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Meeting Abstracts

1197-P: Effect of Somatostatin Receptor 2 Antagonist (SSTR2a) on Glycemia and Glucagon Levels in a Rat Model of Type 2 Diabetes (T2D)

NINOSCHKA C. D'SOUZA, EMILY G. HOFFMAN, SARA C. ATHERLEY, SABRINA CHAMPSI, MARIYA POPKOV, RICHARD LIGGINS, MICHAEL RIDDELL
Journal: Diabetes
Diabetes 2021;70(Supplement_1):1197-P
DOI: https://doi.org/10.2337/db21-1197-P
Published: 01 June 2021
View article titled, 1197-P: Effect of Somatostatin Receptor 2 Antagonist (SSTR2a) on Glycemia and Glucagon Levels in a Rat Model of Type 2 Diabetes (T2D)
Meeting Abstracts

133-OR: Somatostatin Receptor Type 2 Antagonism (SSTR2a) Augments Glucagon Counterregulation and Delays Hypoglycemia Onset in Type 2 Diabetic (T2D), Sprague-Dawley Rats

EMILY G. HOFFMAN, NINOSCHKA DSOUZA, JULIAN AIKEN, RICHARD LIGGINS, MICHAEL RIDDELL
Journal: Diabetes
Diabetes 2021;70(Supplement_1):133-OR
DOI: https://doi.org/10.2337/db21-133-OR
Published: 01 June 2021
View article titled, 133-OR: Somatostatin Receptor Type 2 Antagonism (SSTR2a) Augments Glucagon Counterregulation and Delays Hypoglycemia Onset in Type 2 Diabetic (T2D), Sprague-Dawley Rats
Meeting Abstracts

9-LB: Novel Somatostatin Receptor 2 Antagonist ZT-01 Prevents Hypoglycemia Onset in STZ-Diabetic Rats by Improving Glucagon Secretion

JULIAN AIKEN, NINOSCHKA C. D’SOUZA, ERIC SIMONSON, RAWAD FARHAT, OWEN CHAN, RICHARD LIGGINS, MICHAEL RIDDELL
Journal: Diabetes
Diabetes 2020;69(Supplement_1):9-LB
DOI: https://doi.org/10.2337/db20-9-LB
Published: 01 June 2020
View article titled, 9-LB: Novel Somatostatin Receptor 2 Antagonist ZT-01 Prevents Hypoglycemia Onset in STZ-Diabetic Rats by Improving Glucagon Secretion
Meeting Abstracts

12-LB: Subcutaneous Administration of the Novel Somatostatin Receptor 2 Antagonist ZT-01 Restores the Glucagon Response to Hypoglycemia in STZ-Diabetic Rats to Normal Levels

RAWAD FARHAT, ERIC SIMONSON, MICHAEL RIDDELL, RICHARD LIGGINS, OWEN CHAN
Journal: Diabetes
Diabetes 2020;69(Supplement_1):12-LB
DOI: https://doi.org/10.2337/db20-12-LB
Published: 01 June 2020
View article titled, 12-LB: Subcutaneous Administration of the Novel Somatostatin Receptor 2 Antagonist ZT-01 Restores the Glucagon Response to Hypoglycemia in STZ-Diabetic Rats to Normal Levels
Meeting Abstracts

1182-P: A Selective Nonpeptide Somatostatin Receptor 5 (sst5) Agonist Effectively Decreases Insulin Secretion in the KATPHI Mouse Model

CHRISTINE JULIANA, JINGHUA CHAI, ELIZABETH F. RICO-BAUTISTA, STEPHEN F. BETZ, DIVA D. DE LEON
Journal: Diabetes
Diabetes 2019;68(Supplement_1):1182-P
DOI: https://doi.org/10.2337/db19-1182-P
Published: 01 June 2019
View article titled, 1182-P: A Selective Nonpeptide Somatostatin Receptor 5 (sst5) Agonist Effectively Decreases Insulin Secretion in the KATPHI Mouse Model
Meeting Abstracts

1968-P: Improved Glucose Tolerance via Somatostatin Receptor Antagonism Is an Effect Mediated by the Intestine

