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Meeting Abstracts

224-OR: Antisense Oligonucleotide–Mediated Restriction of Mitochondrial Pyruvate Metabolism Limits DNL in High-Fat Fed C57BL6/J Mice

JORDAN W. STROBER, LAUREN M. PAOLELLA, REBECCA SUH, BRANDON T. HUBBARD, SUE MURRAY, DANIEL F. VATNER

Diabetes 2022;71(Supplement_1):224-OR

DOI: https://doi.org/10.2337/db22-224-OR

Published: 01 June 2022

View article titled, 224-OR: Antisense Oligonucleotide–Mediated Restriction of Mitochondrial Pyruvate Metabolism Limits DNL in High-Fat Fed C57BL6/J Mice

Meeting Abstracts

1342-P: Reduction of Glucokinase and Glucokinase Regulatory Protein Expression by siRNA Is Associated with the Reduction of Lactate and Pyruvate Export from Canine Hepatocytes

MORVARID KABIR, MARILYN ADER, RICHARD N. BERGMAN

Diabetes 2022;71(Supplement_1):1342-P

DOI: https://doi.org/10.2337/db22-1342-P

Published: 01 June 2022

View article titled, 1342-P: Reduction of Glucokinase and Glucokinase Regulatory Protein Expression by siRNA Is Associated with the Reduction of Lactate and Pyruvate Export from Canine Hepatocytes

Meeting Abstracts

213-LB: Mechanisms of Metabolic Cross Talk between Mitochondrial Pyruvate Carrier Inhibition and Branched-Chain Amino Acid Catabolism in Hepatocytes

DANIEL FERGUSON, NICOLE K.H. YIEW, KYLE S. MCCOMMIS, JERRY R. COLCA, BRIAN N. FINCK

Diabetes 2021;70(Supplement_1):213-LB

DOI: https://doi.org/10.2337/db21-213-LB

Published: 01 June 2021

View article titled, 213-LB: Mechanisms of Metabolic Cross Talk between Mitochondrial Pyruvate Carrier Inhibition and Branched-Chain Amino Acid Catabolism in Hepatocytes

Meeting Abstracts

768-P: MSDC-0602 Is a Direct Mitochondrial Pyruvate Carrier Inhibitor That Modulates Central Carbon Metabolism in Mice and Humans

ADAM J. RAUCKHORST, DANIEL J. PAPE, JERRY R. COLCA, ERIC B. TAYLOR

Diabetes 2021;70(Supplement_1):768-P

DOI: https://doi.org/10.2337/db21-768-P

Published: 01 June 2021

View article titled, 768-P: MSDC-0602 Is a Direct Mitochondrial Pyruvate Carrier Inhibitor That Modulates Central Carbon Metabolism in Mice and Humans

Journal Articles

New Antidiabetes Agent Targeting Both Mitochondrial Uncoupling and Pyruvate Catabolism: Two Birds With One Stone

Liangyou Rui

Diabetes 2019;68(12):2195–2196

DOI: https://doi.org/10.2337/dbi19-0024

Published: 13 November 2019

View article titled, New Antidiabetes Agent Targeting Both Mitochondrial Uncoupling and Pyruvate Catabolism: Two Birds With One Stone

Meeting Abstracts

1178-P: MSDC-0602 Directly Inhibits Mitochondrial Pyruvate Transport

ADAM J. RAUCKHORST, LALITA OONTHONPAN, ERIC B. TAYLOR

Diabetes 2019;68(Supplement_1):1178-P

DOI: https://doi.org/10.2337/db19-1178-P

Published: 01 June 2019

View article titled, 1178-P: MSDC-0602 Directly Inhibits Mitochondrial Pyruvate Transport

Meeting Abstracts

135-OR: A Novel Thiazolidinedione (TZD) with Minimal PPAR-γ Activity Maximized for Mitochondrial Pyruvate Carrier (MPC) Modulation: Six-Month Analysis of Glycemia in a 12-Month Nonalcoholic Steatohepatitis (NASH) Study

