anthony C. Keech, Martin K.C. Ng

Diabetes 2019;68(5):1040–1053

https://doi.org/10.2337/db17-0926

Published: 14 February 2019

View article titled, Fenofibrate Rescues Diabetes-Related Impairment of Ischemia-Mediated Angiogenesis by PPARα-Independent Modulation of Thioredoxin-Interacting Protein

Includes: Supplementary data

Journal Articles

In This Issue of Diabetes

Diabetes 2018;67(10):1909–1910

https://doi.org/10.2337/db18-ti10

Published: 12 September 2018

View article titled, In This Issue of Diabetes

Journal Articles

Coordination Among Lipid Droplets, Peroxisomes, and Mitochondria Regulates Energy Expenditure Through the CIDE-ATGL-PPARα Pathway in Adipocytes

Linkang Zhou, Miao Yu, Muhammad Arshad, Wenmin Wang, Ye Lu, Jingyi Gong, Yangnan Gu, Peng Li, Li Xu

Diabetes 2018;67(10):1935–1948

https://doi.org/10.2337/db17-1452

Published: 09 July 2018

View article titled, Coordination Among Lipid Droplets, Peroxisomes, and Mitochondria Regulates Energy Expenditure Through the CIDE-ATGL-PPARα Pathway in Adipocytes

Includes: Supplementary data

Meeting Abstracts

Combination of SGLT2 Inhibitor and Novel Selective PPARα Modulator, Tofogliflozin (Tofo) and Pemafibrate (Pema), Improves Survival Rate in STAM Mice as a Diabetic NASH Model

WATARU YANO, TOSHIAKI TAKIZAWA, YUSUKE SASAKI, MASATO ASAHIYAMA, WAKANA KAMIYA, TAKASHI NAKAGAWA, HIROYUKI YAMAZAKI, KEISUKE INOUE, KEN MIZUNO, JURO SAKAI, TATSUHIKO KODAMA, TOSHIYA TANAKA

Diabetes 2018;67(Supplement_1):1133-P

https://doi.org/10.2337/db18-1133-P

Published: 01 July 2018

View article titled, Combination of SGLT2 Inhibitor and Novel Selective PPARα Modulator, Tofogliflozin (Tofo) and Pemafibrate (Pema), Improves Survival Rate in STAM Mice as a Diabetic NASH Model

Journal Articles

Perilipin 3 Deficiency Stimulates Thermogenic Beige Adipocytes Through PPARα Activation

Yun Kyung Lee, Jee Hyung Sohn, Ji Seul Han, Yoon Jeong Park, Yong Geun Jeon, Yul Ji, Knut Tomas Dalen, Carole Sztalryd, Alan R. Kimmel, Jae Bum Kim

Diabetes 2018;67(5):791–804

https://doi.org/10.2337/db17-0983

Published: 13 February 2018

View article titled, Perilipin 3 Deficiency Stimulates Thermogenic Beige Adipocytes Through PPARα Activation

Includes: Supplementary data

NARROW

Regulation of Monocyte Activation by PPARα Through Interaction With the cGAS-STING Pathway

The Attenuation of Diabetic Nephropathy by Annexin A1 via Regulation of Lipid Metabolism Through the AMPK/PPARα/CPT1b Pathway

Activation of dsRNA-Dependent Protein Kinase R by miR-378 Sustains Metabolic Inflammation in Hepatic Insulin Resistance

CEPT1-Mediated Phospholipogenesis Regulates Endothelial Cell Function and Ischemia-Induced Angiogenesis Through PPARα

Ncor2/PPARα-Dependent Upregulation of MCUb in the Type 2 Diabetic Heart Impacts Cardiac Metabolic Flexibility and Function

370-OR: Hepatic FGF21 Expression Is Under the Regulation of the Canonical Wnt Signaling Pathway

Pathogenic Role of PPARα Downregulation in Corneal Nerve Degeneration and Impaired Corneal Sensitivity in Diabetes

CTRP13 Preserves Endothelial Function by Targeting GTP Cyclohydrolase 1 in Diabetes

A Protective Effect of PPARα in Endothelial Progenitor Cells Through Regulating Metabolism

17-OR: Efficacy and Safety of Chiglitazar, a Novel PPARα/γ/d Pan-Agonist, in Patients with Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Phase 3 Superiority Trial (CMAP)

476-P: Pemafibrate, a PPAR Alpha Agonist, Attenuates Neointima Formation after Vascular Injury in Nondiabetic and Diabetic Mice

180-OR: Tissue-Specific Functions of PPARα Overexpression in Liver, Adipose, and Pancreatic ß Cells

189-LB: Maternal Pharmacological Activation of PPAR-gamma or PPAR-alpha Differentially Affects Adiposity and Energy Metabolism in the Offspring of Rats Born to Mothers Subjected to Caloric Restriction during Pregnancy

1953-P: PPARγ Agonism and FGF-21 Synergize to Robustly Induce Browning of White Fat

1894-P: HIF-2α Induced by Hypoxia Exacerbates Nonalcoholic Fatty Liver Disease Progression via Suppressing PPARα

Fenofibrate Rescues Diabetes-Related Impairment of Ischemia-Mediated Angiogenesis by PPARα-Independent Modulation of Thioredoxin-Interacting Protein

In This Issue of Diabetes

Coordination Among Lipid Droplets, Peroxisomes, and Mitochondria Regulates Energy Expenditure Through the CIDE-ATGL-PPARα Pathway in Adipocytes

Combination of SGLT2 Inhibitor and Novel Selective PPARα Modulator, Tofogliflozin (Tofo) and Pemafibrate (Pema), Improves Survival Rate in STAM Mice as a Diabetic NASH Model

Perilipin 3 Deficiency Stimulates Thermogenic Beige Adipocytes Through PPARα Activation

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