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Journal Articles

A Novel Intron-Encoded Neuropilin-1 Isoform in Pancreatic Islets Associated With Very Young Age of Onset of Type 1 Diabetes

Michael J. MacDonald, Israr-ul H. Ansari, Amy S. Riedemann, Scott W. Stoker, Jens C. Eickhoff, Peter J. Chlebeck, Luis A. Fernandez, Melissa J. Longacre

Diabetes db211070

DOI: https://doi.org/10.2337/db21-1070

Published: 17 June 2022

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Meeting Abstracts

12-OR: Preventing ß-Cell Death under Glucotoxic Conditions: The Role of ChREBPb

LIORA S. KATZ, GABRIEL BRILL, MARK A. HERMAN, ADOLFO GARCIA-OCANA, DONALD SCOTT

Diabetes 2022;71(Supplement_1):12-OR

DOI: https://doi.org/10.2337/db22-12-OR

Published: 01 June 2022

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Meeting Abstracts

316-OR: Genetic Deletion of Beta-Cell Pkm1, Pkm2, and Pck2 Identifies PEP as an Essential Signal for Compartmentalized KATP Closure and Cycling of the Insulin Secretory Pathway

HANNAH R. FOSTER, THUONG HO, EVGENIY POTAPENKO, REBECCA L. CARDONE, RICHARD KIBBEY, IV, MATTHEW J. MERRINS

Diabetes 2022;71(Supplement_1):316-OR

DOI: https://doi.org/10.2337/db22-316-OR

Published: 01 June 2022

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Meeting Abstracts

1304-P: Quantification of Preproinsulin and Insulin Isoforms Derived from Upstream Open Reading Frames in Human Clinical Samples by Selected Reaction Monitoring Assay

QING-RONG LIU, MIN ZHU, PARITOSH GHOSH, CHEE W. CHIA, JOSEPHINE M. EGAN

Diabetes 2022;71(Supplement_1):1304-P

DOI: https://doi.org/10.2337/db22-1304-P

Published: 01 June 2022

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Journal Articles

Genetic Control of Splicing at SIRPG Modulates Risk of Type 1 Diabetes

Morgan J. Smith, Lucia Pastor, Jeremy R.B. Newman, Patrick Concannon

Diabetes 2022;71(2):350–358

DOI: https://doi.org/10.2337/db21-0194

Published: 19 November 2021

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Journal Articles

Novel Human Insulin Isoforms and Cα-Peptide Product in Islets of Langerhans and Choroid Plexus

Qing-Rong Liu, Min Zhu, Pingbo Zhang, Caio H. Mazucanti, Nicholas S. Huang, Doyle L. Lang, Qinghua Chen, Pavan Auluck, Stefano Marenco, Jennifer F. O’Connell, Luigi Ferrucci, Chee W. Chia, Josephine M. Egan

Diabetes 2021;70(12):2947–2956

DOI: https://doi.org/10.2337/db21-0198

Published: 14 October 2021

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Meeting Abstracts

127-OR: In Vivo Genetic Evidence That the Pyruvate Kinase Isoforms PKM1 and PKM2 Differentially Control Beta-Cell Fuel Sensing

HANNAH R. FOSTER, THUONG HO, EVGENIY POTAPENKO, SOPHIE L. LEWANDOWSKI, SOPHIA SDAO, HALENA R. VANDEUSEN, REBECCA L. CARDONE, RICHARD KIBBEY, IV, MATTHEW J. MERRINS

Diabetes 2021;70(Supplement_1):127-OR

DOI: https://doi.org/10.2337/db21-127-OR

Published: 01 June 2021

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Journal Articles

Deletion of the Brain-Specific α and δ Isoforms of Adapter Protein SH2B1 Protects Mice From Obesity

Jessica L. Cote, Lawrence S. Argetsinger, Anabel Flores, Alan C. Rupp, Joel M. Cline, Lauren C. DeSantis, Alexander H. Bedard, Devika P. Bagchi, Paul B. Vander, Abrielle M. Cacciaglia, Erik S. Clutter, Gowri Chandrashekar, Ormond A. MacDougald, Martin G. Myers, Jr., Christin Carter-Su

Diabetes 2021;70(2):400–414

DOI: https://doi.org/10.2337/db20-0687

Published: 19 November 2020

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Meeting Abstracts

225-LB: A High-Throughput CRISPR-Activation Screen Defines Human LncRNA Metabolic Regulators

YONGHE MA, HAIMING CAO

Diabetes 2020;69(Supplement_1):225-LB

DOI: https://doi.org/10.2337/db20-225-LB

Published: 01 June 2020

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Meeting Abstracts

208-OR: Emc10emc10, a Novel Circulating Factor for Systemic Energy and Metabolic Homeostasis

