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Meeting Abstracts

193-OR: Chronotherapy with the Glucokinase Activator AZD1656 Greatly Affects Its Ability to Improve Metabolism in Obese Zucker Rats

TOBIAS KROON, THERESE HAGSTEDT, IDA ALEXANDERSSON, ANNETT FERM, MARIE PETERSSON, STEFANIE MAURER, BADER ZARROUKI, KRISTINA WALLENIUS, NICHOLAS D. OAKES, JEREMIE BOUCHER
Journal: Diabetes
Diabetes 2022;71(Supplement_1):193-OR
https://doi.org/10.2337/db22-193-OR
Published: 01 June 2022
View article titled, 193-OR: Chronotherapy with the Glucokinase Activator AZD1656 Greatly Affects Its Ability to Improve Metabolism in Obese Zucker Rats
Meeting Abstracts

1881-P: The SGLT2 Inhibitor Dapagliflozin Improves Glucose Control and Enhances Liver Fatty Acid Oxidation and Ketone Body Formation in Insulin Resistant Obese Zucker Rats

TOBIAS KROON, THERESE HAGSTEDT, ANN KJELLSTEDT, ANNA LINDBLOM, LARS LÖFGREN, JEREMIE BOUCHER, MARIA SÖRHEDE WINZELL, DANIEL LINDEN, KRISTINA WALLENIUS
Journal: Diabetes
Diabetes 2019;68(Supplement_1):1881-P
https://doi.org/10.2337/db19-1881-P
Published: 01 June 2019
View article titled, 1881-P: The SGLT2 Inhibitor Dapagliflozin Improves Glucose Control and Enhances Liver Fatty Acid Oxidation and Ketone Body Formation in Insulin Resistant Obese Zucker Rats
Journal Articles

The Prostacyclin Analog Beraprost Sodium Ameliorates Characteristics of Metabolic Syndrome in Obese Zucker (Fatty) Rats

Nahoko Sato, Masayuki Kaneko, Mitsutaka Tamura, Hajimu Kurumatani
Journal: Diabetes
Diabetes 2010;59(4):1092–1100
https://doi.org/10.2337/db09-1432
Published: 12 January 2010
View article titled, The Prostacyclin Analog Beraprost Sodium Ameliorates Characteristics of Metabolic Syndrome in Obese Zucker (Fatty) Rats
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Journal Articles

Excess Lipid Availability Increases Mitochondrial Fatty Acid Oxidative Capacity in Muscle: Evidence Against a Role for Reduced Fatty Acid Oxidation in Lipid-Induced Insulin Resistance in Rodents

Nigel Turner, Clinton R. Bruce, Susan M. Beale, Kyle L. Hoehn, Trina So, Michael S. Rolph, Gregory J. Cooney
Journal: Diabetes
Diabetes 2007;56(8):2085–2092
https://doi.org/10.2337/db07-0093
Published: 01 August 2007
View article titled, Excess Lipid Availability Increases Mitochondrial Fatty Acid Oxidative Capacity in Muscle: <subtitle>Evidence Against a Role for Reduced Fatty Acid Oxidation in Lipid-Induced Insulin Resistance in Rodents</subtitle>
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Journal Articles

Effects of Rimonabant (SR141716) on Fasting-Induced Hypothalamic-Pituitary-Adrenal Axis and Neuronal Activation in Lean and Obese Zucker Rats

Christian Doyon, Raphaël G. Denis, Elena-Dana Baraboi, Pierre Samson, Josée Lalonde, Yves Deshaies, Denis Richard
Journal: Diabetes
Diabetes 2006;55(12):3403–3410
https://doi.org/10.2337/db06-0504
Published: 01 December 2006
View article titled, Effects of Rimonabant (SR141716) on Fasting-Induced Hypothalamic-Pituitary-Adrenal Axis and Neuronal Activation in Lean and Obese Zucker Rats
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Journal Articles

Tempol Reduces Oxidative Stress, Improves Insulin Sensitivity, Decreases Renal Dopamine D1 Receptor Hyperphosphorylation, and Restores D1 Receptor–G-Protein Coupling and Function in Obese Zucker Rats

Anees Ahmad Banday, Aditi Marwaha, Lakshmi S. Tallam, Mustafa F. Lokhandwala
Journal: Diabetes
Diabetes 2005;54(7):2219–2226
https://doi.org/10.2337/diabetes.54.7.2219
Published: 01 July 2005
View article titled, Tempol Reduces Oxidative Stress, Improves Insulin Sensitivity, Decreases Renal Dopamine D1 Receptor Hyperphosphorylation, and Restores D1 Receptor–G-Protein Coupling and Function in Obese Zucker Rats
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Journal Articles

Enhanced Sarcolemmal FAT/CD36 Content and Triacylglycerol Storage in Cardiac Myocytes From Obese Zucker Rats

