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Meeting Abstracts

1456-P: Molecular Architecture of AR Action in Insulin Secretion in Male Pancreatic ß-Cells

PAULA MOTA DE SA, MIRZA MUHAMMAD FAHD QADIR, MANUEL BLANDINO-ROSANO, JIA FAN, WEIWEI XU, ERNESTO BERNAL-MIZRACHI, FRANCK MAUVAIS-JARVIS
Journal: Diabetes
Diabetes 2022;71(Supplement_1):1456-P
https://doi.org/10.2337/db22-1456-P
Published: 01 June 2022
View article titled, 1456-P: Molecular Architecture of AR Action in Insulin Secretion in Male Pancreatic ß-Cells
Journal Articles

Altered β-Cell Prohormone Processing and Secretion in Type 1 Diabetes

Teresa Rodriguez-Calvo, Yi-Chun Chen, C. Bruce Verchere, Leena Haataja, Peter Arvan, Pia Leete, Sarah J. Richardson, Noel G. Morgan, Wei-Jun Qian, Alberto Pugliese, Mark Atkinson, Carmella Evans-Molina, Emily K. Sims
Journal: Diabetes
Diabetes 2021;70(5):1038–1050
https://doi.org/10.2337/dbi20-0034
Published: 19 May 2021
View article titled, Altered β-Cell Prohormone Processing and Secretion in Type 1 Diabetes
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Meeting Abstracts

1784-P: Liraglutide Treatment Stimulates Alpha Cells to Produce Glucagon-Like Peptide-1 via Expression of Prohormone Convertase 1/3 in Mice and Human

MRIDUSMITA SAIKIA, MARLENA M. HOLTER, DARLINE GARIBAY, ADOLFO GARCIA-OCANA, CHARLES G. DANKO, BETHANY CUMMINGS
Journal: Diabetes
Diabetes 2020;69(Supplement_1):1784-P
https://doi.org/10.2337/db20-1784-P
Published: 01 June 2020
View article titled, 1784-P: Liraglutide Treatment Stimulates Alpha Cells to Produce Glucagon-Like Peptide-1 via Expression of Prohormone Convertase 1/3 in Mice and Human
Meeting Abstracts

2108-P: Complex Posttranslational Processing of Glucagon Prohormone in Human Pancreatic Islets

ELENA V. ROMANOVA, STANISLAV RUBAKHIN, JONATHAN V. SWEEDLER
Journal: Diabetes
Diabetes 2020;69(Supplement_1):2108-P
https://doi.org/10.2337/db20-2108-P
Published: 01 June 2020
View article titled, 2108-P: Complex Posttranslational Processing of Glucagon Prohormone in Human Pancreatic Islets
Meeting Abstracts

1893-P: The Integrative Role of ER Protein Quality Control Pathways (ERQC) in Prohormone Maturation

GUOJUN SHI, XUYA PAN, HETING WANG, PETER ARVAN, LING QI
Journal: Diabetes
Diabetes 2020;69(Supplement_1):1893-P
https://doi.org/10.2337/db20-1893-P
Published: 01 June 2020
View article titled, 1893-P: The Integrative Role of ER Protein Quality Control Pathways (ERQC) in Prohormone Maturation
Journal Articles

Revisiting Proinsulin Processing: Evidence That Human β-Cells Process Proinsulin With Prohormone Convertase (PC) 1/3 but Not PC2

Adam Ramzy, Ali Asadi, Timothy J. Kieffer
Journal: Diabetes
Diabetes 2020;69(7):1451–1462
https://doi.org/10.2337/db19-0276
Published: 14 April 2020
View article titled, Revisiting Proinsulin Processing: Evidence That Human β-Cells Process Proinsulin With Prohormone Convertase (PC) 1/3 but Not PC2
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Meeting Abstracts

2166-P: Sel1L-Hrd1 ERAD Is a Key Regulator of Beta-Cell Function and Identity

NEHA SHRESTHA, XIN LI, YEWEI JI, RACHEL B. REINERT, PETER ARVAN, LING QI
Journal: Diabetes
Diabetes 2019;68(Supplement_1):2166-P
https://doi.org/10.2337/db19-2166-P
Published: 01 June 2019
View article titled, 2166-P: Sel1L-Hrd1 ERAD Is a Key Regulator of Beta-Cell Function and Identity
Journal Articles

A Switch From Prohormone Convertase (PC)-2 to PC1/3 Expression in Transplanted α-Cells Is Accompanied by Differential Processing of Proglucagon and Improved Glucose Homeostasis in Mice

Rhonda D. Wideman, Scott D. Covey, Gene C. Webb, Daniel J. Drucker, Timothy J. Kieffer
Journal: Diabetes
Diabetes 2007;56(11):2744–2752
https://doi.org/10.2337/db07-0563
Published: 01 November 2007
View article titled, A Switch From Prohormone Convertase (PC)-2 to PC1/3 Expression in Transplanted α-Cells Is Accompanied by Differential Processing of Proglucagon and Improved Glucose Homeostasis in Mice
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Journal Articles

