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Journal Articles

Adipocyte Thyroid Hormone β Receptor–Mediated Hormone Action Fine-tunes Intracellular Glucose and Lipid Metabolism and Systemic Homeostasis

Yiruo Ma, Siyi Shen, Ying Yan, Shengjie Zhang, Shengnan Liu, Zhili Tang, Jing Yu, Mei Ma, Zhoumin Niu, Zhuoyang Li, Yuting Wu, Lin Zhao, Zhiqiang Lu, Chunchun Wei, Weiping J. Zhang, Ying Xue, Qiwei Zhai, Yu Li, Cheng Hu, Jingjing Jiang, Yuying Li, Hao Ying
Journal: Diabetes
Diabetes 2023;72(5):562–574
DOI: https://doi.org/10.2337/db22-0656
Published: 01 February 2023
View article titled, Adipocyte Thyroid Hormone β Receptor–Mediated Hormone Action Fine-tunes Intracellular Glucose and Lipid Metabolism and Systemic Homeostasis
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Journal Articles

Reduced Expression Level of Protein Phosphatase PPM1E Serves to Maintain Insulin Secretion in Type 2 Diabetes

Sevda Gheibi, Luis Rodrigo Cataldo, Alexander Hamilton, Mi Huang, Sebastian Kalamajski, Malin Fex, Hindrik Mulder
Journal: Diabetes
Diabetes 2023;72(4):455–466
DOI: https://doi.org/10.2337/db22-0472
Published: 20 January 2023
View article titled, Reduced Expression Level of Protein Phosphatase PPM1E Serves to Maintain Insulin Secretion in Type 2 Diabetes
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Journal Articles

Human T2D-Associated Gene IMP2/IGF2BP2 Promotes the Commitment of Mesenchymal Stem Cells Into Adipogenic Lineage

Laura Regué, William Wang, Fei Ji, Joseph Avruch, Hua Wang, Ning Dai
Journal: Diabetes
Diabetes 2023;72(1):33–44
DOI: https://doi.org/10.2337/db21-1087
Published: 11 October 2022
View article titled, Human T2D-Associated Gene IMP2/IGF2BP2 Promotes the Commitment of Mesenchymal Stem Cells Into Adipogenic Lineage
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Journal Articles

Dynamic Ins2 Gene Activity Defines β-Cell Maturity States

Chieh Min Jamie Chu, Honey Modi, Cara Ellis, Nicole A.J. Krentz, Søs Skovsø, Yiwei Bernie Zhao, Haoning Cen, Nilou Noursadeghi, Evgeniy Panzhinskiy, Xiaoke Hu, Derek A. Dionne, Yi Han Xia, Shouhong Xuan, Mark O. Huising, Timothy J. Kieffer, Francis C. Lynn, James D. Johnson
Journal: Diabetes
Diabetes 2022;71(12):2612–2631
DOI: https://doi.org/10.2337/db21-1065
Published: 28 September 2022
View article titled, Dynamic Ins2 Gene Activity Defines β-Cell Maturity States
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Journal Articles

TonEBP in Myeloid Cells Promotes Obesity-Induced Insulin Resistance and Inflammation Through Adipose Tissue Remodeling

Hwan Hee Lee, Gyu Won Jeong, Byeong Jin Ye, Eun Jin Yoo, Keoung Sun Son, Dong Ki Kim, Hye-Kyung Park, Byoung Heon Kang, Whaseon Lee-Kwon, Hyug Moo Kwon, Soo Youn Choi
Journal: Diabetes
Diabetes 2022;71(12):2557–2571
DOI: https://doi.org/10.2337/db21-1099
Published: 28 September 2022
View article titled, TonEBP in Myeloid Cells Promotes Obesity-Induced Insulin Resistance and Inflammation Through Adipose Tissue Remodeling
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Journal Articles

REDD1 Ablation Attenuates the Development of Renal Complications in Diabetic Mice

Siddharth Sunilkumar, Esma I. Yerlikaya, Allyson L. Toro, William P. Miller, Han Chen, Kebin Hu, Scot R. Kimball, Michael D. Dennis
Journal: Diabetes
Diabetes 2022;71(11):2412–2425
DOI: https://doi.org/10.2337/db22-0402
Published: 19 August 2022
View article titled, REDD1 Ablation Attenuates the Development of Renal Complications in Diabetic Mice
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Journal Articles

Long Noncoding RNA lncRHPL Regulates Hepatic VLDL Secretion by Modulating hnRNPU/BMAL1/MTTP Axis