KENNETH CUSI, ORVILLE G. KOLTERMAN, STEPHEN A. HARRISON, HOWARD C. DITTRICH

Diabetes 2019;68(Supplement_1):135-OR

DOI: https://doi.org/10.2337/db19-135-OR

Published: 01 June 2019

View article titled, 135-OR: A Novel Thiazolidinedione (TZD) with Minimal PPAR-γ Activity Maximized for Mitochondrial Pyruvate Carrier (MPC) Modulation: Six-Month Analysis of Glycemia in a 12-Month Nonalcoholic Steatohepatitis (NASH) Study

Journal Articles

Absence of TXNIP in Humans Leads to Lactic Acidosis and Low Serum Methionine Linked to Deficient Respiration on Pyruvate

Yurika Katsu-Jiménez, Carmela Vázquez-Calvo, Camilla Maffezzini, Maria Halldin, Xiaoxiao Peng, Christoph Freyer, Anna Wredenberg, Alfredo Giménez-Cassina, Anna Wedell, Elias S.J. Arnér

Diabetes 2019;68(4):709–723

DOI: https://doi.org/10.2337/db18-0557

Published: 12 February 2019

View article titled, Absence of TXNIP in Humans Leads to Lactic Acidosis and Low Serum Methionine Linked to Deficient Respiration on Pyruvate

Includes: Supplementary data

Journal Articles

PDK4 Deficiency Suppresses Hepatic Glucagon Signaling by Decreasing cAMP Levels

Bo-Yoon Park, Jae-Han Jeon, Younghoon Go, Hye Jin Ham, Jeong-Eun Kim, Eun Kyung Yoo, Woong Hee Kwon, Nam-Ho Jeoung, Yong Hyun Jeon, Seung-Hoi Koo, Byung-Gyu Kim, Ling He, Keun-Gyu Park, Robert A. Harris, In-Kyu Lee

Diabetes 2018;67(10):2054–2068

DOI: https://doi.org/10.2337/db17-1529

Published: 31 July 2018

View article titled, PDK4 Deficiency Suppresses Hepatic Glucagon Signaling by Decreasing cAMP Levels

Includes: Supplementary data

Meeting Abstracts

Identification of Mitochondrial Pyruvate Carrier Modulators to Treat Diabetes

KYLE S. MCCOMMIS, WESLEY T. HODGES, YANA CHEN, KARI CHAMBERS, BRIAN N. FINCK

Diabetes 2018;67(Supplement_1):1770-P

DOI: https://doi.org/10.2337/db18-1770-P

Published: 01 July 2018

View article titled, Identification of Mitochondrial Pyruvate Carrier Modulators to Treat Diabetes

Meeting Abstracts

Assessment and Expansion of Models for ¹³C-Metabolic Flux Analysis (MFA) In Vivo

CLINTON HASENOUR, MOHSIN RAHIM, JAMEY YOUNG

Diabetes 2018;67(Supplement_1):258-LB

DOI: https://doi.org/10.2337/db18-258-LB

Published: 01 July 2018

View article titled, Assessment and Expansion of Models for 13C-Metabolic Flux Analysis (MFA) In Vivo

Meeting Abstracts

Hepatic Overexpression of Retinoic Acid Receptor ß Downregulates Mitochondrial Pyruvate Carrier 1 and Protects from Metabolic Dysregulation in ob/ob Mice

FARNAZ KEYHANI NEJAD, DONGHWAN LEE, HANQING CHEN, ZERONG LIANG, NICOLAS MUSI, MENGWEI ZANG

Diabetes 2018;67(Supplement_1):358-OR

DOI: https://doi.org/10.2337/db18-358-OR

Published: 01 July 2018

View article titled, Hepatic Overexpression of Retinoic Acid Receptor ß Downregulates Mitochondrial Pyruvate Carrier 1 and Protects from Metabolic Dysregulation in ob/ob Mice

Journal Articles

Direct Substrate Delivery Into Mitochondrial Fission–Deficient Pancreatic Islets Rescues Insulin Secretion

