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Meeting Abstracts

304-OR: Reduced VDAC1 Limits ROS Release to Restrain Oxidative Damage in Muscle of 3-Year-Old Nonhuman Primates with Early-Life Exposure to Maternal Western Diet or Obesity

KEENAN T. GREYSLAK, CARRIE E. MCCURDY

Diabetes 2023;72(Supplement_1):304-OR

https://doi.org/10.2337/db23-304-OR

Published: 20 June 2023

View article titled, 304-OR: Reduced VDAC1 Limits ROS Release to Restrain Oxidative Damage in Muscle of 3-Year-Old Nonhuman Primates with Early-Life Exposure to Maternal Western Diet or Obesity

Meeting Abstracts

207-OR: Myostatin Inhibition Synergizes with GLP-1R Agonism to Accelerate Weight Loss in Male, Obese Nonhuman Primates

JASON MASTAITIS, DANIEL GOMEZ, VALERIE LE ROUZIC, MICHAEL STEC, NAVEEN KHAN, ERQIAN NA, TOYA MCWILLIAMS, SOO MIN, MARK SLEEMAN

Diabetes 2023;72(Supplement_1):207-OR

https://doi.org/10.2337/db23-207-OR

Published: 20 June 2023

View article titled, 207-OR: Myostatin Inhibition Synergizes with GLP-1R Agonism to Accelerate Weight Loss in Male, Obese Nonhuman Primates

Meeting Abstracts

1330-P: Longitudinal Multiyear Prospective Study in 87 Diabetic Primates: Lack of Support for a Mechanistic Basis for the Disposition Index

LACHLAN SHIVER, CARLOS BELLIDO, ALANIS ROSADO, BARBARA C. HANSEN

Diabetes 2022;71(Supplement_1):1330-P

https://doi.org/10.2337/db22-1330-P

Published: 01 June 2022

View article titled, 1330-P: Longitudinal Multiyear Prospective Study in 87 Diabetic Primates: Lack of Support for a Mechanistic Basis for the Disposition Index

Meeting Abstracts

320-OR: Maternal Overnutrition Confers Increased Spare Respiratory Capacity and Glucose-Stimulated Insulin Secretion in Nonhuman Primate Offspring Islets

DARIAN T. CARROLL, JOSEPH M. ELSAKR, VALERIE F. RICCIARDI, JENNIFER C. DUNN, SARAH R. LINDSLEY, TYLER DEAN, MELISSA KIRIGITI, DIANA L. TAKAHASHI, STEPHANIE R. WESOLOWSKI, CARRIE E. MCCURDY, PAUL KIEVIT, KJERSTI M. AAGAARD, JACOB E. FRIEDMAN, MAUREEN GANNON

Diabetes 2022;71(Supplement_1):320-OR

https://doi.org/10.2337/db22-320-OR

Published: 01 June 2022

View article titled, 320-OR: Maternal Overnutrition Confers Increased Spare Respiratory Capacity and Glucose-Stimulated Insulin Secretion in Nonhuman Primate Offspring Islets

Meeting Abstracts

753-P: Senolytics Improve Diabetes Measures in Type 2 Diabetic Nonhuman Primates: A Pilot Study

ALISTAIRE D. RUGGIERO, MASHA BLOCK, MATTHEW DAVIS, RAVICHANDRA VEMURI, MIRANDA E. ORR, KYLIE KAVANAGH

Diabetes 2021;70(Supplement_1):753-P

https://doi.org/10.2337/db21-753-P

Published: 01 June 2021

View article titled, 753-P: Senolytics Improve Diabetes Measures in Type 2 Diabetic Nonhuman Primates: A Pilot Study

Meeting Abstracts

1201-P: Monocyte Reprogramming in Nonhuman Primate Mother-Child Dyads Based on Maternal Health and Obesity Status

ALISTAIRE D. RUGGIERO, MASHA BLOCK, RAVICHANDRA VEMURI, MATTHEW DAVIS, DARLA DESTEPHANIS, KYLIE KAVANAGH

Diabetes 2021;70(Supplement_1):1201-P

https://doi.org/10.2337/db21-1201-P

Published: 01 June 2021

View article titled, 1201-P: Monocyte Reprogramming in Nonhuman Primate Mother-Child Dyads Based on Maternal Health and Obesity Status