YANLIANG LI, XUANCHUN WANG, GUIFEN QIANG, MAXIMILIAN A. MCCANN, VICTORIA GIL, MATTHIAS BLÜHER, CHONG WEE LIEW

Diabetes 2020;69(Supplement_1):208-OR

DOI: https://doi.org/10.2337/db20-208-OR

Published: 01 June 2020

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Meeting Abstracts

481-P: Renal Distribution and Expression Analysis of ROCK Isoforms in Diabetic Kidney Disease

KEIICHIRO MATOBA, YUSUKE TAKEDA, YOSUKE NAGAI, TOMOYO AKAMINE, YASUSHI KANAZAWA, DAIJI KAWANAMI, KAZUNORI UTSUNOMIYA, RIMEI NISHIMURA

Diabetes 2020;69(Supplement_1):481-P

DOI: https://doi.org/10.2337/db20-481-P

Published: 01 June 2020

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Meeting Abstracts

2175-P: Isoform-Specific Roles of Prolyl Hydroxylase Domain Proteins in Regulating Beta-Cell Function

MONICA HOANG, SARAH M. JANSSEN, JAMIE W. JOSEPH

Diabetes 2019;68(Supplement_1):2175-P

DOI: https://doi.org/10.2337/db19-2175-P

Published: 01 June 2019

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Meeting Abstracts

1762-P: Insulin Receptor Isoforms in Human Adipose Tissue and Adipose Stem Cells

VALENTINA ANNAMARIA GENCHI, ANGELO CIGNARELLI, SEBASTIO PERRINI, STEFANIA PORRO, CRISTINA CACCIOPPOLI, ANNALISA NATALICCHIO, LUIGI LAVIOLA, FRANCESCO GIORGINO

Diabetes 2019;68(Supplement_1):1762-P

DOI: https://doi.org/10.2337/db19-1762-P

Published: 01 June 2019

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Journal Articles

SF1-Specific AMPKα1 Deletion Protects Against Diet-Induced Obesity

Patricia Seoane-Collazo, Juan Roa, Eva Rial-Pensado, Laura Liñares-Pose, Daniel Beiroa, Francisco Ruíz-Pino, Tania López-González, Donald A. Morgan, José Ángel Pardavila, María Jesús Sánchez-Tapia, Noelia Martínez-Sánchez, Cristina Contreras, Miguel Fidalgo, Carlos Diéguez, Roberto Coppari, Kamal Rahmouni, Rubén Nogueiras, Manuel Tena-Sempere, Miguel López

Diabetes 2018;67(11):2213–2226

DOI: https://doi.org/10.2337/db17-1538

Published: 13 August 2018

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Includes: Supplementary data

Meeting Abstracts

Isoform-Selective Targeting of Facilitative Glucose Transporters with Small Molecule Inhibitors

MONIQUE HEITMEIER, RICHARD C. HRESKO, MALA SHANMUGAM, PAUL W. HRUZ

Diabetes 2018;67(Supplement_1):1779-P

DOI: https://doi.org/10.2337/db18-1779-P

Published: 01 July 2018

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Meeting Abstracts

Localization of ChREBPa and ChREBPß in Pancreatic ß Cells

LIORA S. KATZ, ANIL K. LAXMAN, PILI ZHANG, DONALD SCOTT

Diabetes 2018;67(Supplement_1):192-OR

DOI: https://doi.org/10.2337/db18-192-OR

Published: 01 July 2018

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Meeting Abstracts

Mechanistic Role of IP3R Calcium Release Channel in Pancreatic Beta-Cell Function

JUN SHU, JESSICA GAMBARDELLA, DANIELA SORRIENTO, GAETANO SANTULLI

Diabetes 2018;67(Supplement_1):313-LB

DOI: https://doi.org/10.2337/db18-313-LB

Published: 01 July 2018

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Meeting Abstracts

Mitogenic Insulin Receptor A Increases in the Rodent Pituitary at the Onset of Puberty

FARRAH SALEH, HUGH S. TAYLOR, CLARE FLANNERY

Diabetes 2018;67(Supplement_1):245-LB

DOI: https://doi.org/10.2337/db18-245-LB

Published: 01 July 2018

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Journal Articles

T₃ Induces Both Markers of Maturation and Aging in Pancreatic β-Cells

Cristina Aguayo-Mazzucato, Terence B. Lee, Jr., Michelle Matzko, Amanda DiIenno, Habib Rezanejad, Preeti Ramadoss, Thomas Scanlan, Ann Marie Zavacki, P. Reed Larsen, Anthony Hollenberg, Clark Colton, Arun Sharma, Susan Bonner-Weir

Diabetes 2018;67(7):1322–1331

DOI: https://doi.org/10.2337/db18-0030

Published: 06 April 2018

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Includes: Supplementary data

Journal Articles

A Loss-of-Function Splice Acceptor Variant in IGF2 Is Protective for Type 2 Diabetes