Susan L.M. Coort, Danny M. Hasselbaink, Debby P.Y. Koonen, Jodil Willems, Will A. Coumans, Adrian Chabowski, Ger J. van der Vusse, Arend Bonen, Jan F.C. Glatz, Joost J.F.P. Luiken
Journal: Diabetes
Diabetes 2004;53(7):1655–1663
https://doi.org/10.2337/diabetes.53.7.1655
Published: 01 July 2004
View article titled, Enhanced Sarcolemmal FAT/CD36 Content and Triacylglycerol Storage in Cardiac Myocytes From Obese Zucker Rats
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Journal Articles

NN414, a SUR1/Kir6.2-Selective Potassium Channel Opener, Reduces Blood Glucose and Improves Glucose Tolerance in the VDF Zucker Rat

Richard D. Carr, Christian L. Brand, Thora B. Bodvarsdottir, John B. Hansen, Jeppe Sturis
Journal: Diabetes
Diabetes 2003;52(10):2513–2518
https://doi.org/10.2337/diabetes.52.10.2513
Published: 01 October 2003
View article titled, NN414, a SUR1/Kir6.2-Selective Potassium Channel Opener, Reduces Blood Glucose and Improves Glucose Tolerance in the VDF Zucker Rat
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Journal Articles

Central Pro-opiomelanocortin Gene Delivery Results in Hypophagia, Reduced Visceral Adiposity, and Improved Insulin Sensitivity in Genetically Obese Zucker Rats

Gang Li, Charles V. Mobbs, Philip J. Scarpace
Journal: Diabetes
Diabetes 2003;52(8):1951–1957
https://doi.org/10.2337/diabetes.52.8.1951
Published: 01 August 2003
View article titled, Central Pro-opiomelanocortin Gene Delivery Results in Hypophagia, Reduced Visceral Adiposity, and Improved Insulin Sensitivity in Genetically Obese Zucker Rats
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Journal Articles

Leptin Receptor−Deficient Obese Zucker Rats Reduce Their Food Intake in Response to a Systemic Supply of Calories From Glucose

Marc Gilbert, Christophe Magnan, Sophie Turban, Jocelyne André, Michèle Guerre-Millo
Journal: Diabetes
Diabetes 2003;52(2):277–282
https://doi.org/10.2337/diabetes.52.2.277
Published: 01 February 2003
View article titled, Leptin Receptor−Deficient Obese Zucker Rats Reduce Their Food Intake in Response to a Systemic Supply of Calories From Glucose
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Journal Articles

Insulin-Mediated Hemodynamic Changes Are Impaired in Muscle of Zucker Obese Rats

Michelle G. Wallis, Catherine M. Wheatley, Stephen Rattigan, Eugene J. Barrett, Andrew D.H. Clark, Michael G. Clark
Journal: Diabetes
Diabetes 2002;51(12):3492–3498
https://doi.org/10.2337/diabetes.51.12.3492
Published: 01 December 2002
View article titled, Insulin-Mediated Hemodynamic Changes Are Impaired in Muscle of Zucker Obese Rats
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Journal Articles

The Rat Arcuate Nucleus Integrates Peripheral Signals Provided by Leptin, Insulin, and a Ghrelin Mimetic

Adrian K. Hewson, Loraine Y.C. Tung, David W. Connell, Laura Tookman, Suzanne L. Dickson
Journal: Diabetes
Diabetes 2002;51(12):3412–3419
https://doi.org/10.2337/diabetes.51.12.3412
Published: 01 December 2002
View article titled, The Rat Arcuate Nucleus Integrates Peripheral Signals Provided by Leptin, Insulin, and a Ghrelin Mimetic
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Journal Articles

Long-Term Treatment With Dipeptidyl Peptidase IV Inhibitor Improves Hepatic and Peripheral Insulin Sensitivity in the VDF Zucker Rat: A Euglycemic-Hyperinsulinemic Clamp Study

John A. Pospisilik, Sara G. Stafford, Hans-Ulrich Demuth, Christopher H.S. McIntosh, Raymond A. Pederson
Journal: Diabetes
Diabetes 2002;51(9):2677–2683
https://doi.org/10.2337/diabetes.51.9.2677
Published: 01 September 2002
View article titled, Long-Term Treatment With Dipeptidyl Peptidase IV Inhibitor Improves Hepatic and Peripheral Insulin Sensitivity in the VDF Zucker Rat: <subtitle>A Euglycemic-Hyperinsulinemic Clamp Study </subtitle>
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Journal Articles

Isoform-Specific Regulation of 5′ AMP-Activated Protein Kinase in Skeletal Muscle From Obese Zucker (fa/fa) Rats in Response to Contraction