Meeting Abstracts

1826-P: Dietary Models of Nonalcoholic Fatty Liver Disease in Normal and Diabetic Nonhuman Primates

JIAJUN GAO, DAVEY WANG, YANQIN JI, XIAOYU ZHANG, CHEN YANG, JIAPING ZHANG, WEIWEI YE, FENG SHI, MENGNAN JIANG, QIAN JIN, DUNWEI ZHANG, XIAOLI WANG, WEIHUA SONG, KEEFE CHNG, HAISHAN JIANG, YIXIN WANG, YONG-FU XIAO

Diabetes 2020;69(Supplement_1):1826-P

https://doi.org/10.2337/db20-1826-P

Published: 01 June 2020

View article titled, 1826-P: Dietary Models of Nonalcoholic Fatty Liver Disease in Normal and Diabetic Nonhuman Primates

Meeting Abstracts

1833-P: A Novel Genetic Modified and Pegylated FGF21 Analog for the Treatment of Nonalcoholic Steatohepatitis in Nonhuman Primates

AOYUAN CUI, JIAN LI, SHAOHUI JI, FENGGUANG MA, GENBEI WANG, YAQIAN XUE, ZHENGSHUAI LIU, XIAOHUI MA, YU LI

Diabetes 2020;69(Supplement_1):1833-P

https://doi.org/10.2337/db20-1833-P

Published: 01 June 2020

View article titled, 1833-P: A Novel Genetic Modified and Pegylated FGF21 Analog for the Treatment of Nonalcoholic Steatohepatitis in Nonhuman Primates

Journal Articles

The Effects of B1344, a Novel Fibroblast Growth Factor 21 Analog, on Nonalcoholic Steatohepatitis in Nonhuman Primates

Aoyuan Cui, Jian Li, Shaohui Ji, Fengguang Ma, Genbei Wang, Yaqian Xue, Zhengshuai Liu, Jing Gao, Jun Han, Ping Tai, Tony Wang, Jianxun Chen, Xiaohui Ma, Yu Li

Diabetes 2020;69(8):1611–1623

https://doi.org/10.2337/db20-0209

Published: 30 April 2020

View article titled, The Effects of B1344, a Novel Fibroblast Growth Factor 21 Analog, on Nonalcoholic Steatohepatitis in Nonhuman Primates

Meeting Abstracts

35-LB: Response to Anti-VEGF Therapy in a Nonhuman Primate Model of Diabetic Macular Edema

SER MIEN CHIA, LI GONG, SARAH TIU, STACEY L. CONARELLO, JR., SAIRAM BELLUM, LINGZHEN PAN, CHEN FEI LEE, ASAD ABU BAKAR ALI, LEWIS HONG, WEN ZENG, CHIH-LIANG CHIN, NINA X. LI

Diabetes 2019;68(Supplement_1):35-LB

https://doi.org/10.2337/db19-35-LB

Published: 01 June 2019

View article titled, 35-LB: Response to Anti-VEGF Therapy in a Nonhuman Primate Model of Diabetic Macular Edema

Meeting Abstracts

19-OR: Controlled-Release Mitochondrial Protonophore (CRMP) Reverses Hypertriglyceridemia and Hepatic Steatosis in Dysmetabolic Nonhuman Primates

LEIGH GOEDEKE, VALLE MONTALVO ROMERAL, GINA MARIE BUTRICO, MARIO KAHN, SYLVIE DUFOUR, XIAN-MAN ZHANG, GARY CLINE, KITT PETERSEN, KEEFE CHNG, GERALD I. SHULMAN

Diabetes 2019;68(Supplement_1):19-OR

https://doi.org/10.2337/db19-19-OR

Published: 01 June 2019

View article titled, 19-OR: Controlled-Release Mitochondrial Protonophore (CRMP) Reverses Hypertriglyceridemia and Hepatic Steatosis in Dysmetabolic Nonhuman Primates

Meeting Abstracts

FTY720 Treatment Rejuvenates ß-Cell Function and Improves Cardiac Function in Diabetic Nonhuman Primates (NHPs)

