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Meeting Abstracts

1562-P: Hepatic ChREBP-ß Overexpression Enhances Peripheral Glucose and Lipid Homeostasis Independently of FGF21

SARAH HANNOU, ASHOT SARGSYAN, WENXIN TONG, JIE AN, CHRISTOPHER B. NEWGARD, INNA ASTAPOVA, MARK A. HERMAN
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1562-P
https://doi.org/10.2337/db23-1562-P
Published: 20 June 2023
View article titled, 1562-P: Hepatic ChREBP-ß Overexpression Enhances Peripheral Glucose and Lipid Homeostasis Independently of FGF21
Journal Articles

PRMT4 Facilitates White Adipose Tissue Browning and Thermogenesis by Methylating PPARγ

Yi Zhong, Yilong Wang, Xiaoguang Li, Haojie Qin, Shu Yan, Caijun Rao, Di Fan, Duqiu Liu, Fei Deng, Yanli Miao, Ling Yang, Kai Huang
Journal: Diabetes
Diabetes 2023;72(8):1095–1111
https://doi.org/10.2337/db22-1016
Published: 22 May 2023
View article titled, PRMT4 Facilitates White Adipose Tissue Browning and Thermogenesis by Methylating PPARγ
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Journal Articles

Metrnl Alleviates Lipid Accumulation by Modulating Mitochondrial Homeostasis in Diabetic Nephropathy

Yuxia Zhou, Lu Liu, Bangming Jin, Yixuan Wu, Lifen Xu, Xuebing Chang, Laying Hu, Guifang Wang, Yali Huang, Lingyu Song, Tian Zhang, Yuanyuan Wang, Ying Xiao, Fan Zhang, Mingjun Shi, Lingling Liu, Tuanlao Wang, Rui Yan, Bing Guo
Journal: Diabetes
Diabetes 2023;72(5):611–626
https://doi.org/10.2337/db22-0680
Published: 22 February 2023
View article titled, Metrnl Alleviates Lipid Accumulation by Modulating Mitochondrial Homeostasis in Diabetic Nephropathy
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Journal Articles

Isorhapontigenin Attenuates Cardiac Microvascular Injury in Diabetes via the Inhibition of Mitochondria-Associated Ferroptosis Through PRDX2-MFN2-ACSL4 Pathways

Yuqiong Chen, Su Li, Ming Yin, Yafei Li, Chao Chen, Jun Zhang, Kangyun Sun, Xiangqing Kong, Zhangwei Chen, Juying Qian
Journal: Diabetes
Diabetes 2023;72(3):389–404
https://doi.org/10.2337/db22-0553
Published: 11 November 2022
View article titled, Isorhapontigenin Attenuates Cardiac Microvascular Injury in Diabetes via the Inhibition of Mitochondria-Associated Ferroptosis Through PRDX2-MFN2-ACSL4 Pathways
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Journal Articles

Sustained Upregulation of Endothelial Nox4 Mediates Retinal Vascular Pathology in Type 1 Diabetes

Xixiang Tang, Jinli Wang, Hanna E. Abboud, Yanming Chen, Joshua J. Wang, Sarah X. Zhang
Journal: Diabetes
Diabetes 2023;72(1):112–125
https://doi.org/10.2337/db22-0194
Published: 02 November 2022
View article titled, Sustained Upregulation of Endothelial Nox4 Mediates Retinal Vascular Pathology in Type 1 Diabetes
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Journal Articles

The Mechanism for Adipose Endotrophin Production

Yun Sok Lee
Journal: Diabetes
Diabetes 2022;71(8):1617–1619
https://doi.org/10.2337/dbi22-0008
Published: 21 August 2022
View article titled, The Mechanism for Adipose Endotrophin Production
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Journal Articles

Forkhead Box i2 Transcription Factor Regulates Systemic Energy Metabolism Via Neuropeptide AgRP

Yatong Fan, Sufang Sheng, Cunle Guo, Wei Qiao, Yue Jin, Lu Tan, Yong Gao, Lei Zhang, Xi Dong, Jun Zhang, Xiaorong Li, Hui Shen, Yunfei Liao, Yongsheng Chang
Journal: Diabetes
Diabetes 2022;71(10):2106–2122
https://doi.org/10.2337/db22-0002
Published: 20 July 2022
View article titled, Forkhead Box i2 Transcription Factor Regulates Systemic Energy Metabolism Via Neuropeptide AgRP
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Meeting Abstracts

201-LB: Overexpression of GOT1 in Brown Adipose Tissue Enhances Thermogenesis and Glucose Metabolism by Activating the Malate-Aspartate Shuttle

