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Meeting Abstracts

1513-P: IAPP25 in Beta Cells and DNSP11 in Alpha Cells Inhibit IAPP37 Fibrillation

QING-RONG LIU, MIN ZHU, JOSEPHINE M. EGAN

Diabetes 2023;72(Supplement_1):1513-P

https://doi.org/10.2337/db23-1513-P

Published: 20 June 2023

View article titled, 1513-P: IAPP25 in Beta Cells and DNSP11 in Alpha Cells Inhibit IAPP37 Fibrillation

Meeting Abstracts

284-OR: An Alternative Downstream Translational Start Site in PPARG Produces a Novel Protein That Rescues Loss-of-Function Mutations in Humans

KAREN MENDEZ LARA, XIAOMI DU, KIMBERLY GLASS, RUBEN HERNANDEZ, CAMILA DE ARRUDA SALDANHA, SVEN HEINZ, AMIT R. MAJITHIA

Diabetes 2023;72(Supplement_1):284-OR

https://doi.org/10.2337/db23-284-OR

Published: 20 June 2023

View article titled, 284-OR: An Alternative Downstream Translational Start Site in PPARG Produces a Novel Protein That Rescues Loss-of-Function Mutations in Humans

Meeting Abstracts

1549-P: scEMC10 Promotes Glucose Intolerance via the Inhibition of PKA-Mediated Insulin Secretion

JIARONG DAI, SHAN LIU, KUANGYANG CHEN, SHUOSHUO JIN, YAHAO WANG, LIJIAO CHEN, XUANCHUN WANG

Diabetes 2023;72(Supplement_1):1549-P

https://doi.org/10.2337/db23-1549-P

Published: 20 June 2023

View article titled, 1549-P: scEMC10 Promotes Glucose Intolerance via the Inhibition of PKA-Mediated Insulin Secretion

Journal Articles

Sorting Out the Receptor Isoforms Underlying Dopamine Inhibition of Insulin Secretion

Melkam A. Kebede, David W. Piston

Diabetes 2022;71(9):1831–1833

https://doi.org/10.2337/dbi22-0018

Published: 11 August 2022

View article titled, Sorting Out the Receptor Isoforms Underlying Dopamine Inhibition of Insulin Secretion

Journal Articles

A Novel Intron-Encoded Neuropilin-1 Isoform in Pancreatic Islets Associated With Very Young Age of Onset of Type 1 Diabetes

Michael J. MacDonald, Israr-ul H. Ansari, Amy S. Riedemann, Scott W. Stoker, Jens C. Eickhoff, Peter J. Chlebeck, Luis A. Fernandez, Melissa J. Longacre

Diabetes 2022;71(9):2058–2063

https://doi.org/10.2337/db21-1070

Published: 17 June 2022

View article titled, A Novel Intron-Encoded Neuropilin-1 Isoform in Pancreatic Islets Associated With Very Young Age of Onset of Type 1 Diabetes

Meeting Abstracts

12-OR: Preventing ß-Cell Death under Glucotoxic Conditions: The Role of ChREBPb

LIORA S. KATZ, GABRIEL BRILL, MARK A. HERMAN, ADOLFO GARCIA-OCANA, DONALD SCOTT

Diabetes 2022;71(Supplement_1):12-OR

https://doi.org/10.2337/db22-12-OR

Published: 01 June 2022

View article titled, 12-OR: Preventing ß-Cell Death under Glucotoxic Conditions: The Role of ChREBPb

Meeting Abstracts

316-OR: Genetic Deletion of Beta-Cell Pkm1, Pkm2, and Pck2 Identifies PEP as an Essential Signal for Compartmentalized KATP Closure and Cycling of the Insulin Secretory Pathway

HANNAH R. FOSTER, THUONG HO, EVGENIY POTAPENKO, REBECCA L. CARDONE, RICHARD KIBBEY, IV, MATTHEW J. MERRINS

Diabetes 2022;71(Supplement_1):316-OR

https://doi.org/10.2337/db22-316-OR

Published: 01 June 2022

View article titled, 316-OR: Genetic Deletion of Beta-Cell Pkm1, Pkm2, and Pck2 Identifies PEP as an Essential Signal for Compartmentalized KATP Closure and Cycling of the Insulin Secretory Pathway

Meeting Abstracts

1304-P: Quantification of Preproinsulin and Insulin Isoforms Derived from Upstream Open Reading Frames in Human Clinical Samples by Selected Reaction Monitoring Assay

QING-RONG LIU, MIN ZHU, PARITOSH GHOSH, CHEE W. CHIA, JOSEPHINE M. EGAN

Diabetes 2022;71(Supplement_1):1304-P

https://doi.org/10.2337/db22-1304-P

Published: 01 June 2022

View article titled, 1304-P: Quantification of Preproinsulin and Insulin Isoforms Derived from Upstream Open Reading Frames in Human Clinical Samples by Selected Reaction Monitoring Assay