YIXIN WANG, YONGQIANG LIU, QIAO WEI, XIAOLI WANG, GAO SUN, YONG-FU XIAO, GUOLIANG YU, ZHONGMIN A. MA

Diabetes 2018;67(Supplement_1):1121-P

https://doi.org/10.2337/db18-1121-P

Published: 01 July 2018

View article titled, FTY720 Treatment Rejuvenates ß-Cell Function and Improves Cardiac Function in Diabetic Nonhuman Primates (NHPs)

Meeting Abstracts

Comparison of Xenogeneic Encapsulated Islet Transplantation in Nonhuman Primates With and Without Immunosuppression

EUN YOUNG LEE, HEON SEOK PARK, JIWON KIM, YEOREE YANG, JAYOUNG LIM, HUN-SUNG KIM, SEUNG-HWAN LEE, JAE HYOUNG CHO, BONG YUN CHA, KUN-HO YOON

Diabetes 2018;67(Supplement_1):28-OR

https://doi.org/10.2337/db18-28-OR

Published: 01 July 2018

View article titled, Comparison of Xenogeneic Encapsulated Islet Transplantation in Nonhuman Primates With and Without Immunosuppression

Meeting Abstracts

IKKß and Wnt/ß-Catenin Signaling Interaction Regulates Adipogenesis and Osteogenesis in Mesenchymal Stem Cells of Nonhuman Primates and Humans

YIPENG SUI, SE-HYUNG PARK, PHILIP A. KERN, RYAN TEMEL, CHANGCHENG ZHOU

Diabetes 2018;67(Supplement_1):288-LB

https://doi.org/10.2337/db18-288-LB

Published: 01 July 2018

View article titled, IKKß and Wnt/ß-Catenin Signaling Interaction Regulates Adipogenesis and Osteogenesis in Mesenchymal Stem Cells of Nonhuman Primates and Humans

Meeting Abstracts

Continuous Subcutaneous Delivery of a Glucagon Analog, ICA6150349, to Rats and Nonhuman Primates Demonstrates Safety and Tolerability in a 14-Day Toxicity Study

DORIS ZANE, ROSHNI SINGH, JOSEPHINE SHELTON, SHANE ROLLER, MARK PAULIK, JAMES WAY, WILLIAM C. BLACKWELL, III, VED SRIVASTAVA, REBECCA HODGE, PAUL L. FELDMAN, THOMAS R. ALESSI

Diabetes 2018;67(Supplement_1):1997-P

https://doi.org/10.2337/db18-1997-P

Published: 01 July 2018

View article titled, Continuous Subcutaneous Delivery of a Glucagon Analog, ICA6150349, to Rats and Nonhuman Primates Demonstrates Safety and Tolerability in a 14-Day Toxicity Study

Meeting Abstracts

Serum Creatinine Progressively Decreases with Obesity and Type 2 Diabetes in Nonhuman Primates

UDDHAV K. CHAUDHARI, JENNIFER D. NEWCOMB, BARBARA C. HANSEN

Diabetes 2018;67(Supplement_1):1931-P

https://doi.org/10.2337/db18-1931-P

Published: 01 July 2018

View article titled, Serum Creatinine Progressively Decreases with Obesity and Type 2 Diabetes in Nonhuman Primates

Meeting Abstracts

Deep Phenotyping of a Spontaneous Nonhuman Primate Model of Diabetic Macular Edema

SER MIEN CHIA, LI GONG, SARAH TIU, SARAYU PARIMAL ANNAMALAI, NINA X. LI, LINGZHEN PAN, LEWIS HONG, ASAD ABU BAKAR ALI, CHIH-LIANG CHIN, WEN ZENG

Diabetes 2018;67(Supplement_1):35-LB

https://doi.org/10.2337/db18-35-LB

Published: 01 July 2018

View article titled, Deep Phenotyping of a Spontaneous Nonhuman Primate Model of Diabetic Macular Edema

Meeting Abstracts

Maternal High-Fat Diet Persistently Alters Bone Marrow Immune Cell Proportions and Function in a Nonhuman Primate Model

MICHAEL J. NASH, TAYLOR K. SODERBORG, RACHEL C. JANSSEN, ERIC M. PIETRAS, JACOB E. FRIEDMAN

Diabetes 2018;67(Supplement_1):222-OR

https://doi.org/10.2337/db18-222-OR

Published: 01 July 2018

View article titled, Maternal High-Fat Diet Persistently Alters Bone Marrow Immune Cell Proportions and Function in a Nonhuman Primate Model

