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Meeting Abstracts

1807-PUB: Monocarbonyl Curcumin Analogs C66 and B2BrBC Improve Redox Status in Streptozotocin-Induced Diabetic Rats

RADOSLAV STOJCHEVSKI, MARIJA ANGELOVSKI, SARA VELICHKOVIKJ, NIKOLA HADZI-PETRUSHEV, JANE B. BOGDANOV, MITKO MLADENOV, LEONID PORETSKY, DIMITER AVTANSKI

Diabetes 2023;72(Supplement_1):1807-PUB

https://doi.org/10.2337/db23-1807-PUB

Published: 23 June 2023

View article titled, 1807-PUB: Monocarbonyl Curcumin Analogs C66 and B2BrBC Improve Redox Status in Streptozotocin-Induced Diabetic Rats

Meeting Abstracts

426-P: Semaglutide, Empagliflozin, and Cagrilintide Reduce Levels of Serum Endotrophin in Type 2 Diabetic Rats

ALEXANDRA MØLLER, SIMONE A. MELANDER, ANNA T. LARSEN, CLARA F.G. LAURSEN, FEDERICA GENOVESE, MORTEN A. KARSDAL, DANIEL GULDAGER KRING RASMUSSEN, KIM HENRIKSEN

Diabetes 2023;72(Supplement_1):426-P

https://doi.org/10.2337/db23-426-P

Published: 20 June 2023

View article titled, 426-P: Semaglutide, Empagliflozin, and Cagrilintide Reduce Levels of Serum Endotrophin in Type 2 Diabetic Rats

Meeting Abstracts

91-OR: AdoShell Islet, a New Biomaterial for Allogenic Islet Encapsulation Shows Six Months Insulin Secretion in Diabetic Immunocompetent Rats

ALEXANDRE GEISSLER, OUARDANE JOUANNOT, ANNE-LISE GAFFURI, CAMILLE GAUTIER, YANN P. COURBEBAISSE, KARIM BOUZAKRI, ROSY ELOY, OLIVIER SOULA

Diabetes 2023;72(Supplement_1):91-OR

https://doi.org/10.2337/db23-91-OR

Published: 20 June 2023

View article titled, 91-OR: AdoShell Islet, a New Biomaterial for Allogenic Islet Encapsulation Shows Six Months Insulin Secretion in Diabetic Immunocompetent Rats

Meeting Abstracts

587-P: AS160 Expression, but Not AS160 Serine-588, Threonine-642, and Serine-704 Phosphorylation, Is Essential for Elevated Insulin-Stimulated Glucose Uptake by Skeletal Muscle from Female Rats after Acute Exercise

HAIYAN WANG, AMY ZHENG, EDWARD B. ARIAS, SEONGEUN KWAK, XIUFANG PAN, YONGPING YUE, DONGSHENG DUAN, GREGORY D. CARTEE

Diabetes 2023;72(Supplement_1):587-P

https://doi.org/10.2337/db23-587-P

Published: 20 June 2023

View article titled, 587-P: AS160 Expression, but Not AS160 Serine-588, Threonine-642, and Serine-704 Phosphorylation, Is Essential for Elevated Insulin-Stimulated Glucose Uptake by Skeletal Muscle from Female Rats after Acute Exercise

Meeting Abstracts

3-LB: Effects of Sustained Somatostatin Receptor 2 Antagonism (SSTR2a) on Glycemia in Type 2 Diabetic (T2D) Male Rats—A Pilot Study

NADIA ALEALI, NINOSCHKA C. D'SOUZA, DORSA SHAKERI, ERIC SIMONSON, RICHARD LIGGINS, OWEN CHAN, MICHAEL C. RIDDELL

Diabetes 2023;72(Supplement_1):3-LB

https://doi.org/10.2337/db23-3-LB

Published: 20 June 2023

View article titled, 3-LB: Effects of Sustained Somatostatin Receptor 2 Antagonism (SSTR2a) on Glycemia in Type 2 Diabetic (T2D) Male Rats—A Pilot Study