Josep M. Mercader, Rachel G. Liao, Avery D. Bell, Zachary Dymek, Karol Estrada, Taru Tukiainen, Alicia Huerta-Chagoya, Hortensia Moreno-Macías, Kathleen A. Jablonski, Robert L. Hanson, Geoffrey A. Walford, Ignasi Moran, Ling Chen, Vineeta Agarwala, María Luisa Ordoñez-Sánchez, Rosario Rodríguez-Guillen, Maribel Rodríguez-Torres, Yayoi Segura-Kato, Humberto García-Ortiz, Federico Centeno-Cruz, Francisco Barajas-Olmos, Lizz Caulkins, Sobha Puppala, Pierre Fontanillas, Amy L. Williams, Sílvia Bonàs-Guarch, Chris Hartl, Stephan Ripke, Diabetes Prevention Program Research Group, Katherine Tooley, Jacqueline Lane, Carlos Zerrweck, Angélica Martínez-Hernández, Emilio J. Córdova, Elvia Mendoza-Caamal, Cecilia Contreras-Cubas, María E. González-Villalpando, Ivette Cruz-Bautista, Liliana Muñoz-Hernández, Donaji Gómez-Velasco, Ulises Alvirde, Brian E. Henderson, Lynne R. Wilkens, Loic Le Marchand, Olimpia Arellano-Campos, Laura Riba, Maegan Harden, Broad Genomics Platform, Stacey Gabriel, T2D-GENES Consortium, Hanna E. Abboud, Maria L. Cortes, Cristina Revilla-Monsalve, Sergio Islas-Andrade, Xavier Soberon, Joanne E. Curran, Christopher P. Jenkinson, Ralph A. DeFronzo, Donna M. Lehman, Craig L. Hanis, Graeme I. Bell, Michael Boehnke, John Blangero, Ravindranath Duggirala, Richa Saxena, Daniel MacArthur, Jorge Ferrer, Steven A. McCarroll, David Torrents, William C. Knowler, Leslie J. Baier, Noel Burtt, Clicerio González-Villalpando, Christopher A. Haiman, Carlos A. Aguilar-Salinas, Teresa Tusié-Luna, Jason Flannick, Suzanne B.R. Jacobs, Lorena Orozco, David Altshuler, Jose C. Florez

Diabetes 2017;66(11):2903–2914

DOI: https://doi.org/10.2337/db17-0187

Published: 24 August 2017

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Includes: Supplementary data

2 3 4 5

NARROW

A Novel Intron-Encoded Neuropilin-1 Isoform in Pancreatic Islets Associated With Very Young Age of Onset of Type 1 Diabetes

12-OR: Preventing ß-Cell Death under Glucotoxic Conditions: The Role of ChREBPb

316-OR: Genetic Deletion of Beta-Cell Pkm1, Pkm2, and Pck2 Identifies PEP as an Essential Signal for Compartmentalized KATP Closure and Cycling of the Insulin Secretory Pathway

1304-P: Quantification of Preproinsulin and Insulin Isoforms Derived from Upstream Open Reading Frames in Human Clinical Samples by Selected Reaction Monitoring Assay

Genetic Control of Splicing at SIRPG Modulates Risk of Type 1 Diabetes

Novel Human Insulin Isoforms and Cα-Peptide Product in Islets of Langerhans and Choroid Plexus

127-OR: In Vivo Genetic Evidence That the Pyruvate Kinase Isoforms PKM1 and PKM2 Differentially Control Beta-Cell Fuel Sensing

Deletion of the Brain-Specific α and δ Isoforms of Adapter Protein SH2B1 Protects Mice From Obesity

225-LB: A High-Throughput CRISPR-Activation Screen Defines Human LncRNA Metabolic Regulators

208-OR: Emc10emc10, a Novel Circulating Factor for Systemic Energy and Metabolic Homeostasis

481-P: Renal Distribution and Expression Analysis of ROCK Isoforms in Diabetic Kidney Disease

2175-P: Isoform-Specific Roles of Prolyl Hydroxylase Domain Proteins in Regulating Beta-Cell Function

1762-P: Insulin Receptor Isoforms in Human Adipose Tissue and Adipose Stem Cells

SF1-Specific AMPKα1 Deletion Protects Against Diet-Induced Obesity

Isoform-Selective Targeting of Facilitative Glucose Transporters with Small Molecule Inhibitors

Localization of ChREBPa and ChREBPß in Pancreatic ß Cells

Mechanistic Role of IP3R Calcium Release Channel in Pancreatic Beta-Cell Function

Mitogenic Insulin Receptor A Increases in the Rodent Pituitary at the Onset of Puberty

T₃ Induces Both Markers of Maturation and Aging in Pancreatic β-Cells

A Loss-of-Function Splice Acceptor Variant in IGF2 Is Protective for Type 2 Diabetes

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