Journal Articles

Genetic Control of Splicing at SIRPG Modulates Risk of Type 1 Diabetes

Morgan J. Smith, Lucia Pastor, Jeremy R.B. Newman, Patrick Concannon

Diabetes 2022;71(2):350–358

https://doi.org/10.2337/db21-0194

Published: 19 November 2021

View article titled, Genetic Control of Splicing at <em>SIRPG</em> Modulates Risk of Type 1 Diabetes

Journal Articles

Novel Human Insulin Isoforms and Cα-Peptide Product in Islets of Langerhans and Choroid Plexus

Qing-Rong Liu, Min Zhu, Pingbo Zhang, Caio H. Mazucanti, Nicholas S. Huang, Doyle L. Lang, Qinghua Chen, Pavan Auluck, Stefano Marenco, Jennifer F. O’Connell, Luigi Ferrucci, Chee W. Chia, Josephine M. Egan

Diabetes 2021;70(12):2947–2956

https://doi.org/10.2337/db21-0198

Published: 14 October 2021

View article titled, Novel Human Insulin Isoforms and Cα-Peptide Product in Islets of Langerhans and Choroid Plexus

Meeting Abstracts

127-OR: In Vivo Genetic Evidence That the Pyruvate Kinase Isoforms PKM1 and PKM2 Differentially Control Beta-Cell Fuel Sensing

HANNAH R. FOSTER, THUONG HO, EVGENIY POTAPENKO, SOPHIE L. LEWANDOWSKI, SOPHIA SDAO, HALENA R. VANDEUSEN, REBECCA L. CARDONE, RICHARD KIBBEY, IV, MATTHEW J. MERRINS

Diabetes 2021;70(Supplement_1):127-OR

https://doi.org/10.2337/db21-127-OR

Published: 01 June 2021

View article titled, 127-OR: In Vivo Genetic Evidence That the Pyruvate Kinase Isoforms PKM1 and PKM2 Differentially Control Beta-Cell Fuel Sensing

Journal Articles

Deletion of the Brain-Specific α and δ Isoforms of Adapter Protein SH2B1 Protects Mice From Obesity

Jessica L. Cote, Lawrence S. Argetsinger, Anabel Flores, Alan C. Rupp, Joel M. Cline, Lauren C. DeSantis, Alexander H. Bedard, Devika P. Bagchi, Paul B. Vander, Abrielle M. Cacciaglia, Erik S. Clutter, Gowri Chandrashekar, Ormond A. MacDougald, Martin G. Myers, Jr., Christin Carter-Su

Diabetes 2021;70(2):400–414

https://doi.org/10.2337/db20-0687

Published: 19 November 2020

View article titled, Deletion of the Brain-Specific α and δ Isoforms of Adapter Protein SH2B1 Protects Mice From Obesity

Meeting Abstracts

225-LB: A High-Throughput CRISPR-Activation Screen Defines Human LncRNA Metabolic Regulators

YONGHE MA, HAIMING CAO

Diabetes 2020;69(Supplement_1):225-LB

https://doi.org/10.2337/db20-225-LB

Published: 01 June 2020

View article titled, 225-LB: A High-Throughput CRISPR-Activation Screen Defines Human LncRNA Metabolic Regulators

Meeting Abstracts

208-OR: Emc10emc10, a Novel Circulating Factor for Systemic Energy and Metabolic Homeostasis

YANLIANG LI, XUANCHUN WANG, GUIFEN QIANG, MAXIMILIAN A. MCCANN, VICTORIA GIL, MATTHIAS BLÜHER, CHONG WEE LIEW

Diabetes 2020;69(Supplement_1):208-OR

https://doi.org/10.2337/db20-208-OR

Published: 01 June 2020

View article titled, 208-OR: Emc10emc10, a Novel Circulating Factor for Systemic Energy and Metabolic Homeostasis

Meeting Abstracts

481-P: Renal Distribution and Expression Analysis of ROCK Isoforms in Diabetic Kidney Disease

KEIICHIRO MATOBA, YUSUKE TAKEDA, YOSUKE NAGAI, TOMOYO AKAMINE, YASUSHI KANAZAWA, DAIJI KAWANAMI, KAZUNORI UTSUNOMIYA, RIMEI NISHIMURA

Diabetes 2020;69(Supplement_1):481-P

https://doi.org/10.2337/db20-481-P

Published: 01 June 2020

View article titled, 481-P: Renal Distribution and Expression Analysis of ROCK Isoforms in Diabetic Kidney Disease

Meeting Abstracts

1762-P: Insulin Receptor Isoforms in Human Adipose Tissue and Adipose Stem Cells

VALENTINA ANNAMARIA GENCHI, ANGELO CIGNARELLI, SEBASTIO PERRINI, STEFANIA PORRO, CRISTINA CACCIOPPOLI, ANNALISA NATALICCHIO, LUIGI LAVIOLA, FRANCESCO GIORGINO