Brian R. Barnes, Jeffrey W. Ryder, Tatiana L. Steiler, Lee G.D. Fryer, David Carling, Juleen R. Zierath
Journal: Diabetes
Diabetes 2002;51(9):2703–2708
https://doi.org/10.2337/diabetes.51.9.2703
Published: 01 September 2002
View article titled, Isoform-Specific Regulation of 5′ AMP-Activated Protein Kinase in Skeletal Muscle From Obese Zucker (<em>fa/fa</em>) Rats in Response to Contraction
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Journal Articles

Impaired Long-Chain Fatty Acid Oxidation and Contractile Dysfunction in the Obese Zucker Rat Heart

Martin E. Young, Patrick H. Guthrie, Peter Razeghi, Brendan Leighton, Shahrzad Abbasi, Sarita Patil, Keith A. Youker, Heinrich Taegtmeyer
Journal: Diabetes
Diabetes 2002;51(8):2587–2595
https://doi.org/10.2337/diabetes.51.8.2587
Published: 01 August 2002
View article titled, Impaired Long-Chain Fatty Acid Oxidation and Contractile Dysfunction in the Obese Zucker Rat Heart
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Journal Articles

Leptin Potentiates Thermogenic Sympathetic Responses to Hypothermia: A Receptor-Mediated Effect

Martin Hausberg, Donald A. Morgan, Jennifer L. Mitchell, William I. Sivitz, Allyn L. Mark, William G. Haynes
Journal: Diabetes
Diabetes 2002;51(8):2434–2440
https://doi.org/10.2337/diabetes.51.8.2434
Published: 01 August 2002
View article titled, Leptin Potentiates Thermogenic Sympathetic Responses to Hypothermia: <subtitle>A Receptor-Mediated Effect </subtitle>
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Journal Articles

Long-Term Treatment With the Dipeptidyl Peptidase IV Inhibitor P32/98 Causes Sustained Improvements in Glucose Tolerance, Insulin Sensitivity, Hyperinsulinemia, and β-Cell Glucose Responsiveness in VDF (fa/fa) Zucker Rats

J.A. Pospisilik, S.G. Stafford, H-U. Demuth, R. Brownsey, W. Parkhouse, D.T. Finegood, C.H.S. McIntosh, R.A. Pederson
Journal: Diabetes
Diabetes 2002;51(4):943–950
https://doi.org/10.2337/diabetes.51.4.943
Published: 01 April 2002
View article titled, Long-Term Treatment With the Dipeptidyl Peptidase IV Inhibitor P32/98 Causes Sustained Improvements in Glucose Tolerance, Insulin Sensitivity, Hyperinsulinemia, and β-Cell Glucose Responsiveness in VDF (<em>fa/fa</em>) Zucker Rats
Open the PDF for Long-Term Treatment With the Dipeptidyl Peptidase IV Inhibitor P32/98 Causes Sustained Improvements in Glucose Tolerance, Insulin Sensitivity, Hyperinsulinemia, and β-Cell Glucose Responsiveness in VDF (<em>fa/fa</em>) Zucker Rats in another window
Journal Articles

Thiazolidinedione Treatment Normalizes Insulin Resistance and Ischemic Injury in the Zucker Fatty Rat Heart

Robert J. Sidell, Mark A. Cole, Nicholas J. Draper, Martine Desrois, Robin E. Buckingham, Kieran Clarke
Journal: Diabetes
Diabetes 2002;51(4):1110–1117
https://doi.org/10.2337/diabetes.51.4.1110
Published: 01 April 2002
View article titled, Thiazolidinedione Treatment Normalizes Insulin Resistance and Ischemic Injury in the Zucker Fatty Rat Heart
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Journal Articles

Acyl-CoA Binding Protein Expression Is Fiber Type- Specific and Elevated in Muscles From the Obese Insulin-Resistant Zucker Rat

Jesper Franch, Jens Knudsen, Bronwyn A. Ellis, Preben K. Pedersen, Gregory J. Cooney, Jørgen Jensen
Journal: Diabetes
Diabetes 2002;51(2):449–454
https://doi.org/10.2337/diabetes.51.2.449
Published: 01 February 2002
View article titled, Acyl-CoA Binding Protein Expression Is Fiber Type- Specific and Elevated in Muscles From the Obese Insulin-Resistant Zucker Rat
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Journal Articles

Increased Fatty Acid Uptake and Altered Fatty Acid Metabolism in Insulin-Resistant Muscle of Obese Zucker Rats

Lorraine Patricia Turcotte, Jason Richard Swenberger, Michelle Zavitz Tucker, Alice Jane Yee
Journal: Diabetes
Diabetes 2001;50(6):1389–1396
https://doi.org/10.2337/diabetes.50.6.1389
Published: 01 June 2001
View article titled, Increased Fatty Acid Uptake and Altered Fatty Acid Metabolism in Insulin-Resistant Muscle of Obese Zucker Rats
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