Meeting Abstracts

849-P: Antidiabetic Effects of TLC-3595, a Selective ACC2 Inhibitor, in ZDF Rats

ARCHANA VIJAYAKUMAR, EISUKE MURAKAMI, RYAN S. HUSS, NATALIE SRODA, ATSUYUKI SHIMAZAKI, YUTO KASHIWAGI, ROBERT P. MYERS, MANI SUBRAMANIAN, GERALD I. SHULMAN

Diabetes 2023;72(Supplement_1):849-P

https://doi.org/10.2337/db23-849-P

Published: 20 June 2023

View article titled, 849-P: Antidiabetic Effects of TLC-3595, a Selective ACC2 Inhibitor, in ZDF Rats

Meeting Abstracts

840-P: Dual Amylin and Calcitonin Receptor Agonist Treatment Improves Blood Pressure and Glucose Control in ZSF1 Rats

SIMONE A. MELANDER, ANNA T. LARSEN, KHALED ELHADY MOHAMED, MORTEN A. KARSDAL, KIM HENRIKSEN

Diabetes 2023;72(Supplement_1):840-P

https://doi.org/10.2337/db23-840-P

Published: 20 June 2023

View article titled, 840-P: Dual Amylin and Calcitonin Receptor Agonist Treatment Improves Blood Pressure and Glucose Control in ZSF1 Rats

Meeting Abstracts

276-LB: STR-Mediated Glucose Sensing and GLUT2-Regulated Glucose Absorption Are Repaired by DJB Surgery in Diabetic Rats

ANPING WANG, RONGGUAN KOU, XIANGYU ZHAO, SIPENG SUN, YI WANG, ZHIQIN GAO

Diabetes 2023;72(Supplement_1):276-LB

https://doi.org/10.2337/db23-276-LB

Published: 20 June 2023

View article titled, 276-LB: STR-Mediated Glucose Sensing and GLUT2-Regulated Glucose Absorption Are Repaired by DJB Surgery in Diabetic Rats

Meeting Abstracts

1676-P: A Novel GLP1R/GCGR Dual Agonist, DA-1726 Elicits Weight Loss Superior to Semaglutide in Diet-Induced Obese Rats

YUNA CHAE, TAE-HYOUNG KIM, IL-HUN JUNG, HYUNG HEON KIM, MI-KYUNG KIM

Diabetes 2023;72(Supplement_1):1676-P

https://doi.org/10.2337/db23-1676-P

Published: 20 June 2023

View article titled, 1676-P: A Novel GLP1R/GCGR Dual Agonist, DA-1726 Elicits Weight Loss Superior to Semaglutide in Diet-Induced Obese Rats

Meeting Abstracts

208-OR: Comparable Improvement in NAFLD, Weight Loss, and Lipid Metabolism in Rats Treated with Dual GLP-1–GIP Receptor Agonist (Tirzepatide) and Gastric Sleeve

JEHAD ABUBAKER, SALMAN ALSABAH, IRINA AL-KHAIRI, PREETHI T. CHERIAN, NERMEEN A. ABUKHALAF, HOSSEIN AREFANIAN, CAROL DSOUZA, SR., SULEIMAN AL-SABAH, FAHD AL-MULLA, MOHAMED ABU-FARHA

Diabetes 2023;72(Supplement_1):208-OR

https://doi.org/10.2337/db23-208-OR

Published: 20 June 2023

View article titled, 208-OR: Comparable Improvement in NAFLD, Weight Loss, and Lipid Metabolism in Rats Treated with Dual GLP-1–GIP Receptor Agonist (Tirzepatide) and Gastric Sleeve

Meeting Abstracts

883-P: Effects of YG1699 and Sotagliflozin on Blood Glucose and Urinary Glucose Excretion in SD Rats

JACKY LI, ROGER W. XU, JIAOJUAN HE, PABLO LAPUERTA

Diabetes 2023;72(Supplement_1):883-P

https://doi.org/10.2337/db23-883-P

Published: 20 June 2023

View article titled, 883-P: Effects of YG1699 and Sotagliflozin on Blood Glucose and Urinary Glucose Excretion in SD Rats