Diabetes 2019;68(Supplement_1):1762-P

https://doi.org/10.2337/db19-1762-P

Published: 01 June 2019

View article titled, 1762-P: Insulin Receptor Isoforms in Human Adipose Tissue and Adipose Stem Cells

Meeting Abstracts

2175-P: Isoform-Specific Roles of Prolyl Hydroxylase Domain Proteins in Regulating Beta-Cell Function

MONICA HOANG, SARAH M. JANSSEN, JAMIE W. JOSEPH

Diabetes 2019;68(Supplement_1):2175-P

https://doi.org/10.2337/db19-2175-P

Published: 01 June 2019

View article titled, 2175-P: Isoform-Specific Roles of Prolyl Hydroxylase Domain Proteins in Regulating Beta-Cell Function

Journal Articles

SF1-Specific AMPKα1 Deletion Protects Against Diet-Induced Obesity

Patricia Seoane-Collazo, Juan Roa, Eva Rial-Pensado, Laura Liñares-Pose, Daniel Beiroa, Francisco Ruíz-Pino, Tania López-González, Donald A. Morgan, José Ángel Pardavila, María Jesús Sánchez-Tapia, Noelia Martínez-Sánchez, Cristina Contreras, Miguel Fidalgo, Carlos Diéguez, Roberto Coppari, Kamal Rahmouni, Rubén Nogueiras, Manuel Tena-Sempere, Miguel López

Diabetes 2018;67(11):2213–2226

https://doi.org/10.2337/db17-1538

Published: 13 August 2018

View article titled, SF1-Specific AMPKα1 Deletion Protects Against Diet-Induced Obesity

Includes: Supplementary data

Meeting Abstracts

Isoform-Selective Targeting of Facilitative Glucose Transporters with Small Molecule Inhibitors

MONIQUE HEITMEIER, RICHARD C. HRESKO, MALA SHANMUGAM, PAUL W. HRUZ

Diabetes 2018;67(Supplement_1):1779-P

https://doi.org/10.2337/db18-1779-P

Published: 01 July 2018

View article titled, Isoform-Selective Targeting of Facilitative Glucose Transporters with Small Molecule Inhibitors

Meeting Abstracts

Localization of ChREBPa and ChREBPß in Pancreatic ß Cells

LIORA S. KATZ, ANIL K. LAXMAN, PILI ZHANG, DONALD SCOTT

Diabetes 2018;67(Supplement_1):192-OR

https://doi.org/10.2337/db18-192-OR

Published: 01 July 2018

View article titled, Localization of ChREBPa and ChREBPß in Pancreatic ß Cells

NARROW

1513-P: IAPP25 in Beta Cells and DNSP11 in Alpha Cells Inhibit IAPP37 Fibrillation

284-OR: An Alternative Downstream Translational Start Site in PPARG Produces a Novel Protein That Rescues Loss-of-Function Mutations in Humans

1549-P: scEMC10 Promotes Glucose Intolerance via the Inhibition of PKA-Mediated Insulin Secretion

Sorting Out the Receptor Isoforms Underlying Dopamine Inhibition of Insulin Secretion

A Novel Intron-Encoded Neuropilin-1 Isoform in Pancreatic Islets Associated With Very Young Age of Onset of Type 1 Diabetes

12-OR: Preventing ß-Cell Death under Glucotoxic Conditions: The Role of ChREBPb

316-OR: Genetic Deletion of Beta-Cell Pkm1, Pkm2, and Pck2 Identifies PEP as an Essential Signal for Compartmentalized KATP Closure and Cycling of the Insulin Secretory Pathway

1304-P: Quantification of Preproinsulin and Insulin Isoforms Derived from Upstream Open Reading Frames in Human Clinical Samples by Selected Reaction Monitoring Assay

Genetic Control of Splicing at SIRPG Modulates Risk of Type 1 Diabetes

Novel Human Insulin Isoforms and Cα-Peptide Product in Islets of Langerhans and Choroid Plexus

127-OR: In Vivo Genetic Evidence That the Pyruvate Kinase Isoforms PKM1 and PKM2 Differentially Control Beta-Cell Fuel Sensing

Deletion of the Brain-Specific α and δ Isoforms of Adapter Protein SH2B1 Protects Mice From Obesity

225-LB: A High-Throughput CRISPR-Activation Screen Defines Human LncRNA Metabolic Regulators

208-OR: Emc10emc10, a Novel Circulating Factor for Systemic Energy and Metabolic Homeostasis

481-P: Renal Distribution and Expression Analysis of ROCK Isoforms in Diabetic Kidney Disease

1762-P: Insulin Receptor Isoforms in Human Adipose Tissue and Adipose Stem Cells

2175-P: Isoform-Specific Roles of Prolyl Hydroxylase Domain Proteins in Regulating Beta-Cell Function

SF1-Specific AMPKα1 Deletion Protects Against Diet-Induced Obesity

Isoform-Selective Targeting of Facilitative Glucose Transporters with Small Molecule Inhibitors

Localization of ChREBPa and ChREBPß in Pancreatic ß Cells

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