Uma D. Kabra, Katrin Pfuhlmann, Adriana Migliorini, Susanne Keipert, Daniel Lamp, Olle Korsgren, Moritz Gegg, Stephen C. Woods, Paul T. Pfluger, Heiko Lickert, Charles Affourtit, Matthias H. Tschöp, Martin Jastroch

Diabetes 2017;66(5):1247–1257

DOI: https://doi.org/10.2337/db16-1088

Published: 07 February 2017

View article titled, Direct Substrate Delivery Into Mitochondrial Fission–Deficient Pancreatic Islets Rescues Insulin Secretion

Includes: Supplementary data

Journal Articles

Hyperpolarized ¹³C Magnetic Resonance Treatment Response Monitoring: A New Paradigm for Multiorgan Metabolic Assessment of Pharmacological Interventions?

Christoffer Laustsen

Diabetes 2016;65(12):3529–3531

DOI: https://doi.org/10.2337/dbi16-0055

Published: 12 November 2016

View article titled, Hyperpolarized 13C Magnetic Resonance Treatment Response Monitoring: A New Paradigm for Multiorgan Metabolic Assessment of Pharmacological Interventions?

Journal Articles

In This Issue of Diabetes

Diabetes 2016;65(12):3519–3520

DOI: https://doi.org/10.2337/db16-ti12

Published: 12 November 2016

View article titled, In This Issue of Diabetes

Journal Articles

An Intestinal Farnesoid X Receptor–Ceramide Signaling Axis Modulates Hepatic Gluconeogenesis in Mice

Cen Xie, Changtao Jiang, Jingmin Shi, Xiaoxia Gao, Dongxue Sun, Lulu Sun, Ting Wang, Shogo Takahashi, Mallappa Anitha, Kristopher W. Krausz, Andrew D. Patterson, Frank J. Gonzalez

Diabetes 2017;66(3):613–626

DOI: https://doi.org/10.2337/db16-0663

Published: 08 November 2016

View article titled, An Intestinal Farnesoid X Receptor–Ceramide Signaling Axis Modulates Hepatic Gluconeogenesis in Mice

Includes: Supplementary data

Journal Articles

Enhanced GLUT4-Dependent Glucose Transport Relieves Nutrient Stress in Obese Mice Through Changes in Lipid and Amino Acid Metabolism

Jami M. Gurley, Olga Ilkayeva, Robert M. Jackson, Beth A. Griesel, Phillip White, Satochi Matsuzaki, Rizwan Qaisar, Holly Van Remmen, Kenneth M. Humphries, Christopher B. Newgard, Ann Louise Olson

Diabetes 2016;65(12):3585–3597

DOI: https://doi.org/10.2337/db16-0709

Published: 27 September 2016

View article titled, Enhanced GLUT4-Dependent Glucose Transport Relieves Nutrient Stress in Obese Mice Through Changes in Lipid and Amino Acid Metabolism

Journal Articles

Assessment of Metformin-Induced Changes in Cardiac and Hepatic Redox State Using Hyperpolarized[1-¹³C]Pyruvate

Andrew J.M. Lewis, Jack J.J. Miller, Chloe McCallum, Oliver J. Rider, Stefan Neubauer, Lisa C. Heather, Damian J. Tyler

Diabetes 2016;65(12):3544–3551

DOI: https://doi.org/10.2337/db16-0804

Published: 25 August 2016

View article titled, Assessment of Metformin-Induced Changes in Cardiac and Hepatic Redox State Using Hyperpolarized[1-13C]Pyruvate

Includes: Supplementary data

Journal Articles

Inhibition of Pyruvate Dehydrogenase Kinase 2 Protects Against Hepatic Steatosis Through Modulation of Tricarboxylic Acid Cycle Anaplerosis and Ketogenesis

Younghoon Go, Ji Yun Jeong, Nam Ho Jeoung, Jae-Han Jeon, Bo-Yoon Park, Hyeon-Ji Kang, Chae-Myeong Ha, Young-Keun Choi, Sun Joo Lee, Hye Jin Ham, Byung-Gyu Kim, Keun-Gyu Park, So Young Park, Chul-Ho Lee, Cheol Soo Choi, Tae-Sik Park, W.N. Paul Lee, Robert A. Harris, In-Kyu Lee