Impaired NH2-Terminal Processing of Human Proislet Amyloid Polypeptide by the Prohormone Convertase PC2 Leads to Amyloid Formation and Cell Death

Lucy Marzban, Christopher J. Rhodes, Donald F. Steiner, Leena Haataja, Philippe A. Halban, C. Bruce Verchere
Journal: Diabetes
Diabetes 2006;55(8):2192–2201
https://doi.org/10.2337/db05-1566
Published: 01 August 2006
View article titled, Impaired NH<sub>2</sub>-Terminal Processing of Human Proislet Amyloid Polypeptide by the Prohormone Convertase PC2 Leads to Amyloid Formation and Cell Death
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Journal Articles

Aberrant Processing of Human Proislet Amyloid Polypeptide Results in Increased Amyloid Formation

Johan F. Paulsson, Gunilla T. Westermark
Journal: Diabetes
Diabetes 2005;54(7):2117–2125
https://doi.org/10.2337/diabetes.54.7.2117
Published: 01 July 2005
View article titled, Aberrant Processing of Human Proislet Amyloid Polypeptide Results in Increased Amyloid Formation
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Journal Articles

Role of β-Cell Prohormone Convertase (PC)1/3 in Processing of Pro-Islet Amyloid Polypeptide

Lucy Marzban, Genny Trigo-Gonzalez, Xiaorong Zhu, Christopher J. Rhodes, Philippe A. Halban, Donald F. Steiner, C. Bruce Verchere
Journal: Diabetes
Diabetes 2004;53(1):141–148
https://doi.org/10.2337/diabetes.53.1.141
Published: 01 January 2004
View article titled, Role of β-Cell Prohormone Convertase (PC)1/3 in Processing of Pro-Islet Amyloid Polypeptide
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Journal Articles

The Prohormone Convertase Enzyme 2 (PC2) Is Essential for Processing Pro-Islet Amyloid Polypeptide at the NH2-Terminal Cleavage Site

Jing Wang, Jun Xu, Jennifer Finnerty, Machi Furuta, Donald F. Steiner, C. Bruce Verchere
Journal: Diabetes
Diabetes 2001;50(3):534–539
https://doi.org/10.2337/diabetes.50.3.534
Published: 01 March 2001
View article titled, The Prohormone Convertase Enzyme 2 (PC2) Is Essential for Processing Pro-Islet Amyloid Polypeptide at the NH<sub>2</sub>-Terminal Cleavage Site
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Meeting Abstracts

Long-term elevation of free fatty acids leads to delayed processing of proinsulin and prohormone convertases 2 and 3 in the pancreatic beta-cell line MIN6.

H Furukawa, R J Carroll, H H Swift, D F Steiner
Journal: Diabetes
Diabetes 1999;48(7):1395–1401
https://doi.org/10.2337/diabetes.48.7.1395
Published: 01 July 1999
View article titled, Long-term elevation of free fatty acids leads to delayed processing of proinsulin and prohormone convertases 2 and 3 in the pancreatic beta-cell line MIN6.
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Journal Articles

Prohormone Convertase 1 in Obesity, Gestational Diabetes Mellitus, and NIDDM: No Evidence for a Major Susceptibility Role

Kamini Kalidas, Eleanor Dow, Philip J Saker, Nicholas Wareham, David Halsall, Robert S Jackson, Siew-Pheng Chan, Susan Gelding, Mark Walker, Eleni Kousta, Desmond G Johnston, Stephen O'Rahilly, Mark I McCarthy
Journal: Diabetes
Diabetes 1998;47(2):287–289
https://doi.org/10.2337/diab.47.2.287
Published: 01 February 1998
View article titled, Prohormone Convertase 1 in Obesity, Gestational Diabetes Mellitus, and NIDDM: No Evidence for a Major Susceptibility Role
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Journal Articles

Human Prohormone Convertase 3 Gene: Exon-Intron Organization and Molecular Scanning for Mutations in Japanese Subjects With NIDDM

Shinya Ohagi, Hidenobu Sakaguchi, Tokio Sanke, Hitomi Tatsuta, Tadashi Hanabusa, Kishio Nanjo
Journal: Diabetes
Diabetes 1996;45(7):897–901
https://doi.org/10.2337/diab.45.7.897
Published: 01 July 1996
View article titled, Human Prohormone Convertase 3 Gene: Exon-Intron Organization and Molecular Scanning for Mutations in Japanese Subjects With NIDDM
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Journal Articles

Association of the Prohormone Convertase 2 Gene (PCSK2) on Chromosome 20 with NIDDM in Japanese Subjects

Hitomi Yoshida, Shinya Ohagi, Tokio Sanke, Hiroto Furuta, Machi Furuta, Kishio Nanjo
Journal: Diabetes
Diabetes 1995;44(4):389–393
https://doi.org/10.2337/diab.44.4.389
Published: 01 April 1995
View article titled, Association of the Prohormone Convertase 2 Gene (<em>PCSK2</em>) on Chromosome 20 with NIDDM in Japanese Subjects
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