Xuan Shen, Yajun Zhang, Xuetao Ji, Bo Li, Yuzhu Wang, Yun Huang, Xu Zhang, Jingxian Yu, Ruihan Zou, Dongdong Qin, Hongwen Zhou, Qian Wang, John Zhong Li
Journal: Diabetes
Diabetes 2022;71(9):1915–1928
DOI: https://doi.org/10.2337/db21-1145
Published: 30 June 2022
View article titled, Long Noncoding RNA lncRHPL Regulates Hepatic VLDL Secretion by Modulating hnRNPU/BMAL1/MTTP Axis
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Meeting Abstracts

204-OR: The Chd4 Helicase Modulates ß-Cell Function In Vivo

REBECCA K. DAVIDSON, NOLAN CASEY, SUKRATI KANOJIA, JASON SPAETH
Journal: Diabetes
Diabetes 2022;71(Supplement_1):204-OR
DOI: https://doi.org/10.2337/db22-204-OR
Published: 01 June 2022
View article titled, 204-OR: The Chd4 Helicase Modulates ß-Cell Function In Vivo
Meeting Abstracts

9-OR: ADA Presidents' Select Abstract: m6A mRNA Methylation Regulates the Innate Immune Response in Human Beta Cells

DARIO F. DE JESUS, ZIJIE ZHANG, NATALIE K. BROWN, GIORGIO BASILE, LING XIAO, SEVIM KAHRAMAN, CLAYTON E. MATHEWS, ALVIN C. POWERS, MARK A. ATKINSON, DECIO L. EIZIRIK, ROHIT KULKARNI
Journal: Diabetes
Diabetes 2022;71(Supplement_1):9-OR
DOI: https://doi.org/10.2337/db22-9-OR
Published: 01 June 2022
View article titled, 9-OR: ADA Presidents' Select Abstract: m6A mRNA Methylation Regulates the Innate Immune Response in Human Beta Cells
Meeting Abstracts

368-OR: Activation of a Yap1-Dependent Mesenchymal Program Promotes ß-Cell Failure

WENDY MCKIMPSON, NEHAN HOQUE, JINSOOK SON, APRIL Y. LEE, DOMENICO ACCILI
Journal: Diabetes
Diabetes 2022;71(Supplement_1):368-OR
DOI: https://doi.org/10.2337/db22-368-OR
Published: 01 June 2022
View article titled, 368-OR: Activation of a Yap1-Dependent Mesenchymal Program Promotes ß-Cell Failure
Meeting Abstracts

216-LB: Hepatocyte N6-Methyladenosine mRNA Modification in Hepatic Gluconeogenesis and Diabetes

QIANTAO ZHENG, XIAO ZHONG, DECHENG REN, LIANGYOU RUI
Journal: Diabetes
Diabetes 2022;71(Supplement_1):216-LB
DOI: https://doi.org/10.2337/db22-216-LB
Published: 01 June 2022
View article titled, 216-LB: Hepatocyte N6-Methyladenosine mRNA Modification in Hepatic Gluconeogenesis and Diabetes
Meeting Abstracts

1445-P: Ogt Is Dispensable for Beta-Cell Development but Essential for Postnatal Beta-Cell Identity Maintenance via Pdx1

ALICIA L. WONG, BRIAN AKHAPHONG, AMBER D. LOCKRIDGE, EMILYN ALEJANDRO
Journal: Diabetes
Diabetes 2022;71(Supplement_1):1445-P
DOI: https://doi.org/10.2337/db22-1445-P
Published: 01 June 2022
View article titled, 1445-P: Ogt Is Dispensable for Beta-Cell Development but Essential for Postnatal Beta-Cell Identity Maintenance via Pdx1
Meeting Abstracts

1447-P: The Snd1 Coregulator Controls ß-Cell Function

SUKRATI KANOJIA, REBECCA K. DAVIDSON, JASON SPAETH, NOLAN CASEY
Journal: Diabetes
Diabetes 2022;71(Supplement_1):1447-P
DOI: https://doi.org/10.2337/db22-1447-P
Published: 01 June 2022
View article titled, 1447-P: The Snd1 Coregulator Controls ß-Cell Function
Journal Articles

GIPR Is Predominantly Localized to Nonadipocyte Cell Types Within White Adipose Tissue