Diabetes 2016;65(10):2876–2887

DOI: https://doi.org/10.2337/db16-0223

Published: 06 July 2016

View article titled, Inhibition of Pyruvate Dehydrogenase Kinase 2 Protects Against Hepatic Steatosis Through Modulation of Tricarboxylic Acid Cycle Anaplerosis and Ketogenesis

Includes: Supplementary data

Journal Articles

Synergistic Inhibitory Effects of Hypoxia and Iron Deficiency on Hepatic Glucose Response in Mouse Liver

Hyeyoung Nam, Deborah Jones, Robert C. Cooksey, Yan Gao, Sandy Sink, James Cox, Donald A. McClain

Diabetes 2016;65(6):1521–1533

DOI: https://doi.org/10.2337/db15-0580

Published: 18 March 2016

View article titled, Synergistic Inhibitory Effects of Hypoxia and Iron Deficiency on Hepatic Glucose Response in Mouse Liver

Includes: Supplementary data

NARROW

224-OR: Antisense Oligonucleotide–Mediated Restriction of Mitochondrial Pyruvate Metabolism Limits DNL in High-Fat Fed C57BL6/J Mice

1342-P: Reduction of Glucokinase and Glucokinase Regulatory Protein Expression by siRNA Is Associated with the Reduction of Lactate and Pyruvate Export from Canine Hepatocytes

213-LB: Mechanisms of Metabolic Cross Talk between Mitochondrial Pyruvate Carrier Inhibition and Branched-Chain Amino Acid Catabolism in Hepatocytes

768-P: MSDC-0602 Is a Direct Mitochondrial Pyruvate Carrier Inhibitor That Modulates Central Carbon Metabolism in Mice and Humans

New Antidiabetes Agent Targeting Both Mitochondrial Uncoupling and Pyruvate Catabolism: Two Birds With One Stone

1178-P: MSDC-0602 Directly Inhibits Mitochondrial Pyruvate Transport

135-OR: A Novel Thiazolidinedione (TZD) with Minimal PPAR-γ Activity Maximized for Mitochondrial Pyruvate Carrier (MPC) Modulation: Six-Month Analysis of Glycemia in a 12-Month Nonalcoholic Steatohepatitis (NASH) Study

Absence of TXNIP in Humans Leads to Lactic Acidosis and Low Serum Methionine Linked to Deficient Respiration on Pyruvate

PDK4 Deficiency Suppresses Hepatic Glucagon Signaling by Decreasing cAMP Levels

Identification of Mitochondrial Pyruvate Carrier Modulators to Treat Diabetes

Assessment and Expansion of Models for ¹³C-Metabolic Flux Analysis (MFA) In Vivo

Hepatic Overexpression of Retinoic Acid Receptor ß Downregulates Mitochondrial Pyruvate Carrier 1 and Protects from Metabolic Dysregulation in ob/ob Mice

Direct Substrate Delivery Into Mitochondrial Fission–Deficient Pancreatic Islets Rescues Insulin Secretion

Hyperpolarized ¹³C Magnetic Resonance Treatment Response Monitoring: A New Paradigm for Multiorgan Metabolic Assessment of Pharmacological Interventions?

In This Issue of Diabetes

An Intestinal Farnesoid X Receptor–Ceramide Signaling Axis Modulates Hepatic Gluconeogenesis in Mice

Enhanced GLUT4-Dependent Glucose Transport Relieves Nutrient Stress in Obese Mice Through Changes in Lipid and Amino Acid Metabolism

Assessment of Metformin-Induced Changes in Cardiac and Hepatic Redox State Using Hyperpolarized[1-¹³C]Pyruvate

Inhibition of Pyruvate Dehydrogenase Kinase 2 Protects Against Hepatic Steatosis Through Modulation of Tricarboxylic Acid Cycle Anaplerosis and Ketogenesis

Synergistic Inhibitory Effects of Hypoxia and Iron Deficiency on Hepatic Glucose Response in Mouse Liver

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