Journal Articles

In Vivo Visualization of β-Cells by Targeting of GPR44

Olof Eriksson, Peter Johnström, Zsolt Cselenyi, Mahabuba Jahan, Ram K. Selvaraju, Marianne Jensen-Waern, Akihiro Takano, Maria Sörhede Winzell, Christer Halldin, Stanko Skrtic, Olle Korsgren

Diabetes 2018;67(2):182–192

https://doi.org/10.2337/db17-0764

Published: 05 December 2017

View article titled, In Vivo Visualization of β-Cells by Targeting of GPR44

Journal Articles

Temporal Changes in Skeletal Muscle Capillary Responses and Endothelial-Derived Vasodilators in Obesity-Related Insulin Resistance

Scott M. Chadderdon, J. Todd Belcik, Lindsay Bader, Dawn M. Peters, Paul Kievit, Nabil J. Alkayed, Sanjiv Kaul, Kevin L. Grove, Jonathan R. Lindner

Diabetes 2016;65(8):2249–2257

https://doi.org/10.2337/db15-1574

Published: 08 April 2016

View article titled, Temporal Changes in Skeletal Muscle Capillary Responses and Endothelial-Derived Vasodilators in Obesity-Related Insulin Resistance

NARROW

304-OR: Reduced VDAC1 Limits ROS Release to Restrain Oxidative Damage in Muscle of 3-Year-Old Nonhuman Primates with Early-Life Exposure to Maternal Western Diet or Obesity

207-OR: Myostatin Inhibition Synergizes with GLP-1R Agonism to Accelerate Weight Loss in Male, Obese Nonhuman Primates

1330-P: Longitudinal Multiyear Prospective Study in 87 Diabetic Primates: Lack of Support for a Mechanistic Basis for the Disposition Index

320-OR: Maternal Overnutrition Confers Increased Spare Respiratory Capacity and Glucose-Stimulated Insulin Secretion in Nonhuman Primate Offspring Islets

753-P: Senolytics Improve Diabetes Measures in Type 2 Diabetic Nonhuman Primates: A Pilot Study

1201-P: Monocyte Reprogramming in Nonhuman Primate Mother-Child Dyads Based on Maternal Health and Obesity Status

1826-P: Dietary Models of Nonalcoholic Fatty Liver Disease in Normal and Diabetic Nonhuman Primates

1833-P: A Novel Genetic Modified and Pegylated FGF21 Analog for the Treatment of Nonalcoholic Steatohepatitis in Nonhuman Primates

The Effects of B1344, a Novel Fibroblast Growth Factor 21 Analog, on Nonalcoholic Steatohepatitis in Nonhuman Primates

35-LB: Response to Anti-VEGF Therapy in a Nonhuman Primate Model of Diabetic Macular Edema

19-OR: Controlled-Release Mitochondrial Protonophore (CRMP) Reverses Hypertriglyceridemia and Hepatic Steatosis in Dysmetabolic Nonhuman Primates

FTY720 Treatment Rejuvenates ß-Cell Function and Improves Cardiac Function in Diabetic Nonhuman Primates (NHPs)

Comparison of Xenogeneic Encapsulated Islet Transplantation in Nonhuman Primates With and Without Immunosuppression

IKKß and Wnt/ß-Catenin Signaling Interaction Regulates Adipogenesis and Osteogenesis in Mesenchymal Stem Cells of Nonhuman Primates and Humans

Continuous Subcutaneous Delivery of a Glucagon Analog, ICA6150349, to Rats and Nonhuman Primates Demonstrates Safety and Tolerability in a 14-Day Toxicity Study

Serum Creatinine Progressively Decreases with Obesity and Type 2 Diabetes in Nonhuman Primates

Deep Phenotyping of a Spontaneous Nonhuman Primate Model of Diabetic Macular Edema

Maternal High-Fat Diet Persistently Alters Bone Marrow Immune Cell Proportions and Function in a Nonhuman Primate Model

In Vivo Visualization of β-Cells by Targeting of GPR44

Temporal Changes in Skeletal Muscle Capillary Responses and Endothelial-Derived Vasodilators in Obesity-Related Insulin Resistance

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