SARA L. JEPSEN, JENS J. HOLST
Journal: Diabetes
Diabetes 2019;68(Supplement_1):1968-P
DOI: https://doi.org/10.2337/db19-1968-P
Published: 01 June 2019
View article titled, 1968-P: Improved Glucose Tolerance via Somatostatin Receptor Antagonism Is an Effect Mediated by the Intestine
Meeting Abstracts

14-LB: Somatostatin Receptor 2 Antagonism Enhances Plasma Glucagon Levels during Insulin-Induced Hypoglycemia in a Rodent Model of Type 2 Diabetes Mellitus

MEHRAN NEJAD-MANSOURI, PARINAZ ZAREE BAVANI, JULIAN AIKEN, NINOSCHKA C. DSOUZA, EMILY G. HOFFMAN, RICHARD LIGGINS, MICHAEL RIDDELL
Journal: Diabetes
Diabetes 2019;68(Supplement_1):14-LB
DOI: https://doi.org/10.2337/db19-14-LB
Published: 01 June 2019
View article titled, 14-LB: Somatostatin Receptor 2 Antagonism Enhances Plasma Glucagon Levels during Insulin-Induced Hypoglycemia in a Rodent Model of Type 2 Diabetes Mellitus
Meeting Abstracts

GLP-1 Secretion Is Increased upon Blockade of the Somatostatin Receptor Subtype 2 and 5 Resulting in GLP-1 Receptor-Mediated Lowering of Blood Glucose in Mice

SARA L. JEPSEN, NICOLAI J. WEWER ALBRECHTSEN, JENS PEDERSEN, MAJA S. ENGELSTOFT, CAROLYN F. DEACON, JENS J. HOLST
Journal: Diabetes
Diabetes 2018;67(Supplement_1):1968-P
DOI: https://doi.org/10.2337/db18-1968-P
Published: 01 July 2018
View article titled, GLP-1 Secretion Is Increased upon Blockade of the Somatostatin Receptor Subtype 2 and 5 Resulting in GLP-1 Receptor-Mediated Lowering of Blood Glucose in Mice
Meeting Abstracts

Somatostatin Receptor II Antagonism Improves Glucagon Counterregulatory Responses to Recurrent Hypoglycemia in Male Sprague-Dawley Rats

MICHAEL RIDDELL, MAHSA JAHANGIRIESMAILI, ERIN R. MANDEL, CAYLEE A. GREENBERG, AOIBHE M. PASIEKA, TREVOR TEICH, OWEN CHAN, RICHARD T. LIGGINS
Journal: Diabetes
Diabetes 2018;67(Supplement_1):394-P
DOI: https://doi.org/10.2337/db18-394-P
Published: 01 July 2018
View article titled, Somatostatin Receptor II Antagonism Improves Glucagon Counterregulatory Responses to Recurrent Hypoglycemia in Male Sprague-Dawley Rats
Meeting Abstracts

Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis.

U Kumar, R Sasi, S Suresh, A Patel, M Thangaraju, P Metrakos, S C Patel, Y C Patel
Journal: Diabetes
Diabetes 1999;48(1):77–85
DOI: https://doi.org/10.2337/diabetes.48.1.77
Published: 01 January 1999
View article titled, Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis.
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Journal Articles

Insulin, Glucagon, and Somatostatin Receptors on Cultured Cells and Clones from Rat Islet Cell Tumor

Sam J Bhathena, Herbert K Oie, Adi F Gazdar, Nancy R Voyles, Samuel D Wilkins, Lillian Recant
Journal: Diabetes
Diabetes 1982;31(6):521–531
DOI: https://doi.org/10.2337/diab.31.6.521
Published: 01 June 1982
View article titled, Insulin, Glucagon, and Somatostatin Receptors on Cultured Cells and Clones from Rat Islet Cell Tumor
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Journal Articles

Kinetics of Somatostatin Receptor Migration in Isolated Pancreatic Islets

Boris Draznin, J Wayne Leitner, Karl E Sussman
Journal: Diabetes
Diabetes 1982;31(5):467–469
DOI: https://doi.org/10.2337/diab.31.5.467
Published: 01 May 1982
View article titled, Kinetics of Somatostatin Receptor Migration in Isolated Pancreatic Islets
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