Jonathan E. Campbell, Jacqueline L. Beaudry, Berit Svendsen, Laurie L. Baggio, Andrew N. Gordon, John R. Ussher, Chi Kin Wong, Fiona M. Gribble, David A. D’Alessio, Frank Reimann, Daniel J. Drucker
Journal: Diabetes
Diabetes 2022;71(5):1115–1127
DOI: https://doi.org/10.2337/db21-1166
Published: 22 February 2022
View article titled, GIPR Is Predominantly Localized to Nonadipocyte Cell Types Within White Adipose Tissue
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Journal Articles

GPR40 Activation Abolishes Diabetes-Induced Painful Neuropathy by Suppressing VEGF-A Expression

Vanessa Königs, Sandra Pierre, Martin Schicht, Jessica Welss, Lisa Hahnefeld, Vittoria Rimola, Elke Lütjen-Drecoll, Gerd Geisslinger, Klaus Scholich
Journal: Diabetes
Diabetes 2022;71(4):774–787
DOI: https://doi.org/10.2337/db21-0711
Published: 21 January 2022
View article titled, GPR40 Activation Abolishes Diabetes-Induced Painful Neuropathy by Suppressing VEGF-A Expression
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Journal Articles

Obesity-Induced miR-455 Upregulation Promotes Adaptive Pancreatic β-Cell Proliferation Through the CPEB1/CDKN1B Pathway

Qianxing Hu, Jinming Mu, Yuhong Liu, Yue Yang, Yue Liu, Yi Pan, Yanfeng Zhang, Ling Li, Dechen Liu, Jianqiu Chen, Fangfang Zhang, Liang Jin
Journal: Diabetes
Diabetes 2022;71(3):394–411
DOI: https://doi.org/10.2337/db21-0134
Published: 14 January 2022
View article titled, Obesity-Induced miR-455 Upregulation Promotes Adaptive Pancreatic β-Cell Proliferation Through the CPEB1/CDKN1B Pathway
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Journal Articles

Adipose Tissue Inflammation Is Not Related to Adipose Insulin Resistance in Humans

Ana Elena Espinosa De Ycaza, Esben Søndergaard, Maria Morgan-Bathke, Kelli Lytle, Danae A. Delivanis, Paola Ramos, Barbara Gisella Carranza Leon, Michael D. Jensen
Journal: Diabetes
Diabetes 2022;71(3):381–393
DOI: https://doi.org/10.2337/db21-0609
Published: 02 December 2021
View article titled, Adipose Tissue Inflammation Is Not Related to Adipose Insulin Resistance in Humans
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Journal Articles

Human Islet MicroRNA-200c Is Elevated in Type 2 Diabetes and Targets the Transcription Factor ETV5 to Reduce Insulin Secretion

Jones K. Ofori, Alexandros Karagiannopoulos, Mototsugu Nagao, Efraim Westholm, Shaima Ramadan, Anna Wendt, Jonathan L.S. Esguerra, Lena Eliasson
Journal: Diabetes
Diabetes 2022;71(2):275–284
DOI: https://doi.org/10.2337/db21-0077
Published: 09 November 2021
View article titled, Human Islet MicroRNA-200c Is Elevated in Type 2 Diabetes and Targets the Transcription Factor ETV5 to Reduce Insulin Secretion
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Journal Articles

Impact of Proinflammatory Cytokines on Alternative Splicing Patterns in Human Islets

Wenting Wu, Farooq Syed, Edward Simpson, Chih-Chun Lee, Jing Liu, Garrick Chang, Chuanpeng Dong, Clayton Seitz, Decio L. Eizirik, Raghavendra G. Mirmira, Yunlong Liu, Carmella Evans-Molina
Journal: Diabetes
Diabetes 2022;71(1):116–127
DOI: https://doi.org/10.2337/db20-0847
Published: 25 October 2021
View article titled, Impact of Proinflammatory Cytokines on Alternative Splicing Patterns in Human Islets
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Journal Articles

Hepatic p38 Activation Modulates Systemic Metabolism Through FGF21-Mediated Interorgan Communication

Wei Liu, Chao Sun, Ying Yan, Hongchao Cao, Zhoumin Niu, Siyi Shen, Shengnan Liu, Yuting Wu, Yan Li, Lijian Hui, Yuying Li, Lin Zhao, Cheng Hu, Qiurong Ding, Jingjing Jiang, Hao Ying
Journal: Diabetes
Diabetes 2022;71(1):60–72
DOI: https://doi.org/10.2337/db21-0240
Published: 21 October 2021
View article titled, Hepatic p38 Activation Modulates Systemic Metabolism Through FGF21-Mediated Interorgan Communication
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