CHUL-HONG PARK, HELIA CHENG, SANG R. LEE, KENNETH EILERTSEN, JI SUK CHANG
Journal: Diabetes
Diabetes 2022;71(Supplement_1):201-LB
https://doi.org/10.2337/db22-201-LB
Published: 01 June 2022
View article titled, 201-LB: Overexpression of GOT1 in Brown Adipose Tissue Enhances Thermogenesis and Glucose Metabolism by Activating the Malate-Aspartate Shuttle
Meeting Abstracts

12-OR: Preventing ß-Cell Death under Glucotoxic Conditions: The Role of ChREBPb

LIORA S. KATZ, GABRIEL BRILL, MARK A. HERMAN, ADOLFO GARCIA-OCANA, DONALD SCOTT
Journal: Diabetes
Diabetes 2022;71(Supplement_1):12-OR
https://doi.org/10.2337/db22-12-OR
Published: 01 June 2022
View article titled, 12-OR: Preventing ß-Cell Death under Glucotoxic Conditions: The Role of ChREBPb
Journal Articles

Bromodomain Inhibition Reveals FGF15/19 As a Target of Epigenetic Regulation and Metabolic Control

Chisayo Kozuka, Vissarion Efthymiou, Vicencia M. Sales, Liyuan Zhou, Soravis Osataphan, Yixing Yuchi, Jeremy Chimene-Weiss, Christopher Mulla, Elvira Isganaitis, Jessica Desmond, Suzuka Sanechika, Joji Kusuyama, Laurie Goodyear, Xu Shi, Robert E. Gerszten, Cristina Aguayo-Mazzucato, Priscila Carapeto, Silvania DaSilva Teixeira, Darleen Sandoval, Direna Alonso-Curbelo, Lei Wu, Jun Qi, Mary-Elizabeth Patti
Journal: Diabetes
Diabetes 2022;71(5):1023–1033
https://doi.org/10.2337/db21-0574
Published: 31 January 2022
View article titled, Bromodomain Inhibition Reveals FGF15/19 As a Target of Epigenetic Regulation and Metabolic Control
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Journal Articles

Human Islet MicroRNA-200c Is Elevated in Type 2 Diabetes and Targets the Transcription Factor ETV5 to Reduce Insulin Secretion

Jones K. Ofori, Alexandros Karagiannopoulos, Mototsugu Nagao, Efraim Westholm, Shaima Ramadan, Anna Wendt, Jonathan L.S. Esguerra, Lena Eliasson
Journal: Diabetes
Diabetes 2022;71(2):275–284
https://doi.org/10.2337/db21-0077
Published: 09 November 2021
View article titled, Human Islet MicroRNA-200c Is Elevated in Type 2 Diabetes and Targets the Transcription Factor ETV5 to Reduce Insulin Secretion
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Meeting Abstracts

114-OR: Overexpression of Alpha-1 Antitrypsin in MSCs Delays Onset of Type 1 Diabetes in the NOD Mice by Increasing Their Antiinflammatory and Protection Functions

HUA WEI, WENYU GOU, CHARLIE STRANGE, HONGJUN WANG
Journal: Diabetes
Diabetes 2021;70(Supplement_1):114-OR
https://doi.org/10.2337/db21-114-OR
Published: 01 June 2021
View article titled, 114-OR: Overexpression of Alpha-1 Antitrypsin in MSCs Delays Onset of Type 1 Diabetes in the NOD Mice by Increasing Their Antiinflammatory and Protection Functions
Journal Articles

Overexpression of Nrf2 in Renal Proximal Tubular Cells Stimulates Sodium–Glucose Cotransporter 2 Expression and Exacerbates Dysglycemia and Kidney Injury in Diabetic Mice

Shuiling Zhao, Chao-Sheng Lo, Kana N. Miyata, Anindya Ghosh, Xin-Ping Zhao, Isabelle Chenier, Jean-Francois Cailhier, Jean Ethier, Jean-Baptiste Lattouf, Janos G. Filep, Julie R. Ingelfinger, Shao-Ling Zhang, John S.D. Chan
Journal: Diabetes
Diabetes 2021;70(6):1388–1403
https://doi.org/10.2337/db20-1126
Published: 05 March 2021
View article titled, Overexpression of Nrf2 in Renal Proximal Tubular Cells Stimulates Sodium–Glucose Cotransporter 2 Expression and Exacerbates Dysglycemia and Kidney Injury in Diabetic Mice
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Journal Articles