Meeting Abstracts

209-OR: DJB Surgery Improves Oxidative Stress and Alleviates Neuron Cell Injury of Hypothalamus in T2DM Rats by Nrf2/HO-1 Signal

HUAIJIE WANG, QINGTAO YAN, MEIHUA QU

Diabetes 2023;72(Supplement_1):209-OR

https://doi.org/10.2337/db23-209-OR

Published: 20 June 2023

View article titled, 209-OR: DJB Surgery Improves Oxidative Stress and Alleviates Neuron Cell Injury of Hypothalamus in T2DM Rats by Nrf2/HO-1 Signal

Meeting Abstracts

77-LB: A Novel Glucagon-Like Peptide-1 (GLP-1R) and Glucagon (GCGR) Receptor Dual Agonist, Mazdutide (IBI362), Attenuates Hyperuricemia in Hyperuricemic Rats

HONGWEI JIANG, YANZHAO ZHANG, YAN SHUANG REN

Diabetes 2023;72(Supplement_1):77-LB

https://doi.org/10.2337/db23-77-LB

Published: 20 June 2023

View article titled, 77-LB: A Novel Glucagon-Like Peptide-1 (GLP-1R) and Glucagon (GCGR) Receptor Dual Agonist, Mazdutide (IBI362), Attenuates Hyperuricemia in Hyperuricemic Rats

Meeting Abstracts

78-LB: PK Studies in Rats and Minipigs of GB-7001, a Novel Monthly Microsphere Formulation Containing High Drug Content of Semaglutide

EUNYOUNG SEOL, YEJIN KIM

Diabetes 2023;72(Supplement_1):78-LB

https://doi.org/10.2337/db23-78-LB

Published: 20 June 2023

View article titled, 78-LB: PK Studies in Rats and Minipigs of GB-7001, a Novel Monthly Microsphere Formulation Containing High Drug Content of Semaglutide

Meeting Abstracts

144-OR: Norepinephrine Mediates Severe Hypoglycemia–Induced Fatal Heart Block in Rats

EMILY H. NUIBE, MATT CHAMBERS, CANDACE M. RENO-BERNSTEIN

Diabetes 2023;72(Supplement_1):144-OR

https://doi.org/10.2337/db23-144-OR

Published: 20 June 2023

View article titled, 144-OR: Norepinephrine Mediates Severe Hypoglycemia–Induced Fatal Heart Block in Rats

Meeting Abstracts

1635-P: Sex Differences in Skeletal Muscle Mitochondrial Function in Rats Fed a High-Fat/High-Sucrose Diet

LESLIE KNAUB, SARA HULL, NICHOLAS A. HULETT, AMY C. KELLER, JANE E.B. REUSCH, REBECCA L. SCALZO

Diabetes 2023;72(Supplement_1):1635-P

https://doi.org/10.2337/db23-1635-P

Published: 20 June 2023

View article titled, 1635-P: Sex Differences in Skeletal Muscle Mitochondrial Function in Rats Fed a High-Fat/High-Sucrose Diet

Meeting Abstracts

1542-P: Commercially Available Aspartame-Based Sweetener Damages Morphology of Major Organs Both in Normal and Type 2 Diabetic Rats

SIPHIWE N. DLAMINI, SHAHIDUL ISLAM

Diabetes 2023;72(Supplement_1):1542-P

https://doi.org/10.2337/db23-1542-P

Published: 20 June 2023

View article titled, 1542-P: Commercially Available Aspartame-Based Sweetener Damages Morphology of Major Organs Both in Normal and Type 2 Diabetic Rats

Meeting Abstracts

6-LB: GPR119 Agonist PRM A Increases Glucagon Response to Hypoglycemia in Rats

DAVID W.K. KWOK, DIANE ALEXANDER, NIGEL R.A. BEELEY, DAVID KELLEY

Diabetes 2023;72(Supplement_1):6-LB

https://doi.org/10.2337/db23-6-LB

Published: 20 June 2023

View article titled, 6-LB: GPR119 Agonist PRM A Increases Glucagon Response to Hypoglycemia in Rats

Journal Articles

Astrocyte Glycogen Is a Major Source of Hypothalamic Lactate in Rats With Recurrent Hypoglycemia

Gong Su, Rawad Farhat, Anil K. Laxman, Kimberly Chapman-Natewa, Irvane E. Nelson, Owen Chan

Diabetes 2023;72(8):1154–1160

https://doi.org/10.2337/db22-0902

Published: 22 May 2023

View article titled, Astrocyte Glycogen Is a Major Source of Hypothalamic Lactate in Rats With Recurrent Hypoglycemia

Journal Articles

Leucine Supplementation Ameliorates Early-Life Programming of Obesity in Rats

Yuchen Sun, Bo Sun, Xuesong Han, Anshan Shan, Qingquan Ma

Diabetes 2023;72(10):1409–1423

https://doi.org/10.2337/db22-0862

Published: 17 May 2023

View article titled, Leucine Supplementation Ameliorates Early-Life Programming of Obesity in Rats

NARROW

1807-PUB: Monocarbonyl Curcumin Analogs C66 and B2BrBC Improve Redox Status in Streptozotocin-Induced Diabetic Rats

426-P: Semaglutide, Empagliflozin, and Cagrilintide Reduce Levels of Serum Endotrophin in Type 2 Diabetic Rats

91-OR: AdoShell Islet, a New Biomaterial for Allogenic Islet Encapsulation Shows Six Months Insulin Secretion in Diabetic Immunocompetent Rats

587-P: AS160 Expression, but Not AS160 Serine-588, Threonine-642, and Serine-704 Phosphorylation, Is Essential for Elevated Insulin-Stimulated Glucose Uptake by Skeletal Muscle from Female Rats after Acute Exercise

3-LB: Effects of Sustained Somatostatin Receptor 2 Antagonism (SSTR2a) on Glycemia in Type 2 Diabetic (T2D) Male Rats—A Pilot Study

849-P: Antidiabetic Effects of TLC-3595, a Selective ACC2 Inhibitor, in ZDF Rats

840-P: Dual Amylin and Calcitonin Receptor Agonist Treatment Improves Blood Pressure and Glucose Control in ZSF1 Rats

276-LB: STR-Mediated Glucose Sensing and GLUT2-Regulated Glucose Absorption Are Repaired by DJB Surgery in Diabetic Rats

1676-P: A Novel GLP1R/GCGR Dual Agonist, DA-1726 Elicits Weight Loss Superior to Semaglutide in Diet-Induced Obese Rats

208-OR: Comparable Improvement in NAFLD, Weight Loss, and Lipid Metabolism in Rats Treated with Dual GLP-1–GIP Receptor Agonist (Tirzepatide) and Gastric Sleeve

883-P: Effects of YG1699 and Sotagliflozin on Blood Glucose and Urinary Glucose Excretion in SD Rats

209-OR: DJB Surgery Improves Oxidative Stress and Alleviates Neuron Cell Injury of Hypothalamus in T2DM Rats by Nrf2/HO-1 Signal

77-LB: A Novel Glucagon-Like Peptide-1 (GLP-1R) and Glucagon (GCGR) Receptor Dual Agonist, Mazdutide (IBI362), Attenuates Hyperuricemia in Hyperuricemic Rats

78-LB: PK Studies in Rats and Minipigs of GB-7001, a Novel Monthly Microsphere Formulation Containing High Drug Content of Semaglutide

144-OR: Norepinephrine Mediates Severe Hypoglycemia–Induced Fatal Heart Block in Rats

1635-P: Sex Differences in Skeletal Muscle Mitochondrial Function in Rats Fed a High-Fat/High-Sucrose Diet

1542-P: Commercially Available Aspartame-Based Sweetener Damages Morphology of Major Organs Both in Normal and Type 2 Diabetic Rats

6-LB: GPR119 Agonist PRM A Increases Glucagon Response to Hypoglycemia in Rats

Astrocyte Glycogen Is a Major Source of Hypothalamic Lactate in Rats With Recurrent Hypoglycemia

Leucine Supplementation Ameliorates Early-Life Programming of Obesity in Rats

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