Lipoprotein Lipase Overexpression in Skeletal Muscle Attenuates Weight Regain by Potentiating Energy Expenditure

David M. Presby, Michael C. Rudolph, Vanessa D. Sherk, Matthew R. Jackman, Rebecca M. Foright, Kenneth L. Jones, Julie A. Houck, Ginger C. Johnson, Janine A. Higgins, P. Darrell Neufer, Robert H. Eckel, Paul S. MacLean
Journal: Diabetes
Diabetes 2021;70(4):867–877
https://doi.org/10.2337/db20-0763
Published: 03 February 2021
View article titled, Lipoprotein Lipase Overexpression in Skeletal Muscle Attenuates Weight Regain by Potentiating Energy Expenditure
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Journal Articles

Heme Oxygenase-1 Regulates Ferrous Iron and Foxo1 in Control of Hepatic Gluconeogenesis

Wang Liao, Wanbao Yang, Zheng Shen, Weiqi Ai, Quan Pan, Yuxiang Sun, Shaodong Guo
Journal: Diabetes
Diabetes 2021;70(3):696–709
https://doi.org/10.2337/db20-0954
Published: 06 January 2021
View article titled, Heme Oxygenase-1 Regulates Ferrous Iron and Foxo1 in Control of Hepatic Gluconeogenesis
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Journal Articles

Interphotoreceptor Retinol-Binding Protein Ameliorates Diabetes-Induced Retinal Dysfunction and Neurodegeneration Through Rhodopsin

Jianglei Chen, Yan Shao, Temmy Sasore, Gennadiy Moiseyev, Kelu Zhou, Xiang Ma, Yanhong Du, Jian-xing Ma
Journal: Diabetes
Diabetes 2021;70(3):788–799
https://doi.org/10.2337/db20-0609
Published: 17 December 2020
View article titled, Interphotoreceptor Retinol-Binding Protein Ameliorates Diabetes-Induced Retinal Dysfunction and Neurodegeneration Through Rhodopsin
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Journal Articles

Defective FXR-SHP Regulation in Obesity Aberrantly Increases miR-802 Expression, Promoting Insulin Resistance and Fatty Liver

Sunmi Seok, Hao Sun, Young-Chae Kim, Byron Kemper, Jongsook Kim Kemper
Journal: Diabetes
Diabetes 2021;70(3):733–744
https://doi.org/10.2337/db20-0856
Published: 16 December 2020
View article titled, Defective FXR-SHP Regulation in Obesity Aberrantly Increases <em>miR-802</em> Expression, Promoting Insulin Resistance and Fatty Liver
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Journal Articles

Ncor2/PPARα-Dependent Upregulation of MCUb in the Type 2 Diabetic Heart Impacts Cardiac Metabolic Flexibility and Function

Federico Cividini, Brian T. Scott, Jorge Suarez, Darren E. Casteel, Sven Heinz, Anzhi Dai, Tanja Diemer, Jorge A. Suarez, Christopher W. Benner, Majid Ghassemian, Wolfgang H. Dillmann
Journal: Diabetes
Diabetes 2021;70(3):665–679
https://doi.org/10.2337/db20-0779
Published: 10 December 2020
View article titled, Ncor2/PPARα-Dependent Upregulation of MCUb in the Type 2 Diabetic Heart Impacts Cardiac Metabolic Flexibility and Function
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Journal Articles

Lysosomal Acid Lipase Drives Adipocyte Cholesterol Homeostasis and Modulates Lipid Storage in Obesity, Independent of Autophagy

Camille Gamblin, Christine Rouault, Amélie Lacombe, Francina Langa-Vives, Dominique Farabos, Antonin Lamaziere, Karine Clément, Emmanuel L. Gautier, Laurent Yvan-Charvet, Isabelle Dugail
Journal: Diabetes
Diabetes 2021;70(1):76–90
https://doi.org/10.2337/db20-0578
Published: 02 November 2020
View article titled, Lysosomal Acid Lipase Drives Adipocyte Cholesterol Homeostasis and Modulates Lipid Storage in Obesity, Independent of Autophagy
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Journal Articles

Induction of Core Circadian Clock Transcription Factor Bmal1 Enhances β-Cell Function and Protects Against Obesity-Induced Glucose Intolerance

Kuntol Rakshit, Aleksey V. Matveyenko
Journal: Diabetes
Diabetes 2021;70(1):143–154
https://doi.org/10.2337/db20-0192
Published: 21 October 2020
View article titled, Induction of Core Circadian Clock Transcription Factor Bmal1 Enhances β-Cell Function and Protects Against Obesity-Induced Glucose Intolerance
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